• The Korean Journal of Rehabilitation Nursing
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• v.15 no.2
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• pp.73-82
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• 2012

Purpose: The purpose of this study was to identify the influencing factors on mental health related quality of life (MHRQoL) in adults across the lifespan. Methods: A total of 688 Korean adults aged 19 years and older were selected. Data were collected by personal interviews or self report using structured questionnaires. For data analysis, t-test, ANOVA, Pearson's correlation coefficients and Stepwise multiple regression were used. Results: Mental health related quality of life (MHRQoL) differed significantly according to life cycle, especially showing a lower score in the elderly than others. In addition, elderly adulthood reported the highest stress and depression. The most significant predictors of MHRQoL in young and middle aged people were stress, depression, and subjective health status. Predictors of MHQoL in the elderly were stress and religion. Conclusion: The results indicate that MHRQoL of adult is associated with stress and depression. When the programs are developed to enhance mental health in elderly adulthood, religion should be considered as well as stress.

• Korean Journal of Clinical Laboratory Science
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• v.42 no.2
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• pp.92-96
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• 2010

The National Health Insurance Corporation (NHIC) was performed population health checkup survey program with especially two target ages, 40 years and 66 years old that were called as "life transition period" for national collective prophylaxis of cardiovascular diseases in Korea. We were investigated and compared between two age groups with the serum levels of cholesterol and triglyceride from data of the survey in Daegu province, Korea at April, 2007. Data of one hundred persons per each age (40 years and 66 years old) were collected and investigated for risk factors for chronic degenerative diseases including serum lipid concentration, health habits of drinking, smoking, exercise etc. In spite of the definite difference of life transition of the each age, the transition from adolescence to adulthood at 40 years old, and from adulthood to senescence at 66 years old, there were no significant difference of total cholesterol and triglyceride between two age groups.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.16 no.3
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• pp.353-361
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• 2009

Purpose: The purpose of this study was to examine the relationship of adult the women's satisfaction with their appearance, self-esteem, depression and stress to health related quality of life (HRQOL) across the lifespan. Method: In this study a convenience sample of Korean women aged 20 years and over was used. There were 1152 women and data were collected from November 2007 to February 2008. Results: There was no difference in satisfaction with appearance in all age group. Elderly women reported lowest self esteem and HRQOL and highest depression and stress. There were statistical significances between satisfaction with appearance, self-esteem, depression, stress and HRQOL for all age groups. The most significant predictors of HRQOL in early adulthood women were stress and depression. The most significant predictors of HRQOL in middle adulthood women were stress, disease, depression, self-esteem, and monthly income. The most significant predictors of HRQOL in elderly women were stress, disease, depression, and satisfaction with appearance. Conclusion: The results indicate that HRQOL of Korean women is associated with psychological distress as with stress and depression. When developing programs to enhance health in elderly women, consideration should be given to body image as well as psychological distress and chronic conditions.

• Journal of Genetic Medicine
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• v.19 no.1
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• pp.22-26
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• 2022

Cerebrotendinous xanthomatosis (CTX) is a rare genetic disease caused by a deficiency of enzymes for the synthesis of bile acid, resulting in the accumulation of cholestanol with reduced chenodeoxycholic acid (CDCA) production and causing various symptoms such as chronic diarrhea in infancy, juvenile cataracts in childhood, tendon xanthomas in adolescence and young adulthood, and progressive neurologic dysfunction in adulthood. Because oral CDCA replacement therapy can effectively prevent disease progression, early diagnosis and treatment are critical in CTX. This study reports the case of CTX in a 10-year-old male who presented with Achilles tendon xanthoma and mild intellectual disability. Biochemical testing showed normal cholesterol and sitosterol levels but elevated cholestanol levels. Genetic testing showed compound heterozygous variants of CYP27A1, c.379C>T (p.Arg127Trp), and c.1214G>A (p.Arg405Gln), which confirmed the diagnosis of CTX. The patient had neither cataracts nor other focal neurologic deficits and showed no abnormalities on brain imaging. The patient received oral CDCA replacement therapy without any adverse effects; thereafter, the cholestanol level decreased and no disease progression was noted. The diagnostic possibility of CTX should be considered in patients with tendon xanthoma and normolipidemic conditions to prevent neurological deterioration.

• Korean Journal of Culture and Social Issue
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• v.10 no.1
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• pp.31-82
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• 2004

The purpose of this study was development of a synthetic scale to measure young adults' views of life and death. Participants were 610 university students. The authors developed a View of Life and Death Scale including several subscales of afterlife views(belief in afterlife and retribution, belief in souls' effects and transmigration), meanings of death(liberation, nature, integration, collapse, impact, futility), death anxiety, death concern(death acceptance, death awareness) and life respect will(suicide inhibition, abortion inhibition, organ donation intention). The present study contributed to enhance our understanding of view of life and death in young adulthood. This study, therefore, could work as a stepping stone to investigate the structural relationship among elements included in views of life and death in young adulthood and to explore the consequences and determinants of personal view of life and death.

• Clinical and Experimental Pediatrics
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• v.56 no.5
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• pp.191-195
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• 2013

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma can allow further modulation of the natural history of severe asthma and may provide the pathophysiologic rationale for appropriate management strategies.

• Journal of Interdisciplinary Genomics
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• v.4 no.1
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• pp.11-14
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• 2022

Primary ciliary dyskinesia (PCD) is a genetic disorder that affects approximately 1 in 15,000-30,000 people, with the majority of patients inheriting the disorder via autosomal recessive inheritance. PCD is characterized by abnormal ciliary ultrastructure and/or function, which results in impaired mucociliary clearance and recurrent respiratory infections. Despite the presence of symptoms from birth, many patients with PCD remain undiagnosed until adulthood. Many advances in the diagnosis of PCD have occurred in recent years, including nasal nitric oxide assays, ciliary motility tests, and genetic sequencing. Early diagnosis and symptom management may reduce morbidity and mortality from PCD improving the patient's quality of life.

• Journal of Families and Better Life
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• v.20 no.3
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• pp.39-47
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• 2002

This study analyses young adults'perceptions of the meanings and motivations of parenthood. It also verifies the relationship between the meanings and motivations of parenthood by young adults. The sample population included 311 university students. Our findings show that young adults perceived parenthood variously as a personal lifestyle, and as an statement of social maturation and sound mind and of marital satisfaction. There were no differences by gender in their perceptions on the meaning of parenthood. As for the motivation to become parents, strengthening biological family ties, traditional norms, emotional and altruistic reasons, deepening marital bonds, and perpetuating one's self through the passing on of genes. Among these, altruistic-emotional motivation and marital cohesion were stronger than other motivations. Finally, we provide recommendations for future research.

• Journal of Yeungnam Medical Science
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• v.37 no.4
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• pp.341-344
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• 2020

Hereditary neuropathy with liability to pressure palsy (HNPP) is a rare neurological genetic disease caused by deletion of the peripheral myelin protein 22 gene and presents in childhood or young adulthood. We report four cases of HNPP with typical and rare presentations, reflecting the broad clinical spectrum of this disease. Two patients presented with mononeuropathies that are frequently observed in HNPP; the remaining two presented with bilateral neuropathy or mononeuropathy anatomically present in the deep layer. This reflects the broad clinical presentation of HNPP, and clinicians should differentiate these conditions in young patients with monoparesis or bilateral paresis. Although HNPP is currently untreatable, early diagnosis in the emergency department can lead to early detection, eventually resulting in less provocation and recurrence which may cause early motor nerve degeneration.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.31 no.2
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• pp.88-93
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• 2020

Objectives: Mood disorder is highly comorbid with attention deficit/hyperactivity disorder (ADHD), and comorbid ADHD symptoms are associated with suicide risk. The aim of this study was to examine the association between comorbid ADHD symptoms and the number of suicide attempts among patients with unipolar and bipolar depression. Methods: In this cross-sectional study, 100 patients with either unipolar or bipolar depression constituted the final sample. Pearson's correlation and multiple regression analyses were conducted to examine the association between comorbid ADHD symptoms and suicide risk. Results: Among patients with bipolar depression, the number of suicide attempts was significantly correlated with ADHD symptoms (r=0.324, p<0.01). ADHD symptoms significantly predicted the number of suicide attempts (β=0.249, p<0.05). Conclusion: Our findings underscore the importance of screening and assessing ADHD symptoms in male young adults with depressive disorders.