• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4677-4681
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• 2012

Objective: Egg consumption has been suggested to increase the risk of colorectal and some other cancers. The present study summarized and quantified the current evidence relating dietary intake of eggs and prostate cancer. Materials and methods: Literature searches were conducted to identify peer-reviewed manuscripts published up to July 2012. Twenty manuscripts from nine cohort studies and 11 case-control studies were identified. Summary risk estimates with 95% confidence intervals (CIs) were calculated for case-control and cohort studies separately. Results: Neither the case-control not the cohort studies showed any association of prostate cancer incidence with egg consumption (case-control studies: odds ratio 1.09, 95% CI 0.86-1.31; cohort studies: relative risk 0.97, 95% CI 0.97-1.07). The results were consistent in subgroup analysis. Furthermore, no association was observed between egg consumption and prostate cancer-specific mortality. Conclusions: Our analyses provided no evidence of a significant influence of egg consumption on prostate cancer incidence and mortality. However, more studies, particularly large prospective studies, are needed.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 춘계학술발표대회
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• pp.527-530
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• 2000

중국산 야생키위로 total RNA를 추출하고 RT-PCR를 실시해서 증폭된 1.2kb fragment를 얻어 pGEM-T Easy에 cloning한 후 염기서열과 아미노산 서열을 비교 분석한 결과 actinidin gene인 것으로 분석되었다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.1337-1339
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• 2003

In this article, a new remote sensing image fusion model based on modified Kohonen networks is given. And a new fusion rule based on modified voting rule was established. Select Shaoxing City as the study site, located at Zhejiang Province, P.R.China. The fusion experiment between Landsat TM data (30m) and IRS-C Pan data (5.8m) was performed using the given fusion method. The fusion results show that the new method can gain better result in apply ing to the lower hill area, and the whole classification accuracy was 10% higher than the basic Kohonen method. The confusion between the woodlands and the waterbodies was also diminished.

• International journal of advanced smart convergence
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• 제9권4호
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• pp.52-61
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• 2020

The AHP method was used in 30 provinces of China to construct the index system of creative space efficiency evaluation and determine the weight of each index. The fuzzy comprehensive evaluation method was further used to score the indexes at all levels, and then the total efficiency score was sorted. The purpose of this study is to adjust the regional layout of creative space reasonably and implement financial policies accurately through the evaluation of the efficiency of creative space. The results is ranking top in weight of several indicators, which include the number of incubated Startups, the number of innovation and entrepreneurship mentors, the survival rate of incubator, the innovative training activities, etc. It was also found that Beijing, Shanghai, Jiangsu, Guangdong and Zhejiang ranked first in the score of creative space efficiency. This study is meaningful in that it was In order to effectively solve the problem of the imbalance of the creative space efficiency in China's province, by coordinating the regional pattern, establishing a sound service system and improving the efficiency evaluation system.

• 융합경영연구
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• 제1권1호
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• pp.1-14
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• 2013

Firstly, this article expounds that business service industry plays an important role in adjusting industrial structure, transforming mode of economic growth, improving people's living standards, enhancing Enterprise's Kernel Competitiveness and promoting the development of service industry. Then it analyzes the development of business services in Shandong from two perspectives. The first perspective, by using methodology for statistical analysis, it will review the development scale, professional level, the number of opening units, quantity of employment, and operating revenue of business services in Shandong. On this basis, the article will summarize its development characteristics, experience and existing shortcomings. The second perspective, by using comparison analysis methodology, to compare the development of Shandong with Jiangsu, Guangdong, Zhejiang and Shanghai's and found the subjective and objective factors that restrict the development of business service industry in Shandong. In the light of restricting factors, countermeasures have been developed based on the experience at home and abroad. These countermeasures will contribute to promoting the optimization and upgrading of industrial structure, improving industrial competitiveness and speeding up the economic development rapidly and stably.

• 산업경영시스템학회지
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• 제45권3호
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• pp.197-203
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• 2022

Urban space expansion is an important symbol of the urbanization process and has always been an important topic in urban studies. In addition, for sustainable city management, it is important to identify factors that can influence, such as the driving force and direction of urban space expansion, from the stage of establishing an urban development plan. To understand these factors, by observing the expansion process of a specific city, it is possible to sufficiently observe how the urban spatial dimension changes. Through a series of processes, the spatial growth characteristics of the city are analyzed, and the influence and results of important factors are analyzed. For this purpose, this paper examines the changes in the city's outer boundary and land use structure through monitoring data on urban areas of 14 cities in Hunan Province, China from 2000 to 2016. Temporal and spatial regularity according to the urban space expansion of these cities were analyzed, and a preliminary assessment was made on whether the urban space expansion is coordinated with the urban population growth. The assessment result showed: (1) The urban space of most cities has been extended rapidly in 2000-2015 however, the rate and the intensity of urban space expanding has been declining. (2) The construction of the industrial park is the core driving force of the urban space expanding, and the change of the urban space structure is manifested as enclave city expansion because that the industrial park is usually far away from the city center. (3) The population agglomeration is another driving force of the urban space expanding. At this time, the urban space expanding is like boundary extension. (4) Except Changsha city, all of the cities has a high urbanization-area-growth elastic coefficient. It means that most of the cities should enhance the land use degree.

• Parasites, Hosts and Diseases
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• 제54권6호
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• pp.703-710
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• 2016

The trichomonad species Tritrichomonas foetus and Pentatrichomonas hominis were recently detected in the feces of dogs with diarrhea. However, little information is available on the prevalence and pathogenicity of these parasites in the canine population. Therefore, the aim of this study was to determine the prevalence and molecular characterization of trichomonads infecting pet dogs in Anhui and Zhejiang provinces, east China. In total, 315 pet dogs, with or without diarrhea, from 7 pet hospitals were included in this epidemiological survey. Microscopy and PCR detected P. hominis in 19.7% (62/315) and 31.4% (99/315) of fecal samples, respectively. T. foetus infection was detected in 0% (0/315) of samples with microscopy and in 0.6% (2/315) with PCR. The prevalence of P. hominis was significantly higher in young dogs (${\leq}12months$) than in adult dogs (>12 months), and was significantly higher in diarrheic dogs (50.6%) than in non-diarrheic dogs (24.3%; P<0.05). Infection with T. foetus did not correlate with any risk factors evaluated in this study. A sequence analysis of the P. hominis PCR products showed minor allelic variations between our sequences and those of P. hominis strains from other hosts in different parts of the world. Type CC1 was the most common strain in dogs in east China. The internal transcribed spacer 1 (ITS1)-5.8S rRNA gene sequences from the 2 T. foetus isolates detected in this study displayed 100% identity and were homologous to the sequences of other strains isolated from domestic cats in other countries.

• 건축역사연구
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• 제16권3호
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• pp.7-20
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• 2007

A bridge is a space used as a passage. This space should be functional, solid, and beautiful. Since the beginning of human life, bridge architecture has given importance to function as a connection from one place to another. Stepping stones in the stream were the connections between divided spaces in the agricultural life, the bridge on the entrances of a town was the place for separation, expectation, and communication for people gathering around the community. Southern Chinese provinces such as Zhejiang, Hunan, Yunnan, and Guizhon is famous for it's spectacular scenary, and tribes like the 'Miao' and 'Dong' live in a cooperate community. The 'Dong' tribe is one of the 'Yue' genealogy where the people have settled down in this place in the days of 'Qin Shi Huang(Qin dynasty)'. As the population of the 'Dong' tribe growed, they used a bridge to connect town to town. The scale became larger with additional design, giving splendid achievement to bridge architecture. The 'Fungyu bridge' in Tongdao and 'Chungyang bridge' in Sanjiang are some fine examples. The Fungyu bridge could be defined as a bridge which blocks wind and rain, this has the same function as the lounge bridge in Taishun located in southern Zhejiang province. In Taishun, 5 minority races such as the 'Dong' and 'Miao' people have been living together as a clan society for centuries on mountains as high as 1000m following their own tradition. The 'Xiliu river' flowing thorough has a variety of bridges remaining in it's original form, and it is recently known as a museum of ancient bridges. The formation of the bridges in Tongdao and Taishun shows that it is different with the arch and straight bridges remaining in Korea. In this study, it is readjusting the base data, showing plan characteristics and describing the construction of the wooden structure above the bridge post.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5983-5987
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• 2013

Radix Tetrastigma Hemsleyani Flavone (RTHF) is widely used as a traditional herb for its detoxification and anti-inflammation activity. Recently, several studies have shown that RTHF can inhibit growth and induce apoptosis in human cancer cell lines. However, the mechanisms are not completely understood yet. In this study we investigated the potential effects of RTHF on growth and apoptosis in human lung adenocarcinoma A549 cells as well as its mechanisms. A549 cells were treated with RTHF at various concentrations for different times. In vitro the MTT assay showed that RTHF had obvious anti-proliferation effects on A549 cells in a dose- and time-dependent manner. Cell morphological changes observed by inverted microscope and Hoechst33258 methods were compared with apoptotic changes observed by fluorescence microscope. Cell apoptosis inspected by flow cytometry showed significant increase in the treatment group over the control group (P<0.01). Expression of apoptosis related Bax/Bcl-2, caspases and MAPK pathway proteins were detected by Western blotting. The results showed that RTHF up-regulated the Bax/Bcl-2 ratio and cle-caspase3/9, cle-PARP expression in a dose-dependent manner. Expression of p-p38 increased, p-ERK decreased significantly and that of p-JNK was little changed in the RTHF group when compared with the control group. These results suggest that RTHF might exert anti-growth and apoptosis activity against lung cancer A549 cells through activation of caspases and Bcl-2 family proteins and the MAPK pathway, therefore presenting as a promising therapeutic agent for the treatment of lung cancer.

• Nutrition Research and Practice
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• 제17권6호
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• pp.1070-1083
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• 2023

BACKGROUND/OBJECTIVES: Sanghuangporus sanghuang (SS) has various medicinal effects, including anti-inflammation and anticancer activities. Despite the extensive research on SS, its molecular mechanisms of action on lung cancer are unclear. This study examined the impact of an SS alcohol extract (SAE) on lung cancer using in vitro and in vivo models. MATERIALS/METHODS: Different concentrations of SAE were used to culture lung cancer cells (A549 and H1650). A cell counting kit-8 assay was used to detect the survival ability of A549 and H1650 cells. A scratch assay and transwell cell invasion assay were used to detect the migration rate and invasive ability of SAE. Western blot analysis was used to detect the expression of B-cell lymphoma-2 (Bcl-2), Bcl2-associated X (Bax), cyclin D1, cyclin-dependent kinases 4 (CDK4), signal transducer and activator of transcription 3 (STAT3), and phosphorylated STAT3 (p-STAT3). Lung cancer xenograft mice were used to detect the inhibiting ability of SAE in vivo. Hematoxylin and eosin staining and immunohistochemistry were used to detect the effect of SAE on the structural changes to the tumor and the expression of Bcl-2, Bax, cyclin D1, CDK4, STAT3, and p-STAT3 in lung cancer xenograft mice. RESULTS: SAE could inhibit lung cancer proliferation significantly in vitro and in vivo without cytotoxicity. SAE suppressed the viability, migration, and invasion of lung cancer cells in a dose and time-dependent manner. The SAE treatment significantly decreased the proapoptotic Bcl-2/Bax ratio and the expression of pro-proliferative proteins Cyclin D1 and CDK4 in vitro and in vivo. Furthermore, SAE also inhibited STAT3 expression. CONCLUSIONS: SAE reduced the cell viability and suppressed cell migration and invasion in human lung cancer cells. Moreover, SAE also exhibited anti-proliferation effects in vivo. Therefore, SAE may have benefits in cancer therapy.