• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2011년도 추계학술논문집 1부
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• pp.280-282
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• 2011

Silica-gold composite particles were prepared by wet chemical route including impregnation method. Obtained composite particles were characterized using FE-SEM, and XPD.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1553-1556
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• 2012

Introduction: Antimetabolites may cause severe toxicity and even toxic death in cancer patients. Our aim was to evaluate the relationship between antimetabolite toxicity and pharmacogenetics in patients with severe clinical toxicity or alanine transaminase (ALT) elevation after fluorouracil (5FU), capecitabine or methotrexate administration. Patients and Methods: Cancer patients with severe antimetabolite toxicity were evaluated for methylenetetrahydrofolate reductase (MTHFR) gene C667T, thymidilate synthase (TS) gene 5´UTR variable number of tandem repeats (VNTR), dihydroprymidine dehydrogenase (DPYD) gene IVS14+1G/A, Xeroderma pigmentosum (XPD) gene Lys751Gln and X-ray repair cross-complementing group 1 (XRCC1) gene Arg399Gln polymorphisms. Results: Eighteen patients were enrolled, with a male/female ratio of 0.8. They had osteosarcoma in methotrexate group (n=7), gastrointestinal malignancies in 5FU group (n=9) and breast cancer in the capecitabine group (n=2). Mucositis and dermatitis occurred in all groups, together with ALT elevation in the methotrexate group and 2 toxic deaths were encountered. DPYD, TS, MTHFR, XPD and XRCC1 gene polymorphism rare allele frequencies were observed to be higher than in the general population. Conclusion: Pharmacogenetics might contribute to tailored therapy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.941-946
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• 2013

Objective: The nucleotide excision repair (NER) and base excision repair (BER) pathways, two DNA repair pathways, are related to platinum resistance in cancer treatment. In this paper, we studied the association between single nucleotide polymorphisms (SNPs) of involved genes and response to platinum-based chemotherapy in epithelial ovarian cancer. Method: Eight SNPs in XRCC1 (BER), XPC and XPD (NER) were assessed in 213 patients with epithelial ovarian cancer using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR) techniques. Results: The median progression-free survival (PFS) of patients carrying the Lys/Lys and Lys/Gln+Gln/Gln genotype of the XPC Lys/Gln polymorphism were 25 and 12 months, respectively (P=0.039); and the mean overall survival (OS) of patients was 31.1 and 27.8 months, respectively (P=0.048). Cox's multivariate analysis suggested that patients with epithelial ovarian cancer with the Gln allele had an increased risk of death (HR=1.75; 95% CI=1.06-2.91) compared to those with the Lys/Lys genotype. There are no associations between the XPC PAT+/-, XRCC1 Arg194Trp, Arg280His, Arg399Gln, and XPD Asp312Asn, Lys751Gln polymorphisms and the survival of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy. Conclusion: Our results indicated that the XPC Lys939Gln polymorphism may correlate with clinical outcome of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy in Northern China.

• 한국전자파학회논문지
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• 제11권4호
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• pp.505-513
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• 2000

본 논문에서는 편파 다이버서티(j:X)larization diversity)용 광대역 안테나에 대한 성능을 개선하기 위한 새로운 구조를 제안하였다. 이중 편파 마이크로스트립 안테나를 구현하기 위하여 십자형 개구변을 두었고, 개구면 위와 아래에 두 j:X)rt가 서로 수직이 되도록 급전부를 셜계하였다. 그리고 방사소자와 급전부에 air gap을 주었으며 후 방 방사를 줄이기 위해 아래 급전부로부터 $\lambda$/4 떨어뜨려서 반사판을 두었다. 더욱 넓은 대역폭을 가지도록 방 사 패치에 톱니 모양의 perturbation을 주었으며, 패치의 perturbation 효과에 의해 안테나 크기가 줄어들게 됨으 로써 배열 안테나의 크기도 상당히 줄어들었다. 제안된 단일 소자 안테나를 이용하여 $1\times4$ 배열 안테나 구조를 가진 PCS 기지국용 편파 다이버시티 안테나 를 제작하였다. 단일 소자 안테나는 각각 port 당 10.3 %, 11.3 %(VSWR<1.3)의 대역폭을 가지고 두 port간의 분리도가 -40 dB 이상이다. 또한 배열 안테나의 대역폭은 각각 13.2 %, 12.7 %(VSWR <1.3)이고 -36 dB의 분 리도와 10 dB의 XPD를 가진다.

• 한국결정성장학회지
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• 제4권1호
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• pp.105-110
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• 1994

L-arginine phosphate monohydrate (LAP)와 tris(hydroxymethyl)aminomethane sulfate(THAMS)는 레이저의 파장변환소자등과 같은 소자응용에 있어서 새로운 유기 비선형광학재료이다. 본 연구에서는 온도강하법과 온도차법을 이용하여 LAP와 THAMS 단결정의 육성을 시도하였으며 이들 방벙에 따른 육성조건을 확립하였다. 그리고 육성결정의 특성을 광학현미경, XPD, FTIR 등을 통하여 평가하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9347-9353
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• 2014

Background: Excision repair crossing-complementing group 2 (ERCC2), also called xeroderma pigmentosum complementary group D (XPD), plays a crucial role in the nucleotide excision repair (NER) pathway. Previous epidemiological studies have reported associations between ERCC2 polymorphisms and non-Hodgkin lymphoma (NHL) risk, but the results have remained controversial. Materials and Methods: We conducted this meta-analysis based on eligible case-control studies to investigate the role of two ERCC2 polymorphisms (Lys751Gln and Asp312Asn) in determining susceptibility to NHL. Ten case-control studies from several electronic databases were included in our study up to August 14, 2014. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effects models to estimate the association strength. Results: The combined results based on all studies did not show any association between Lys751Gln/Asp312Asn polymorphisms and NHL risk for all genetic models. Stratified analyses by histological subtype and ethnicity did not indicate any significant association between Lys751Gln polymorphism and NHL risk. However, a significant reduced risk of NHL was found among population-based studies (Lys/Gln versus Lys/Lys: OR=0.87, 95% CI=0.77-0.99, P=0.037) but not hospital-based studies. As for Asp312Asn polymorphism, there was no evidence for the association between this polymorphism and the risk of NHL in all subgroup analyses. Conclusions: This meta-analysis suggests that there may be no association between Lys751Gln/Asp312Asn polymorphism and the risk of NHL and its two subtypes, whereas ERCC2 Lys751Gln heterozygote genotype may provide protective effects against the risk of NHL in population-based studies. Therefore, large-scale and well-designed studies are needed to clarify the effects of haplotypes, gene-gene, and gene-environment interactions on these polymorphisms and the risk of NHL and its different histological subtypes in an ethnicity specific population.

• 한국통신학회논문지
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• 제41권11호
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• pp.1608-1618
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• 2016

본 논문에서는 군용 통신망에 대한 주파수 지정 문제를 그래프 이론 관점에서 접근하여 해결하는 방법을 소개한다. 선행 연구에서 제안한 알고리즘을 본 문제에 맞게 구현하였으며, 새로운 알고리즘을 제안하여 얻은 해의 성능이 최적의 값에 거의 근접함을 증명하였다. 또한, 이중 편파 안테나의 편파를 동시에 배정하여 주파수 지정 문제 해의 성능을 극대화하는 알고리즘을 소개하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1999년도 제17회 학술발표회 논문개요집
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• pp.29-29
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• 1999

The synthesis of layered structures on the nanometer scale has become essential for continued improvements in the operation of various electronic and magnetic devices. Abrupt metal-metal interfaces are desired for applications ranging from metallization in semiconductor devices to fabrication of magnetoresistive tunnel junctions for read heads on magnetic disk drives. In particular, characterizing the interface structure between various transition metals (TM) and aluminum is desirable. We have used the techniques of MeV ion backscattering and channeling (HEIS), x-ray photoemission (ZPS), x-ray photoelectron diffraction(XPD), low-energy ion scattering (LEIS), and low-energy electron diffraction(LEED), together with computer simulations using embedded atom potentials, to study solid-solid interface structure for thin films of Ni, Fe, Co, Pd, Ti, and Ag on Al(001), Al(110) and Al(111) surfaces. Considerations of lattice matching, surface energies, or compound formation energies alone do not adequately predict our result, We find that those metals with metallic radii smaller than Al(e.g. Ni, Fe, Co, Pd) tend to form alloys at the TM-Al interface, while those atoms with larger atomic radii(e.g. Ti, Ag) form epitaxial overlayers. Thus we are led to consider models in which the strain energy associated with alloy formation becomes a kinetic barrier to alloying. Furthermore, we observe the formation of metastable fcc Ti up to a critical thickness of 5 monolayers on Al(001) and Al(110). For Ag films we observe arbitrarily thick epitaxial growth exceeding 30 monolayers with some Al alloying at the interface, possible driven by interface strain relief. Typical examples of these interface structures will be discussed.

• 한국통신학회논문지
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• 제41권8호
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• pp.954-957
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• 2016

군용 통신망의 작전상황 등에서 빠른 시간 내에 주파수 배정 문제의 해를 찾는 상황은 빈번하게 발생한다. 이때 사용되는 자원 개수를 최소화하는 것은 비용과 연관되어 중요한 문제이다. 이중 편파 안테나의 편파를 적절히 분배하면 주파수 자원 개수 성능을 최소화하는데 도움이 된다. 본 논문은 그래프의 매칭 이론을 기반으로 하여 편파와 주파수를 $O(N^2)$의 복잡도 이내에 배정하는 알고리즘을 제시한다. 제시하는 알고리즘의 해는 단일 편파 알고리즘 대비 2배에 가까운 성능개선을 보이며 이론적인 최적의 값에 근접함을 확인하였다.

• 한국통신학회논문지
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• 제30권9A호
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• pp.788-794
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• 2005

In this paper, we focus on the potential of dual polarized antennas in mobile system. thus, this paper designs exact dual polarized channel with Spatial Channel Model (SCM) and investigates the performance for certain environment. Using proposed the channel model; we know estimates of the channel capacity as a function of cross polarization discrimination (XPD) and spatial fading correlation. It is important that the MIMO channel matrix consists of Kronecker product dividable spatial and polarized channel. Through the channel characteristics, we propose an algorithm for the adaptation of transmit antenna configuration to time varying propagation environments. The optimal active transmit antenna subset is determined with equal power allocated to the active transmit antennas, assuming no feedback information on types of the selected antennas. We first consider a heuristic decision strategy in which the optimal active transmit antenna subset and its system capacity are determined such that the transmission data rate is maximized among all possible types. This paper then proposes singular values decision procedure consisting of Kronecker product with spatial and polarize channel. This method of singular value decision, which the first channel environments is determined using singular values of spatial channel part which is made of environment parameters and distance between antennas. level of correlation. Then we will select antenna which have various polarization type. After spatial channel structure is decided, we contact polarization types which have considerable cases It is note that the proposed algorithms and analysis of dual polarized channel using SCM (Spatial Channel Model) optimize channel capacity and reduce the number of transmit antenna selection compare to heuristic method which has considerable 100 cases.