• Communications for Statistical Applications and Methods
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• v.16 no.3
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• pp.501-509
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• 2009

Recently the interval estimation of binomial proportions is revisited in various literatures. This is mainly due to the erratic behavior of the coverage probability of the well-known Wald confidence interval. Various alternatives have been proposed. Among them, the Agresti-Coull confidence interval, the Wilson confidence interval and the Bayes confidence interval resulting from the noninformative Jefferys prior were recommended by Brown et al. (2001). However, unlike the binomial distribution case, little is known about the properties of the confidence intervals in finite population sampling. In this note, the property of confidence intervals is investigated in anile population sampling.

• The Korean Journal of Applied Statistics
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• v.18 no.3
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• pp.607-615
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• 2005

Recently the interval estimation of a binomial proportion is revisited in various literatures. This is mainly due to the erratic behavior of the coverage probability of the will-known Wald confidence interval. Various alternatives have been proposed. Among them, Agresti-Coull confidence interval has been recommended by Brown et al. (2001) with other confidence intervals for large sample, say n $\ge$ 40. On the other hand, a noninformative Bayesian approach called Polya posterior often produces statistics with good frequentist's properties. In this note, an interval estimator is developed using weighted Polya posterior. The resulting interval estimator is essentially the Agresti-Coull confidence interval with some improved features. It is shown that the weighted Polys posterior produce an effective interval estimator for small sample size and a severely skewed binomial distribution.

• Journal of Genetic Medicine
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• v.8 no.1
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• pp.53-57
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• 2011

Purpose: Wilson disease is an autosomal recessive disorder which causes excessive copper accumulation in the hepatic region. So far, ATP7B gene is the only disease-causing gene of Wilson disease known to date. However, ATP7B mutations have not been found in ~15% of the patients. This study was performed to identify any causative gene in Wilson disease patients without an ATP7B mutation in either allele. Materials and Methods: The sequence of the coding regions and exon-intron boundaries of the five ATP7B-interacting genes, ATOX1, COMMD1, GLRX, DCTN4, and ZBTB16, were analyzed in the 12 patients with Wilson disease. Results: Three nonsynonymous variants including c.1084A>G (p.Thr362Ala) in the exon 12 of the DCTN4 gene were identified in the patients examined. Among these, only p.Thr362Ala was predicted as possibly damaging protein function by in silico analysis. Examination of allele frequency of c.1084A>G (p.Thr362Ala) variant in the 176 patients with Wilson disease and in the 414 normal subjects revealed that the variant was more prevalent in the Wilson disease patients (odds ratio [OR]=3.14, 95% confidence interval=1.36-7.22, P=0.0094). Conclusion: Our result suggests that c.1084A>G (p.Thr362Ala) in the ATP7B-interacting DCTN4 gene may be associated with the pathogenesis of Wilson disease.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.1
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• pp.53-61
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• 2024

Purpose: Although the 24-hours urinary copper excretion is useful for the diagnosis of Wilson disease (WD), there are practical difficulties in the accurate and timed collection of urine samples. The purpose of this study was to verify if the spot morning urinary Copper/Zinc (Cu/Zn) ratio could be used as a replacement parameter of 24-hours urinary copper excretion in the diagnosis of WD. Methods: A cross-sectional study was conducted at the Department of Pediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from June 2019 to May 2021 on 67 children over three years of age who presented with liver disease. Twenty-seven children who fulfilled the inclusion criteria for WD were categorized into the test group, and the remaining forty children were considered to have non-Wilsonian liver disease and were categorized into the control group. Along with other laboratory investigations, spot morning urinary samples were estimated for the urinary Cu/Zn ratio in all patients and were compared to the 24-hour urinary copper excretion. The diagnostic value of the Cu/Zn ratio was then analyzed. Results: Correlation of spot morning urinary Cu/Zn ratio with 24-hours urinary copper excretion was found to be significant (r=0.60). The area under ROC curve with 95% confidence interval of morning urinary Cu/Zn ratio measured using 24-hours urine sample was 0.84 (standard error, 0.05; p<0.001). Conclusion: Spot morning urinary Cu/Zn ratio seems to be a promising parameter for the replacement of 24-hours urinary copper excretion in the diagnosis of WD.

• Journal of The Korean Astronomical Society
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• v.55 no.2
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• pp.59-66
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• 2022

Stellar magnetic activity is important for formulating the evolution of the star. To represent the stellar magnetic activity, the S index is defined using the Ca II H+K flux measure from the Mount Wilson Observatory. Mg II lines are generated in a manner similar to the formation of Ca II lines, which are more sensitive to weak chromospheric activity. Mg II flux data are available from the International Ultraviolet Explorer (IUE). Thus, the main purpose of this study was to analyze the magnetic activity of stars. We used 343 high-resolution IUE spectra of 14 main-sequence G stars to obtain the Mg II continuum surface flux and Mg II line-core flux around 2,800 Å. We calculated S index using the IUE spectra and compared it with the conventional Mount Wilson S index. We found a color (B - V ) dependent association between the S index and the Mg II emission line-core flux. Furthermore, we attempted to obtain the magnetic activity cycles of these stars based on the new S index. Unfortunately, this was not successful because the IUE observation interval of approximately 17 years is too short to estimate the magnetic activity cycles of G-type stars, whose cycles may be longer than the 11 year mean activity cycle of the sun.

• Journal of Ecology and Environment
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• v.43 no.2
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• pp.226-245
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• 2019

To understand the dynamics of radial growth of trees and micro-climate at a site of Korean fir (Abies koreana Wilson) forest on high-altitude area of Mt. Hallasan National Park, Jeju Island, Korea, high precision dendrometers were installed on the stems of Korean fir trees, and the sensors for measuring micro-climate of the forest at 10 minutes interval were also installed at the forest. Data from the sensors were sent to nodes, collected to a gateway wireless, and transmitted to a data server using mobile phone communication system. By analyzing the radial growth data for the trees during the growing season in 2016, we can estimate that the radial growth of Korean fir trees initiated in late April to early May and ceased in late August to early September, which indicates that period for the radial growth was about 4 months in 2016. It is interesting to observe that the daily ambient temperature and the daily soil temperature at the depth of 20 cm coincided with the values of about 10 ℃ when the radial growth of the trees initiated in 2016. When the radial growth ceased, the values of the ambient temperature went down below about 15 ℃ and 16 ℃, respectively. While the ambient temperature and the soil temperature are evaluated to be the good indicators for the initiation and the cessation of radial growth, it becomes clear that radii of tree stems showed diurnal growth patterns affected by diurnal change of ambient temperature. In addition, the wetting and drying of the surface of the tree stems affected by precipitation became the additional factors that affect the expansion and shrinkage of the tree stems at the forest site. While it is interesting to note that the interrelationships among the micro-climatic factors at the forest site were well explained through this study, it should be recognized that the precision monitoring made possible with the application of high resolution sensors in the measurement of the radial increment combined with the observation of 10 minutes interval with aids of information and communication technology in the ecosystem observation.

• Journal of Astronomy and Space Sciences
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• v.13 no.1
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• pp.19-31
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• 1996

We have analyzed collected photoelectric light curves for light variations of SW Lac. The method of Fourier analysis was adopted to quantify the light variation from season to season. We found the linear relation between the Fourier coefficient, B1 and the magnitude difference between two maxima. The total light of the system has been decreased as much as 0m.04 during approxiamately 20 years time interval. Photoelectric parameters including spot parameters for all light curves were obtained by the method of the Wilson and Devinney differential correction in order to secure the variations of parameters from season to season. SW Lac, not like RS CVn type stars, required to adjust all parameters as well as spot parameters for a reasonable fit to the observations of each epoch. A surface temperature of cooler star is one of the most sensitive parameters to affect a shape of light curve of SW Lac. We conclude that the shape of light curve of SW Lac varies even during one season as well as season to season. The light curve is mainly caused by inhomogeneous surface temperature due to strong chromospheric activity of the system.

• Journal of Gastric Cancer
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• v.20 no.4
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• pp.355-375
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• 2020

Selective accumulation of a photosensitizer and the subsequent response in only the light-irradiated target are advantages of photodynamic diagnosis and therapy. The limited depth of the therapeutic effect is a positive characteristic when treating surface malignancies, such as peritoneal carcinomatosis. For photodynamic diagnosis (PDD), adjunctive use of aminolevulinic acid- protoporphyrin IX-guided fluorescence imaging detects cancer nodules, which would have been missed during assessment using white light visualization only. Furthermore, since few side effects have been reported, this has the potential to become a vital component of diagnostic laparoscopy. A variety of photosensitizers have been examined for photodynamic therapy (PDT), and treatment protocols are heterogeneous in terms of photosensitizer type and dose, photosensitizer-light time interval, and light source wavelength, dose, and dose rate. Although several studies have suggested that PDT has favorable effects in peritoneal carcinomatosis, clinical trials in more homogenous patient groups are required to identify the true benefits. In addition, major complications, such as bowel perforation and capillary leak syndrome, need to be reduced. In the long term, PDD and PDT are likely to be successful therapeutic options for patients with peritoneal carcinomatosis, with several options to optimize the photosensitizer and light delivery parameters to improve safety and efficacy.

• Journal of Astronomy and Space Sciences
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• v.27 no.4
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• pp.263-278
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• 2010

Many filtered CCD measures form the basis of six new light curves of the eclipsing system SW Lyn. From these measures and additional observations for eclipse timing, 47 new times of minimum light over the time-interval of about 13 years have been calculated. The complex period variability can be sorted into a linear period improvement with 5.8-year and 33.9-year periodic terms. The shorter cyclic term of these is ascribed to a cool companion of the eclipsing pair but the longer one has no testable interpretation at present. The new light curves are synthesized by the 2003 version of the Wilson-Devinney differential corrections computer code. The results incorporate a source of "third light" which comes from the cool companion star that had been identified by the cycling of the period of the eclipsing pair and also had previously been identified spectroscopically. There is a measure of satisfaction with current understanding of the SW Lyn eclipsing system because of consistent syntheses of all historical light curves. This agreeable convergence, however, comes partly at the expense of an unanticipated temperature of the hot star and of a photospheric spot that has no obvious basis in the detached character modeled for the binary. We offer predictions of changes in the stellar parameters if the modeled detached-configuration should be wrong. The SW Lyn stellar system is still difficult to understand.