• Title/Summary/Keyword: Yamada

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Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans

  • Kunii, Ryuichi;Yamaguchi, Masaru;Tanimoto, Yasuhiro;Asano, Masaki;Yamada, Kunihiko;Goseki, Takemi;Kasai, Kazutaka
    • The korean journal of orthodontics
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    • v.43 no.6
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    • pp.294-301
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    • 2013
  • Objective: To determine the interleukin (IL)-6 levels in gingival crevicular fluid (GCF) of patients with severe root resorption after orthodontic treatment and investigate the effects of different static compressive forces (CFs) on IL-6 production by human periodontal ligament (hPDL) cells and the influence of IL-6 on osteoclastic activation from human osteoclastic precursor (hOCP) cells in vitro. Methods: IL-6 levels in GCF samples collected from 20 patients (15 and 5 subjects without and with radiographic evidence of severe root resorption, respectively) who had undergone orthodontic treatment were measured by ELISA. The levels of IL-6 mRNA in hPDL cells and IL-6 protein in conditioned medium after the application of different uniform CFs (0, 1.0, 2.0, or 4.0 $g/cm^2$ for up to 72 h) were measured by real-time PCR and ELISA, respectively. Finally, the influence of IL-6 on mature osteoclasts was investigated by using hOCP cells on dentin slices in a pit-formation assay. Results: Clinically, the IL-6 levels were significantly higher in the resorption group than in the control group. In vitro, IL-6 mRNA expression significantly increased with increasing CF. IL-6 protein secretion also increased in a time- and magnitude-dependent manner. Resorbed areas on dentin slices were significantly greater in the recombinant human IL-6-treated group and group cultured in hPDL cell-conditioned medium with CF application (4.0 $g/cm^2$) than in the group cultured in hPDL cell-conditioned medium without CF application. Conclusions: IL-6 may play an important role in inducing or facilitating orthodontically induced inflammatory root resorption.

SURVEY OF DUSTY ACTIVE GALACTIC NUCLEI BASED ON THE MID-INFRARED ALL-SKY SURVEY CATALOG

  • Oyabu, S.;Ishihara, D.;Yamada, R.;Kaneda, H.;Yamagishi, M.;Toba, Y.;Matsuhara, H.;Nakagawa, T.;Malkan, M.;Shirahata, M.
    • Publications of The Korean Astronomical Society
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    • v.27 no.4
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    • pp.265-270
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    • 2012
  • Many observations have found evidence of the presence of a large number of heavily obscured Active Galactic Nuclei (AGNs). However, the nature of this population is only poorly understood because heavy obscuration by dust prevents one from finding them at optical wavelengths. Mid-infrared AGN searches can overcome this obstacle by penetrating through dust and by detecting direct emission from the dust torus. Thus, we can identify most of the AGN population, including type-2 and buried AGNs. Using the AKARI mid-infrared all-sky survey, we performed an AGN search in the nearby universe. Utilizing the 2MASS photometry, we selected mid-infrared-excess sources and carried out near-infrared spectroscopic observations in the AKARI Phase 3. During these follow-up observations, we have found three galaxies that show strong near-infrared red continuum from hot dust with a temperature of about 500 K, but do not show any AGN features in other wavelengths. The most suitable explanation of near-infrared continuum is the presence of central AGNs. Therefore, we conclude that they are AGNs obscured by dust. We performed X-ray observations of the two galaxies with SUZAKU. No detections in the 0.4-10 keV suggest that the column density may be much higher than $N_H=10^{23.5}cm^{-2}$. Comparing the masses of the host galaxies with those of the SDSS AGNs, we find that the host galaxies of the dusty AGNs discovered with AKARI are less massive populations than those of optically selected AGNs.

A Method for Determination of Nitrogen in Ruminant Feedstuffs and Products

  • Islam, M.R.;Ishida, M.;Ando, S.;Nishida, T.;Yamada, T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.10
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    • pp.1438-1442
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    • 2003
  • A method for the determination of nitrogen in ruminant feedstuffs, products and excreta (e.g. milk and urine) using a spectrophotometer is developed, where samples processed for P determination are also used to determine N. Samples are digested with sulphuric acid and subsequently with hydrogen peroxide in Kjeldahl tubes. Digested solutions along with phenol and buffered alkaline hypochlorite reagents are incubated in a water bath at $37^{\circ}C$ for 30 min and presented in the spectrophotometer. The spectrophotometer set at 625 nm measures the concentration of N of each sample. Nitrogen in 261 of the samples was also determined by the classical Kjeldahl method in order to develop a relationship between N determined by the Kjeldahl method (Y) and the colorimetric method (X). The mean value of Y was as high as that of X (0.92 vs. 0.96; p>0.05). The colorimetric method predicted Kjeldahl N highly significantly (Y=0.985X-0.024, $R^2=0.993$, p<0.001; or more simply Y=0.974X, $R^2=0.993$, p<0.001). An analysis of regression found no difference (p>0.05; both t-test and F-test) between colorimetric (0.96% N) and adjusted (0.96% N) N. In comparison with the Kjeldahl method, the analytical capacity of N by colorimetric method increases greatly, where 200-300 determinations of N are possible in a working day. In addition, the system provides an opportunity to use not only the same digested solution for both N and P determination of a particular sample, but also uses the same spectrophotometer to assay both N and P. Therefore, the system may be attractive in situations where both elements of a sample are to be determined. In conclusion, the speed of N determination, low cost, efficient use of labour, time and reagents, fewer items of equipment, and the reduction of environmental pollution by reducing effluent and toxic elements are the advantages of this method of N determination.

Fundamental Study on Nutritional Evaluation for Rapeseed Meal (탈지유채종자의 영양평가에 관한 기초적 연구)

  • Tadahiro Tadokoro;Kazuhiro Kubo;Kazuhiro Yamada;Toru Ota;Akio Maekawa;Han, Yang-Il
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.23 no.3
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    • pp.409-413
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    • 1994
  • This fundamental study was undertaken to evaluate the nutritional value of Canola rapeseed meal which has been increasingly used as a by-product with the demand for the food oil resource. To compare the nutritive values among rapeseed meal and soybean meal, two experiments were carried out by using rats. One was a digestibility test of rapessed meal and the other was the growth rate of rats for 21 days. The chemical compositions , blucosinolate and amino acids of defatted repeseed meal and defatted soybean meal were analyzed. After one week feeding, nitrogen excretion in rats was measured to study FER, PER , TD , BW , and NPU of the meals. The amount of crude proteins in defatted rapeseed meal and defatted soybean meal were 45.5% and 37.9%. The glucosinolate content of defatted rapeseed meal was 0.04% . The body weight gain of defatted rapeseed meal was not signficantly different from that of defatted soybean meal (p>0.01). After one week feeding, there was no significant differencess in organ weight and serum components between two groups(p>0.01). It was presumed that the rapeseed meal has enough possibility for developing food to use as a protein source like a soybean meal protein. However, more careful experiments are needed to clarify the nutritional value of rapeseed meal of Canola since the lipids composition of blood tended to be different when the rapeseed meal and soybean meal were used.

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Purification and Chemical Properties of Anti-complementary Polysaccharide from Capsici Fructus (고추의 항보체 다당의 정제와 특성)

  • Ra, Kyung-Soo;Yamada, Haruki;Sung, Ha-Jin;Cyong, Jong-Chol;Yang, Han-Chul
    • Applied Biological Chemistry
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    • v.32 no.4
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    • pp.378-385
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    • 1989
  • Water-soluble crude polysaccharide (CAP-0) obtained from the Capsici Fructus(the fruits of Capsium annuum L.) showed a potent anti-complementary activity. The anti-complementary activity did not change by pronase digestion of CAP-0, but decreased by the periodate oxidation. CAP-0 was fractionated into four polysaccharide fractions, CAP-1,2,3 and 4, by the addition of cetyltrimethylammonium bromide. CAP-1, showing the highest anti-complementary activity, was refractioned by anion-exchange chromatography to give three major fractions(CAP-1-III, IV and V). CAP-1-III was shown to have low anti-complementary activity, but CAP-1-IV and V had high activity. CAP-1-III and IV were purified on Sephadex G-100 to give each two fractions(CAP-1-IIIa and IIIb, CAP-1-IVa and IVb), respectively. From the results of gel filtration and electrophoresis, these four fractions and CAP-1-V were found to be homogeneous polysaccharides. High molecular polysaccharies(M.W. CAP-1-IIIa 70,000, IVa 195,000, V 140,000) showed relatively higher anti-complementary activity than low molecular polysaccharides(CAP-1-IIIb and IVb).

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Simultaneous gap arthroplasty and intraoral distraction and secondary contouring surgery for unilateral temporomandibular joint ankylosis

  • Sharma, Aditi;Paeng, Jun-Young;Yamada, Tomohiro;Kwon, Tae-Geon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.38
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    • pp.12.1-12.6
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    • 2016
  • Background: Temporomandibular joint (TMJ) ankylosis can be accompanied by various degrees of functional and esthetic problems. Adequate mouth opening, occlusal stability, and harmonious facial form are the main goals of treatment for ankylosis. Distraction osteogenesis has proven to be an excellent treatment for lengthening the ramus-condyle unit. However, various timings for distraction have been suggested, and there is no consensus on selection criteria for performing the procedure in stages or simultaneously with other treatments. Case presentation: In this case report, concomitant intraoral distraction and gap arthroplasty was planned to treat TMJ ankylosis and associated facial asymmetry. After gap arthroplasty and 23 mm of distraction, the ramus-condyle segment was successfully lengthened and mouth opening range was significantly increased. The resultant interocclusal space was stably maintained with an occlusal splint for 4 months after distraction. Finally, good occlusion was achieved after prosthetic treatment. The remaining mandibular asymmetry was corrected with osseous contouring and augmentation surgery. The mouth-opening range was maintained at 35 mm 24 months after treatment. Conclusion: Gap arthroplasty with intraoral distraction as a one-stage treatment and subsequent contouring surgery can be applied to correct ankylosis with moderate malocclusion and facial asymmetry.

PROPERTIES OF DUST IN VARIOUS ENVIRONMENTS OF NEARBY GALAXIES

  • Kaneda, Hidehiro;Kokusho, Takuma;Yamada, Rika;Ishihara, Daisuke;Oyabu, Shinki;Kondo, Toru;Yamagishi, Mitsuyoshi;Yasuda, Akiko;Onaka, Takashi;Suzuki, Toyoaki
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.135-139
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    • 2017
  • We have performed systematic studies of the properties of dust in various environments of nearby galaxies with AKARI. The unique capabilities of AKARI, such as near-infrared (near-IR) spectroscopy combined with all-sky coverage in the mid- and far-IR, enable us to study processing of dust, particularly carbonaceous grains includings polycyclic aromatic hydrocarbons (PAHs), for unbiased samples of nearby galaxies. In this paper, we first review our recent results on individual galaxies, highlighting the uniqueness of AKARI data for studies of nearby galaxies. Then we present results of our systematic studies on nearby starburst and early-type galaxies. From the former study based on the near-IR spectroscopy and mid-IR all-sky survey data, we find that the properties of PAHs change systematically from IR galaxies to ultraluminous IR galaxies, depending on the IR luminosity of a galaxy or galaxy population. From the latter study based on the mid- and far-IR all-sky survey data, we find that there is a global correlation between the amounts of dust and old stars in early-type galaxies, giving an observational constraint on the origin of the dust.

A COSMOLOGICAL PAH SURVEY WITH SPICA

  • Wada, Takehiko;Egami, Eiichi;Fujishiro, Naofumi;Goto, Tomotsugu;Imanishi, Masatoshi;Inami, Hanae;Ishihara, Daisuke;Kaneda, Hidehiro;Kohno, Kotaro;Koyama, Yusei;Matsuhara, Hideo;Matsuura, Shuji;Nagao, Tohru;Ohyama, Youichi;Onaka, Takashi;Oyabu, Shinki;Pearson, Chiris;Sakon, Itsuki;Takeuchi, Tsutomu T.;Tomita, Keisuke;Yamada, Toru;Yamagishi, Mitsuhosi
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.317-319
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    • 2017
  • We propose a cosmological survey to probe star formation and nuclear activity in galaxies at redshifts of z=2-4 by polycyclic aromatic hydrocarbon (PAH) features using the SPICA mid-infrared instrument (SMI) with a spectral resolution of R=20. We will cover a wavelength range of $20-36{\mu}$ that corresponds to z=2-4 for the PAH features (11.3, 7.7, and $6.2{\mu}$). The sensitivity will be $1{\times}10^{-19}W/m^2(5{\sigma})$ in case of a reference survey that covers 4 arcmin2 field in a one-hour observation. It corresponds to $L_{IR}=2{\times}10^{11}L_{\odot}$ at z=3 and will give us more than 10000 galaxies in a 450 hour survey.

MultiHammer: A Virtual Auction System based on Information Agents

  • Yamada, Ryota;Hattori, Hiromitsy;Ito, Takayuki;Ozono, Tadachika;Chintani, Toramastsu
    • Proceedings of the Korea Inteligent Information System Society Conference
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    • 2001.01a
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    • pp.73-77
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    • 2001
  • In this paper, we propose a virtual action system based on information agents, We call the system the MultiHammer, MultiHammer can be used for studying and analyzing online actions. MuiltiHammer provides functions of implement-ing a meta online action site and an experiment environ-ment. We have been using MultiHammer as an experiment as an experiment environment for BiddinBot. BiddingBot aims at assisting users to bid simultaneously in multiple online auctions. In order to bid simultaneously in multiple online auctions. In order to analyze the behavior of BiddngBot, we need to pur-chase a lot of items. It is hard for us to prepare a lot of fund to show usability and advantage of BiddingBot. MultiHam-mer enables us to effectively analyze the behavior of BiddingBot. MultiHammer consists of three types of agents for information collecting data storing and auctioning. Agents for information wrappers. To make agent work as wrarp-pers, we heed to realize software modules for each online action site. Implementing these modules reguires a lot of time and patience. To address this problem, we designed a support mechanism for developing the modules. Agents for data storing record the data gathered by agents for informa-tion collecting. Agents for auctioning provide online services using data recorded by agents for data storing. By recording the activities in auction sites. MultiHammer can recreate any situation and trace auction for experimentation, Users can participate in virtual using the same information in real online auctions. Users also participate in real auc-tions via wrapper agents for information collecting

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A Study on the Environmental Education Experience and Environmental Perceptions of Citizens in Daegu (대구시민의 환경교육경험과 환경인식에 대한 연구)

  • Yamada, Keiko
    • Journal of Environmental Science International
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    • v.23 no.8
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    • pp.1469-1480
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    • 2014
  • This study, through the survey of citizens of Daegu in regard to the environment education experience and citizens perception, seeks to identify the order of importance and perception on the severity of environment. The survey has found that 36.4% citizens of Daegu have environment education experience. Those who have experience have high standard of living, live in high population density area and where pollutant generating plants are prevalent. In addition they are likely to live in apartment, are younger, and the higher the education level, more opportunities they have in getting environment education. The study has found that the environment education experience gives noticeable influence on environment perception, environment attitude, and environment activities. Also, those who have the environment education are likely to be interested in environment, know green growth policies, and are positive about local environment activities. Thus, they are willing to participate in activities to improve local environment and have emphasized the need for more environment education. As for what environment elements are most severe, they pointed to the "global warming and climate change" and "everyday garbage" and as for what are important, they chose "drinking water quality" and "global warming and climate change." Based on the study, we came to the conclusion that more environment education should be provided to elevate the interest in environment and subsequently, foster the sense of responsibility and civic mind toward the preservation of environment. In light of above, local governments must expand their supports and fully utilize the Local Agenda 21 to promote the education and increase the perception of citizens on the environment.