• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2010년도 추계학술대회 논문집
• /
• pp.267-268
• /
• 2010

• 융합정보논문지
• /
• 제11권6호
• /
• pp.181-187
• /
• 2021

화장품 시장은 2026년의 초고령사회(Super aged society)가 예측되는 만큼 타 산업과 비교하여 지속적 시장 창출이 기대되는 산업이고, 우리나라 역시 고령화 시대의 진입 속에서 항노화에 관한 관심이 증대되고, 이에 관한 결과로 기능성 화장품에 대한 수요가 증가가 나타났다. 특히, 노년층을 위한 기능성 성분 소재에 관한 연구가 증가하고 있다. 소재 개발의 연구는 화장품 산업에 있어서 신제품 개발로 이어지는 아주 중요한 과정이다. 본 연구는 학술정보시스템(Research information Shining Service, RISS)을 이용하여 국내 천연주름 개선 기능성 화장품 소재개발을 주제로 한 연구를 중심으로 주름 개선화장품의 연구 방향에 대한 여러 가지 주름생성 저해 방법을 실험한 결과와 신소재에 대한 안전하면서도 주름 개선기능이 탁월한 천연 소재 주름 개선 기능성 성분에 관한 최신 연구 동향을 살펴보았다.

• 약학회지
• /
• 제45권3호
• /
• pp.310-319
• /
• 2001

To compare skin irritation and cytotoxicity of anti-wrinkle agents, we examined skin irritation of six anti-wrinkle agents (ascorbic acid, glycolic acid, all trans-retinoic acid, ginseng extract, retinol, EB) in New Zealand white rabbit. Cytotoxicity of these agents was determined by MTT [tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] at multi-time points in cultured HaCaT cell, a human immortalized keratinocyte cell. We then analyzed correlation between skin irritation and cytotoxicity by spearman's rank correlation analysis. All trans-retinoic acid showed the highest primary irritation index (0.92) in skin irritation test. Being all the six agents not irritant, retinal showed the most cytotoxic agents. The correlation between skin irritation and cytotoxicity ($IC_{50}$/ at different time point was 0.814, 0.757, 0.814 and 0.7 at 3, 24, 48 and 72 h, respectively. We also fecund that IC$_{20}$ and IC$_{80}$ of these agents showed similar correlation with skin irritation. These results therefore demonstrated that there is close correlation between skin irritation and cytotoxicity $IC_{50}$/ value by MTT in HaCaT cell at early time points by anti-wrinkle agents or IC$_{20}$ value. $IC_{50}$/ at earily time point or IC$_{20}$ values may be reliable alternative determinant of skin irritation.n.

• Journal of Biosystems Engineering
• /
• 제22권4호
• /
• pp.433-438
• /
• 1997

The freshness of apple was evaluated by characterizing the surface texture of flesh cells. The freshness index which was related to the amount of wrinkles on the cell surface was defined to quantify the freshness. Four parameters relevant to the amount of the cell wrinkles were selected and measured using image analysis including wrinkle extraction procedure and Fast Fourier Transform of a wrinkle-extracted image. Out of 4 parameters, three parameters had highly significant correlations with the time elapsed after harvest. But it was concluded that two parameters out of such 3 parameters could be used for description of freshness index.

• 디지털융복합연구
• /
• 제12권7호
• /
• pp.239-245
• /
• 2014

본 논문에서는 얼굴의 전체적인 특징(윤곽선, 얼굴크기, 눈, 코) 분석에 기반을 둔 가중치 주름 검출 방법을 제안한다. 첫째 입력된 영상에서 능동적 외향 방법을 이용하여 얼굴의 전체적인 주요 성분을 검출하게 되는데, 크게 형태 기반과 외향 방법으로 구성되어 있다. 이것은 얼굴 모델을 학습하고, 학습된 모델을 기반으로 새로운 영상에서 얼굴을 정합할 때 사용된다. 두 번째로는 영상에서 얼굴과 배경을 분리하고, 얼굴에서 주름 확률이 가장 큰 곳 네 곳을 선정하여 주름 가중치를 높게 부과하다. 마지막으로 가중치를 부여한 관심 영역에 대해서 캐니에지 알고리즘을 적용하여 주름을 검출하게 된다. 제안한 알고리즘은 다양한 종류의 영상을 사용하여 실험 하였으며, 실험결과 대부분의 영상에서 높은 성능의 얼굴 및 주름 검출 결과를 보였다.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2007년도 Proceedings of The Convention
• /
• pp.153-158
• /
• 2007

Background: Naturally occurring antioxidants were used to regulate the skin damage caused by ultraviolet (UV) radiation because several antioxidants have demonstrated that they can inhibit wrinkle formation through prevention of matrix metalloproteinases (MMPs) and/or increase of collagen synthesis. We examined the effect of oral administration of the antioxidant mixture ("L-Skin Care") on UVB-induced wrinkle formation. In addition, we investigated the possible molecular mechanisms of photoprotection against UVB through inhibition of collagen-degrading MMP activity or through enhancing of pro collagen synthesis in mouse dorsal skin. Methods: Female SKH-l hairless mice were orally administrated "L-Skin Care" (test group) or vehicle (control group) for 10 weeks with UVB irradiation by three times a week. The intensity of irradiation was gradually increased from 30 to $180mJ/cm^2$. Microtopographic and histological assessments of the dorsal skins were carried out at the end of 10 weeks to evaluate wrinkle formation. Western blot analysis and EMSA were also carried out to investigate the changes in the balance of collagen synthesis and collagen degradation. Results: Our "L-Skin Care" significantly reduced UVB-induced wrinkle formation, accompanied by significant reduction of epidermal thickness, and UVB-induced hyperplasia, acanthosis and hyperkeratosis. Oral administration of "L-Skin Care" significantly prevented UVB-induced expressions of MMPs, mitogen-activated protein (MAP) kinases and activation of activator protein (AP)-1 transcriptional factor in addition to enhanced type I procollagen and transforming growth factor-$\beta$ (TGF-$\beta$) expression. Conclusion: Oral administration of "L-Skin Care" significantly inhibited wrinkle formation caused by chronic UVB irradiation through significant inhibition of UVB-induced MMP activity accompanied with enhancement of collagen synthesis.

• 한국정보전자통신기술학회논문지
• /
• 제15권5호
• /
• pp.321-327
• /
• 2022

본 논문에서는 UV/Ozone 처리를 통해 Polydimethylsiloxane(PDMS) 표면에 주름 구조를 형성하고, 물리화학적 특성 분석을 통해 줄금 구조 형성 메커니즘을 밝혔다. 30분의 UV/Ozone 처리를 통해 PDMS 표면에 주름 구조를 형성하였으며, 주사전자현미경의 단면 촬영으로 PDMS 표면의 주기적인 주름 형성을 확인할 수 있었다. 또한, XPS 스펙트럼 분석을 통해 PDMS 표면에 SiOx의 실리카 경질 표면이 UV/Ozone에 의해 만들어지는 것을 확인하였고, PDMS 표면의 경질층과 내부의 연질층 사이의 탄성 계수 불일치는 PDMS의 주름 형성의 팽윤 메커니즘을 확인시켜 준다. 본 연구 결과는 UV/Ozone 처리에 의한 PDMS 표면의 주름 구조 형성 메커니즘의 이해도를 향상시킬 뿐만 아니라, 향후 UV/Ozone 조사 조건에 따라 주름 구조의 진폭과 주기를 조정하는데 기초 연구로 쓰일 수 있을 것이다.

• Fibers and Polymers
• /
• 제1권2호
• /
• pp.116-121
• /
• 2000

It has been considered that malic acid, $\alpha$-hydroky succinic acid, could not form crosslinks in the cellulosic materials unless activated by other polycarboxylic acids such as butanetetracarboxylic acid or citric acid because there are only two carboxylic acids per molecule available fur the formation of one anhydride intermediate. However we found that the dicarboxylic malic acid with sodium hypophosphite catalyst without the addition of other crosslinkers was able to improve wrinkle resistance of cotton up to $294^{\circ}$(dry WRA) and $285^{\circ}$ (wet WRA), which is a measure of crosslinking level in cotton. $^1$H FT-NMR, FT-IR and GPC analysis indicated the in-situ formation of an trimeric $\alpha$, $\beta$-rnalic acid with a composition of 1:3 through the esterification between hydroxyl group and one of carboxylic groups in malic acid during curing. The crosslinking of cotton was attributed to the trimeric $\alpha$, $\beta$-malic acid, a tetracarboxylic acid, which can form two anhydride rings during curing. The influence of crosslinking conditions such as concentrations of malic acid and catalyst, pH of the formulation bath, and curing temperature were investigated in terms of imparted wrinkle resistance and whiteness. The addition of reactive polyurethane resin in the formulation slightly increased the mechanical strength retention of crosslinked fabric coupled with additional increase in wrinkle resistance.

• 대한화장품학회지
• /
• 제45권3호
• /
• pp.299-306
• /
• 2019

Ginseng berry(GB)는 진세노사이드Re를 함유하고 있으며, 항염, 피부 주름 완화의 기능을 가지고 있다. 본 연구에서는 Ginseng berry 아미노산 복합체의 TLC 분획 fraction 1, 2, 4를 확인하고 HPLC로 분석하였으며, fraction 1의 LC/MASS 분석을 통해 peptide (AP-1)를 동정하였다. AP-1에 의한 NO 생성 억제 효과를 조사하여 항염증 활성을 확인하였다. 또한 procollagen type I C-peptide (PIP) ELISA kit를 이용한 collagen 합성은 대조군 대비 50% 이상의 효과를 보였다. 이상의 결과로부터 진생베리 아미노산 복합체로부터 분리한 펩타이드는 항염과 주름개선 효능을 가진다고 사료되며, 향후 항염 및 항노화 화장품 원료로서의 이용 가능성을 보였다.

• Fibers and Polymers
• /
• 제2권4호
• /
• pp.184-189
• /
• 2001

Continuous photografting/crosslinking of polyethyleneglycol dimethacrylate oligomers onto cotton using a water-soluble benzophenone photoinitiator was investigated. Photografting increased with increasing irradiation dose, oligomer concentration and photoinitiator concentration. Maximum grafting efficiency of DM 400 and 600 were 83% and 79%, respectively. the photografting increased the wrinkle resistance of cotton implying surface crosslinking of cotton. bothsurface crosslinking and bulk crosslinking of cotton were accomplished via dual curing of a mixed formulation containing both a thermally curable component (BTCCA/SHP) and a UV-curable component. The wrinkle resistance of the crosslinked cotton was found to be higher when cured by thermal curing due to the facile post-polymerization of the UV active component. The presence of crosslinks in the dually crosslinked cotton was verified with FT-IR and thermogravimetric analysis.