• Natural Product Sciences
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• v.16 no.4
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• pp.265-270
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• 2010

The methanol extract of Zanthoxylum rhetsa (MZRR) were evaluated for its ability to suppress the formation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. MZRR presented an inhibition of LPS-induced production of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) in RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that MZRR significantly inhibited the protein and mRNA expressions of iNOS and COX-2 in LPS-activated macrophages in a dose-dependent manner. LPS-induced COX-2, iNOS, and nuclear factor kappa beta (NF-${\kappa}B$) activity were also decreased in the presence of MZRR. The production of tumor necrosis factor-$\alpha$ (TNF-$\alpha$), the mRNA expression levels of pro-inflammatory cytokines, including TNF-$\alpha$ and IL-$1{\beta}$, were reduced after MZRR administration in a dose dependent-manner. These results suggest that the MZRR extract involved in the inhibition of iNOS and COX-2 via the NF-${\kappa}B$ pathway, revealing a partial molecular basis for anti-inflammatory properties of the MZRR extract.

• Journal of Forest and Environmental Science
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• v.39 no.3
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• pp.155-166
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• 2023

Consumption and selling of Non Timber Forest Products (NTFPs) are important means to meet nutritional requirements and improve the socio-economic conditions of the rural population. The purpose of this study was to document the status and utilization pattern and assess the economic value of NTFPs sold in the markets of the Itanagar Capital Region (ICR) of Arunachal Pradesh. Five major markets with 182 vendors were surveyed, and a total of 94 plant-based products under 63 species belonging to 32 families were found to be sold in the markets. Species like Acmella oleracea, Clerodendrum glandulosum, Dioscorea alata, Houttuynia cordata, Phoebe goalparensis, Piper pedicellatum, Zanthoxylum rhetsa, etc. are found to be highly preferred and have a higher demand in the local markets. The edible products of species like Piper pedicellatum and Phoebe goalparensis though highly consumed in the study area, are used only within the region, and the national and international demands of the species are nil. The animal-base products are not included in the study.