• Communications for Statistical Applications and Methods
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• 제16권3호
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• pp.501-509
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• 2009

Recently the interval estimation of binomial proportions is revisited in various literatures. This is mainly due to the erratic behavior of the coverage probability of the well-known Wald confidence interval. Various alternatives have been proposed. Among them, the Agresti-Coull confidence interval, the Wilson confidence interval and the Bayes confidence interval resulting from the noninformative Jefferys prior were recommended by Brown et al. (2001). However, unlike the binomial distribution case, little is known about the properties of the confidence intervals in finite population sampling. In this note, the property of confidence intervals is investigated in anile population sampling.

• 응용통계연구
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• 제18권3호
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• pp.607-615
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• 2005

최근 여러 학자들에 의해 이항 비율의 구간 추정에 많이 사용되고 있는 Wald 신뢰구 간의 문제점이 재조명되고 있고, 이에 대한 대안으로 이항 비율의 새로운 신뢰구간들이 발표되고 있다. 본 논문에서는 가중 Polya posterior를 이용한 베이지안 구간추정을 구하였다. 이 구간추정은 이항분포의 공액분포인 베타 사전분포에서 구한 전통적인 베이지안 구간추정과 같으나 추정의 편의를 위하여 정규근사에 의한 신뢰구간을 구할 때, 표본크기가 크면 실제적으로 Argresti와 Coull (1998)의 신뢰구간과도 일치하였다. 또 새로운 신뢰구간은 표본크기가 작은 경우와 비율이 극히 작은 경우에도 매우 유용한 신뢰구간이 된다는 것을 살펴보았다.

• Journal of Genetic Medicine
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• 제8권1호
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• pp.53-57
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• 2011

목 적: 윌슨병은 간조직에 구리의 과도한 침착으로 발병하는 상염색체 열성 유전질환이다. 지금까지 ATP7B 유전자가 유일한 원인유전자로 알려져 왔다. 그러나, 약 15%의 환자에서는 ATP7B 유전자 돌연변이가 발견되지 않는다. 본 연구는 ATP7B 유전자의 돌연변이가 발견되지 않은 윌슨병 환자를 대상으로 새로운 원인 유전자를 발견하기 위하여 시행되었다. 대상 및 방법: ATP7B 돌연변이가 발견되지 않은 12명의 윌슨병 환자를 대상으로 ATP7B 와 상호작용을 하는 것으로 알려진 ATOX1, COMMD1, GLRX, DCTN4와 ZBTB16 유전자의 전사부위와 엑손-인트론 경계부위의 염기서열을 분석하였다. 결 과: DCTN4 유전자의 12번 엑손에 존재하는 c.1084A>G(p.Thr362Ala)를 포함하는 3가지의 변이가 환자에서 발견되었다. in silico 분석을 통해 3가지 변이 중 c.1084A>G가 유일하게 단백질 기능 변화를 일으킬 것으로 예측되었다. 176명의 윌슨병 환자와 414명의 정상인을 대상으로 이 변이의 빈도를 조사한 결과, 정상인보다 윌슨병 환자에서 더 높은 빈도를 나타내었다(상대비, odds ratio [OR]=3.14, 95% 신뢰도=1.36-7.22, P=0.0094). 결 론: 본 연구의 결과는 ATP7B 와 상호작용하는 DCTN4 유전자의 c.1084A>G (p.Thr362Ala) 다형성이 윌슨병의 발병과 연관이 있음을 시사한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권1호
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• pp.53-61
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• 2024

Purpose: Although the 24-hours urinary copper excretion is useful for the diagnosis of Wilson disease (WD), there are practical difficulties in the accurate and timed collection of urine samples. The purpose of this study was to verify if the spot morning urinary Copper/Zinc (Cu/Zn) ratio could be used as a replacement parameter of 24-hours urinary copper excretion in the diagnosis of WD. Methods: A cross-sectional study was conducted at the Department of Pediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from June 2019 to May 2021 on 67 children over three years of age who presented with liver disease. Twenty-seven children who fulfilled the inclusion criteria for WD were categorized into the test group, and the remaining forty children were considered to have non-Wilsonian liver disease and were categorized into the control group. Along with other laboratory investigations, spot morning urinary samples were estimated for the urinary Cu/Zn ratio in all patients and were compared to the 24-hour urinary copper excretion. The diagnostic value of the Cu/Zn ratio was then analyzed. Results: Correlation of spot morning urinary Cu/Zn ratio with 24-hours urinary copper excretion was found to be significant (r=0.60). The area under ROC curve with 95% confidence interval of morning urinary Cu/Zn ratio measured using 24-hours urine sample was 0.84 (standard error, 0.05; p<0.001). Conclusion: Spot morning urinary Cu/Zn ratio seems to be a promising parameter for the replacement of 24-hours urinary copper excretion in the diagnosis of WD.

• 천문학회지
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• 제55권2호
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• pp.59-66
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• 2022

Stellar magnetic activity is important for formulating the evolution of the star. To represent the stellar magnetic activity, the S index is defined using the Ca II H+K flux measure from the Mount Wilson Observatory. Mg II lines are generated in a manner similar to the formation of Ca II lines, which are more sensitive to weak chromospheric activity. Mg II flux data are available from the International Ultraviolet Explorer (IUE). Thus, the main purpose of this study was to analyze the magnetic activity of stars. We used 343 high-resolution IUE spectra of 14 main-sequence G stars to obtain the Mg II continuum surface flux and Mg II line-core flux around 2,800 Å. We calculated S index using the IUE spectra and compared it with the conventional Mount Wilson S index. We found a color (B - V ) dependent association between the S index and the Mg II emission line-core flux. Furthermore, we attempted to obtain the magnetic activity cycles of these stars based on the new S index. Unfortunately, this was not successful because the IUE observation interval of approximately 17 years is too short to estimate the magnetic activity cycles of G-type stars, whose cycles may be longer than the 11 year mean activity cycle of the sun.

• Journal of Ecology and Environment
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• 제43권2호
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• pp.226-245
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• 2019

To understand the dynamics of radial growth of trees and micro-climate at a site of Korean fir (Abies koreana Wilson) forest on high-altitude area of Mt. Hallasan National Park, Jeju Island, Korea, high precision dendrometers were installed on the stems of Korean fir trees, and the sensors for measuring micro-climate of the forest at 10 minutes interval were also installed at the forest. Data from the sensors were sent to nodes, collected to a gateway wireless, and transmitted to a data server using mobile phone communication system. By analyzing the radial growth data for the trees during the growing season in 2016, we can estimate that the radial growth of Korean fir trees initiated in late April to early May and ceased in late August to early September, which indicates that period for the radial growth was about 4 months in 2016. It is interesting to observe that the daily ambient temperature and the daily soil temperature at the depth of 20 cm coincided with the values of about 10 ℃ when the radial growth of the trees initiated in 2016. When the radial growth ceased, the values of the ambient temperature went down below about 15 ℃ and 16 ℃, respectively. While the ambient temperature and the soil temperature are evaluated to be the good indicators for the initiation and the cessation of radial growth, it becomes clear that radii of tree stems showed diurnal growth patterns affected by diurnal change of ambient temperature. In addition, the wetting and drying of the surface of the tree stems affected by precipitation became the additional factors that affect the expansion and shrinkage of the tree stems at the forest site. While it is interesting to note that the interrelationships among the micro-climatic factors at the forest site were well explained through this study, it should be recognized that the precision monitoring made possible with the application of high resolution sensors in the measurement of the radial increment combined with the observation of 10 minutes interval with aids of information and communication technology in the ecosystem observation.

• Journal of Astronomy and Space Sciences
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• 제13권1호
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• pp.19-31
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• 1996

We have analyzed collected photoelectric light curves for light variations of SW Lac. The method of Fourier analysis was adopted to quantify the light variation from season to season. We found the linear relation between the Fourier coefficient, B1 and the magnitude difference between two maxima. The total light of the system has been decreased as much as 0m.04 during approxiamately 20 years time interval. Photoelectric parameters including spot parameters for all light curves were obtained by the method of the Wilson and Devinney differential correction in order to secure the variations of parameters from season to season. SW Lac, not like RS CVn type stars, required to adjust all parameters as well as spot parameters for a reasonable fit to the observations of each epoch. A surface temperature of cooler star is one of the most sensitive parameters to affect a shape of light curve of SW Lac. We conclude that the shape of light curve of SW Lac varies even during one season as well as season to season. The light curve is mainly caused by inhomogeneous surface temperature due to strong chromospheric activity of the system.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.355-375
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• 2020

Selective accumulation of a photosensitizer and the subsequent response in only the light-irradiated target are advantages of photodynamic diagnosis and therapy. The limited depth of the therapeutic effect is a positive characteristic when treating surface malignancies, such as peritoneal carcinomatosis. For photodynamic diagnosis (PDD), adjunctive use of aminolevulinic acid- protoporphyrin IX-guided fluorescence imaging detects cancer nodules, which would have been missed during assessment using white light visualization only. Furthermore, since few side effects have been reported, this has the potential to become a vital component of diagnostic laparoscopy. A variety of photosensitizers have been examined for photodynamic therapy (PDT), and treatment protocols are heterogeneous in terms of photosensitizer type and dose, photosensitizer-light time interval, and light source wavelength, dose, and dose rate. Although several studies have suggested that PDT has favorable effects in peritoneal carcinomatosis, clinical trials in more homogenous patient groups are required to identify the true benefits. In addition, major complications, such as bowel perforation and capillary leak syndrome, need to be reduced. In the long term, PDD and PDT are likely to be successful therapeutic options for patients with peritoneal carcinomatosis, with several options to optimize the photosensitizer and light delivery parameters to improve safety and efficacy.

• Journal of Astronomy and Space Sciences
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• 제27권4호
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• pp.263-278
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• 2010

Many filtered CCD measures form the basis of six new light curves of the eclipsing system SW Lyn. From these measures and additional observations for eclipse timing, 47 new times of minimum light over the time-interval of about 13 years have been calculated. The complex period variability can be sorted into a linear period improvement with 5.8-year and 33.9-year periodic terms. The shorter cyclic term of these is ascribed to a cool companion of the eclipsing pair but the longer one has no testable interpretation at present. The new light curves are synthesized by the 2003 version of the Wilson-Devinney differential corrections computer code. The results incorporate a source of "third light" which comes from the cool companion star that had been identified by the cycling of the period of the eclipsing pair and also had previously been identified spectroscopically. There is a measure of satisfaction with current understanding of the SW Lyn eclipsing system because of consistent syntheses of all historical light curves. This agreeable convergence, however, comes partly at the expense of an unanticipated temperature of the hot star and of a photospheric spot that has no obvious basis in the detached character modeled for the binary. We offer predictions of changes in the stellar parameters if the modeled detached-configuration should be wrong. The SW Lyn stellar system is still difficult to understand.