• Biomolecules & Therapeutics
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• 제27권1호
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• pp.85-91
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• 2019

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent complications of diabetes, affect sensory, motor, and autonomic nerves. This study aimed to investigate whether 7,8-dihydroxyflavone (7,8-DHF) protects SH-SY5Y neuronal cells against high glucose-induced toxicity. In the current study, we found that diabetic patients exhibited higher lipid peroxidation caused by oxidative stress than healthy subjects. 7,8-DHF exhibits superoxide anion and hydroxyl radical scavenging activities. High glucose-induced toxicity severely damaged SH-SY5Y neuronal cells, causing mitochondrial depolarization; however, 7,8-DHF recovered mitochondrial polarization. Furthermore, 7,8-DHF effectively modulated the expression of pro-apoptotic protein (Bax) and anti-apoptotic protein (Bcl-2) under high glucose, thus inhibiting the activation of caspase signaling pathways. These results indicate that 7,8-DHF has antioxidant effects and protects cells from apoptotic cell death induced by high glucose. Thus, 7,8-DHF may be developed into a promising candidate for the treatment of diabetic neuropathy.

• Biomolecules & Therapeutics
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• 제27권4호
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• pp.395-403
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• 2019

Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 ($PM_{2.5}$) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and $PM_{2.5}$ severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or $PM_{2.5}$. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and $PM_{2.5}$.

• Journal of Yeungnam Medical Science
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• 제36권1호
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• pp.36-42
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• 2019

Background: The purpose of this study was to evaluate the efficacy and feasibility of non- coplanar whole brain radiotherapy (NC-WBRT) for parotid sparing. Methods: Fifteen cases, previously treated with WBRT were selected. NC-WBRT plans were generated. The beam arrangement for the non-coplanar plans consisted of superior anterior, right, and left beams. After generation of the non-coplanar plans a field-in-field technique was applied to the bilateral parallel opposed beams in order to reduce maximum dose and increase dose homogeneity. The NC-WBRT plans were subsequently compared with the previously generated bilateral WBRT (B-WBRT) plans. A field-in-field technique was also used with the B-WBRT plans according to our departmental protocol. As per our institutional practice a total dose of 30 Gy in 10 fractions of WBRT was administered 5 days a week. Results: The mean dose to the parotid gland for the two different plans were 16.2 Gy with B-WBRT and 13.7 Gy with NC-WBRT (p<0.05). In the NC-WBRT plan, the V5Gy, V10Gy, V15Gy, V20Gy, and V25Gy of the parotid were significantly lower (p<0.05) than those of the B-WBRT plan. The $D_{max}$ of the lens was also lower by 10% with NC-WBRT. Conclusion: The use of NC-WBRT plans could be a simple and effective method to reduce irradiated volumes and improve the dose-volume parameters of the parotid gland.

• Composites Research
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• 제34권4호
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• pp.199-211
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• 2021

적층제조 기술의 발전으로 복잡한 구조의 제조가 용이해짐에 따라, 기존에 존재하지 않은 특성을 지닌 메타물질에 대한 관심이 커지고 있다. 기존에 존재하지 않은 기계, 음향, 열, 전자기 및 광학 특성을 지닌 메타물질은 높은 공학응용(Engineering applications) 가능성을 보여, 새로운 메타물질 개발 및 설계방안에 대한 연구를 지속적으로 진행하고 있다. 이에 본 논문에서는 메타물질의 여러 특성 중 기존에 존재하지 않은 기계적 특성을 지닌 메타물질의 특성, 거동 및 물성을 소개하고 설계방안을 제시하고자 한다. 또한 설계한 메타물질을 제조하기 위해 여러 적층제조 방식별 메타물질 제조특성 들을 검토하여, 메타물질의 산업에서의 활용 가능성을 제시하고자 한다.

• Journal of Yeungnam Medical Science
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• 제39권2호
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• pp.108-115
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• 2022

Background: This study was aimed at comparing and analyzing the results of FractionLab (Varian/Mobius Medical System) with those of portal dosimetry that uses an electronic portal imaging device. Portal dosimetry is extensively used for patient-specific quality assurance (QA) in intensity-modulated radiotherapy (IMRT). Methods: The study includes 29 patients who underwent IMRT on a Novalis-Tx linear accelerator (Varian Medical System and Brain-LAB) between June 2019 and March 2021. We analyzed the multileaf collimator DynaLog files generated after portal dosimetry to evaluate the same condition using FractionLab. The results of the recently launched FractionLab at various gamma indices (0.1%/0.1 mm-1%/1 mm) are analyzed and compared with those of portal dosimetry (3%/3 mm). Results: The average gamma passing rates of portal dosimetry (3%/3 mm) and FractionLab are 98.1% (95.5%-100%) and 97.5% (92.3%-99.7%) at 0.6%/0.6 mm, respectively. The results of portal dosimetry (3%/3 mm) are statistically comparable with the QA results of FractionLab (0.6%/0.6 mm-0.9%/0.9 mm). Conclusion: This paper presents the clinical performance of FractionLab by the comparison of the QA results of FractionLab using portal dosimetry with various gamma indexes when performing patient-specific QA in IMRT treatment. Further, the appropriate gamma index when performing patient-specific QA with FractionLab is provided.

• 한국의학물리학회지:의학물리
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• 제32권4호
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• pp.107-115
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• 2021

Purpose: The purpose of this study was to compare the clinical quality assurance results of portal dosimetry using an electronic portal imaging device, a method that is extensively used for patient-specific quality assurance, and the newly released Mobius3D for intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). Methods: This retrospective study includes data from 122 patients who underwent IMRT and VMAT on the Novalis Tx and VitalBeam linear accelerators between April and June 2020. We used a paired t-test to compare portal dosimetry using an electronic portal imaging device and the average gamma passing rates of MobiusFX using log files regenerated after patient treatment. Results: The average gamma passing rates of portal dosimetry (3%/3 mm) and MobiusFX (5%/3 mm) were 99.43%±1.02% and 99.32%±1.87% in VitalBeam and 97.53%±3.34% and 96.45%±13.94% in Novalis Tx, respectively. Comparison of the gamma passing rate results of portal dosimetry (3%/3 mm) and MobiusFX (5%/3 mm as per the manufacturer's manual) does not show any statistically significant difference. Conclusions: Log file-based patient-specific quality assurance, including independent dose calculation, can be appropriately used in clinical practice as a second-check dosimetry, and it is considered comparable with primary quality assurance such as portal dosimetry.

• 한국정보통신학회논문지
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• 제26권5호
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• pp.731-742
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• 2022

PIPO는 ICISC'20에서 발표된 최신 국산 경량 블록암호로, 리소스가 제한된 IoT 상에서 구현하기 용이하도록 경량화 되어있다는 특징이 있다. 본 논문에서는 자바스크립트(Javascript), 웹어셈블리(WebAssembly)와 같은 웹 기반 언어를 사용하여 PIPO 64/128비트, 64/256비트를 구현하였다. PIPO의 비트슬라이스(BitSlice)와 TLU를 구현하여 성능평가를 진행하였으며 for문을 사용하여 작성한 일반 루프(Looped)와 for문을 풀어 작성한 루프 풀기(Unrolled)도 구현하여 성능을 비교했다. Google Chrome, Mozilla Firefox, Opera, Microsoft Edge와 같은 다양한 웹 브라우저와 윈도우즈, Linux, Mac, iOS, 안드로이드와 같은 OS별 다양한 환경에서 성능평가를 수행한다. 또한 C언어로 구현된 PIPO와 성능 비교도 수행하였다. 이는 웹상에서의 PIPO 블록암호 적용을 위한 지표로 사용될 수 있다.

• 한국식생활문화학회지
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• 제38권4호
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• pp.191-202
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• 2023

Food upcycling has emerged as an effective approach to sustainably utilize the food waste generated within the food supply chain. This review article examines upcycled food with respect to its definition, consumers' knowledge and perception on it, and the process by which by-products from the food supply chain are utilized for the creation of upcycled food products. The definition of upcycled food varied among manufacturers, research institutions, and the Upcycled Food Association, depending on the specific values and objectives of each sector. This has resulted in the use of different keywords to highlight the distinctive characteristics of their respective interpretations of upcycled food. This review also summarizes the various consumer traits that can influence the awareness and acceptance of upcycled food, encompassing functional, empirical and emotional, symbolic and self-expressive, and economic benefits. Additionally, the review presents strategies to utilize by-products produced in large quantities in Korea, while also addressing the control of hazardous components to ensure biological or chemical safety and the changes in nutritional value that may occur during the utilization of these byproducts.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.1113-1116
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• 2009

The attempt to use a 3D model each field such as design, structure, construction, facilities, and estimation in the construction project has recently increased more and more while BIM (Building Information Modeling) that manages the process of generating and managing building data has risen during life cycle of a construction project. While the 2D Drawing based work of each field is achieved in the already existing construction project, the BIM based construction project aims at accomplishing 3D model based work of each field efficiently. Accordingly, the solution that fits 3D model based work of each field and supports plans in order to efficiently accomplish the relevant work is demanded. The estimation, one of the fields of the construction project, has applied BIM to calculate quantity and cost of the building materials used to construction works after taking off building quantity information from the 3D model by a item for a Quantity Take-off grouping the materials relevant to a 3D object. A 3D based estimation program has been commonly used in abroad advanced countries using BIM. The program can only calculate quantity related to one 3D object. In other words, it doesn't support the take-off process considering quantity of a contiguous object. In case of temporary materials used in the frame construction, there are instances where quantity is different by the contiguous object. For example, the formwork of the temporary materials quantity is changed by dimensions of the contiguous object because formwork of temporary materials goes through the quantity take-off process that deduces quantity of the connected object when different objects are connected. A worker can compulsorily adjust quantity so as to recognize the different object connected to the contiguous object and deduces quantity, but it mainly causes the confusion of work because it must complexly consider quantity of other materials related to the object besides. Therefore, this study is to propose the solution that automates the formwork 3D modeling to efficiently accomplish the quantity take-off of formwork by preventing the confusion of the work which is caused by the quantity deduction process between the contiguous object and the connected object.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.472-478
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• 2009

The scopes of the supply chain management in construction projects has expanded from the field management focusing on field storage, transportation, and lifting to the whole supply chain from the materials to field. The expansion of the supply chain management can raise the possibilities of leaner production, which enables shortened lead time of the difficult-to-operate materials, and prevents the work interference or delay. However, the expanded management range requires more information and management than an existing management style currently used for factory production of iron frame, curtain wall, PC, etc. In addition, there are limitations that expand the existing management style into the new supply chain management in construction projects and therefore it is required to automate the existing management style in order to extend the management range. The objective of this study is to propose the process and equipment that can manage the supply chain of the materials which range from the factory production to the field storage based on RFID/USN techniques, introducing small-sized transportation equipment(intelligent pallet), the vehicle tool kit(intelligent trailer), and in-and-out management equipment(Gate Sensor) as a prototype to effectively develop the appliances for operating the proposed process, and present the application possibility of the appliances. The full paper will present then the test results that the proposed appliances for the supply chain management automatically transmit and receive the generated information between the appliances or the appliance and sever under various wireless network circumstances such as zigbee, wibro, Wi-Fi, and CDMA.