• 대한의생명과학회지
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• 제29권4호
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• pp.302-313
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• 2023

Y chromosomal short tandem repeat (Y-STR) markers have been developed continuously to complement forensic DNA analyses and population genetic studies. Initially, we collected data from previously reported Korean population Y-STR haplotype studies on 1133 individuals. We then conducted a marker expansion analysis using a dataset from the Y-STR Haplotype Reference Database (YHRD), covering up to 29 Y-STRs, referred to as Ymax. Additionally, we examined the impact of rapidly mutating (RM) Y-STRs included in this expanded marker set on the discrimination capacity. We observed that marker expansions both with (0.9896), and without (0.9510), RM Y-STR improved the discrimination capacity. Subsequently, we focused on 16 individuals belonging to seven distinct groups sharing identical haplotypes. These particular haplotypes had been previously identified among 476 unrelated males using 23 Y-STR markers from the PowerPlex^® Y23 System. We expanded the marker panel up to Ymax to explore how discrimination improved with an expansion of Y-STR markers for these 16 individuals. Among the expanded markers, DYS627, which had high discriminatory power, had a high mutation rate (1.10 × 10^-2) and high gene diversity (0.83). In contrast, DYF387S1 displayed high gene diversity (0.95) but a relatively low mutation rate (2.80 × 10^-3). We propose that these findings will be valuable in the selection of suitable Y-STR markers, depending on the objectives of forensic analyses. Additionally, the presence of frequently observed Y-haplotypes in Korean population will facilitate statistical interpretation in Y-STR DNA profiling.

• The Korean Journal of Physiology and Pharmacology
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• 제28권2호
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• pp.153-164
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• 2024

This study aimed to identify metabolic biomarkers and investigate changes in intestinal microbiota in the feces of healthy participants following administration of Lactococcus lactis GEN-001. GEN-001 is a single-strain L. lactis strain isolated from the gut of a healthy human volunteer. The study was conducted as a parallel, randomized, phase 1, open design trial. Twenty healthy Korean males were divided into five groups according to the GEN-001 dosage and dietary control. Groups A, B, C, and D1 received 1, 3, 6, and 9 GEN-001 capsules (1 × 10¹¹ colony forming units), respectively, without dietary adjustment, whereas group D2 received 9 GEN-001 capsules with dietary adjustment. All groups received a single dose. Fecal samples were collected 2 days before GEN-001 administration to 7 days after for untargeted metabolomics and gut microbial metagenomic analyses; blood samples were collected simultaneously for immunogenicity analysis. Levels of phenylalanine, tyrosine, cholic acid, deoxycholic acid, and tryptophan were significantly increased at 5-6 days after GEN-001 administration when compared with predose levels. Compared with predose, the relative abundance (%) of Parabacteroides and Alistipes significantly decreased, whereas that of Lactobacillus and Lactococcus increased; Lactobacillus and tryptophan levels were negatively correlated. A single administration of GEN-001 shifted the gut microbiota in healthy volunteers to a more balanced state as evidenced by an increased abundance of beneficial bacteria, including Lactobacillus, and higher levels of the metabolites that have immunogenic properties.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2007년도 추계학술발표대회
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• pp.1014-1017
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• 2007

무선랜에서는 작은 셀 크기로 인해 노드들의 이동에 따른 빈번한 핸드오프가 이루어진다. 그래서 무선랜에서는 지속적인 통신 서비스를 제공하기 위한 방법으로 모바일 아이피와 같은 방법을 개발하고 있다. 모바일 아이피는 모바일 노드가 한 장소에서 다른 장소로 이동할 때 IP 주소의 변경 없이도 이동할 수 있도록 해준다. 그러나 모바일 아이피는 긴 시간의 등록과정과 연결 재설정 때문에 시간지연이나 패킷 손실과 같은 오버헤드를 발생시킨다. 따라서 무선랜의 QOS(Quality Of Service)를 향상시키기 위해서 Mobile IP 의 핸드오프 시간을 줄여야만 한다. 본 논문은 이러한 문제를 해결하기 위해 핸드오프 지연 시간을 감소시키는 기법을 제안한다. 제안기법의 기본 아이디어는 모바일 노드의 이동 네트워크를 예상하여, 미리 패킷 포워딩을 수행하는데 있다. 우리는 각 모바일 노드들에게 connection proxy table 정보를 추가하였다. 그리고 이 테이블 정보를 이용함으로써 모바일 노드들은 홈에이전트와 포린에이전트에 COA(Care of address)를 미리 등록하는 것이 가능해졌다. 그 결과로 이동 노드들은 홈 네트워크를 완전히 벗어나지 않고도 핸드오프가 이루어져 지속적인 서비스가 가능하였다. 본 논문에서 제안하는 기법이 기존 Mobile IP 와 비교해 볼 때 핸드오프가 이루어지는 동안 비 연결 시간을 줄일 수 있다는 것을 실험결과를 통해서 확인할 수 있었다.

• 반도체디스플레이기술학회지
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• 제23권1호
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• pp.92-96
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• 2024

The application of the technology for forming Al₂O₃ thin films using ALD(atomic layer deposition) method is rapidly increasing in the semiconductor and display fields. In order to increase the efficiency of the ALD process in a mass production line, metallic by-products generated from the ALD process chamber must be effectively collected. By collecting by-products flowing out of the chamber with a cold trap device before they go to the vacuum pump, damage to the vacuum pump can be prevented and the work room can be maintained stably, resulting in increased process flow rate. In this study, a cold trap was installed between the ALD process chamber and the dry pump to measure and analyze by-products generated during the Al₂O₃ thin film deposition process. As a result, it was confirmed that Al and O elements were discharged, and the collection forms were two types: bulk and powder. And the binding energy peaked at 73.7 ~ 74.3 eV, the binding energy of Al 2p, and 530.7 eV, the binding energy of O 1s, indicating that the binding structure was Al-O.

• The Korean journal of internal medicine
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• 제39권1호
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• pp.200-200
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• 2024

• 대한한방소아과학회지
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• 제38권3호
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• pp.66-96
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• 2024

Objectives This study aimed to establish a foundation for research on Korean medicine for epilepsy by analyzing its etiology, syndrome differentiation, and the use of herbal medicines. Methods Articles were extracted from five databases in Korea, Japan, and China: the Oriental Medicine Advanced Searching Integrated System (OASIS), Citation Information by the National Institute of Informatics (CiNii), Chinese National Knowledge Infrastructure (CNKI), Wangfang Database, and Chinese Scientific Journal Database (VIP). The etiology, syndrome differentiation, and herbal medicines used for epilepsy were investigated. Results A total of 64 articles were selected, including seven clinical studies, 16 case reports, and 41 reviews. Epilepsy is a complex disease with various etiologies, and among the five viscera, syndrome differentiation mainly involved the liver, spleen, and kidney, with pathological factors that included phlegm, wind, and blood stasis. Frequently used herbal medicines included Modified Jeongganhwan, Sihogyejitang, Yukgunjatang, and Sihogayonggolmoryotang. Conclusions This study analyzed epilepsy's etiology, syndrome differentiation, and herbal treatments. Further evidence is needed to better understand the efficacy and safety of Korean herbal medicine for treating epilepsy.

• 한국식품위생안전성학회지
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• 제34권6호
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• pp.595-600
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• 2019

본 연구는 아이스플랜트의 기능성 소금 대체제로서의 가능성을 조사하고자 천연 및 정제소금과의 NaCl, D-pinitol, 총 페놀, 총 플라보노이드 및 DPPH 라디칼 소거능에 대한 기초자료를 비교 조사하였다. 아이스플랜트 동결건조분말의 NaCl 함량을 분석한 결과 19%이었고 D-pinitol의 함량은 777 mg/100 g으로 천일염 및 정제염에 비해 NaCl 함량은 유의적으로 낮으나 D-pinitol을 함유하고 있어 건강기능성에는 도움이 될 것으로 사료된다. 또한, 아이스플랜트 동결건조분말의 총 페놀 및 플라보노이드 함량은 각각 115 mg/100 g 및 985 mg/100 g을 함유하고 있어 DPPH라디칼 소거능의 항산화효과를 갖는 것으로 나타났다. 따라서 아이스플랜트 분말의 bioactive compound을 함유한 대체 소금 천연소재로서 가능성을 확인한 기초 연구를 제공하였다.

• Journal of Acupuncture Research
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• 제32권4호
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• pp.177-186
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• 2015

Objectives : This study was performed to analyze treatment outcomes of idiopathic and secondary frozen shoulder patients with clinical characteristics, as well as percentage of pain reduction, and to find out relevant factors for pain reduction in the frozen shoulders of each patient group. Methods : Data were collected from outpatients who visited the Acupuncture and Moxibustion department and treated with traditional Korean Medical treatments at a Korean Medicine Hospital from June 12, 2006 to June 30, 2015. Patients were divided into two groups; idiopathic and secondary frozen shoulder, based on imaging and medical records. Clinical characteristics (demographic characteristics, disease characteristics, treatment characteristics) and percentage pain reduction were collected. Percentage pain reduction was compared between two groups and relevant factors for pain reduction were analyzed. Results : 78 outpatients'medical records were reviewed. There was no significant difference of clinical characteristics between idiopathic and secondary frozen shoulder patients. In percentage pain reduction, there was no significant difference between the two groups. In the idiopathic frozen shoulder group, patients who had a short duration from the onset had a tendency for less pain (p<0.05). In the secondary frozen shoulder group, patients taking herbal medicine experienced significantly less pain (p<0.05). Conclusions : We could find no significant difference in percentage pain reduction with traditional Korean medicine between idiopathic and secondary frozen shoulder. Duration from the onset could be relevant in percentage pain reduction in idiopathic frozen shoulder, and taking herbal medicine could be relevant in the percentage pain reduction in secondary frozen shoulder.

• Journal of Acupuncture Research
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• 제32권4호
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• pp.167-175
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• 2015

Objectives : This study was performed to confirm the effectiveness of East-West collaborative hospital treatment on the prognosis of Bell's palsy. Methods : We screened patients who visited the Facial Palsy Center in Kyung Hee University Korean Medicine Hospital at Gangdong between June 2006 and June 2014 by inclusion/exclusion criteria. We reviewed the medical records of 270 patients, including demographics and results of electromyography. We tried to compare the recovery rate of Bell's palsy in the medical records with that of the previous study by calculating the odds ratio after 2, 3 and 6 months from the onset. Results : The odds ratio between our data and that from the previous study after 6 months from the onset was 4.899. Additionally, the odds ratios after 2 and 3 months from the onset were 1.471 and 2.054, respectively. All the odds ratios showed statistical significance. Conclusions : East-West collaborative hospital treatment showed significant effectiveness on the prognosis of Bell's palsy.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.121-131
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• 2014

Objectives : This study was performed to find the relation between prognosis of peripheral facial palsy and blink reflex. Methods : Data was collected from patients who were admitted and treated by East-West Collaborative Treatment of Facial Palsy Center in Kyung Hee University Hospital at Gangdong from January 2012 to June 2013. Patients were screened by inclusion/exclusion criteria and 163 patients' medical records were reviewed including blink reflex performed $14{\pm}2$ days after onset and House-Brackmann grade. Patients were divided into three groups, normal, delayed and absent group by blink reflex test. Trends of each recovery rate to House-Brackmann grade II and I depending on three group were analyzed at 1 month, 3 months and 6 months after onset using Linear by linear association. Results : At 1 month, 3 months and 6 months after onset, both recovery rate to House-Brackmann grade II and I had a tendency to be decreased statistically significantly in order of normal, delayed and absent group. Conclusions : We could find feasibility of blink reflex as a prognostic factor of peripheral facial palsy. Further study will be necessary.