• Nutrition Research and Practice
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• v.11 no.6
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• pp.461-469
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• 2017

BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress in airways resulted in eosinophilia and epithelial apoptosis. The current study investigated whether glutathione-containing dry yeast extract (dry-YE) ameliorated eosinophilia, goblet cell hyperplasia and mucus overproduction. MATERIALS/METHOD: This study employed $2{\mu}g$/mL lipopolysaccharide (LPS)- or 20 ng/mL eotaxin-1-exposed human bronchial epithelial cells and ovalbumin (OVA)-challenged mice. Dry-YE employed in this study contained a significant amount of glutathione (140 mg in 100 g dry yeast). RESULTS: Human bronchial epithelial cell eotaxin-1 and mucin 5AC (MUC5AC) were markedly induced by the endotoxin LPS, which was dose-dependently attenuated by nontoxic dry-YE at 10-50 ${\mu}g$/mL. Moreover, dry-YE inhibited the MUC5AC induction enhanced by eotaxin-1, indicating that eotaxin-1-mediated eosinophilia may prompt the MUC5AC induction. Oral supplementation with 10-100 mg/kg dry-YE inhibited inflammatory cell accumulation in airway subepithelial regions with a reduction of lung tissue level of intracellular adhesion molecule-1. In addition, ${\geq}50$ mg/kg dry-YE diminished the lung tissue levels of eotaxin-1, eosinophil major basic protein and MUC5AC in OVA-exposed mice. Alcian blue/periodic acid schiff staining revealed that the dry-YE supplementation inhibited goblet cell hyperplasia and mucus overproduction in the trachea and bronchiolar airways of OVA-challenged mice. CONCLUSIONS: Oxidative stress may be involved in the induction of eotaxin-1 and MUC5AC by endotoxin episode and OVA challenge. Dry-YE effectively ameliorated oxidative stress-responsive epithelial eosinophilia and mucus-secreting goblet cell hyperplasia in cellular and murine models of asthma.

• 건강소식
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• v.9 no.12 s.85
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• pp.4-5
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• 1985

• Construction Engineering and Management
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• v.4 no.3 s.15
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• pp.38-40
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• 2003

• KOREAN POULTRY JOURNAL
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• v.54 no.6
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• pp.179-181
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• 2022

• The Journal of the Acoustical Society of Korea
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• v.38 no.5
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• pp.511-521
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• 2019

In this study, we theoretically study the acoustic scattering of an obliquely incident plane wave from a finite elastic cylindrical shell. A heuristic scattering method of Ye [Z. Ye, J. Acoust. Soc. Am. 102, 877-884 (1997)] for a finite fluid cylinder is extended into a finite elastic cylindrical shell since no analytic solutions exist in the finite cylinder. The elastic cylindrical shell is modeled with the 3D elastic wave theory considering internal fluid. Using the derived analytic solution, we observe the effect of the internal fluid on the scattering field, the scattering field for the Rayleigh parameter, and the far-field scattering function for the elastic property of the cylindrical shell.

• Journal of Microbiology and Biotechnology
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• v.3 no.2
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• pp.86-90
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• 1993

CMCase positive clones were screened from Cellulomonas sp. YE-5 and named pCE1, pCE2 and pCE3. Among the positive clones pCE1 was used for this study, because it has the smallest insert and the highest CMCase activity among the 3 clones, and its nucleotide sequence was determined. The CMCase gene in pCE1 was composed of 1071 bp of nucleotides coding 357 amino acids. Computer analysis showed that the pCE1 has 65% sequence homology with the endoglucanase from Cellulomonas fimi.

• Railway Journal
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• v.15 no.4
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• pp.10-14
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• 2012

• Construction Engineering and Management
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• v.10 no.3
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• pp.14-16
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• 2009

• 한국사회복지학회:학술대회논문집
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• 2008.04a
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• pp.219-225
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• 2008

• 한국사회복지학회:학술대회논문집
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• 2008.04a
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• pp.226-232
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• 2008