• Journal of Nutrition and Health
• /
• 제40권7호
• /
• pp.593-600
• /
• 2007

Recent studies described the ${\varepsilon}4$ allele of apoE confers a two-to fourfold increased risk for late-onset Alzheimer#s disease (LOAD), but LOAD pathology does not all fit neatly around apo E. Therefore, the goal of this study was to find the association between Alzheimer and apo E4 genotype in the 107 elderly between 50 to 64 years old who visited to FHWC of Sungshin Women#s University. We conducted the questionnaire survey (general & 24 hr dietary recall), anthropometerics (BP, waist & BMI) and blood biochemistry (FBS & lipid profiles). LDL-c and HOMA-IR were calculated by Friedwald#s and Matthew#s formulas. The apo E genotyping was performed by PCR-RFLP method and subjects were divided into three allele groups (${\varepsilon}3$; wild, ${\varepsilon}2$ & ${\varepsilon}4;$ mutants). The apo E allele frequencies were 7.0% for the ${\varepsilon}2$, 83.6% for the ${\varepsilon}3$ and 9.3% for the ${\varepsilon}4$. In comparison with biochemistry characteristics by apo E genotype, FBS was significantly higher in ${\varepsilon}4(129.2{\pm}6.8)$ than that in the others (${\varepsilon}2$: $117{\pm}7.4$, ${\varepsilon}3$: $107.3{\pm}2.2)$ (p<0.01). More than forty percents of ${\varepsilon}4$ group shown the dyslipidemia [high TG (>150mg/dl) & low HDL (<40 mg/dl:male or <50 mg/dl: female)]. The cytokines levels such as IL-1 ${\beta}$, IL-6 and $TNF-{\alpha}$ were not different among three apoE alleles. After the adjusting sex, age & dietary fiber, LDL-c level was siginificantly higher in ${\varepsilon}4$ ($108.3{\pm}7.7$) than that in ${\varepsilon}2$ ($100.4{\pm}8.4$) (p<0.05). According to food intake and the recipe on the basis of 24 hr dietary recall, the elder]y with ${\varepsilon}4$ allele took higher intake frequency of the light -colored vegetable (radish, onion & cabbage) and pan-fried foods (sauteed beef and vegetables, stir-fried vienna with vegetables) than the others. We knew that the elderly with ${\varepsilon}4$ allele had been restricted the calories intakes with high dietary fiber (33.6+2.5 g/d) to maintain the normal level of FBS and LDL-c. On next study, the prevalence of Alzheimer#s disease in this population who has ${\varepsilon}4$ allele on the condition of calories restriction will be continually follow-up.

• 한국주거학회:학술대회논문집
• /
• 한국주거학회 2006년도 추계학술발표대회 논문집
• /
• pp.123-130
• /
• 2006

This is a basic study to investigate possibility to application of cohousing model into Korea. Purpose of this study is to grasp respondents' housing value, and its influence on intention to live in cohousing. Research method used for this study was a social survey. Respondents were 214 married people residing in Seoul and its outskirts by accidential sampling. The collected data were analyzed by SPSS 12.0 program using frequency, mean, average, factor analysis, t-test, one-way ANOVA, Duncan's multiple range test, multiple regression and logit analysis. Result of this study was as follows. Housing values were classified into three categories named as individualism oriented housing value, tradition oriented housing value, and economy oriented housing value. Housing values were different by respondents groups. For example, individualism oriented housing value showed difference according to age and housing area. Tradition oriented housing value showed difference according to sex, occupation, and period of residence, while economy oriented housing value showed difference according to number of family members, housing type, and home ownership. In detail, men than women, single-income family than double-income family, and detached house resident than flat resident had higher tradition oriented housing value. The younger than the elder, and Seoul resident than outskirts resident had higher economy oriented housing value. Also home owner than tenant, and the higher tradition oriented group had stronger intention to live in cohousing than others.

• Journal of Animal Science and Technology
• /
• 제53권3호
• /
• pp.195-202
• /
• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• 한국콘텐츠학회논문지
• /
• 제15권9호
• /
• pp.195-209
• /
• 2015

본 연구는 노인의 주관적 안녕감의 국내 연구를 분석하여 주관적 안녕감의 성별차이를 밝히고자 노인 대상의 연구가 활발하게 시작된 2000년 이후부터 2013년까지의 연구들을 메타 분석하였다. 노인의 주관적 안녕감에 대한 성에 따른 차이에 대해 아직까지 일관된 결과를 제시해 주고 있지 않기 때문에 그동안의 연구를 통합하여 분석하는 메타분석을 실시하였다. 선정기준에 적합한 총 74개의 논문을 대상으로 성별차이의 효과크기와 가중평균을 계산하고, 논문특성에 따른 분석을 위해 SPSS에서 메타분석 macro를 활용한 메타분석과 메타회귀분석을 수행하였다. 분석 결과, 남성노인의 주관적 안녕감이 여성노인보다 높은 것으로 밝혀졌고, 주관적 안녕감의 성별차이의 효과크기(es = .1157)는 95%의 신뢰구간 .0528에서 .1787로 통계적으로 유의하였다. 조절변인으로서의 논문의 특성에 따라 성별효과크기의 차이가 통계적으로 유의하지 않음이 밝혀졌다. 다수의 연구가 건강과 사회적 관계의 영향요인을 분석하였으나 성별차이와의 상호작용을 검증한 논문은 극히 일부였다. 이러한 연구결과를 바탕으로 함의점을 제시하였다.

• 대한교통학회지
• /
• 제18권4호
• /
• pp.19-30
• /
• 2000

환승은 대중교통 이용시 불가피하게 발생하여 승객에게 불편을 초래하는 통행저항(travel impedance)으로 작용하지만, 대부분의 기존 연구에서는 이를 제대로 고려하지 못하였다. 따라서 본 연구는 환승이 경로선택에 어떠한 영향을 미치는지를 살펴보기 위해서 서울시 지하철 이용자를 대상으로 선호의식(Stated Preference: SP) 및 현시선호(Revealed Preference: RP) 자료를 구축하여 분석하였으며, 차내시간, 환승횟수, 환승시간 그리고 에스컬레이터 유무의 가치를 추정하기 위한 모형식을 구축하였다. 연구 결과, SP분석과 RP분석의 결과가 조금씩 차이가 나지만 대체적으로 서울시 지하철 이용객들은 차내시간을 기준으로 할 때 환승시간은 1∼2배, 환승 1회는 10∼15분, 에스컬레이터 유무는 2∼4분의 가치를 부여하는 것으로 나타났다. 시장분할을 통해 통행특성별로 살펴본 결과 여자가 남자에 비해서 그리고 나이가 들수록 환승에 더 많은 가치를 부여함으로써 환승을 더 불편하게 느끼고 있는 것으로 나타났다. 또한 분석자료별로 차이가 있지만 귀가·하교 통행이 환승에 대한 저항이 크고, 출근·등교·업무 통행이 비교적 낮았다. 또한 통행시간 및 환승시간이 길수록 환승에 대한 저항이 크게 나타났다.

• 지역사회간호학회지
• /
• 제15권2호
• /
• pp.289-297
• /
• 2004

Purpose: This study was conducted to determine factors affecting workers' physiological somatic complain using the Job Stress Model proposed by the National Institute for Occupational Safety and Health (NIOSH). Method: Data were collected from the 1st to the 30th of December 1999. The subjects were 2.123 workers employed at 155 work sites. Collected date were analyzed through SAS/PC program. Result: According to individual characteristics, younger and women groups showed significantly higher physiological somatic complaint than elder men groups. By work condition, groups with higher physiological somatic complaint included workers of irregular shift work. Dark lighting, improper temperature in winter, improper ventilation, inappropriate humidity, unpleasant work environment and crowded work place were significantly related with physiological somatic complaint. By work-related factor, physiological somatic complaint was high in those with higher variance in work load, quantitative work load, role conflict, job burden, role ambiguity and future ambiguity. On the other hand, physiological somatic complaint was low in those with little underutilization of ability. As for the relationships between physiological somatic complaint and non-work related factors, physiological somatic complaint was high in workers who had a side job, were bringing up infants alone, cleaned the house alone, cared for the elderly and disabled persons, were studying, were volunteering at another organization, and were spending 5-10 hours in religious activities per week. Physiological somatic complain was in significantly negative correlations with overall social support, supervisory support and family support, but in significantly positive correlations with co-worker support. Conclusion: The main predictors of physiological somatic complain were gender, shift work pattern, overtime work, ventilation, role ambiguity, role conflict, future ambiguity, job control, variance in work load, overall social support, worker with side job, worker who cleans the house alone, worker who is studying. These predictors explained 19.10% of the total variance of physiological somatic complain.

• 지역사회간호학회지
• /
• 제12권1호
• /
• pp.32-38
• /
• 2001

This study focused on the understanding the life of the elderly in the institution by phenomenological method. The participants were seven. who were 4 men and 3 women living in the elderly institution in Taegu. The data were collected through the indepth interviews and participant observation from June 20. 1999 to January 10. 2000 and analyzed by phenomenological analytic method by Giorgi. The structure of the meaning were as follows: Unhappy life: irresponsibility. self-centered thought. hardness. Irresistible life: misfortune. unhealthiness. Reading their son's intention. Bitter life: unfair treatment from their sons and daughters, betrayed feeling for their being thrown away. Outside oriented life: a fear of others' attention, wrong information about institutionalized life, maladjustment. Self-consolation life: comfortableness, convenience, economic merit of low cost. Dissatisfied life: discomfort from communal living. unkindness of the institution staffs, depreciated tendency to the elder people, irrational social security system. economic distress, physical pain, restrained feeling. Tenacity to their sons and daughters longingness for their sons and daughters, regretableness, waiting, Regretable life: remorse for their past life. agony, guilty, loneliness, grief, self-abandonment, self-depreciation, other residents' death in common. Inharmonious life with other residents complaint, conflict, ignorance, selfishness. Yearning life for opposite sex: sexual interest. Preparing for their life: control over their body and mind, consideration for others. A life with hope: blessing death, forever healthfulness, affiliation to their family. From the results of this study an education and consultation should be done as soon as possible to remove the negative recognition of the institutional life to the facility residents. the family and the future consumers of elderly institution. To minimize the maladjustment to facility life of residents, a new program and interventions for the new comer's are needed. The thesis with above results will widen the understandings of institutional residents and an important guidance for a better nursing care in elderly institutions of korea.

• Journal of Korean Medical Science
• /
• 제33권52호
• /
• pp.339.1-339.11
• /
• 2018

Background: Hip pain is a common musculoskeletal complaint in general practice. Although comprehensive diagnostic approach on hip pain is mandatory for adequate treatment, un- or mis-diagnosis is not rare in primary care. The aim of this study was to analyze descriptively un- or mis-diagnosed hip pain cases referred from primary care to a tertiary hospital, especially in young adults ${\leq}50years\;old$. Methods: We retrospectively analyzed a consecutive cohort of 150 patients (${\leq}50years\;old$) with chronic hip pain (${\geq}6weeks$), which was not diagnosed or misdiagnosed based on the information provided on the referral form. Results: Overall an average 32 cases/month were referred due to hip pain without a diagnosis or with an incorrect diagnosis. Among them, 150 patients were enrolled in this study and 146 (97.3%) could be allocated to a specific disease by using data from routine clinical practice. Four common final diagnoses were femoroacetabular impingement (FAI) syndrome (55.3%), hip dysplasia (HD, 13.3%), referred pain from the lumbar spine (9.3%), and spondyloarthritis (SpA, 7.3%). In patients with FAI syndrome, 37 (44.0%) had pincer-type FAI and 33 (39.8%) had combined-type. Although the pain site or gender was not tightly clustered, the distribution of final diagnosis was significantly different according to hip pain location or gender. Especially, SpA or HD was not observed in younger women subgroup or elder men subgroup, respectively, when stratified by the mean age of participants. Conclusion: Most (> 80%) young patients with hip pain, a difficult issue to diagnosis for many primary physicians, had FAI syndrome, HD, spine lesions, and SpA. This study could give a chance to feedback information about cases with un- or mis-diagnosed hip pain, and it suggests that primary physicians need to be familiar with the diagnostic approach for these 4 diseases.

• 대한토목학회논문집
• /
• 제26권2D호
• /
• pp.225-231
• /
• 2006

소비자가 쇼핑통행을 하지 않으면서 인터넷을 통하여 물건을 주문하고, 집이나 직장 등 소비자가 원하는 장소에서 물건을 배달 받는 온라인 쇼핑은 운송산업 구조, 산업입지 패턴, 화물운송수요 및 통행패턴에 종전과 전혀 다른 변화를 초래할 것이다. 우리나라의 경우 장래 예상되는 여성인구의 사회활동 참여 증대, 고령인구의 증가, 대량생산에서 소량 다품목 고부가 가치 생산으로 변화하는 산업구조 등 사회 경제적 변혁은 앞으로 온라인 쇼핑의 가능성을 더욱 확대시킬 것이다. 따라서 장래 통행수요 및 통행패턴에도 상당한 변화를 초래할 것이며 이러한 변화는 장래 교통정책 방향에 지대한 영향을 미칠 것이다. 온라인 쇼핑의 통행에 미치는 영향이 매우 큼에도 불구하고 아직 우리나라에서는 이에 대한 연구가 이루어진 적이 전혀 없으며 교통정책 수립 시 전혀 반영되지 못하고 있는 실정이다. 따라서 본 연구에서는 온라인 쇼핑이 개인통행에 미치는 영향을 파악하고, 이러한 변화에 대응하기 위하여 장래 교통정책에서 다루어야 할 과제와 정책방향을 검토하고 제시한다.

• 한국엔터테인먼트산업학회논문지
• /
• 제13권2호
• /
• pp.279-287
• /
• 2019

본 연구는 노년기의 노년초월, 가족지지, 사회적지지, 자아존중감, 죽음불안의 정도와 이들 간의 관계를 파악하는 것이다. 서울시 거주 만 60세 이상 성인 50명을 대상으로 구조화된 질문지를 이용하여 조사하여 다음과 같은 결과를 도출하였다. 일반적 특성 중 연령은 사회적지지와 죽음불안과 관계가 있었으며, 결혼상태는 가족지지와 연관이 있었고, 생활만족은 가족지지와 관련이 있었다. 노년초월과 죽음불안이 상관관계가 있었으며, 가족지지와 자아존중감과 상관관계가 있었고, 사회적 지지는 자아존중감과 죽음불안과 상관관계가 있었다. 결론적으로 이 연구를 통하여 노년기의 노년초월은 죽음불안과 연관이 있음이 밝혀졌으며, 노년기의 가족지지가 자아존중감과 생활만족에 영향을 미치는 것으로 조사되었다. 향후의 연구에서는 성인후기의 집단을 대상으로 노년초월의 정도, 생활만족과 노년초월의 관계 등을 포함한 연구들이 진행될 필요성을 가지고 있다.