• Investigative Magnetic Resonance Imaging
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• v.5 no.1
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• pp.24-32
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• 2001

Purpose : We investigated the reproducibility of language lateralization by 4 different word generation paradigms or the rest contents in each paradigm using functional magnetic resonance imaging in normal volunteers Materials and Methods Nine normal volunteers with left-handedness (mean age: 25 yrs) were examined on a 1.57 MR unit using a single-shot gradient echo epibold sequence. Four different word generation paradigms of noun, verb, adjective and adverb were used in each normal volunteer for investigating language system. In each paradigm, two different rest contents consisted of only seeing the " +" symbol or reading the meaningless letters. Each task consisted of 96 phases including 3 activations and 6 rests of 2 different contents. Two activation maps in one task were obtained under two different rest contents using the correlation method. We evaluated the detection rates of Broca and Wernicke areas and the differences of language lateralization among four different word generation paradigms, or between the rest contents. Results : The detection rates of Broca and Wernicke areas were over 67 % in 4 different language paradigms and there was no significant difference of them among language paradigms, or between two different rest contents. Language dominances, in all 4 different language paradigms, were shown to be consistent in 66 %, but were contrary with language paradigms in some subjects. The rest contents made no significant effect on dominant language dominance determination, but the success rates of the dominant language dominances determined from 4 language paradigms were higher in reading the meaningless letter (100%, n=9) than in only seeing "+" on screen at the rest task (78%, n=7).

• Speech Sciences
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• v.11 no.4
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• pp.151-161
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• 2004

The characteristics of generative naming ability between fluent aphasiacs and non-fluent aphasics were investigated for 10 fluent aphasics (6 Wernicke's and 4 conduction type) and 10 non-fluent aphasics (6 Broca's and 4 transcortical motor type). Subjects were given 2 types of generative naming task and asked to generate lists of words to categorical ('animal', 'things at a supermarket') and phonetic ('ㄱ', 'ㅇ', 'ㅅ') cues. The total numbers of correct and incorrect response and error type ratios were calculated. The results of the present study were as follows: (1) Fluent aphasics had higher generative naming scores than non-fluent aphasics. (2) A remarkable dissociation between performance on categorical and phonetic cue in both aphasic groups was observed. Both aphasic groups produced a large number of responses in the categorical cue. (3) There was no significant group-difference in the error type. (4) Any correlation between generative naming and confrontation naming in K - WAB was not found.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.745-761
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• 2000

Literatural study for Delirious speech and Fading murmuring, the results were as follows. 1. Delirious speech and Fading murmuring are given at the speech impediment. Derious speech to be out of language's order and slur the end of his words, and Fading murmuring is to repeat in losing conscious. 2. In constrast with Delirious speech and Fading murmuring, Maniac speech is induced by a general term for manic-depressive psychosis. Luoyan is to say in a feeble voice and mumble in a sleeping condition, and Paraphasia and Solioquy are appeared in a clear mental condition. The speech impediment is caused by damages of the nervous system and speech organ, and Yuyancuoluan is appeared in a feverless condition. 3. The symptoms of Delirious speech are to utter ravings and have a loud and heavy voice, and these resemble the delirium which specially has a speech impediment and muddle in the western medical world. The symptoms of Fading murmuring are to speak ambigously, repeatedly, and illogically and so are similar to the Wernicke dysphasia which is caused by a incomprehensible conversation. 4. The causes of Delirious speech are to spread a stomach heat and the lungs pathogenic qi into heart, not to sweat in cold damage, the Three Yang Combination of syndrome, stomach repletion, yang collapse due to excessive sweat, diarrhea, after diarrhea, heat to enter the blood chamer, feces to remain in the stomach, stasis blood to enter the viscera, to carry anger to extremity, and to be constipated. the cause of Fading murmuring is to despair vacuity desertion of vital essence and energy after a serious illness. 5. The causes of delirium are general infection, postoperative states, and metabolism disorders and those of Wernicke dysphasia are disorders of the blood vessel, brain tumors and traumas. 6. Delirious speech is cured with the discrimination of vacuity and repletion. Baitong Tang(白通湯), Chaihu Guizhi Tang(柴胡桂枝湯), Chaihu Jia Longgu Muli Tang(柴胡加龍骨牡蠣湯) are prescribed in case of vacuity, while Chengqi Tang(承氣湯), Baihu Tang(白虎湯), Liangge San(凉膈散) are in case of repletion. Fading murmuring is treated with Xiao Chaihu Tang(小柴胡湯), Fuzi Tang Jiawei(附子湯加味), Shengmai San(生脈散), and Renshen Sanbai Tang(人蔘三白湯). 7. To acupunture Qimen-Xue(期門穴) is required when it is late to prescribe a medical decoction or the hyperactive liver qi attacking the spleen.

• Molecules and Cells
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• v.25 no.1
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• pp.7-19
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• 2008

Complexins play a critical role in the control of fast synchronous neurotransmitter release. They operate by binding to trimeric SNARE complexes consisting of the vesicle protein Synaptobrevin and the plasma membrane proteins Syntaxin and SNAP-25, which are key executors of membrane fusion reactions. SNARE complex binding by Complexins is thought to stabilize and clamp the SNARE complex in a highly fusogenic state, thereby providing a pool of readily releasable synaptic vesicles that can be released quickly and synchronously in response to an action potential and the concomitant increase in intra-synaptic $Ca^{2+}$ levels. Genetic elimination of Complexins from mammalian neurons causes a strong reduction in evoked neurotransmitter release, and altered Complexin expression levels with consequent deficits in synaptic transmission were suggested to contribute to the etiology or pathogenesis of schizophrenia, Huntington's disease, depression, bipolar disorder, Parkinson's disease, Alzheimer's disease, traumatic brain injury, Wernicke's encephalopathy, and fetal alcohol syndrome. In the present review I provide a summary of available data on the role of altered Complexin expression in brain diseases. On aggregate, the available information indicates that altered Complexin expression levels are unlikely to have a causal role in the etiology of the disorders that they have been implicated in, but that they may contribute to the corresponding symptoms.

• Journal of Korean Neurosurgical Society
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• v.59 no.3
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• pp.306-309
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• 2016

Using diffusion tensor tractography (DTT), we demonstrated injury of the arcuate fasciculus (AF) in the nondominant hemisphere in two patients who showed subfalcine herniation after intracerebral hemorrhage (ICH) in the dominant hemisphere. Two patients (patient 1 and patient 2) with ICH and six age-matched control patients who have ICH on the left corona radiata and basal ganglia without subfalcine herniation were recruited for this study. DTT was performed at one month after onset in patient 1 and patient 2. AFs of both hemispheres in both patients were disrupted between Wernicke's and Broca's areas. The fractional anisotropy value and tract numbers of the right AFs in both patients were found to be more than two standard deviations lower than those of control patients. In contrast, the apparent diffusion coefficient value was more than two standard deviations higher than those of control patients. Using the configuration and parameters of DTT, we confirmed injury of the AF in the nondominant hemisphere in two patients with subfalcine herniation following ICH in the dominant hemisphere. Therefore, DTT would be a useful tool for detection of underlying injury of the AF in the nondominant hemisphere in patients with subfalcine herniation.

• Speech Sciences
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• v.7 no.3
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• pp.263-272
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• 2000

The purpose of this study was to compare receptive language performance and expressive language performance in 13 patients with aphasia by using three stimulus presentation modes: Stimulus mode I (picture), Stimulus mode II (written word), Stimulus m (question using verbal explanation). The stimulus consisted of 10 words. They included 5 functional words and 5 non-functional words. The 13 subjects with aphasia were divided into 2 aphasic types: 5 Broca's aphasics and 8 anomie aphasics. The results were as follows: Firstly, the three stimulus modes didn't affect receptive language performance of aphasia subjects. Secondly; the three stimulus modes were effective on expressive language performance of aphasia subjects. Particularly, stimulus mode II (written words) was effective in naming the aphasia subjects. Thirdly, the functional words with high frequency were better than non-functional words with low frequency on expressive language performance, but not on receptive language performance of aphasia subjects. Finally, the interaction between three stimulus modes and the functional (nonfunctional) words affected expressive language performance only, but not receptive language performance. Particularly, presenting stimulus in written words which are functional words produced the best expressive language performance.

• The Journal of Dong Guk Oriental Medicine
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• v.3
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• pp.163-169
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• 1994

Alcohol is a major risk factor for several diseases and excessive, long-term alcohol consumption are caues physical alteration-fatty liver, hepatitis, cirrhosis, breaking down, Wernicke-karsakoff's syndrome, weight loss, and poor immunity-in virtually all organ and tissue. This study was observed that liver, kidney, and stomach were altered in mouse by the effect of chronic alcohol administration. The mouse were sacrificed to obtain the tissue after mouse were orally injected with 25 % ethanol $18m{\ell}/kg/day$ for 120days. The tissue were stained by hematoxylin and eosin and then observed by light microscope. The results of this study were as follows : 1. The congestion was appeared in liver after 120days alcohol admistration. 2. The destruction of glomerulus were increased and the parietal cell of Bowman's capsule were swelled such as cuboidal cell after 120days alcohol administration. The congestion was appeared in alcohol administrated group. 3. The mucosa and gastric pit were destructed and the ulceration was appeared in stomach after 120days administration. The parietal cells and chief cells were damaged. Above results were shown that the tissue were damaged by chronic alcohol administration.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.1014-1022
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• 2003

Aphasia is speech disorder caused by injuries on the speech nerve center. It usually occur due to a disease in the right cerebral cortex and is divided into the various aphasia such as Global aphasia, Broca's aphasia, Wernicke's aphasia, conduction aphasia, Anomic aphasia, etc. Jihwangumja is used the cerebral infarction with Aphasia due to deficiency syndrome of kidneys. The purpose of this study is to examine the efficacy of oriental treatment for cerebral infarction with aphasia by Jihwangumsa. In the hospital, the patient showed the symptoms of mental disorder, Rt. hemiparesis G3/G4, aphasia, chest discomfort, obstipation, frequent urination, etc. The case showed that acute infarction on Lt. fronto-temporo-parietal lobe in Brain-CT. We identified the patient's clinical conditions and treated accordingly. As a result of treatment, symptoms were markedly improved and he was discharged. Further elaboration of oriental diagnostic classification could possibly lead to the fundamental treatment.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.203-207
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• 2002

본 연구에서는 한국사람이 모국어인 한국어 단어를 산출할 때와 외국어인 영어 단어를 산출할 때 관여하는 대뇌 영역을 fMRI 를 통해 조사하였다. 또한, 단일 언어를 산출할 때와 두 언어를 수시로 바꾸어서 인출할 때 관련되는 뇌 영역이 어디인지를 조사하였다. 실험에 참가한 피험자는 외국어를 공식적인 교육을 통해 12 세 근처에서 배우기 시작한 대학생이었다. 흔히 분류하는 방식으로 late learner로 구분되는 학생들이었다. 한 피험자가 세 종류의 실험 모두에 참여하였다. 피험자의 실험과제는 그림을 보고 그림에 해당되는 이름을 인출하여 말하는 과제였다. 실험 1, 2, 3 모두에서 사건관련 fMRI(event-related fMRI) 기법을 사용하였다. 실험 1에서는 그림을 보고 그림 이름에 해당되는 한국어 어휘와 외래어 어휘를 산출하게 하였다. 언어관련 뇌영역인 Wernicke 영역, Broca 영역, SMA 영역, SMG 영역 등에서 유의미한 활성화가 있었다. 실험 2 에서는 실험 1 에서 사용하지 않았던 그림을 사용하여 그림의 영어 이름과 외래어 이름을 인출하게 하였다. 외국어인 영어 단어를 산출할 때에도 모국어 단어를 산출할 때와 유사한 영역이 활성화되었다. 특히 외래어 산출 시에는 뇌 활성화 영역이 모국어와 영어 단어 산출할 때와 모국어 산출할 때 활성화되는 공통 영역이 활성화되었다. 모국어 산출과 영어 단어 산출의 차이점은 외국어 산출 시에 활성화 영역이 전반적으로 더 컸다는 것과 외국어 단어 산출 시에 Broca 영역보다 조금 밑쪽에서 그리고 모국어 단어 산출시에는 전전두엽 영역에서 더 많은 활성화가 있었다. 실험 3 에서도 실험 1 과 실험 2 에 사용하지 않았던 그림을 사용하였다. 실험 3 의 특이한 결과는 언어 switching 이 있는 경우에 전통적인 언어 영역 활성화 외에 전전두엽의 활성화가 컸다는 것이다. 아마도 언어를 바꾸어 가면서 단어를 산출하는 것이 전전두엽의 정보선택과정에 많은 영향을 주었던 것으로 해석된다. 전체적으로 어휘 산출시에 모국어 어휘, 외국어 어휘, 외래어 등을 산출할 때 공통되는 언어 영역과 언어 특성적 영역이 활성화된다고 결론지을 수 있을 것 같다.

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.28-30
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• 2013

A 66-year-old male with chronic alcoholism presented with tremor, gait disturbance, memory impairment, insomnia, decreased appetite, and confusion. The patient had been taking lithium daily for treatment of bipolar disorder. Brain CT showed no specific abnormality, and serum lithium and ammonia levels were 3.63 mEq/L (therapeutic range, 0.6~1.2 mEq/L) and $85{\mu}g/dL$ (reference range: $19{\sim}54{\mu}g/dL$), respectively. Therefore, the initial differential diagnosis included chronic lithium intoxication, hepatic encephalopathy, Wernicke encephalopathy, or alcohol withdrawal syndrome. Even with the provision of adequate hydration, the patient's neurologic status did not show improvement, so that lactulose enema, thiamine replacement, and continuous venovenous hemodiafiltration (CVVHDF) were started on the third admission day. By the fifth admission day he had made a rapid neurologic recovery, and was discharged on the 20th admission day. Therefore, CVVHDF might be a treatment for patients with chronic lithium intoxication, because, even if serum lithium concentration is normal, lithium concentration in the brain may be different from that of the serum.