• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3615-3617
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• 2016

Background: Breast cancer molecular analysis by linkage analysis has the advantage of facilitating early diagnosis in asymptomatic genetic carriers, with a view to the preventive follow-up of these subjects and genetic counseling. The aim of this study was to evaluate BRCA1 gene D17S855 and D17S1322 markers in breast cancer patients. Materials and Methods: A series of 85 BC patients and 85 unrelated healthy women were recruited for haplotype analysis performed using two short tandem repeat markers located within the BRCA1 gene locus. Each marker was amplified with PCR genomic DNA from each individual and fluorescently end-labeled primers. Results: Both D17S855 and D17S1322 markers included 12 kinds of alleles. Results indicate that most of the BC patients shared two common 121-150 (11.2%, RR=1.56 and p=0.02) and 121-146 (5.6%, RR=1.9 and p=0.02) haplotypes. Conclusions: Our results should be helpful to understand the haplotype phase in the BRCA1 gene and establish a genetic screening strategy in the Iranian population.

• Structural Engineering and Mechanics
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• 제37권6호
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• pp.575-592
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• 2011

For seismic resistant design of critical structures, a dynamic analysis, either response spectrum or time history is frequently required. Owing to the lack of recorded data and the randomness of earthquake ground motion that may be experienced by structure in the future, usually it is difficult to obtain recorded data which fit the requirements (site type, epicenteral distance, etc.) well. Therefore, the artificial seismic records are widely used in seismic designs, verification of seismic capacity and seismic assessment of structures. The purpose of this paper is to develop a numerical method using Artificial Neural Network (ANN) and wavelet packet transform in best basis method which is presented for the decomposition of artificial earthquake records consistent with any arbitrarily specified target response spectra requirements. The ground motion has been modeled as a non-stationary process using wavelet packet. This study shows that the procedure using ANN-based models and wavelet packets in best-basis method are applicable to generate artificial earthquakes compatible with any response spectra. Several numerical examples are given to verify the developed model.

• Industrial Engineering and Management Systems
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• 제15권4호
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• pp.385-395
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• 2016

Game theory is a powerful tool for analyzing the Supply chain (SC) with different conflicting elements. Among them, the Stackelberg game is the one in which a player as leader has more power than the other ones as followers. Since in many SC systems one element has, in essence, more power than the others; the Stackelberg game has found many applications in SC studies. In this paper, we apply the Stackelberg game-theoretic approach and the corresponding equilibrium point to formulate and analyze a two echelon VMI SC. Comprehensive computational results on an experimental case are conducted to numerically analyze the performance of VMI system against three groups of critical parameters. Moreover, a critical comparison demonstrates the poorer performance of decentralized VMI system than centralized one. This naturally necessitates designing proper contracts between VMI partners in order to more effectively implement the realistic decentralized system.

• Structural Engineering and Mechanics
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• 제52권5호
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• pp.937-956
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• 2014

The MEMS structures usually are made from silicon; consideration of the viscoelastic effect in microbeams duo to the phenomena of silicon creep is necessary. Application of the fractional model of microbeams made from viscoelastic materials is studied in this paper. Quasi-static and dynamical responses of an electrically actuated viscoelastic microbeam are investigated. For this purpose, a nonlinear finite element formulation of viscoelastic beams in combination with the fractional derivative constitutive equations is elucidated. The four-parameter fractional derivative model is used to describe the constitutive equations. The electric force acting on the microbeam is introduced and numerical methods for solving the nonlinear algebraic equation of quasi-static response and nonlinear equation of motion of dynamical response are described. The deflected configurations of a microbeam for different purely DC voltages and the tip displacement of the microbeam under a combined DC and AC voltages are presented. The validity of the present analysis is confirmed by comparing the results with those of the corresponding cases available in the literature.

• Smart Structures and Systems
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• 제20권6호
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• pp.641-656
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• 2017

The effects of vertical component of earthquakes on torsional amplification due to mass eccentricity in seismic responses of base-isolated structures subjected to near-field ground motions are studied in this paper. 3-, 6- and 9-story superstructures and aspect ratios of 1, 2 and 3 have been modeled as steel special moment frames mounted on Triple Concave Friction Pendulum (TCFP) bearings considering different period and damping ratios. Three-dimensional linear superstructures resting on nonlinear isolators are subjected to both 2 and 3 component near-field ground motions. Effects of mass eccentricity and vertical component of 25 near-field earthquakes on the seismic responses including maximum isolator displacement and base shear as well as peak superstructure acceleration are studied. The results indicate that the effect of vertical component on the responses of asymmetric structures, especially on the base shear is significant. Therefore, it can be claimed that in the absence of the vertical component, mass eccentricity has a little effect on the base shear increase. Additionally, the impact of this component on acceleration is remarkable so the roof acceleration of a nine-story structure has been increased 1.67 times, compared to the case that the structure is subjected to only horizontal components of earthquakes.

• Smart Structures and Systems
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• 제22권6호
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• pp.663-673
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• 2018

In this study, the effect of particle size on the cracks propagation and coalescence or cracking pattern of the edge notched disc specimens are investigated. Firstly, calibration of PFC3D was performed using Brazilian experimental test output. Then micro parameters were used to build edge notched disc specimen. The horizontal wall of the assembly is let to move downward with a standard low speed of 0.016 m/s. The numerical results show that the tensile cracks are dominant failure pattern for the modeled discs. These tensile cracks initiate from the pre-existing notch tip and propagate parallel to the loading direction then interact with the upper boundary of the modeled specimen. As the size of the balls (ball diameter) decrease the number of tensile cracks increase. The tensile fracture toughness of the samples also decreases as the particle size increases. Understanding the crack propagation and crack coalescence phenomena in brittle materials such as concretes and rocks is of paramount importance in the stability analyses for engineering structures such as rock slopes, underground structures and tunneling.

• Structural Engineering and Mechanics
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• 제69권1호
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• pp.43-50
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• 2019

In this research, the effect of bedding layer on the tensile failure mechanism of rocks has been investigated using PFC2D. For this purpose, firstly calibration of PFC2d was performed using Brazilian tensile strength. Secondly Brazilian test was performed on the bedding layer. Thickness of layers were 5 mm, 10 mm and 20 mm. in each thickness layer, layer angles changes from $0^{\circ}$ to $90^{\circ}$ with increment of $15^{\circ}$. Totally, 21 model were simulated and tested by loading rate of 0.016 mm/s. The results show that when layer angle is less than 15, tensile cracks initiates between the layers and propagate till coalesce with model boundary. Its trace is too high. With increasing the layer angle, less layer mobilizes in failure process. Also, the failure trace is very short. It's to be noted that number of cracks decrease with increasing the layer thickness. Also, Brazilian tensile strength is minimum when bedding layer angle is between $45^{\circ}$ and $75^{\circ}$. The maximum one is related to layer angle of $90^{\circ}$.

• Nuclear Engineering and Technology
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• 제53권4호
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• pp.1277-1283
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• 2021

It is important for operators of poly-pipelines in petroleum industry to continuously monitor characteristics of transferred fluid such as its type and amount. To achieve this aim, in this study a dual energy gamma attenuation technique in combination with artificial neural network (ANN) is proposed to simultaneously determine type and amount of four different petroleum by-products. The detection system is composed of a dual energy gamma source, including americium-241 and barium-133 radioisotopes, and one 2.54 cm × 2.54 cm sodium iodide detector for recording the transmitted photons. Two signals recorded in transmission detector, namely the counts under photo peak of Americium-241 with energy of 59.5 keV and the counts under photo peak of Barium-133 with energy of 356 keV, were applied to the ANN as the two inputs and volume percentages of petroleum by-products were assigned as the outputs.

• Structural Engineering and Mechanics
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• 제84권6호
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• pp.743-765
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• 2022

Near-surface excavations may cause the tilting and destruction of the adjacent superstructures in big cities. The stability of a huge excavation and its nearby superstructures was studied in this paper. Some test instruments monitored the deformation and loads at the designed location. Then the numerical models of the excavation were made in FLAC3D (a three-dimensional finite difference code) and Plaxis-3D (a three-dimensional finite element code). The effects of different supporting and reinforcement tools such as nails, piles, and shotcretes on the stability and bearing capacity of the foundation were analyzed through different numerical models. The numerically approximated results were compared with the corresponding in-field monitored results and reasonable compatibility was obtained. It was concluded that the displacement in excavation and the settlement of the nearby superstructure increases gradually as the depth of excavation rises. The effects of support and reinforcements were also observed and modeled in this study. The settlement of the structure gradually decreased as the supports were installed. These analyses showed that the pile significantly increased the bearing capacity and decreased the settlement of the superstructure. As a whole, the monitoring and numerical simulation results were in good consistency with one another in this practically important project.

• Computers and Concrete
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• 제31권1호
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• pp.71-84
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• 2023

In this paper, the effects of the thickness of cubic samples on the tensile strength of concrete blocks were studied using experimental tests in the laboratory and numerical simulation by the particle flow code in three dimensions (PFC3D). Firstly, the physical concrete blocks with dimensions of 150 mm×190 mm (width×height) were prepared. Then, three specimens for each of seven different samples with various thicknesses were built in the laboratory. Simultaneously with the experimental tests, their numerical simulations were performed with PFC3D models. The widths, heights, and thicknesses of the numerical models were the same as those of the experimental samples. These samples were tested with a new tensile testing apparatus. The loading rate was kept at 1 kg/sec during the testing operation. Based on these analyses, it is concluded that when the thickness was less than 5 cm, the tensile strength decreased by increasing the sample thickness. On the other hand, the tensile strength was nearly constant when the sample thickness was raised to more than 5 cm (which can be regarded as a threshold limit for the specimens' thickness). The numerical outputs were similar to the experimental results, demonstrating the validity of the present analyses.