• 약학회지
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• 제42권5호
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• pp.513-518
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• 1998

Fluoxetine is a nontricyclic antidepressant which blocks serotonin reuptake selectively. Its N-demethyl metabolite, norfluoxetine is also selective inhibitor of serotonin uptake . This study was carried out to compare the bioavailability of Myung-in fluoxetine (20mg/cap.) with that of Prozac$^{\circde{R}}$. The bioavailability was conducted on 24 healthy volunteers who received a single dose (80mg) of each drug in the fasting state, in a randomized balanced 2-way crossover design. After closing, serial blood samples were collected for a period of 48 hours, Plasma was analyzed for fluoxetine and norfluoxetine by a sensitive and validated HPLC assay. The major pharmacokinetic parameters ($AUC_{0-48\;hr}$, Cmax, Tmax , $AUC_{inf.}$, MRT. $T_{1/2}$, Vd and Cl) were, calculated from the plasma fluoxetine concentration-time data of each volunteer. The microcomputer program, 'WinNonlin' was used for compartmental analysis. A two-compartment model with first-order input, first-order output and no lag time was chosen as the most appropriate pharmacokinetic model. The data were best described by using a weighting factor of $1/y^2$. Though the plasma fluoxetine concentrations of Myung-in fluoxetine were higher than those of Prozac$^{\circde{R}}$ at all observed time from 7.9% to 16.9% (P<0.05 at 6.7 and 10 hr), the bioavailability of Myung-in fluoxetine appeared to be bioequivalent with that of Prozac$^{\circde{R}}$. There were no statistical significant differences between the two drugs in all pharmacokinetic parameters including $AUC_{0-48\;hr}$ of norfluoxetine.

• International Journal of Control, Automation, and Systems
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• 제2권4호
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• pp.423-434
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• 2004

In this paper, we introduce a new topology of Self-Organizing Polynomial Neural Networks (SOPNN) based on genetically optimized Multi-Layer Perceptron (MLP) and discuss its comprehensive design methodology involving mechanisms of genetic optimization. Let us recall that the design of the 'conventional' SOPNN uses the extended Group Method of Data Handling (GMDH) technique to exploit polynomials as well as to consider a fixed number of input nodes at polynomial neurons (or nodes) located in each layer. However, this design process does not guarantee that the conventional SOPNN generated through learning results in optimal network architecture. The design procedure applied in the construction of each layer of the SOPNN deals with its structural optimization involving the selection of preferred nodes (or PNs) with specific local characteristics (such as the number of input variables, the order of the polynomials, and input variables) and addresses specific aspects of parametric optimization. An aggregate performance index with a weighting factor is proposed in order to achieve a sound balance between the approximation and generalization (predictive) abilities of the model. To evaluate the performance of the GA-based SOPNN, the model is experimented using pH neutralization process data as well as sewage treatment process data. A comparative analysis indicates that the proposed SOPNN is the model having higher accuracy as well as more superb predictive capability than other intelligent models presented previously.reviously.

• 정보처리학회논문지D
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• 제8D권3호
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• pp.233-240
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• 2001

소프트웨어 개발 기술이 발전하고 소프트웨어 정량화의 중요성이 커지면서 많은 메트릭들이 여러 시스템 개체의 정량화를 위해 제안되었다. 이들은 크게 스칼라 메트릭 형태나 벡터 형태를 취한다. 최근에 몇몇 연구들에서 스칼라 메트릭의 조합 형태에서 오는 위험성을 지적하였지만 아직도 유용성 등의 큰 이점 때문에 많은 스칼라 메트릭들이 사용되고 있다. 본 논문은 기존 메트릭 연구들의 분석 과정을 통해 스칼라 메트릭 형태는 외부 복잡도에 가중을 둔 혼성 메트릭 형태가 가장 적당하다는 결론을 얻었으며 이를 토대로 개발 방법론과 개발 시스템 형태에 의존하지 않는 일반적인 혼성 복잡도 메트릭 제작 프레임워크를 제안한다. 제안 프레임워크는 구조적 방법론의 분석 단계와 객체지향 실시간 시스템 설계 단계의 정량화 프로젝트에 사용되었으며 두 프로젝트 모두 만족할만한 결과를 얻었다. 정량화 목적을 갖는 개발 집단은 제안 프레임워크를 이용하여 단시간 내에 여러 종류의 시스템 개체를 정량화할 수 있다.

• 약학회지
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• 제58권2호
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• pp.99-106
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• 2014

This study explores the prescribing pattern of generic drugs and the relationship between socio-demographic factors and the use of generics in South Korea. The analysis was based on claims data of 2011 from Korean National Health Insurance. We examined utilization, costs, and market share of oral preparations by original and generic product. Multiple logistic regression was performed to evaluate the predictive factors of generic use among multi-source medications. Generics accounted for 37~41% of utilization and 34~41% of costs in the insured market of oral preparations. In the generic market, costly generics made up about 58~61%, 56~66% of volume and value, respectively. Other things being equal, institutional factors affected generic use to the largest degree. The odds of having generics were 6 times higher in clinics, 4 times higher in hospitals, and 1.7 times higher in general hospitals than in teaching hospitals. Those in metropolitan or rural area were more likely to prescribe generics than those in the capital area. While generics were frequently prescribed for off-site pharmacy (OR=1.173), the odds of having generics was 0.88 after weighting the data by units prescribed. This study empirically presented the pattern of generic prescribing, confirming the widely accepted view that costly generics were more likely to be utilized in the Korean market. Up to two thirds of the generic market consisted of costly products. The strongest factors affecting generic use were institutional variables.

• 한국수자원학회논문집
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• 제39권12호
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• pp.1067-1080
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• 2006

공공사업이나 공공의 목적으로 제공되는 재화의 경험적 평가에 있어 다기준의사결정기법은 광범위한 평가기준을 고려할 수 있기 때문에 의사결정권자에게 적절한 의사결정 도구를 제공하였다. 대립관계문제의 의사결정 방법으로 다기준의사결정기법은 도로, 댐 및 항만건설 등 공공사업 분야에서 이의 유용성을 입증하였다. 본 연구에서는 다기준의사결정기법의 장점을 활용하기 위하여 사회, 경제, 환경 및 사업실현성 측면에서 댐 사업 평가지표를 수자원의 지속가능성에 바탕을 두고 개발하고, 설문조사를 통하여 지표의 중요도를 도출하였다. 사업투자우선순위결정을 위하여 개발된 평가지표를 실제 재개발을 위하여 조사중인 6개의 기존 댐에 적용하였다. 아울러 근래 공공사업의 추진과정에서 문제점으로 나타나고 있는 지자체 및 지역주민의 동의와 협조가 사업시행의 핵심인 점을 고려하여 사업실현성이 경제성, 환경성 및 사회성과 마찬가지로 중요한 요소임을 알 수 있었다.

• 한국철도학회논문집
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• 제7권4호
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• pp.332-338
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• 2004

The two projects about the high speed train have been performed in Korea, one project is the commercial run of high speed train(KTX) from Seoul to Busan and the other is the development of original high speed train(HSR 350x). As the successful results, the service run of KTX had been launched on the 1st of April, 2004 and HSR 350x had been fabricated in June, 2002 and has been tested in the Kyoungbu line and Honam line since then. The railway has the track irregularities which cause vibrations, such as rail joints, turnout, level crossing, transition curves and super-elevation ramps, and variations in the track level(z-axis) and the gauge(y-axis). Generally, the ride comfort for railway is evaluated by using the vibrations. In this paper, the ride comfort indices according to mc 513R and ISO 10056 have been reviewed when the high-speed trains are operated on both Kyoungbu line and Honam line. Also, the ride characteristics for KTX and HSR 350x on the high speed line and the conventional line have been analyzed and evaluated. The results show that the high-speed train has no problem from the viewpoint of the comfort ride on the high speed line and the conventional line and the ride index for HSR 350x is same as that for KTX in the high speed(300 km/h).

• 한국산업정보학회논문지
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• 제20권4호
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• pp.1-9
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• 2015

본 연구에서는 다속성 의사결정(MADM)과 게임 이론을 결합하여 무선 자원의 이용효율을 향상시키는 호 수락제어 방법을 제시한다. 다속성 의사결정 방법으로 그레이 관계분석(GRA), 단순부가가중치법(SAW), TOPSIS들을 이용하였는데, 이 방법들은 서로 다른 서비스 품질(QoS)을 갖는 서비스들이 선호하는 대상 네트워크들의 선호도를 계산할 것이다. 이 선호도 값들을 이용한 효용함수를 바탕으로, 사용자가 요구하는 서비스 중에서 서비스 제공자들에게 적합한 서비스를 선택할 수 있도록 비협력적 게임이 진행된다. 요청되는 모든 서비스가 선택될 때까지 게임은 반복적으로 진행되며, 각 단계에서 내쉬균형을 이루는 서비스가 선택되도록 하였다. 서로 다른 특성을 갖는 4개의 무선 랜(WLAN) 시스템 중에서 임의의 2개의 네트워크가 중첩하여 존재하는 경우들을 각각 분석한 결과, 모든 다속성 의사결정 방법들은 서비스 제공자가 얻는 최대 보수의 차이는 있었으나 게임의 각 단계에서 동일한 서비스 선택하는 결과를 얻을 수 있었다.

• 환경영향평가
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• 제2권1호
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• pp.39-55
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• 1993

The importance of urban and regional natural park increases because of the needs for preserving the natural resources and providing with natural recreation space in nature. This planning of natural park management should be established based on the research of the various natural resources in the park. But for the lack of effective data synthesizing methods and concepts, only some restricted factors for zoning plan are considered even though GIS computer system for large complex simulation is used. Therefore, in this study three ecological zoning models such as Basic Factor Model (BFM), Visual Landscape Model (VLM) and Comprehensive Ecological Model (CEM) are proposed and applied to Byounsan Peninsula Nature Park(BPNP) for comparison with the current natural park zoning. The BFM has three components -elevation, slope and vegetation. The VLM has applied with six components -elevation, slope, vegetation, road type, and the visual distance. Finally the CEM's modelling factors have included all of BFM, VLM components are added with the land use type, nature and historic resource factors. The zoning concept of BPNP was based on "Minimization" focused on the specific factors. But introduced modelling concept is "Optimization" based on the total ecological environment. So the result of the modelling has larger area for preservation and development zoning compared with the current zoning whose characteristics are ambiguous which allows the environmental destruction. The future study issues will be the determination of the weighting factor, component reconsideration based on the ground truth data and the agriculture residential area zoning.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.155-155
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• 2012

최근 집중호우에 따른 자연재해가 크게 증가하여 수문 및 기상분야에서 강우를 관측 및 예측하기 위한 레이더 활용성이 증대되고 있으며, 이에 따라 정부 각 관련부처에서는 레이더의 도입 및 확충을 위한 방안을 계획 제시하고 있다. 특히, 레이더강우 자료는 수문해석분야에서의 GIS 등 디지털정보를 이용하여 유역매개변수를 추정함에 따라 더 정확하고 상세한 수문자료 확보가 가능하게 되어, 격자기반의 분포형 강우-유출모형 등을 이용하여 수문해석을 하는데 있어 그 활용성이 크게 증가하고 있다. 그러나 레이더강우 자료의 정확성은 아직까지 만족할 만한 수준에 이르지 못하고 있기 때문에, 그 불확실성으로 인하여 레이더강우 자료의 활용 및 적용에 한계를 가지고 있는 실정이다. 본 연구에서는 지상강우를 이용한 레이더강우 보정을 위하여 SOA(Statistical Objective Analysis)보정방법을 이용하였으며, 기존 SOA방법에서의 거리에 따른 가중치($_{kd}$)와 함께 지형(고도)에 따른 가중치($W_{ike}$), 바람의 영향에 따른 가중치($W_{ikw}$)를 추가로 산정하여 적용하였으며, 이를 통하여 보정된 강우장을 생성하였다. SOA방법을 통해 생성된 강우장이 어느 정도의 강우정확도를 가지고 강우분포를 재현하는지 검증하기 위하여 2011년 7~9월의 수문학적 분석에 활용 가능한 강우사상과 낙동강유역을 대상으로, 분포형모형인 $Vflo^{TM}$ 모형을 이용하여 산정된 유출량과 관측 유출량과의 비교를 실시하였다. 또한, 유출량에 대한 오차 및 ME(Model Efficiency)를 통해 레이더강우 자료의 유출모형에서의 효율성을 검토하고자 하였다. 본 연구에서 수행된 보정 강우장에 따른 유출량 비교를 통해 레이더 강우의 정확도에 대한 정량적 평가 방법 도출이 가능할 것으로 판단된다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 추계학술대회논문집
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• pp.330-335
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• 2000

This paper deals with sensing ability of smart sensor that has a sensing ability of distinguish materials. We have developed new signal processing method that have distinguish different materials. We made the two type of smart sensors for experiment. The first type of smart sensor is H2 type. The second type of smart sensor is HH type. The smart sensor was developed for recognition of material. And then we developed estimation method of sensing ability of smart sensors. The first method(Sensing Ability Index) is developed for H2 smart sensor. The second method($R_{SAI}$ Index) is developed for HH smart sensor. We estimated sensing ability of smart sensor with new SAI and $R_{SAI}$ method. This paper describes our primary study for a new method of estimate sensing ability of smart sensor, which is need for precision work system. This is a study of dynamic characteristics of smart sensor according to frequency and displacement changing with new SAI and $R_{SAI}$ method. Experiment and analysis are executed for proper dynamic sensing condition. First, we developed advanced smart sensors. Second, we develop new SAI and $R_{SAI}$ methods that have a sensing ability of distinguish materials. Dynamic characteristics of smart sensor are evaluated through new SAI and $R_{SAI}$ method relatively. We can use the new SAI and $R_{SAI}$ method for finding materials. Applications of this method are finding abnormal condition of object(auto-manufacturing), feeling of object(medical product), robotics, safety diagnosis of structure, etc.