• Title/Summary/Keyword: Y153H variation

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The Y153H Variant of the STOX1 Gene in Korean Patients with Preeclampsia

  • Kim, Shin-Young;Park, So-Yeon;Lim, Ji-Hyae;Yang, Jae-Hyug;Kim, Moon-Young;Park, Hyun-Young;Lee, Kwang-Soo;Kim, Young-Ju;Ryu, Hyun-Mee
    • Journal of Genetic Medicine
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    • v.6 no.1
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    • pp.56-61
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    • 2009
  • Purpose: Preeclampsia is a multifactorial disorder with genetic and environmental components. Recently, the STOX1 gene, identified as a candidate gene for preeclampsia in Dutch women, has been shown to be placentally expressed and subject to imprinting with preferential transmission of the maternal allele. The purpose of this study is to investigate whether there is an association between the STOX1 Y153H variation and preeclampsia in Korean pregnant women. Materials and Methods: This study involved 202 preeclamptic and 204 healthy pregnant women who were genotyped for the Y153H variant of the STOX1 gene using a commercially available SNapShot assay kit and an ABI Prism 3730 DNA Analyzer. Results: There were no significant differences in genotype frequencies of the Y153H variant of the STOX1 gene between preeclamptic patients and normal controls (P>0.05). The H allele frequency of the STOX1 Y153H variation was similar in patients with preeclampsia (87.1%) and in normal controls (86.5%). In addition, multiple logistic regression analysis showed that the YH, HH, and YH/HH genotypes were not associated with an increased risk of preeclampsia when compared to the YY genotype. Conclusion: This is the first study to characterize the Y153H variant of the STOX1 gene in Korean patients with preeclampsia. We found no differences in the genotype and allele frequencies between preeclamptic and normal pregnancies. Although limited by a relatively small sample size, our study suggests that the STOX1 Y153H variation is not associated with the development of preeclampsia in Korean pregnant women.

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A Study on PIV Measurement of Multi-Channel Flow with Inclination angle (경사각을 갖는 다층채널 흐름의 PIV 계측에 관한 연구)

  • 조대환
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2000.05a
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    • pp.153-158
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    • 2000
  • Flow visualization and PIV measurements were conducted to investigate the flow characteristics of multi-channel with inclination angle. The water flow seeded with tiny vegetable powder as tracers revealed details of flow field. The PIV measurement to acquire multi-point velocity data simulatneously was carried out at three space of plates for 5, 10, and 15mm with variation of inlet flow rates of $0.25m^3/h$ and <$0.5m^3/h.$ Experiment results show that space of plates acts a significant role in separating process.

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Electric Energy Saving System for Lighting with Power Conditioning (전력품질개선 기능을 갖는 조명 에너지 절약 시스템)

  • Kwon, H.D.;Park, C.S.;Jo, S.P.;Ko, S.H.;Lee, S.W.;Lee, S.R.
    • Proceedings of the KIPE Conference
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    • 2008.06a
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    • pp.151-153
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    • 2008
  • This paper deals with the electric energy saving system for lighting with power conditioning, which aims at the integration of power quality improvement and energy saving. The system consists of a CCVSI(Current-Controlled Voltage Source Inverter) and VCVSI(Voltage-Controlled Voltage Source Inverter). The CCVSI is connected in parallel to a grid, which can be operated to compensate the reactive power demanded by nonlinear and variation loads. The VCVSI is connected to the CCVSI through the DC capacitor (DC side) and in series on the AC side(lighting load), which can perform the energy saving. The operation of the proposed system is confirmed through the simulation and its usefulness is discussed.

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Genetic Structure in Korean Populations of Hosta capitata (Liliaceae)

  • Chung, Myong-Gi
    • Journal of Plant Biology
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    • v.37 no.3
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    • pp.277-284
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    • 1994
  • I investigated levels of genetic diversity, population genetic structure, and gene flow in Hostacapitata, a herbaceous perennial native to South Korea and southwestern Japan. Starch gel electrophoresis was conducted on leaves collected from 310 plants in 19 Korean populations. Twenty-two of 25 putative loci examined were polymorphic in at least one populatin and the mean number of alleles per locus was 1.65. In addition, mean expected heterozygosity within populations (Hep=0.153) was higher than average values for species with similar life history traits. Significant differences in allele frequency were detected between populations at all loci (P<0.01), and slightly over 30% of the genetic variation was found among populatins (GST=0.308). Indirect estimates of the number of migrants per generation (Nm) (0.506, calculated from GST; 0.852, calculated from the mean frequency of ten private alleles) indicate that gene flow is restricted among the isolated Korean populations of H. capitata. Factors contributing to the high levels of genetic differentiation among populations of H. capitata include small and discrete populations, human disturbance, and low frequencies of pollinator foraging behavior.

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ORFEUS OBSERVATIONS OF ULTRAVIOLET EXCITED HIGH-J MOLECULAR HYDROGEN

  • Lee, Dae-Hee;Dixon, W. Van Dyke;Min, Kyoung-Wook;Pak, Soo-Jong
    • Journal of The Korean Astronomical Society
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    • v.42 no.6
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    • pp.145-153
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    • 2009
  • We present measurements of diffuse interstellar $H_2$ absorption lines in the continuum spectra of 10 early-type stars. The data were observed with the Berkeley Extreme and Far-Ultraviolet Spectrometer (BEFS) of the ORFEUS telescope on board the ORFEUS-SPAS I and II space-shuttle missions in 1993 and 1996, respectively. The spectra extend from the interstellar cutoff at 912 $\AA$ to about 1200 $\AA$ with a resolution of ~ 3000 and statistical signal-to-noise ratios between 10 and 65. Adopting Doppler broadening velocities from high-resolution optical observations, we obtain the $H_2$ column densities of rotational levels J" = 0 through 5 for each line of sight. The kinetic temperatures derived from J" = 0 and 1 states show a small variation around the mean value of 80 K, except for the component toward HD 219188, which has a temperature of 211 K. Based on a synthetic interstellar cloud model described in our previous work, we derive the incident UV intensity IUV and the hydrogen density $n_H$ of the observed components to be -0.4 $\leq$ log $I_{UV}\leq2.2$ and $6.3{\leq}n_H2500cm^{-3}$, respectively.

A Study on the Chemical Characteristics of Acid Rain in Taejon City (대전지역 산성강우의 화학적 특성에 관한 연구)

  • 구자공;박경렬
    • Journal of Korean Society for Atmospheric Environment
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    • v.9 no.2
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    • pp.147-153
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    • 1993
  • From March 1990 to August 1991, every each 5mm bulk precipitation samples were collected at one residental area in Taejon City to investigate chemical characteristics of acid rain. Major ion concentrations of rain samples $(pH, SO_4^{2-}, NO_3^-, CL^-, NH_4^+, Na^+, K^+, Ca^{2+}, Mg^{2+})$ were analysed and compared with the concentration of air pollutants (T. S. P, $SO_2, NO_x$) that were measured by Ministry of Environment. The results of statistical analysis are as followings. Rain pH was relatively high on October and January and relatively low on August, November and February. Major anion is sulfate, and it's concentration is 2.36 times higher than nitrate's, and major cations are ammonium, sodium and calcium ion. Monthly variation of sulfate and calcium concentrations are higher than the others. Ion concentration and rain pH were correlated negatively with rainfall amount. Major ions in rain samples were $SO_4^{2-}, NO_3^-, NH_4^+, Ca^{2+}$ and regression equations are proposed by multiple regression of measured data. Also, regression equation between air pollutants(T. S. P, $SO_2$) and $SO_4^{2-}, Na^+, K^+, Ca^{2+}, Mg^{2+} ions in rain samples were made. From this wer can predict rain pH.

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Repair Cost Analysis for RC Structure Exposed to Carbonation Considering Log and Normal Distributions of Life Time (탄산화에 노출된 철근콘크리트 구조물의 로그 및 정규 수명분포를 고려한 보수비용 해석)

  • Woo, Sang-In;Kwon, Seung-Jun
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.6 no.3
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    • pp.153-159
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    • 2018
  • Many researches have been carried out on carbonation, a representative deterioration in underground structure. The carbonation of RC (Reinforced Concrete) structure can cause steel corrosion through pH drop in concrete pore water. However extension of service life in RC structures can be obtained through simple surface protection. Unlike the conventional deterministic maintenance technique, probabilistic technique can consider a variation of service life but it deals with only normal distributions. In the work, life time-probability distributions considering not only normal but also log distributions are induced, and repair cost estimation technique is proposed based on the induced model. The proposed technique can evaluate the repair cost through probabilistic manner regardless of normal or log distribution from initial service life and extended service life with repair. When the extended service life through repair has log distribution, repair cost is effectively reduced. The more reasonable maintenance strategy can be set up though actual determination of life-probability distribution based on long term tests and field investigations.

A Study on the Fabrication of Superconductor Using Pyrolysis Methods for Electric power Machinery (열분해법에 의한 전력기기용 초전도 합성 기술에 관한 연구)

  • Lee, Sang-Heon;Lee, Young-Hie
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2005.11a
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    • pp.153-154
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    • 2005
  • A high Tc superconducting with a nominal composition of $Bi_2Sr_2Ca_2Cu_3O_Y$ was prepared by the citarte method. The solid precursor produced by the dehydration of the gel at 120$^{\circ}C$ for 12h is not in the amorphous state as expected but in a crystalline state. X-ray diffraction peaks of nearly the same angular position as the peaks of high Tc phase were observed in the precursor. After pyrolysis at 400$^{\circ}C$ and calcination at 840$^{\circ}C$ for 4h, the (001)peak of the high Tc phase was cleary observed. Experimental results suggest that the intermediate phase formed before the formation of the superconducting phase may be the most important factro in determining whether it is easy to form the high Tc phase or not, because the nucleation barriers of the two superconducting phase may be altered by the variation of the crystal structures of those intermediate phase.

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Characteristics of Surface Ozone in a Valley Area Located Downwind from Coastal Cities under Sea-breeze Condition: Seasonal Variation and Related Winds (연안 대도시 해풍 풍하측 계곡지역의 지표오존 분포 특성: 계절변화와 바람과의 관계)

  • Kang, Jae-Eun;Oh, In-Bo;Song, Sang-Keun;Kim, Yoo-Keun
    • Journal of Environmental Science International
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    • v.21 no.2
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    • pp.153-163
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    • 2012
  • The seasonal variations of ozone ($O_3$) concentrations were investigated with regard to the relationship between $O_3$ and wind distributions at two different sites (Jung Ang (JA): a semi-closed topography and Seo Chang (SC): a closed topography) within a valley city (Yangsan) and their comparison between these sites (JA and SC) and two non-valley sites (Dae Jeo (DJ) and Sang Nam (SN)) located downwind from coastal cities (Busan and Ulsan). This analysis was performed using the data sets of hourly $O_3$ concentrations, meteorological factors (especially, wind speed and direction), and those on high $O_3$ days exceeding the 8-h standard (60 ppb) during 2008-2009. In summer and fall (especially in June and October), the monthly mean values of the daily maximum $O_3$ concentrations and the number of high $O_3$ days at JA (and SC) were relatively higher than those at DJ (and SN). The increase in daytime $O_3$ concentrations at JA in June was likely to be primarily impacted by the transport of $O_3$ and its precursors from the coastal emission sources in Busan along the dominant southwesterly winds (about 5 m/s) under the penetration of sea breeze condition, compared to other months and sites. Such a phenomenon at SC in October was likely to be mainly caused by the accumulation of $O_3$ and its precursors due to the relatively weak winds under the localized stagnant weather condition rather than the contribution of regional transport from the emission sources in Busan and Ulsan.

Development of Wireless Neuro-Modulation System for Stroke Recovery Using ZigBee Technology (ZigBee를 이용한 뇌졸중 치료용 무선 전기 자극기 개발)

  • Kim, G.H.;Ryu, M.H.;Shin, Y.I.;Kim, H.I.;Kim, N.G.;Yang, Y.S.
    • Journal of Biomedical Engineering Research
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    • v.28 no.1
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    • pp.153-161
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    • 2007
  • Stroke is the second most significant disease leading to death in Korea. The conventional therapeutic approach is mainly based on physical training, however, it usually provides the limited degree of recovery of the normal brain function. The electric stimulation therapy is a novel and candidate approach with high potential for stroke recovery. The feasibility was validated by preliminary rat experiments in which the motor function was recovered up to 80% of the normal performance level. It is thought to improve the neural plasticity of the nerve tissues around the diseased area in the stroked brain. However, there are not so much research achievements in the electric stimulation for stroke recovery as for the Parkinson's disease or Epilepsy. This study aims at the developments of a wireless variable pulse generator using ZigBee communication for future implantation into human brain. ZigBee is widely used in wireless personal area network (WPAN) and home network applications due to its low power consumption and simplicity. The developed wireless pulse generator controlled by ZigBee can generate various electric stimulations without any distortion. The electric stimulation includes monophasic and biphasic pulse with the variation of shape parameters, which can affect the level of recovery. The developed system can be used for the telerehabilitation of stroke patient by remote control of brain stimulation via ZigBee and internet. Furthermore, the ZigBee connection used in this study provides the potential neural signal transmission method for the Brain-Machine Interface (BMI).