• The Journal of Dong Guk Oriental Medicine
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• v.7 no.2
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• pp.149-154
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• 1999

The effect of Yukilsunki-tang extracts on global cerebral ischemia were investigated in this study. The multiple parameters of global cerebral ischemia assessed in mice included the duration of KCN-induced(1.8mg/kg i.v.) coma, the survival time of KCN-induced(3.0mg/kg i.v.) coma, the survival time exposed to hypoxia induced by vacuum pump. In the case of global cerebral ischemia International Cancer Research mice were used and divided into two groups at random Group A, normal control, was treated after oral administration of normal saline. Group B, experimental control, was treated after oral administration of 13.2mg/20g of Yukilsunki-tang extracts. Each treatment was KCN-induced(1.8mg/kg i.v.) coma, KCN-induced(3.0mg/kg i.v.) coma and exposure to hypoxia induced by vacuum pump. The results were obtained as follows ; In global cerebral ischemia, Yukilsunki-tang extracts significantly prolonged the duration of KCN-induced(1.8mg/kg i.v.) coma, the survival time of KCN-induced(3.0mg/kg i.v.) coma and the survival time of exposure to hypoxia induced by vacuum pump in mice. Conclusion Yukisunki-tang extracts had a significant effect on Global cerebral ischemia.