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Computer-Aided Detection of Clustered Microcalcifications using Texture Analysis and Neural Network in Digitized X-ray Mammograms (X-선 유방영상에서 텍스처 분석과 신경망을 이용한 군집성 미세석회화의 컴퓨터 보조검출)

  • 김종국;박정미
    • Journal of Biomedical Engineering Research
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    • v.19 no.1
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    • pp.1-8
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    • 1998
  • Clustered microcalcifications on X-ray mammograms are an important sign for early detection of breast cancer. This paper proposes a computer-aided diagnosis method for the detection of clustered microcalcifications and marking their locations on digitized mammograms. The proposed detection method consists of the region of interest (ROI) selection, the film-artifact removal, the surrounding texture analysis method for the detection of clustered microcalcifications, which is based on the second-order histogram in two nested surrounding regions on the current pixel. This paper also describes the effectiveness of the proposed film-artifact removal filter in terms of the classification performance with the receiver operating-characteristics(ROC) analysis. A three-layer backpropagation neural network is employed as a classifier. The appropriate marking for the locations of clustered microcalcifications can be used to alert radiologists to locations of suspicious lesions.

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A Study on BMPR-IB Genes of Bayanbulak Sheep

  • Zuo, Beiyao;Qian, Hongguang;Wang, Ziyu;Wang, Xu;Nisa, Noor;Bayier, Aierdin;Ying, Shijia;Hu, Xiaolong;Gong, Changhai;Guo, Zhiqin;Wang, Feng
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.1
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    • pp.36-42
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    • 2013
  • The average twin lambing rate of Bayanbulak sheep is 2% to 3%. However, a flock of sheep with a close genetic relationship and an average of 2 to 3 lambs per birth has been found recently. To determine the major genes controlling the prolificacy of the flock in the present study, the flock was designated A while 100 normal Bayanbulak sheep were randomly selected to comprise the control flock B. Ligase detection reaction method was applied to detect and analyze the 10 mutational loci of the 3 candidate prolificacy genes including bone morphogenetic protein type I receptors, bone morphogenetic protein 15, and growth differentiation factor 9. The 10 mutational loci are as follows: FecB locus of the BMPR-IB gene; $FecX^I$, $FecX^B$, $FecX^L$, $FecX^H$, $FecX^G$, and $FecX^R$ of the BMP15 gene; and G1, G8, and FecTT of the GDF9 gene. Two mutations including BMPR-IB/FecB and GDF9/G1 were found in Bayanbulak sheep. Independence test results of the two flocks demonstrate that the FecB locus has a significant effect on the lambing number of Bayanbulak sheep. However, the mutation frequency of the G1 locus in GDF9 is very low. Independence test results demonstrate that the GDF9 locus does not have a significant impact on the lambing performance of Bayanbulak sheep. Among the 10 detected loci, BMPR-IB/FecB is the major gene that influences the high lambing rate of Bayanbulak sheep.

Preparation of SiO2-TiO2-MxOy ( M = Co, Cr or Cu ) Thin Films by the Chemical Solution Process (스핀코팅에 의한 SiO2-TiO2-MxOy (M = CO, Cr or Cu)계 비정질 박막의 제조)

  • Kim, Sangmoon;Lim, Yongmu;Hwang, Kyuseog
    • Journal of Korean Ophthalmic Optics Society
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    • v.3 no.1
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    • pp.223-228
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    • 1998
  • Glass films of $SiO_2-TiO_2-M_xO_y$ (M = Co, Cr or Cu) have been prepared on soda-lime-silica slide glasses by the chemical solution method using a spin-coating technique. Commercially available tetraethyl orthosilicate, titanium trichloride, and cobalt-, chromium- and copper-nitrates were used as starting materials. No crystalline segregations of $Co_3O_4$, $Cr_2O_3$ and CuO were observed by X-ray diffraction ${\theta}-2{\theta}$ scans. From the optical transmission analysis, cobalt existed as $ Co^{2+}$ in tetrahedral coordination, chromium as $Cr^{6+}$ in tetrahedral symmetry and copper as $Cu^{2+}$ in octahedral coordination. Films with a crack-free and no texture exhibited homogeneous interfaces between the films and the substrates along the cross-section.

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Design and Fabrication of Voltage Control Oscillator at X-band using Dielectric Resonator (유전체 공진기를 이용한 X-band 전압제어 발진기 설계 및 제작)

  • Han, Sok-Kyun;Choi, Byung-Ha
    • Journal of Navigation and Port Research
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    • v.27 no.5
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    • pp.513-517
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    • 2003
  • In this paper, a VCDRO(Voltage Control Dielectric Resonator Oscillator} applied to X-band as stable source is implementea and constructed with a MESFET for low noise, a dielectric resonator of high frequency selectivity and high Q varactor diode to obtain a good phase noise performance and stable sweep characteristics. The designed circuits is simulated through the harmonic balance simulation technique to provide the optimum performance. The measured results of a fabricated VCDRO show that output is 2.22dBm at 12.05GHz. harmonic suppression -30dBc. phase noise -130dBc at 100kHz offset. and sweep range of varactor diode $\pm$18.7MHz. respectively. This oscillator will be available to X-band application.

Studies on Piroplasmosis Infection and Morphological Development of Piroplasma in Experimental Animals (피로풀라스마병(病)에 관(關)한 연구(硏究) 실험동물(實驗動物)에 대(對)한 감염시험(感染試驗) 및 그 형태학적(形態學的) 변화(變化)에 대(對)하여)

  • Han, T.W.
    • Korean Journal of Veterinary Research
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    • v.8 no.2
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    • pp.98-109
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    • 1968
  • The small type piroplasma which is known to be prevailing in Korean cattle was injected to un-susceptible hosts such as mice, guinea pigs, rats, rabbits, fowls and developing chicken eggs by i.v., i.p, and intra C.A.M. routes, and its morphological development in each animal species was observed. 1. The small type piroplasma of cattle did not produce any pathogenicity in the experimental animals such as mice, guinea pigs, rats, rabbits, fowls and developing chicken embryos. However, only a partial sign for developing cycle of the organism was observed in the peritoneal fluid. The schizogony of protozoa was not detected in any organs of the inoculated animals. 2. In the animals inoculated, the parasites of I-III types, relative to the process of time in the host, have changed their shapes into IV-VI types and then VI-X types however, the type X was not restored to the type I. In guinea pigs, more grape type was detected then X type in number, and in process of time, the shape was changed from round to elliptic, and the pointed end of the organism appeared in flesh color. 3. None of the organisms were found from the blood stream of inoculated animals excepts only a few piroplasma as were found in the experimental mice shortly after inoculation or i.v. route, No protozoa was also found in the organs of the animals autopsied. 4. The form change of protozoa was more clear in these animals than that in susceptible host. The most piroplasmas have changed their forms into VI-X types 30 hours after inoculation and were dispersed from R.B.C. Tracing of piroplasrna beyond this stage was not attempted. 5. The small type piroplasma comprises in I. X types and it is further believed that VII-X types which were freed from one cell proceeded to invade others. The from of development resembles to the small type of piroplasma which is prevailing in Japan.

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A Study on the Development of Electrophotographic Photoreceptor by Metal free-Phthalocyanine Dye Sensitized System (무금속프탈로시아닌 색소계를 이용한 전자사진 감광체의 개발에 관한 연구)

  • Jeong, Eun-Sil;Kim, Yeong-Sun;Jeong, Pyeong-Jin
    • Korean Journal of Materials Research
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    • v.10 no.1
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    • pp.7-14
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    • 2000
  • The object of this study was to improve electrophotographic photoreceptor using metal free-phthalocyanine dye sensitized system. In here a various types of metal free-phthalocyanine and polymers and hydrazone were used as charge generation material(CGM) and binder, respectively, and also the hydrazone derivative or zinc complex was used as charge transport material(CTM). It was found that $x-H_2Pc$ showed the highest sensitivity among the ${\alpha}-$, ${\beta}-$ and x- metal free-phthalocyanine($x-H_2Pc$) as CGM. The photoreceptor made by $x-H_2Pc$ and hydrazone derivative as CGM and CTM, respectively, showed the highest ratio of dark decay having 73.1% and the good sensitivity of $1.50lux{\cdot}sec$ compared to other photoreceptors.

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Growth and Characterization of $CuInTe_2$ Single Crystal thin Films by Hot Wall Epitaxy (Hot Wall Epitaxy(HWE) 방법에 의한 $CuInTe_2$ 단결정 박막 성장과 특성에 관한 연구)

  • 홍광준;이관교;이상열;유상하;정준우;정경아;백형원;방진주;신영진
    • Korean Journal of Crystallography
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    • v.11 no.4
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    • pp.212-223
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    • 2000
  • A stochiometric mix of CuInTe₂ polycrystal was prepared in a honizonatal furnace. To obtain the single crystal thin films, CuInTe₂ mixed crystal was deposited on throughly etched GaAs(100) by the HWE system. The source and substrate temperatures were 610℃ and 450℃ respectively, and the thickness of the deposited single crystal thin film was 2.4㎛. CuInTe₂ single crystal thin film was proved to be the optimal growth condition when the excition emission spectrum was the strongest at 1085.3 nm(1.1424 eV) of photoluminescence spectrum at 10 K, and also FWHM of Double Crystal X-ray Rocking Curve (DCRC) was the smallest, 129 arcsec. The Hall effect on this sample was measured by the method of Van der Pauw, and the carrier density and mobility dependent on temperature were 9.57x10/sup 22/ electron/㎥, 1.31x10/sup -2/㎡/V·s at 293 K, respectively. The ΔCr(Crystal field splitting) and the ΔSo (spin orbit coupling splitting( measured at f10K from the photocurrent peaks in the short wavelength of the CuInTe₂ single crystal thin film were about 0.1200 eV, 0.2833 eV respectively. From the PL spectra of CuInTe₂ single crystal thin film at 10 K, the free exciton (E/sub x/) was determined to be 1064.5 nm(1.1647 eV) and the donor-bound exciton(D/sup 0/, X) and acceptor-bound exciton (A/sup 0/, X) were determined to be 1085.3 nm(1.1424 eV) and 1096.8 nm(1.1304 eV0 respectively. And also, the donor-acciptor pair (DAP)P/sub 0/, DAP-replica P₁, DAP-replica P₂ and self-activated (SA) were determined to be 1131 nm (1.0962 eV), 1164 nm(1.0651 eV), 1191.1 nm(1.0340 eV) and 1618.1 nm (0.7662 eV), respectively.

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Low Temperature Sintering and Microwave Dielectric Properties of Ca[Ti1-x(Ni1/3Nb2/3)x]O3 Ceramics (Ca[Ti1-x(Ni1/3Nb2/3)x]O3 세라믹스의 저온소결 및 마이크로파 유전특성)

  • Lee, Young-Gyu;Kim, Hyo-Tae;Nam, Joong-Hee;Kim, Jong-hee;Paik, Ungyu
    • Journal of the Korean Ceramic Society
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    • v.43 no.1 s.284
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    • pp.55-61
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    • 2006
  • The microwave dielectric properties and low temperature sintering of $Ca[Ti_{1-x}(Ni_{1/3}Nb_{2/3})_x]O_3$ system were investigated at the sintering temperature $1,200\~1,350^{\circ}C$. The density and quality factors $(Q{\times}f)$ increased while dielectric constants slightly decreased with the decrease of Ti. The dielectric constant, quality factor, and temperature coefficient of resonance frequency $(\tau_f)$ were 64, 17,000 GHz, and $-9.1\;ppm/^{\circ}C$ respectively, when $CaTi_{1/2}(Ni_{1/3}Nb_{2/3})_{1/2}O_3$ ceramics were sintered at $1,300^{\circ}C$ for 4 h. $2Li_2O-B_2O_3$ was added to $CaTi_{1/2}(Ni_{1/3}Nb_{2/3})_{1/2}O_3$ to decrease the sintering temperature for LTCC application. The microwave dielectric properties of the samples sintered at $925^{\circ}C$ for 2 h with the addition of $6\;wt\%\;2Li_2O-B_2O_3$ were $\varepsilon_r=48.7,\;Q{\times}f=8,460\;GHz$, and $\tau_f=+5.6ppm/^{\circ}C$. Compatibility test of the composition with silver electrode shows no reaction with silver electrode, implying the feasibility as a high-K LTCC material.

The Perception and Utilization patterns of Complementary and Alternative Medicines in Patients with Fibromyalgia Syndrome (섬유근통 증후군 환자의 보완대체요법에 대한 인식과 이용행태)

  • Kong, Kyoung Ran;Lee, Eun Nam;Jeong, Won Tae
    • Journal of muscle and joint health
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    • v.23 no.3
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    • pp.187-196
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    • 2016
  • Purpose: The purpose of this study was to investigate the perception and utilization patterns of complementary and alternative medicines (CAM) in patients with fibromyalgia syndrome. Methods: A total of 92 fibromyalgia syndrome patients participated in this study. Data were collected using a structured questionnaire and were analyzed with SPSS/WIN 23.0 program. Results: As a result, 59.8% of subjects had an experience of CAM and 33.7% of subjects have used until now. There were significant differences of the use of CAM between the group of CAM users and non-CAM users by education ($x^2$=4.04, p=.044), period of illness ($x^2$=15.03, p=.001), and period of treatment ($x^2$=12.10, p=.002). Relatively large numbers of patients understanded as that CAM was effective (58.7%) and fibromyalgia syndrome was controllable (75.0%). Moreover, there were significant differences of the use of CAM by the perception of CAM effects ($x^2$=4.15, p=.042), fibromyalgia syndrome ($x^2$=6.55, p=.038), and best treatment for fibromyalgia ($x^2$=11.03, p=.001). Conclusion: These results could be utilized as a basic data for developing nursing intervention for fibromyalgia syndrome.

Enhancement of Image Sharpness in X-ray Digital Tomosynthesis Using Self-Layer Subtraction Backprojection Method (관심 단층 제거 후 역투사법을 이용한 X-선 디지털 영상합성법에서의 단층영상 선명도 향상에 관한 연구)

  • Shon, Cheol-Soon;Cho, Min-Kook;Lim, Chang-Hwy;Cheong, Min-Ho;Kim, Ho-Kyung;Lee, Sung-Sik
    • Journal of the Korean Society for Nondestructive Testing
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    • v.27 no.1
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    • pp.8-14
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    • 2007
  • X-ray digital tomosynthesis is widely used in the nondestructive testing and evaluation, especially for the printed circuit boards (PCBs). In this study, we propose a simple method to reduce the blur artefact, frequently claimed in the conventional digital tomosynthesis based on SAA (shift-and-add) algorithm, and thus restore the image sharpness. The proposed method is basically based on the SAA, but has a correction procedure by finding blur artefacts from the forward-and back-projection for the firstly obtained, manipulated backprojection data. The manipulation is the replacement of the original data at the POI (plane-of-interest) by zeros. This method has been compared with the conventional SAA algorithm using the experimental measurements and Monte Carlo simulation for the designed PCB phantom. The comparison showed a much enhancement of sharpness in the images obtained from the proposed method.