• 응용통계연구
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• 제23권6호
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• pp.1067-1080
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• 2010

임상시험을 위한 표본 수 산정방법에 대해 지금까지 많은 방법이 개발되었고 현재 국내외 임상시험 기관에서 이 방법들을 토대로 표본 수를 산정하고 있다. 하지만 마이크로어레이칩 을 이용한 실험에 필요한 표본 수 산정에 대한 연구는 아직 미비하여 제대로 이용되지 않고 있다. 본 연구의 목적은 마이크로어레이 실험에 필요한 표본 수를 산정하는 데 있어 실제 마이크로어레이 자료의 재현성에 대한 정보를 이용하여 그 지침을 제공하는데 있다. 재현성 비교에서는 5가지 검정방법 즉, Fold change, Two-sample t-test, Wilcoxon rank-sum test, SAM, LPE 방법 별로 재현성을 측정하였다. 발현 값의 표준화 방법에 있어서는 MAS5, RMA 두 가지로 세분화 하였으며 반복수에 따라 상위 20개 또는 100개 유전자에 대한 일치성도 측정하였다. 또한, 표본수를 산정하는데 있어 기존에 제시한 방법에 현실적인 정보를 이용하여 좀 더 세분화하여 실험에 필요한 표본수를 산정해 보았다.

• 한국융합학회논문지
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• 제11권11호
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• pp.461-473
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• 2020

본 연구는 코로나바이러스감염증-19 특별재난지역의 간호대학생들을 대상으로 웹기반 원격 방문간호교육 프로그램을 적용하여 학생들의 방문간호 지식, 지각된 동기, 학습 몰입에 미치는 효과를 검증하기 위해 수행되었다. K시 소재 일개 간호대학생 49명에게 비동등성 대조군 전·후 실험설계의 유사 실험연구를 수행하였으며, 개발한 웹기반 원격 방문간호교육 프로그램을 2주간 실시하였다. 자료 수집 기간은 2020년 6월 1일부터 6월 12일까지이며, 수집된 자료는 SPSS PC+ 19.0을 이용하여 Fisher' exact test, Wilcoxon rank sum test, ANCOVA 분석을 하였다. 효과를 검증한 결과 실험군이 대조군보다 방문간호 지식, 지각된 동기, 학습 몰입에서 유의한 차이가 있는 것으로 나타났다. 본 연구에서 개발된 웹기반 원격 방문간호교육 프로그램은 간호대학생의 학습 몰입 중재를 통해 지각된 동기를 유발하여 방문간호 지식을 높이는 데 효과적인 프로그램으로 사용될 수 있을 것이다.

• 한국경영과학회지
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• 제42권3호
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• pp.35-49
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• 2017

The main objective of this paper is to empirically analyze the efficiency effects of mergers on Korean pharmaceutical firms and suggests managerial or policy implications for managers or policy makers. This study selects non-merging control firms close to the size of merging firms, as well as a set of merging firms, and measures the effects of mergers on efficiency three years before and after the merger using the non-parametric data envelopment analysis (DEA) method. To compare the differences of efficiency means among several groups, Wilcoxon rank sum test or Wilcoxon signed rank test is used. It showed that the long-term effects after the merger appeared partially. Furthermore, it was observed that there was no difference statistically in the efficiency between merging and non-merging firms. Also, there was no difference statistically in the efficiency between the pre- and post-merger periods. In conclusion, there was not any observed synergy effect through group (or affiliated) mergers between affiliates or related mergers for Korean pharmaceutical firms.

• 한국병원경영학회지
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• 제5권1호
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• pp.84-104
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• 2000

This paper analyzes the technical efficiency of thirty two hospitals in Korea using DEA(Data Envelopment Analysis). DEA provides an efficiency measure for each hospital compared to the most efficient one. The amount and sources of inefficiency that are identified by the DEA are useful for benchmarking to improve efficiency. The results from multiple regression analysis and Wilcoxon Rank Sum test show that bed turnover, hospital size, and average length of stay are related to hospital efficiency.

• 응용통계연구
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• 제21권6호
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• pp.947-957
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• 2008

비열등성 시험시에 치료군(treatment group)과 활성대조군(active control group)을 이용한 모형으로 Hauschke 등 (1999)이 제안한 모수적 검정법이 있다. 이 방법은 위약군(placebo group)과 직접적인 비교가 불가능하므로 Pigeot 등 (2003)이 세 군으로 확장한 검정법을 제안하였다. 그러나 이와 같은 두 검정법은 구체적인 분포가정이 필요하다. 이런 단점을 보완하기 위하여 본 논문에서는 비모수적 방법으로서 두 군 설계에 Wilcoxon 순위합 검정(Wilcoxon, 1945)을 이용한 방법을, 세 군 설계에 Scheirer 등 (1976)이 제안한 선형대비검정을 확장한 새로운 방법을 제안한다. 또한 모의실험을 통하여 모수적 방법과 비모수적 방법간의 검정력을 비교하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4109-4114
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• 2015

Background: Full-field digital mammography (FFDM) with dense breasts has a high rate of missed diagnosis, and digital breast tomosynthesis (DBT) could reduce organization overlapping and provide more reliable images for BI-RADS classification. This study aims to explore application of COMBO (FFDM+DBT) for effect and significance of BI-RADS classification of breast cancer. Materials and Methods: In this study, we selected 832 patients who had been treated from May 2013 to November 2013. Classify FFDM and COMBO examination according to BI-RADS separately and compare the differences for glands in the image of the same patient in judgment, mass characteristics display and indirect signs. Employ Paired Wilcoxon rank sum test was used in 79 breast cancer patients to find differences between two examine methods. Results: The results indicated that COMBO pattern is able to observe more details in distribution of glands when estimating content. Paired Wilcoxon rank sum test showed that overall classification level of COMBO is higher significantly compared to FFDM to BI-RADS diagnosis and classification of breast (P<0.05). The area under FFDM ROC curve is 0.805, while that is 0.941 in COMBO pattern. COMBO shows relation of mass with the surrounding tissues, the calcification in the mass, and multiple foci clearly in breast cancer tissues. The optimal sensitivity of cut-off value in COMBO pattern is 82.9%, which is higher than that in FFDM (60%). They share the same specificity which is both 93.2%. Conclusions: Digital Breast Tomosynthesis (DBT) could be used for the BI-RADS classification in breast cancer in clinical.

• 대한간호학회지
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• 제42권6호
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• pp.843-852
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• 2012

Purpose: In this study a recreational combination gymnastics program was provided for women 75 years of age or older and the effects on physical fitness (grip strength, static balance, ability to do complex movement), depression, cognitive function and quality of life were examined. Methods: A quasi-experimental study employing a nonequivalent control group, pre-post design was conducted. Participants included 53 women elders whose cognitive function was within the normal range. The women were assigned to an experimental group (27) or a control group (26). The intervention was conducted twice a week for a period of 12 weeks. Chi-square test, t-test, paired t-test, Wilcoxon rank sum test and Wilcoxon signed rank test were used for data analysis. Results: Following completion of the program, left grip strength (t=2.17, p=.035), right grip strength (t=2.04, p=.046), static balance (t=-2.18, p=.030), depression (z=-2.88, p=.004), cognitive function (t=3.96, p<.001), and quality of life (t=-3.19, p=.002) were significantly better in the experimental group. Conclusion: Findings from this study indicate that recreational combination gymnastics programs are effective in enhancing physical fitness, cognitive function, and quality of life and in decreasing depression for female elders and could therefore be regarded as positive programs for promotion of physical and mental health for older women.

• 대한간호학회지
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• 제40권5호
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• pp.724-735
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• 2010

Purpose: In this study a cognitive enhancement group training program of 10 sessions was provided for communitydwelling elders and the effects on cognitive function, depression and quality of life were tested. Methods: A quasi-experimental study using a nonequivalent control group, pre-post design was used. The participants were 87 elders whose cognitive function was within the normal range. Of these elders, 45 were assigned to the experimental group and 42 to the control group. The intervention was conducted once a week for 10 weeks. Chi-square test, t-test, paired t-test, Wilcoxon rank sum test and Wilcoxon signed rank test were used to analyze the data. Results: After the program, the cognitive function (t=-2.85, p=.006), depression (z=2.82, p=.005) and quality of life (t=2.79, p=.007) of the experimental group was significantly better than those of the control group. Especially, immediate recall (z=2.45, p=.014) and concentration (z=2.58, p=.010) in the subcategory of cognitive function were significantly better than that of the control group. Conclusion: The findings indicate that the cognitive enhancement group training program was effective in enhancing the cognitive function, depression and quality of life for elders and could therefore be considered as a positive program for emotional and cognitive support for community-dwelling elders.

• 대한간호학회지
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• 제52권1호
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• pp.36-51
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• 2022

Purpose: The purpose of this study was to examine the effects of electroencephalogram (EEG) biofeedback training for emotion regulation and brain homeostasis on anxiety about COVID-19 infection, impulsivity, anger rumination, meta-mood, and self-regulation ability of late adolescents in the prolonged COVID-19 pandemic situation. Methods: A non-equivalent control group pretest-posttest design was used. The participants included 55 late adolescents in the experimental and control groups. The variables were evaluated using quantitative EEG at pre-post time points in the experimental group. The experimental groups received 10 sessions using the three-band protocol for five weeks. The collected data were analyzed using the Shapiro-Wilk test, Wilcoxon rank sum test, Wilcoxon signed-rank test, t-test and paired t-test using the SAS 9.3 program. The collected EEG data used a frequency series power spectrum analysis method through fast Fourier transform. Results: Significant differences in emotion regulation between the two groups were observed in the anxiety about COVID-19 infection (W = 585.50, p = .002), mood repair of meta-mood (W = 889.50, p = .024), self-regulation ability (t = - 5.02, p < .001), self-regulation mode (t = - 4.74, p < .001), and volitional inhibition mode (t = - 2.61, p = .012). Neurofeedback training for brain homeostasis was effected on enhanced sensory-motor rhythm (S = 177.00, p < .001) and inhibited theta (S = - 166.00, p < .001). Conclusion: The results demonstrate the potential of EEG biofeedback training as an independent nursing intervention that can markedly improve anxiety, mood-repair, and self-regulation ability for emotional distress during the COVID-19 pandemic.

• 한국보육학회지
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• 제19권3호
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• pp.183-197
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• 2019

본 연구는 치료놀이를 활용한 집단프로그램이 만 2세 영아의 친사회적 행동에 미치는 영향과 프로그램 과정에서 영아의 친사회적 행동 변화 양상을 알아보기 위해 실시되었다. W시의 한 어린이집에 재원 중인 영아 12명을 실험집단과 통제집단에 배정하였고 실험집단에 주 2회씩, 총 11회의 집단프로그램을 실시하였다. 적응적 사회적 행동 척도(Hogan et al., 1992)로 사전-사후검사를 실시하고 Wilcoxon rank-sum test로자료를 분석해 프로그램의 효과를 알아보았다. 실험집단을 대상으로 한 프로그램의 전 회기를 녹화하고 Padgett(2001)의 제안을 따라 분석해 친사회적 행동이 어떻게 변화하는지를 살펴보았다. 연구결과, 실험집단의 친사회적 행동이 유의미하게 향상되었다. 또한 친사회적 행동은 프로그램의 전 과정에 걸쳐 점진적으로 개선되었다. 본 연구의 결과는 치료놀이를 활용한 집단프로그램이 만 2세 영아의 친사회적 행동 증진에 효과적임을 의미한다.