• Archives of Pharmacal Research
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• v.26 no.5
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• pp.394-404
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• 2003

Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. In the present study, the effects of six well-known PAHs, such as benzo[a]pyrene, benz[a]anthracene, dibenz[a,h]anthracene, chrysene, benzo[k]fluorancene and benzo[b]fluorancene, on the activities of hepatic and pulmonary CYP enzymes were investigated in male ICR mice. When mice were treated intraperitoneally with 3, 10 and 30 mg/kg of individual PAHs for 3 consecutive days, the activities of ethoxyresorufin- and methoxyresorufin-Ο-dealkylases were significantly and differentially induced in both liver and lung. Moreover, other CYP isozyme-associated monooxygenase activities were also induced significantly in liver and lung with characteristic induction profiles. Our present results suggest that individual PAHs might have inductive effects on CYP isozymes, and that the characteristic inductive effects of individual PAHs on certain CYP isozymes would be developed as a marker for determining exposure to certain PAHs.

• Archives of Pharmacal Research
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• v.29 no.11
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• pp.984-989
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• 2006

1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has been characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis $factor-{\alpha}$. In the present studies, the phase 1 metabolism of FPP-3 was investigated in rat liver microsomes and cytosols. When FPP-3 was incubated with rat liver microsomes and cytosols in the presence of NADPH. 2 major peaks were detected on a liquid chromatography/electrospray ionization-mass spectrometry. Two metabolites (i.e., M1 and M2) were characterized as reduced forms on propenone: M1 (1-furan-2-yl-3-pyridin-2-yl-propan-1-one) was the initial metabolite and M2 (1-furan-2-yl-3-pyridin-2-yl-propan-1-ol) was a secondary alcohol believed to be formed from M1.

• Journal of Hydrogen and New Energy
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• v.14 no.2
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• pp.177-186
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• 2003

Today, human beings are faced with crisis of environmental pollution and fuel exhaustion because energy consumption has increased rapidly as a rise in population, therefore human beings are in need of hydrogen energy as a substitute energy. Hydrogen has the advantages of cleanness and boundlessness, but it has difficulties of storage and safety. Making a nameless hydrogen burner for household in consideration of hydrogen's peculiarity was tried. This hydrogen burner utilized the heat of reaction that was emitted when water was formed by reaction of hydrogen and oxygen, It was tried to impregnate Pt catalyst in ceramic fiber(substrate) for the reaction of hydrogen and oxygen to be reacted more easily. This experiment was inquired that hydrogen is appropriate for being used as burner fuel in home and found out whether its safe usefulness is possible or not.

• Tuberculosis and Respiratory Diseases
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• v.58 no.2
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• pp.174-178
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• 2005

The bronchial varices in mitral stenosis are uncommon and incidentally discovered during bronchoscopy. Although bronchial varices are primarily associated with bronchial or pulmonary disease, the bronchial vein can be dilated with increased pulmonary venous pressure secondary to mitral stenosis. The bronchial varices may present massive hemoptysis. The hemoptysis can be controlled by mitral commissurotomy or mitral valve replacement in case of mitral stenosis. We report a case of bronchial varies in a patient with severe mitral stenosis. The bronchial varices were found incidentally during bronchoscopy and they were nearly disappeared by mitral valve replacement.

• Journal of Drive and Control
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• v.21 no.2
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• pp.23-29
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• 2024

Potatoes are one of the world's four major crops, and domestic consumption is currently increasing in Korea. However, the mechanization rate of potatoes is very low, and especially, harvesting is the most labor-intensive task in potato production. In Korea, potato-collecting work depends on manpower, so it is necessary to develop a gathering-type harvester that can be used for processes from digging to harvesting. Therefore, in this study, a self-propelled-type potato harvester was developed, and its performance was analyzed to mechanize harvesting. The potato harvester was developed to have a crawler-type driving part with a 60 hp diesel engine and consisted of a digging part that digs potatoes from the ground, a vertical transporting part that transfers the dug potatoes to the height of the collection bag, a separating part that separates debris, such as stones and soil, and a collecting part that loads the collection box. A field test of the potato harvester was conducted, and performance was evaluated by the damage, loss, and debris mixing proportions, which were 2.5%, 2.8%, and 2.6%, respectively. The working capacity was 1.2 h/10 a. The economic analysis results showed that the cost of harvesting work could be reduced by 12.7% compared to manual harvesting.

• Journal of Drive and Control
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• v.21 no.2
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• pp.30-35
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• 2024

Domestic rice is more expensive than imported products, so it is necessary to reduce production costs to secure competitiveness. Low-density planting developed in Japan is a cultivation technology that reduces labor and production costs without yield loss. The area of low-density cultivation is continuously increasing. However, research on how rice transplanters adapt to low-density planting has not been conducted. Therefore, this study was carried out to determine the optimal working conditions of a rice transplanter for low-density planting. Three types of rice transplanters were used and treated based on 3 conveying distance levels. The number of picked seedlings, pick missing rate, the number of planted seedlings, and the mis-planted rate were investigated to evaluate planting accuracy according to the transfer distance to the seedling tray. The results showed that the number of planted seedlings was 4.31~4.95 EA with an L1 seedling tray transfer distance (horizontal 9 mm, vertical 8 mm), but the mis-planted rate was higher than in other conditions. At L2 (horizontal 9 mm, vertical 10 mm) and L3 (horizontal 11 mm, vertical 8 mm) transfer distance conditions, the number of planted seedlings were 4.89-5.68 EA and 4.69-5.66 EA, respectively, with a low mis-planted rate of less than 3%. The results showed that if the transfer distance is adjusted properly, a rice transplanter can be used for low-density planting with high planting accuracy.

• Journal of Drive and Control
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• v.21 no.2
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• pp.36-43
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• 2024

The yield is basic and necessary information in precision agriculture that reduces input resources and enhances productivity. Yield information is important because it can be used to set up farming plans and evaluate farming results. Yield monitoring systems are commercialized in the United States and Japan but not in Korea. Therefore, such a system must be developed. This study was conducted to develop a yield monitoring system that improved performance by correcting a previously developed flow sensor using a grain tank-weighing system. An impact-plated type flow sensor was installed in a grain tank where grains are placed, and grain tank-weighing sensors were installed under the grain tank to estimate the weight of the grain inside the tank. The grain flow rate and grain weight prediction models showed high correlations, with coefficient of determinations (R2) of 0.9979 and 0.9991, respectively. A main controller of the yield monitoring system that calculated the real-time yield using a sensor output value was also developed and installed in a combine harvester. Field tests of the combine harvester yield monitoring system were conducted in a rice paddy field. The developed yield monitoring system showed high accuracy with an error of 0.13%. Therefore, the newly developed yield monitoring system can be used to predict grain weight with high accuracy.

• Biomolecules & Therapeutics
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• v.17 no.4
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• pp.446-454
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• 2009

1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis factor-$\alpha$. In the present study, adverse effects of FPP-3 on immune functions were determined in female BALB/c mice. When mice were administered orally with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days, FPP-3 suppressed the number of antibody-forming cells and reduced thymus weight at 500 mg/kg. In addition, FPP-3 administered mice exhibited reduced splenic cellularity and numbers of splenocyte subsets, such as $CD3^+$ cells, $CD3^+CD4^+$ cells, $CD3^+CD8^+$ cells and macrophages. IL-4 mRNA expression was significantly suppressed by FPP-3 treatment. Moreover, the number of $CD4^+IL-4^+$ cells was reduced following the treatment of mice with 500 mg/kg of FPP-3. These results suggested that FPP-3 at 500 mg/kg might be immunotoxic, and that FPP-3-induced immunotoxicity might be mediated, at least in part, through the inhibition of cytokine production, such as IL-4.

• Biomolecules & Therapeutics
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• v.17 no.3
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• pp.318-324
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• 2009

1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide. In the present study, adverse effects of FPP-3 on hepatic functions were determined in female BALB/c mice. When mice were administered with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days orally, FPP-3 significantly increased absolute and relative weights of liver with a dose-dependent manner. In addition, FPP-3 administration dramatically increased the hepatotoxicity parameters in serum at 500 mg/kg, in association of hepatic necrosis. FPP-3 significantly induced several phase I enzyme activities. To elucidate the possible mechanism(s) involved in FPP-3 induced hepatotoxicity, we investigated the hepatic activities of free radical generating and scavenging enzymes and the level of hepatic lipid peroxidation. FPP-3 treatment significantly elevated the hepatic lipid peroxidation, measured as the thiobarbituric acid-reactive substance, and the activity of superoxide dismutase. Taken together, the present data indicated that reactive oxygen species might be involved in FPP-3-induced hepatotoxicity.

• Biomolecules & Therapeutics
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• v.22 no.2
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• pp.136-142
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• 2014

We investigated the protective effects of chlorogenic acid (CGA), a polyphenol compound, on oxidative damage induced by UVB exposure on human HaCaT cells. In a cell-free system, CGA scavenged 1,1-diphenyl-2-picrylhydrazyl radicals, superoxide anions, hydroxyl radicals, and intracellular reactive oxygen species (ROS) generated by hydrogen peroxide and ultraviolet B (UVB). Furthermore, CGA absorbed electromagnetic radiation in the UVB range (280-320 nm). UVB exposure resulted in damage to cellular DNA, as demonstrated in a comet assay; pre-treatment of cells with CGA prior to UVB irradiation prevented DNA damage and increased cell viability. Furthermore, CGA pre-treatment prevented or ameliorated apoptosis-related changes in UVB-exposed cells, including the formation of apoptotic bodies, disruption of mitochondrial membrane potential, and alterations in the levels of the apoptosis-related proteins Bcl-2, Bax, and caspase-3. Our findings suggest that CGA protects cells from oxidative stress induced by UVB radiation.