• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• Geomechanics and Engineering
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• 제29권6호
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• pp.615-626
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• 2022

The soft clays are widely distributed, and one of the prominent engineering problems is the creep behavior. In order to predict the creep deformation of soft clays in an easier and more acceptable way, a simple creep constitutive model has been proposed in this paper. Firstly, the triaxial creep test data indicated that, the strain-time (𝜀-t) curve showing in the 𝜀-lgt space can be divided into two lines with different slopes, and the time referring to the demarcation point is named as t_EOP. Thereafter, the strain increments occurred after the time t_EOP are totally assumed to be the creep components, and the elastic and plastic strains had occurred before t_EOP. A hyperbolic equation expressing the relationship between creep volumetric strain, stress and time is proposed, with several triaxial creep test data of soft clays verifying the applicability. Additionally, the creep flow law is suggested to be similar with the plastic flow law of the modified Cam-Clay model, and the proposed volumetric strain equation is used to deduced the scaling factor for creep strains. Therefore, a creep constitutive model is thereby established, and verified by successfully predicting the creep principal strains of triaxial specimens.

• 대한기계학회논문집A
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• 제23권7호
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• pp.1164-1172
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• 1999

In this study, to investigate the fatigue crack retardation behavior and the variability of retardation cycles, fatigue crack growth tests were conducted on 7075-T6 aluminum alloy under single tensile overload. A retardation coefficient, D was introduced to describe fatigue crack retardation behavior and a random variable, Z to describe the variability of fatigue crack growth. The retardation coefficient was separately formulated according to retardation behavior which is composed of delayed retardation part and retardation part. The random variable, Z was evaluated from experimental data which was obtained from fatigue crack growth tests under constant amplitude load. Using these variables, a probabilistic model was developed on the basis of the modified Forman's equation, and retardation behavior and cycles were predicted under certain overload condition. The predicted retardation curve well agrees with the trend of experimental crack retardation behavior. And this model well predicts the scatter of experimental retardation cycles.

• 한국수산과학회지
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• 제47권6호
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• pp.901-907
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• 2014

We investigated the population ecology of blackthroat seaperch, Doederleinia berycoides, from samples collected in the southern seas of Korea from January to December, 2006. Population ecological parameters included survival rate, the instantaneous coefficient of natural and fishing mortality, and age at first capture. The survival rate (S) of blackthroat seaperch was estimated as 0.4966 using the catch curve method. The instantaneous coefficient of total mortality (Z) was 0.8598/year. The instantaneous coefficient of natural mortality (M) was estimated as 0.4694/year. From the estimates of Z and M, the instantaneous coefficient of fishing mortality (F) was calculated as 0.3904/year. The age at first capture ($t_c$), based on the Pauly method, was 2.87 years.

• KEPCO Journal on Electric Power and Energy
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• 제2권4호
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• pp.601-608
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• 2016

접지전극이 매설되는 토양의 전기적 특성은 지역, 계절, 환경적 요인에 따라 저항률이 다양하게 변화한다. 접지전극 주변에서의 전기적 방전현상은 매우 다르게 발생하고, 이는 접지의 성능에 큰 영향을 미친다. 접지시스템의 설계 시에 다양한 조건에서 토양의 방전 특성과 이온화 현상에 관한 분석이 필요하다. 본 연구의 목적은 토양의 이온화 현상과 과도접지임피던스의 상관관계를 파악하는데 있다. 본 논문에서는 뇌임펄스전압에 의해 접지극 주변에서 발생하는 토양의 이온화 작용과 관련된 파라미터와 과도적인 접지저항에 관한 실험적 연구결과를 기술하였다.

• Nuclear Engineering and Technology
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• 제16권2호
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• pp.89-96
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• 1984

현재 서울대학교 원자핵공학과에서 제작중인 SNUT-79 토카막 장치에서의 고온 플라즈마의 구속을 위해서 순인장력 D형 곡선을 가진 토로이달 자장 코일을 수치 해석적 방법으로 설계하였다. 16개의 D형 토로이달 코일 뭉치는 플라즈마가 없는 경우 자장의 세기가 3T가 되도록 설계하였다. 토로이달 리플은 플라즈마영역에서 평균 토로이달 자장의 4%이하이다. 6개로 된 평형 코일의 위치와 전류 값을 Fredholm 제1종 적분 방정식을 선형 방정식으로 변환하여 얻었다. 평형 자장의 곡률도는 플라즈마 루프의 수직 수평 방향의 변위에 대한 안정화 조건을 만족시켰다.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.387-391
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• 2002

The oral absorption and disposition of itraconazole were studied in rats, rabbits and dogs. Serum levels of itraconazole and its active metabolite, hydroxyitraconazole, were determined by a validated HPLC method. The absorption of itraconazole was relatively rapid in rats and dogs but was slower in rabbits. The terminal elimination half-life ($T_{1/2,{\lambda}z}$), time to the peak concentration ($T_{max}$), dose and weight normalized area under the curve (AUC) and the peak concentration ($C_{max}$) of itraconazole found in the dog were comparable to those reported in humans. As in humans, the metabolite to parent drug AUC ratios in rats and dogs were greater than unity but was less in rabbits. The dog appears to be an appropriate animal model while the rat, not the rabbit, may be used as an alternative animal model in predicting the oral absorption of itraconazole in humans.

• 수산해양기술연구
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• 제19권2호
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• pp.111-116
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• 1983

국산 자기컴퍼스의 제작에 필요한 기초자료를 제공하기 위하여 인공자기장 발생장치를 제작하여 그 특성을 조사하였고, 인공자장내에서의 자기컴퍼스의 제진 특성을 시험하여 자기컴퍼스의 성능을 부석, 검토한 결과는 다음과 같다. 1. 코일의 굵기 1mm, 직경 1 m, 권회수 117회인 인공자장발생장치의 전류(I sub(i))와 자장의 세기와의 사이에는 수직자장: Z(Gauss)=0.34+1.506 I sub(i) 수평자장: H(Gauss)=0.1834+1.506 I sub(i)의 관계가 있다. 2. T190형 자기컴퍼스는 T165형 자기컴퍼스에 비하여 전 tnbud자장 범위에서 주기는 길었으며, 진폭은 0.08 Gauss 이상에서는 크고, 그 이하에서는 작은 경향을 보였다. 3. 수평자장이 강할수록 주기와 자기자오선에 복귀하는 시간은 짧아지고, 진폭과 주행각은 커졌으며, 제진곡선의 주요점까지의 경과시간(Ti)은 수평자장(H)의 -0.65승에 비례하였고, 과행각(P sub(i))은 0.18승에 비례하였다.

• Journal of Pharmaceutical Investigation
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• 제39권1호
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• 수산해양기술연구
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• 제40권4호
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• pp.319-327
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• 2004

本 硏究에서 試驗制作한 電子컴퍼스는 3軸磁氣센서와 傾斜角센서, 그리고 光자이로센서로 構成하였으며, 이들 각 센서의 出力特性과 性能 및 自差補正의 精度를 확인한 結果는 다음과 같다. 1) 3軸 磁氣센서의 出力特性은, X軸에서 측정된 磁界는 cos커브, Y軸에서는 -sin 커브, 그리고 Z軸에서는 그 값이 일정하게 나타나고 있어서 3軸 磁氣센서로서의 기능이 충분하다고 사료되며, 이때 出力電壓으로부터 算出된 地磁氣의 水平成分 H와 垂直成分 V는 각각 H=33.2${\mu}$T, V=23.95${\mu}$T였다. 2)光자이로 센서를 電動回轉台에 고정시키고, 시계방향으로 10$^{\circ}$/sec, 20$^{\circ}$/sec, 30$^{\circ}$/sec의 속도로 회전시켰을 때, 光자이로센서의 出力과 回轉角度와의 관계는 모두 일정한 값으로 비례함을 알 수 있다. 3) 補正前 自差는 磁界에 의해 誘導되고 있기 때문에, 최대 -25$^{\circ}$까지 크게 나타나고 있으나, 포와숀 補正法을 이용한 補正後의 자差는 ${\pm}2^{\circ}$ 범위 이내로 補正前에 비하여 自差가 현저히 작게 나타나고 있어서, 이번 硏究에서 試驗制作한 電子컴퍼스로 自動自差修正이 가능함을 확인할 수 있었다.