• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.301-311
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• 2011

This study was performed to determine the self-perceived fatigue and its association with job stress contents and psychosocial factors among white collar male workers. The self-administered questionnaires were given to 872 workers employed in 42 work places during the period from February 1st to April 30th, 2009. As a results, in terms of levels of self-perceived fatigue according to the job stress contents and psychosocial factors, under significantly higher level of self-perceived fatigue were those with higher level of job demand, lower job autonomy, lower supervisor support and higher locus of control than their respective counterparts. Multiple stepwise analysis revealed that the factors of influence on self-perceived fatigue included age, subjective status of health, job career, experience of sick absence, sense of satisfaction in work, regular exercise, sleeping hours, visiting out-patient department, job demand, supervisor support and self-esteem. The study results indicated that the level of self-perceived fatigue is so complicatedly influenced by variable factors as well as socio-demographic characteristics, job-related characteristics and health-related behaviors, to a greater extent, by JCQ and psychosocial factors.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7169-7174
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• 2014

Background: NPAS2 is a product of the circadian clock gene. It acts as a putative tumor suppressor by playing an important role in DNA damage responses, cell cycle control and apoptosis. Chronic lymphocytic leukemia (CLL) appears to be an apoptosis related disorder and alteration in the NPAS2 gene might therefore be directly involved in the etiology of CLL. Here, the Ala394Thr polymorphism (rs2305160:G>A) in the NPAS2 gene was genotyped and melatonin concentrations were measured in a total of seventy-four individuals, including thirty-seven CLL cases and an equal number of age- and sex-matched healthy controls in order to examine the effect of NPAS2 polymorphism and melatonin concentrations on CLL risk in a Pakistani population. Materials and Methods: Genotyping of rs2305160:G>A polymorphism at NPAS2 locus was carried out by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Melatonin concentrations were determined by enzyme linked immunosorbent assay (ELISA). Statistical analysis was performed using Statistical Package for Social Sciences software. Results: Our results demonstrated no association of the variant Thr genotypes (Ala/Thr and Thr/Thr) with risk of CLL. Similarly, no association of rs2305160 with CLL was observed in either females or males after stratification of study population on a gender basis. Moreover, when the subjects with CLL were further stratified into shift-workers and non-shift-workers, no association of rs2305160 with CLL was seen in either case. However, significantly low serum melatonin levels were observed in CLL patients as compared to healthy subjects (p<0.05). Also, lower melatonin levels were seen in shift-workers as compared to non-shift-workers (p<0.05). There was no significant difference (p>0.05) in the melatonin levels across NPAS2 genotypes in all subjects, subjects with CLL who were either shift workers or non-shift-workers. General Linear Model (GLM) univariate analysis revealed no significant association (p>0.05) of the rs2305160 polymorphism of the NPAS2 gene with melatonin levels in any of the groups. Conclusions: While low melatonin levels and shift-work can be considered as one of the risk factors for CLL, the NPAS2 rs2305160 polymorphism does not appear to have any association with risk of CLL in our Pakistani population.