• Tuberculosis and Respiratory Diseases
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• 제54권6호
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• pp.645-650
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• 2003

저자들은 우측 흉부 불편감을 주소로 내원한 25세 여자 환자를 개흉 조직 검사를 시행하여 원발성 횡격막 기원 악성 섬유성 조직구종을 진단하였고 ifosfamide, doxorubicin으로 항암 화학 요법 시행 후 부분 관해가 있었으나 진단 후 12개월째 외래 추적 검사 중 뇌전이로 사망한 젊은 여성 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2010년도 한국우주과학회보 제19권1호
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• pp.38.3-39
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• 2010

While major solar proton events (SPEs) come from the coronal mass eject (CME)-driven shocks in solar wind, there are many evidences that potentiality of CMEs to generate SPEs depends on its early evolution near the Sun and on different solar activities observed around the CME liftoff time. To decipher origin of SPE release, we have investigated onset time comparison of the SPE with CME, metric type II radio burst, and hard X-ray flare. For this, we select 30 SPEs observed from 1997 to 2006 by using the particle instrument ERNE onboard SOHO, which allows proton flux anisotropy measurement in the energy range ~10 - 50MeV. Onset time of the SPEs is inferred by considering the energy-dependent proton transport time. As results, we found that (1) SPE onset time is comparable to that of type II but later than type III onset time and HXR start time, (2) SPE onset time is mostly later than the peak time of HXR flare, (3) almost half of the SPE onsets occurred after the HXR emission, and (4) there are two groups of CME height at the onset time of SPE; one is the height below 5 Rs (low corona) and the other is above 5Rs (high corona). In this talk, we will present the onset time comparison and discuss about the origin of the SPE onset.

• 한국운동역학회지
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• 제24권4호
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• pp.435-443
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• 2014

The purposes of this study was to investigate the physical compensation for gait on induced equinus in normal subjects. Ten subjects were participate in the experiment (age: $23.8{\pm}2.8yrs$, height: $177.3{\pm}4.3cm$, weight: $70.8{\pm}4.6kg$). The study method adopted 3D analysis with six cameras and ground reaction force with two force-plate. Induced equinus were classify as gait pattern on unilateral and bilateral equinus. The results were as follows; In displacement of COM, medio-lateral and anterior-posterior COM were no significant, but in vertical COM, unilateral equinus gait was higher than bilateral equinus gait. In displacement hip joint, left hip joint was more extended in FC1 and FC2 during unilateral equinus gait. In displacement knee joint, left knee joint was more extended in FC2, right knee joint was more extended in all event during unilateral equinus gait. In trunk tilt, unilateral equinus gait was more forward tilt in TO1 and TO2. ROM of each joint was no significant. In Displacement of pelvic tilt angle, X axis of unilateral equinus gait was more increase than bilateral equinus gait at FC2, TO2 and MS2. Y axis of unilateral equinus gait was more increase than bilateral equinus gait at MS1, FC2 and MS2. Z axis was no significant in both equinus gait. In GRF, right Fx and Fy were no significant in both equinus gait, Fz was more bigger vertical force in bilateral equinus gait. Left Fx was more bigger internal force in unilateral equinus gait, Fy and Fz were no significant in both equinus gait.

• 대한조선학회지
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• 제11권1호
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• pp.27-34
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• 1974

This study is aimed at a validation of the vigilance simulation model which was proposed earlier (2). The model estimates a perceived danger value, an alertness level and the probability of detection at a given elapsed time of vigilance. Twenty-nine male and seven female subjects were given a simple task. They were asked to detect a number(four numbers out of six digits in the telephone directory which have the probability of occurrence in the range of 0.0010-0.0018) in six different experimental conditions, for periods of two to three hours. Analysis of the experiments showed that although the mean detection rate varied slightly in two hours, the within-subject variance and the number of cyclic performance fluctuations increased significantly. A primal factor that affects the performance seems to be the frequency of target occurrence. By curve fitting, the relation between the probability of detection and the percentages of danger event occurrence was derived; $y=0.50(1-{\varepsilon}^{-50x^2})+0.39$. Assuming the equation represents the normal detection rate(100% performance), the Relative Vigilance Performance Rating was calculated. This rating method could be a useful criterion in selecting and training of the vigilance personnel. The results show that the simulation model is a good estimator of human a performance when the probability of danger occurrence is greater than 0.0015; it gives a good reference for improving the vigilance system. Suggestions are made that (1) the validity of proposed functional equations over the extended range of danger probability be studied, (2) an analysis of the cyclic fluctuations of the alertness level be accomplished, and (3) the cost functions of detection reliability be included in any future model.

• 대기
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• 제29권2호
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• pp.183-196
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• 2019

High-quality and high-resolution meteorological information is essential to reduce damages due to disastrous weather phenomena such as flash flood, strong wind, and heat/cold waves. There are many meteorological observation stations operated by Korea Meteorological Administration (KMA) in Seoul Metropolitan Area (SMA). Nonetheless, they are still not enough to represent small-scale weather phenomena like convective storm cells due to its poor resolution, especially over urban areas with high-rise buildings and complex land use. In this study, feasibilities to use additional pre-existing networks (e.g., operated by local government and private company) are tested by investigating the effects of network density on the gridded horizontal distribution of two meteorological variables (temperature and precipitation). Two heat wave event days and two precipitation events are chosen, respectively. And the automatic weather station (AWS) networks operated by KMA, local-government, and SKTechX in Incheon area are used. It is found that as network density increases, correlation coefficients between the interpolated values with a horizontal resolution of 350 m and observed data also become large. The range of correlation coefficients with respect to the network density shows large in nighttime rather than in daytime for temperature. While, the range does not depend on the time of day, but on the precipitation type and horizontal distribution of convection cells. This study suggests that temperature and precipitation sensors should be added at points with large horizontal inhomogeneity of land use or topography to represent the horizontal features with a resolution higher than 350 m.

• 대한한방부인과학회지
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• 제34권4호
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• pp.163-174
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• 2021

Objectives: The purpose of this study is to report the improvement of paralytic ileus caused by ovarian cancer after integrative Korean Medicine treatment. Methods: The patient who complained paralytic ileus caused by ovarian cancer was treated by acupuncture, electroacupunture, moxibustion, and herbal medicine for 13 days. The effect of treatment was evaluated by abdominal X-ray, dietary change of patient, Numeral Rating Scale (NRS) and blood examination including white blood cell (WBC), creactive protein(CRP), erythrocyte sedimentation rate (ESR), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and electrocytes. Results: After the treatment, the patient could have taken with her mouth. In addition, the clinical symptoms were improved with no adverse event. Conclusions: This case shows that paralytic ileus caused by ovarian cancer was improved after the integrative Korean Medicine treatment. Therefore, it can be effective an complementary option for paralytic ileus caused by ovarian cancer.

• 동의신경정신과학회지
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• 제33권2호
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• pp.157-180
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• 2022

Objectives: To perform a systematic review of placenta pharmacopuncture for treating neuropsychiatric diseases, focusing on its efficacy and the safety so that evidence on its clinical use could be obtained, thus contributing to further studies. Methods: Through Korean, English, and Chinese databases (OASIS, Korean TK, KISS, RISS, ScienceON, Pubmed, Cochrane, EMBASE, CINAHL, AMED, CNKI, and Wanfang), combinations of keywords (placenta, pharmacopuncture, etc.) were used to select clinical studies published until January 2021 about placenta pharmacopuncture for neuropsychiatric diseases. Interventions included combined treatments. Study design included cases studies, series, and clinical trials. Cohort studies, literature reviews, in vitro and animal experiments were excluded. The primary outcomes involved measurements of symptoms, Visual Analogue Scale, or questionnaires. Data extracted from databases were imported to Endnote X7 to remove duplicates. The quality of the literature was assessed based on CAse REports Guidelines and Cochrane's Risk of Bias (ROB). Results: Twenty-one studies were selected, including ten case reports, three case series, two one-armed clinical trials, one non-randomized clinical trial, and five randomized clinical trials. There were six studies on sleep disorders, five studies on stroke sequela, two on mood disorders, two on enuresis, two on Guillain-Barré syndrome, two on multiple sclerosis, one on neurocognitive disorder, and one on vertigo. The most frequent combined treatment was acupuncture in both the experimental group (n=10) and the control group (n=3). Acupoints were ST36, SP6, BL23, CV4, GB20, GV20, N-HN54, and so on. All studies reported improvement of symptoms. The quality of case studies was relatively high. Assessment of ROBs resulted in low risks. Conclusions: Placenta pharmacopuncture is effective for neuropsychiatric diseases such as sleep disorders, mood disorders, enuresis, and neurocognitive disorders. Regarding insomnia, several studies have reported significant improvements with placenta pharmacopuncture. There was no adverse event associated with placenta pharmacopuncture.

• Biomolecules & Therapeutics
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• 제31권6호
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• pp.682-691
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• 2023

Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the development of new therapeutic strategies. Licorice extract contains various bioactive compounds, which have been reported to have anticancer and anti-inflammatory effects. This study investigated the cancer preventive efficacy of licochalcone D (LicoD), a chalcone derivative in licorice extract, in EGF and TPA-induced transformed skin keratinocyte cells. LicoD effectively suppressed EGF-induced cell proliferation and anchorage-independent colony growth. EGF and TPA promoted the S phase of cell cycle, while LicoD treatment caused G1 phase arrest and down-regulated cyclin D1 and up-regulated p21 expression associated with the G1 phase. LicoD also induced apoptosis and increased apoptosis-related proteins such as cleaved-caspase-3, cleaved-caspase-7, and Bax (Bcl2-associated X protein). We further investigated the effect of LicoD on the AKT signaling pathway involved in various cellular processes and found decreased p-AKT, p-GSK3β, and p-NFκB expression. Treatment with MK-2206, an AKT pharmacological inhibitor, suppressed EGF-induced cell proliferation and transformed colony growth. In conclusion, this study demonstrated the potential of LicoD as a preventive agent for skin carcinogenesis.

• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.467-478
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• 2009

2003년 10월 28일에 X18 급의 태양 플레어가 발생한 다음날인 10월 29일부터 10월 31일까지 할로윈 이벤트로 불리는 초대형 지자기 폭풍이 전 지구적으로 발생하였다. 할로윈 이벤트 기간 동안 한반도 상공 전리권 양상을 살펴보기 위해서 GPS 신틸레이션 S4 지수와 GPS 토모그래피 기법을 사용한 최대 전자밀도($NmF_2$)의 변화를 날짜별로 분석하였다. GPS 신호손실과 신틸레이션의 총 발생 횟수는 10월 28일과 29일이 각각 1,094회와 1,387회로 30일과 31일의 604회와 897회에 비해 높게 나타났다. 이는 지자기 폭풍이 반드시 전리권 교란을 발생하지 않음을 의미 한다. 그러므로 지자기 폭풍이 아닌 전리권 교란을 감시하기 위해서는 지자기 교란 지수보다 S4 지수가 유용할 것이다. 전리권 전자밀도 변화 양상은 GPS 토모그래피 기법으로 산출된 전리권 최대전자밀도($NmF_2$) 값을 날짜별로 분석하였다. 10월 28일에 가장 높은 $NmF_2$ 값을 보이고 있다. 이는 안양 이온존데에서 관측된 $NmF_2$ 값의 변화와 일치되는 경향을 보이며, 전자밀도가 낮은 30일과 31일에 GPS 신틸레이션과 신호손실 총 발생회수가 낮게 나타나는 양상을 보이고 있다. 결론적으로 지자기 폭풍과 GPS 신호 품절의 상관성은 나타나지 않고 있으나 전자멸도가 감 소할수록 GPS 신호품질은 양호한 것으로 나타나고 있다. 향후 장기관측 자료 분석을 통해 평상시와 지자기 폭풍 기간 동안의 GPS 신호품질과 전자멸도 변화에 대해 연구가 진행될 것이다.

• 인지과학
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• 제16권2호
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• pp.141-154
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• 2005

본 연구의 목적은 암시적$\cdot$명시적 상황인식 지도가 의사결정과 ERP에 미치는 영향을 조사하기 위함이었다. 36명의 피험자들은 암시적 상황인식, 명시적 상황인식, 그리고 통제집단에 각각 12명씩 무작위로 할당되었다. 피험자들은 미국테니스협회에서 주관하는 국가테니스등급 프로그램 2-2.5수준에 해당하는 사람들로 구성하였다. 피험자들은 스크린에 비춰지는 단식수비, 단식공격, 복식수비 장면을 상황인식하다가 화면이 멈춰졌을 때 방향을 예측한 후 가능한 한 빨리 자기 앞에 놓여있는 스위치를 방향을 결정하는 것이었다. 종속변수는 두정엽, 중심구, 전두엽의 P300 잠재기와 진폭이었다. 본 연구에서는 암시적 $\cdot$명시적 상황인식이 의사결정과 ERP에 미치는 영향을 알아보기 위해 3(집단) x 3(조건) x 3(영역) 분산분석을 하였다. ERP는 시간 매김된 신호만 보존하여 앙상블 평균화 작업을 하였다. 연구결과 통제집단의 반응시간이 가장 짧은 것으로 나타났으나, 암시적 상황인식 집단의 P300 잠재기가 명시적 상황인식 또는 통제집단보다 짧은 것으로 나타났다. 또한 클립간에 는 단식수비가 단식공격이나 복식수비보다도 잠재기가 긴 것으로 나타났다. P300 진폭은 처치집단(명시적$\cdot$암시적 집단)이 더 큰 것으로 나타났고, 영역간에는 Cz 영역의 P300 잠재기가 가장 짧았다. 본 연구결과 암시적 명시적 상황인식지도는 서로 다른 형태로 피험자의 의사결정에 영향을 미치는 것으로 여겨진다.