• Pediatric Infection and Vaccine
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• v.16 no.1
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• pp.54-60
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• 2009

Purpose : Yellow fever, a mosquito-borne viral hemorrhagic fever, is one of the most lethal diseases. Recently there have been an increasing number of Korean children who have travelled to yellow fever endemic zones and were administered yellow fever vaccine (YFV). Therefore, we carried out this study to provide child travelers with safety information of YFV. Methods : This study was conducted at the International Clinic of National Medical Center in Seoul between April 2007 and June 2008 for the evaluation of adverse events of YFV. One hundred twenty-five children received YFV (17-DD) and were prospectively monitored for adverse events through telephone interviews on day 3, 6, 9, 16, 23 and 30 after vaccination. Results : Adverse events were observed in 31 (24.8%) of 125 child travelers who received the YFV. The mean age was 12.5${\pm}$5.0 years. Sixty-six of the child travelers (52.8%) were males. The common adverse events were pain in 11 (8.8%), swelling in 8 (6.4%) and redness in 7 children (5.6%) at the injection site. The systemic adverse events included mild fever in 5 (4.0%), headache in 5 (4.0%), cough in 4 (3.2%), abdominal pain in 3 (2.4%), and vomiting in 2 children (1.6%). Most of the adverse events were detected within 7 days of administration and there were no differences in adverse events by gender or age. All travelers who had complained of symptoms improved spontaneously or following symptomatic treatment. Conclusion : This study showed that YFV is well-tolerated and there were no reports of severe adverse events. Studies are ongoing to clarify the cause and risk factors for rare adverse events.

• The Journal of Internal Korean Medicine
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• v.10 no.1
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• pp.65-80
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• 1989

About Oui-Ga-Sil(胃家實) in order to considerate the contents recorded in Nai-Gyung Sang-Han-Lon and latter literature, definition, etiopathology, syndrome, differential diagnosis, therapy, Prognosis and prevention were classified. And the results were as follows: 1. Oui-Ga(胃家)was a term which indicated the whole digestive system such as stomach, small intestine, large intestine, rectum and anus. Sil(實)could be defined as the peculiar concept pertaining to the acute and last stage which was invaded to inside bowels because of abundance with evil influence. 2. Eliology of Oui-Ga-Sil was abunt gastric fever originally, injured mucus because of mistreatment, the invasion to inside of outside evil influence through meridian. Pathology was the opening and shutting appearance of gastric abundance with intestinal emptiness, and intestinal abundance with gastric emptiness, Oui-Ga-Sil could be occurred because of gastric abundant dryness and splenic humidifying capacity decrease. 3. Symptom of Oui-Ga-Sil was classified as for the sunlight outside syndrome and the inside abundant syndrome. The sunlight outside syndrome was body fever, sweating, no chilling, on the contrary hatred of fever. The chief complaint of inside abundant syndrome was daily fever, talking in delirium, hand and foot sweating, abdominal distention, difficult defection and those could be pertained to sunlight bowel syndrome. 4. Diagnostic views of Oui-Ga-Sil were that pulse was descending abundant large strong and smooth quick, a coated tongue was yellow, deep yellow, old yellow, thick, scorching dry rough or gray black. On abdominal diagnosis, pressing by hand, patient was conscious of pain, excessive pain, rejection against press, impossible press or intermittent abdominal pain and bowel cutting pain without press. 5. Differential diagnosis was that the sunlight of Nai-Gyung-Fever-Theory was outside desease making meridian the prime object, Baik-Ho-Tang syndrome was making figureless abundant fever the pivotal point. And important differential standard of splenic shrink syndrome was that a daily fever, an irritation with fever were not occurred. 6. Theory of Oui-Ga-Sil was that Seng-Gi-Tang classes had been used in attacking downward or making balance, and moxibustion on Jung-Wan, honey boiling induction theory had been also used. Attacking downward therapy was invigorating method to preserve mucus, and if mucus had been exausted with complicating emptiness prognosis had been appeared badly. 7. Preventing from Oui-Ga-Sil diet by rule, fitness to cold and warmth may be needed to prevent outside evil influence attack and inside evil influence occurrence. Prudence with being very busy, fatigue, wine and woman may be also needed not to be an injury to splanic and gastric spirit.

• The Journal of Internal Korean Medicine
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• v.11 no.1
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• pp.1-13
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• 1990

We objerved the following results from The Yellow Emperior's Canon of Internal medicine through the investigation of literature about fever. 1. Fever is divieded two type asthenic fever sthenic heat and It accused two type of excess of Yang-exoganous heat, deficiency of Yin-internal fever 2. The cause of fever is divieded three type, exoganous cause, internal cause non-exoganouse and internal cause Among the cause of fever Exoganous cause is almost affected by cold-evil Internal cause is affected by deficiency of Yin and seven emotion caused by having sex after intoxigation or over-exertion, and non-exoganous and internal cause bring about the difference of a personal life and food and drink 3. The sympton produced by fever is appeared differently through-pulse and meridian and they are indication of Diagnosis 4. The theory of treatment about fever are as follows Drinking cold-water Practising acupuncture Trerating hot-evil by cold Dispel cold by warm Treating cold-evil by heat Promote vital energy circulation by cold Treating warm-evil by cold Promating circulation by cold Treating cold-evil by warm Promoting circulation by heat.

• Parasites, Hosts and Diseases
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• v.57 no.3
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• pp.283-290
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• 2019

A rapid diagnostic test (RDT) kit was developed to detect non-structural protein 1 (NS1) of yellow fever virus (YFV) using monoclonal antibody. NS1 protein was purified from the cultured YFV and used to immunize mice. Monoclonal antibody to NS1 was selected and conjugated with colloidal gold to produce the YFV NS1 RDT kit. The YFV RDTs were evaluated for sensitivity and specificity using positive and negative samples of monkeys from Brazil and negative human blood samples from Korea. Among monoclonal antibodies, clones 3A11 and 3B7 proved most sensitive, and used for YFV RDT kit. Diagnostic accuracy of YFV RDT was fairly high; Sensitivity was 0.0% and specificity was 100% against Dengue viruses type 2 and 3, Zika, Chikungunya and Mayaro viruses. This YFV RDT kit could be employed as a test of choice for point-of-care diagnosis and large scale surveys of YFV infection under clinical or field conditions in endemic areas and on the globe.

• Journal of Korean Medical classics
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• v.20 no.1
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• pp.1-10
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• 2007

"The Essence of the Synopsis of the Golden Chamber" is an annotated book on the "Synopsis of the Golden Chamber" written by You-Yi(尤怡) of the Qing Dynasty (1729). Chapter 3 of this annotated book contains explanations of BaiheDisease(百合病). You-Yi(尤怡) maintained that the cause of Baihe-Disease(百合病) is a deficient-type fever(虛熱) induced by lung-fluid deficiency(肺陰不足). Generally, a higher fever led to a worse prognosis, and this disease was mainly treated by supplement methods(補法). In his pharmacological explanations, You-Yi(尤怡) often used the analogical inference of the five evolutive phases(五行歸類), and he frequently quoted "The Yellow Emperor's Canon of Internal Medicine(黃帝內經)" and "The Medical Secret of an Official(外臺秘要)" to explain the texts.

• The Journal of Internal Korean Medicine
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• v.13 no.2
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• pp.35-47
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• 1992

This study has been carried out to compare the exogenous cough(外感咳嗽) to western medicine. The results were as follows: 1. The exogenous cough(外感咳嗽) on the oriental medicine was similar to U.R.I., Infectious pneumonia, acute bronchitis on the western medicine and acute bronchitis was most similar to the exogenous cough(外感咳嗽). 2. The exogenous cough(外感咳嗽) was caused by the six devils of the environment(六淫) involving the lung and clinically divided into poonghan cough(風寒咳嗽), poongyul cough(風熱咳嗽) and poongjo cough(風燥咳嗽). 3. The symptom of the exogenous cough(外感咳嗽). a. poonghan cough(風寒咳嗽): sputum-rare and white color, laryngeal voice and tickel, stuffed-up and running nose, chilling and fever, headache and generalache, seoltae(舌苔) - thin and white color, pulse - boogin(浮緊). b. poongyul cough(風熱咳嗽): sputum-thick and yellow color, difficult expectoration sore thraot and thirsty, fever and chilling, sweating or headache, seoltae(舌苔) - thin and white color, pulse - boosak(浮數). c. poongjo cough (風燥咳嗽): dry cough with no or a little sputum and difficult expectoration, chest pain, dryness on the pharynx and lips, chilling and fever, seoltae(舌苔) - thin and dry, yellow color, pulse - sesak(細數) 4. The treatment of the exogenous cough(外感咳嗽). a. poonghan cough(風寒咳嗽) : sopoongsanhan sunpyuegihae (疎風散寒 宣肺止咳) b. poongyul cough(風熱咳嗽) : sopoongcheongyul sunpyuegihae (疎風淸熱 宣肺止咳) c. poongjo cough(風操咳嗽) : chungpyueyunjo saenggingihae (淸肺潤燥 生津止咳)

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.1-16
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• 2008

Backgrounds : There have not been so many studies about the correlation of logical background between acupuncture and herbal medicine. Objectives : This study was aimed to find out the logical relationship between acupuncture points of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) for the treatment of fever disease. Methods : I investigated the background of rationale of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) through survey of classical text include Yellow Emperor's Classic of Medicine(.帝.經內經, Hwang Di Nei Jing), Liujing(類經), Zhenjiujiayijing(鍼灸甲乙經) and Huangdisuwenxuanmingfanglun(黃帝素問宣明方論). Results & Conclusions : The words "Wushijiuyu(五十九兪) and Wushijiuci(五十九刺)" are founded in the Yellow Emperor's Classic of Medicine(黃帝內經) are either prescription of the acupuncture points for the treatment of fever disease. However, acupuncture points of two methods are not same. According to Liujing(類經), Wushijiuyu(五十九兪) have used acupuncture points located in head, upper and lower extremities, trunk, and back. However Wushijiuci(五十九刺) just select acupuncture points of head and extremities without those of trunk and back. Acupuncture points located in yang meridian(45points) and Dumai(督脈, 5points) are significantly used more than those of yin meridian(8 points) and Renmai(任脈, 2points) in Wushijiuyu(五十九兪) and Wushijiuci(五十九刺). The distribution of acupuncture points used Wushijiuyu(五十九兪) have closer correlation with Fangfengtongshengsan(防風通聖散) than Wushijiuci(五十九刺) in the prescription.

• KOREAN POULTRY JOURNAL
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• v.36 no.7 s.417
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• pp.96-101
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• 2004

사람들이 모기를 싫어하는 이유는 많다. 모기는 사람과 가축에 각종 병원체를 옮기며, 또한 많은 스트레스를 주고, 이로 인한 정신적인 피해가 크기 때문이다. 가축에서는 가축이 수면을 제대로 취하지 못하게 하고, 질병을 일으켜서 경제적인 피해를 입히기도 한다. 모기로 인해 육계는 성장이 늦어지고, 산란계에서는 산란율이 떨어진다. 사람이 모기에 물리게 되면 간지럽고, 빨갛게 붓는 피부 알러지가 생기고, 잠잘 때 윙윙 소리를 내어 수면을 방해한다는 점, 그로 인한 불쾌감, 정신적 스트레스 등의 피해를 입는다. 그러나 무엇보다도 모기가 주는 가장 큰 피해는 각종 질병을 옮기고 다닌다는 것이다. 모기로 인해 옮겨지는 병으로는 뇌염(encephalitis), 마랄리아(malaria), 상피병(filaria), 황열병(yellow fever), 뎅기열(dengue fever) 등을 들 수 있다. 그 중에서도 국내에서 발병하는 병은 일본뇌염(Japanese encephalitis), 말라리아, 상피병 등이 알려져 있다. 가축에서 오는 모기 매개 질병은 소의 아까바네병, 유행열, 이바라기병 및 츄잔병, 아이노바이러스 감염증 등이 있고, 돼지에서는 사람에게 뇌염을 일으킬 수 있는 돼지일본뇌염이 있고 닭에서는 닭류코사이토준병이 있다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1133-1140
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• 2003

Clinical feature of the urticaria is characterised by sudden appearance on the certain positions of the body, scarlet or light yellow, enlarging and merging into stretches with scraching. The most common menifestations are burning heat, severe itching, fever, abdominal pain etc. It Is classified on the basis of the color. There are red and white urticaria in the classics of the Oriental medicine. Red urticaria is caused by warm-heat evil on the other hand white urticaria is caused by cold-wetness evil. It is advisable to follow the therapeutic principles of expelling warm-heat and cold-wetness evils, regulating yin-yang.

• Journal of Preventive Medicine and Public Health
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• v.31 no.3 s.62
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• pp.540-563
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• 1998

This Study has been carried out to make a recommendation for the next amendment of the Infectious Disease Prevention Act with a specific focus on the kind of notifyable disease. Korean, Japanese, German, U.S, English and French acts on infectious diseases prevention were reviewed, compared with and analized in regards of numbers and kinds of notifyable infectious diseases and their tendency of amendments. An criteria was designed to assess the level of validity of diseases to be designated in the act. Four items, the fatality (greater than 10% or not), the possibility to make a big epidemic, the availability of efficient vaccination and the usefulness of isolation, are used in the assessment. This index is applied to the diseases in Korean and other countries' Infectious Disease Prevention Acts. Results are as follows: 1. The Korean Infectious Disease Preventon Act has a unique way of classifying the notifyable infectious disease, that is, the first, the second and the third class. But the author cannot find the basis of classification. No other countries reviewed have the similar classification. 2. The ten diseases, cholera, plague, yellow fever, diphtheria, typhoid fever, poliomyelitis, rabies, tetanus, malaria, and meningococcal meningitis are designated as the notifyable diseases not only in Korea but also in Japan, Germany, United States, England and france. 3. Thirty seven diseases including small pox, Lassa fever, anthrax, influenza, German measles, Legionellosis, infection with E. coli O157:H7, Q-fever, brucellosis, Lyme disease are designated as legal disease at least one of the above mentioned countries. 4. The Korea has been coped with the change of the infectious disease occurrence for last fifty years in amendment of the Infectious Disease Prevention Act. 5. Japan has a special infectious surveillance system composed of 3,880 clinics throughout the whole country. 6. Germany has classified infectious diseases in five categories which are based on seriousness of disease. Any confirmed death, cases and suspected cases in class I should be reported within 24 hours. But only confirmed death and cases in class II, but not suspected cases, are reportable in Germarny. 7. Plague, bacillary dysentery, pertussis, mumps, Japanese encephaltis and Korean hemorrhagic fevers are diseases with high credits validity index among Korean legal disease. 8. German measles, anthrax, E. coli O157 : H7 infection, Lassa fever, Q-fever, brucellosis are high in validity index among those which are not designated in Korea but designated in other countries. In conclusion, the Korean Infectious Disease Prevention Act has well been coped with the changes of infectious disease occurrence for last fifty years, but the classification basis and the validity of diseases to be designated as legal diseases is worth reevaluating.