• 대한한의학방제학회지
• /
• 제16권2호
• /
• pp.183-191
• /
• 2008

Acetaminophen (N-acety1-p-aminophenol, paracetamol) is widely used as an over-the-counter analgesic and antipyretic drug. Intake of a over dose of acetaminophen may result in severe hepatic necrosis. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of acetaminophen and the possible protective effects of administration (50-200 mg/kg body weight) of SB-Ex on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of SB-Ex on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase (${\sigma}$-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. Acetaminophen caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were general statistically significant losses in the activities of SOD, catalase, ${\sigma}$-ALA-D, and GPx and an increase in TBARS in the liver of acetaminophen-treated group compared with the control group. However, SB-Ex was able to counteract these effects. These results suggest that SB-Ex can act as hepatoprotectives against acetaminophen toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.

• 한국산림과학회지
• /
• 제80권3호
• /
• pp.303-310
• /
• 1991

해송엽(海松葉) litter의 분해(分解)와 그에 따른 양분방출(養分放出)의 동태(動態)를 일본지방(日本地方)의 해안(海岸) 해송림(海松林)에서 litterbag법(法)으로 조사(調査)하였다. litter의 분해(分解)에 따른 건물중(乾物重)의 소실(消失)은 초기(初期) 1년간(年間)에 빨랐고 그후는 보다 둔화(鈍化)하였으며, 분해(分解) 1년동안의 소실율(消失率)은 약(約) 40%였다. 분해계수(分解係數)는 0.5-6.0, 반감기(半減期)(년(年))는 l.1-l.4의 범위였다. 분해(分解)에 따른 잔존(殘存) litter내의 N과 P의 양분농도(養分濃度)는 경시적(經時的)으로 증가(增加)하는 경향(傾向)이었으나 K의 농도(濃度)는 감소(減少)하였다. K의 양분(養分)의 절대량(絶對量)은 분해(分解)가 진행(進行)하는 동안 현저히 감소하였으나 N의 절대량(絶對量)은 증가하는 경향을 보였다. 분해(分解)에 따른 방출(放出)은 K>P>N의 순(順)이었다. 실험기간중 N의 무기화(無機化) 단계는 나타나지 않았다.

• 수산해양기술연구
• /
• 제26권1호
• /
• pp.45-50
• /
• 1990

장어 통발어업의 어로작업을 자동기계화하기 위한 기초조사로서, 통발어선과 어구 및 어로작업시간 등을 설문 조사한 다음 각 단계별 어로작업시간을 측정\ulcorner분석하였으며, 자동기계화에 적당한 통발어구의 구조와 규격 등을 파악하기 위한 해상 시험조업으로 어획성능과 실용성 등을 비교 검토한 결과는 다음과 같다. 1. 플라스틱 장어통발의 직경이 13cm인 대형통발과 11cm인 소형통발의 어획시험 결과 통발당 어획미수나 어획량은 차이가 거의 없었으며, 소형통발을 사용할 경우 유수저항을 20%이상 감소시킬 수 있었다. 2. 외측돌기물에 의한 회전개폐식 입구의 경우 부설 중의 분실률은 끈으로 고정시키는 입구의 경우와 거의 같아 1% 정도이나, 회전개폐식의 작업시간은 훨씬 짧아서 3인이 하던 작업을 2인으로도 충분하였다. 3. 통발의 모릿줄에 다는 납침자와 돌을 제거하고, P\ulcorner P연심로프를 침강력이 동일하도록 납줄이 2~3가닥 들어 있는 연심로프 대체하면 고달이 부분의 직경이 감소되면서 요철이 원만하게 되어 자동기계화에 의한 연속작업이 가능해진다.

• 대한수의학회지
• /
• 제35권1호
• /
• pp.137-142
• /
• 1995

Anaplasmosis is a tick-borne disease of large and small ruminants, causing losses through mortality, abortion, weight loss and reduced milk production. In one dairy farm, for example, 250 of a total of 800 imported goats were diagnosed with a mysterious type of anemia during the summer and autumn of 1992. The etiologic agent was identified as Anaplasma spp by acridine orange and ultrastructure by electron microscopy. In order to monitor variations in blood biochemical and hematological parameters associated with the disease, blood samples were collected by jugular venipuncture from 50 goats at 3 month intervals between the period of February and October, 1993. The levels of RBCs, HB and HCT decreased from $18.48{\pm}1.96$ to $13.47{\pm}2.48X10^6/mm^3$, $12.25{\pm}1.41$ to $9.54{\pm}1.77g/dl$, and $43.09{\pm}4.75$ to $30.93{\pm}5.78%$, respectively. The values of MCH(Mean corpuscular hemoglobin), MCHC(Mean corpuscular hemoglobin concentration) and PLT(Platelet) were elevated from $6.58{\pm}0.30$ to $7.05{\pm}0.47pg$, $28.40{\pm}1.20$ to $30.82{\pm}1.85g/dl$ and $1688.34{\pm}750$ to $2046.82{\pm}783X10^3/mm^3$, respectively. Percent parasitized erythrocytes(PPE) increased from $0.61{\pm}0.5$ to $2.22{\pm}1.9%$, clinical biochemical parameters aspartate aminotransferase and alanine aminotransferase were $66.64{\pm}23.1K.U$ and $14.90{\pm}6.59K.U$, respectively and persisted at high levels throughout the observation period. The level of albumin(2.46)0.52 g/dl) was decreased corresponding to an elevated globulin and a reduced albumin/globulin ratio in October as compared with the values in February. It is concluded that caprine anaplasmosis may be an important cause of anemia and hepatic malfunction in goats.

• 자원환경지질
• /
• 제29권3호
• /
• pp.269-279
• /
• 1996

Dehydroxylation and mullitization of primary and secondary kaolins were investigated in order to compare and understand the differences in thermal behaviours by DTA and TG up to $1,100^{\circ}C$. Chemical analyses and EPMA of the samples revealed nearly ideal unit-cell formulae of kaolins. The weight losses of dickite and halloysite are 14% and 12.5% on the average, respectively. The activation energies of dehydroxylation of kaolin minerals were calculated according to Kissinger's approach which uses various heating rates in DTA to estimate the activation energy of thermal reactions. The activation energies of dehydroxylation of halloysites from Daemoung and Buksam mines are about $163kJmor^{-1}$ (white), $168kJmor^{-1}$ (pink), and $176kJmor^{-1}$ respectively. The activation energies of dickites collected from Sungsan and Ogmae mines are about $166kJmor^{-1}$ and $387kJmor^{-1}$. The asymmetric shape of endothermic peak in DTA, the relative intensities of OH-stretching bands in FTIR spectroscopy and the existence of residual XRD peaks of the samples which were heated at $550^{\circ}C$ for 2 hours indicate that Sungsan dickite may be more disordered than Ogmae dickite. The new phase formed in thermally treated samples in the range of $900^{\circ}C$ to $1,100^{\circ}C$ was identified as mullite by XRD on the basis of disappearing of the characteristic peaks of kaolins and increasing of amorphous background upon heat treatment. On further heating, loss of more water from dehydroxylate resulted in the formation of mullite and the characteristic X-ray diffraction patterns of mullite began to appear at about $900{\sim}1,000^{\circ}C$ in kaolins.

• 한방재활의학과학회지
• /
• 제23권2호
• /
• pp.49-61
• /
• 2013

Objectives : This study was conducted to determine whether or not Kangwhaldoche-tang(Qianghuodaozhi-tang) (KDT) aqueous extracts can protect articular cartilage losses on the Freund's complete adjuvant(FCA)-induced rat rheumatoid arthritis. Methods : 520, 260 or 130 mg/kg of KDT were orally administered once a day for 14 days from 14 days after FCA treatments, and 15 mg/kg of dexamethasone was intraperitoneally administered as reference drug in this experiment. Changes on the body weight, knee circumferences, gross arthritis score, inflammatory tissue prostaglandin(PG) $E_2$ levels were monitored with cartilage collagen components and glucosaminoglycans(GAGs) compositions - chondroitin sulphate, heparin sulphate and hyaluronic acid in the present study. Results : As results of FCA treatment, classic rheumatoid arthritis featuring dramatic decreases of the body weights, cartilage collagen and GAGs contents with increases of the knee circumferences, gross arthritis scores and inflammatory tissue $PGE_2$ levels, were demonstrated in the present study. However, these changes from FCA - induced rheumatoid arthritis were clearly inhibited by treatment of dexamethasone and all three different dosages of KDT. Although overall anti-inflammatory effects of KDT 520 mg/kg were lowered than those of dexamethasone 15 mg/kg treated rats, KDT 520 mg/kg showed more favorable preserve effects on the cartilage GAGs and KDT 260 mg/kg treated rats showed similar preserve effects as compared with dexamethasone 15 mg/kg in this experiment. Conclusions : The present results supported that over 75 mg/kg of KDT showed favorable anti-arthritic effects on the FCA-induced arthritis mediated by suppression of $PGE_2$, representative inflammatory mediator, and may help improve rheumatoid arthritis.

• 한국농공학회지
• /
• 제29권4호
• /
• pp.132-141
• /
• 1987

The objective of the study was to obtain the compressive the tensile and the fleniril strengthes, thermal resistance, chemical resistance and fire resistance of the reclaimed plastic corcrete in order to investigate the feasibility as a new construction material This reclaimed plastic concrete is a compositive material which is composed of sand and blend of 50% of LDPE(Low density polyethylene) and 50% of HDPE (High density polyethylene) which are inexpensive and easy to reclaim. The results obtained in the study are summarized as follows: 1. As the binder content ranging from 20 to 40 % increase, the compresie, the splitting tensile and the flexural strengthes were increased. The compressive strenzth of the specimen tested was the highest and flexural strength the next and tensile strength the lowest 2. The compressive, the tensile and flexural strengthes of specimens made of fine sand were higher than those of coarse sand. The compressive, the tensile and the flexural strengthes of specimens made of high pressure molding were higher than those of low pressure molding. 3.In comparison with different additives, the specimens with carbon black was excellent and B. H. T. good and ferric oxide poor for thermal resistance. 4. In relationship between the flexural strength with varying temperature from -23$^{\circ}C$ to 80$^{\circ}C$. The flexural strengthes were decreared as temperature increased at 25 %, 30 % and 35 % of binder contents, respectively. Especially at 60$^{\circ}C$, the flexural strength was significantly decreased. 5. The decrement of flexural strengthes and the weight losses after 7 days immersion in acid or alkali solutions were not significant. 6. Fire resistance of the reclaimed plastic concrete was not significantly influenced by the contents of sand. However, the fire resistance of the reclaimed plastic concrete was depend upon melting and ignition properties of the binder itself. Therefore. a proper selection of the binder and the fire retardant are recommended in arder to improve fire resistance of the reclaimed plastic concrete.

• Restorative Dentistry and Endodontics
• /
• 제41권4호
• /
• pp.255-261
• /
• 2016

Objectives: This study aimed to analyze the mineral composition of naturally- and artificially-produced caries-affected root dentin and to determine the elemental incorporation of resin-modified glass ionomer (RMGI) into the demineralized dentin. Materials and Methods: Box-formed cavities were prepared on buccal and lingual root surfaces of sound human premolars (n = 15). One cavity was exposed to a microbial caries model using a strain of Streptococcus mutans. The other cavity was subjected to a chemical model under pH cycling. Premolars and molars with root surface caries were used as a natural caries model (n = 15). Outer caries lesion was removed using a carbide bur and a hand excavator under a dyeing technique and restored with RMGI (FujiII LC, GC Corp.). The weight percentages of calcium (Ca), phosphate (P), and strontium (Sr) and the widths of demineralized dentin were determined by electron probe microanalysis and compared among the groups using ANOVA and Tukey test (p < 0.05). Results: There was a pattern of demineralization in all models, as visualized with scanning electron microscopy. Artificial models induced greater losses of Ca and P and larger widths of demineralized dentin than did a natural caries model (p < 0.05). Sr was diffused into the demineralized dentin layer from RMGI. Conclusions: Both microbial and chemical caries models produced similar patterns of mineral composition on the caries-affected dentin. However, the artificial lesions had a relatively larger extent of demineralization than did the natural lesions. RMGI was incorporated into the superficial layer of the caries-affected dentin.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
• /
• pp.529-532
• /
• 2008

우리나라에 제설제 피해가 발생하는 곳은 일평균기온이 0$^{\circ}C$이하로 되는 경우이므로 국내에서는 거의 모든 지역이 해당될 수 있다. 따라서, 다소 정도의 차이는 있으나 전국적으로 대부분의 강재 및 콘크리트 구조물이 동결융해 및 염해의 피해를 받고 있다고 볼 수 있다. 현재 주로 사용되고 있는 제설제는 염화물계인 염화칼슘과 소금이나, 이러한 염화물계 제설제를 많이 사용하게 됨에 따라 콘크리트 구조물의 조기 손상 및 환경피해로 인한 유지관리 비용이 크게 증가하고 있다. 따라서, 염화물계 제설제가 대량 살포되고 동결융해에 의한 동해를 받는 적설한랭지에서의 콘크리트 구조물 및 환경에 미치는 심각한 악영향에 대한 대책 방안을 강구하여야 하는 실정이다. 위와같은 취지로서 본 연구에서는 염화물계 제설제의 대체제로 친환경적인 비염화물계 제설제의 적용방안을 검토하기 위하여 강재의 부식 및 콘크리트의 동결융해에 미치는 영향을 평가하고자 비염화물계 제설제와 일반 제설제와의 pH 및 유해물질 함유량을 비교하였고 강재부식성 시험 및 동결융해 저항성 시험을 실시하여 그 성능을 평가하였다.

• 한국응용곤충학회지
• /
• 제23권3호
• /
• pp.153-157
• /
• 1984

포장조건하에서 수잉기와 출수기에 벼멸구를 인위적으로 가해시킨 후 출수후 고사시기별로 수량수율을 조사하여 다음과 같은 결과를 얻었다. 1. 출수후 23일경에 고사된 벼는 무접종구에 비하여 등숙율은 $32.2\~37.5\%$ 현미천립중은$ 3.2\~3.5g$ 감소되었다. 2. 고사시기가 같아도 수잉기부터 가해구는 출수기부터 가해구보다 등숙율 현미천립중, 현미수량이 낮았다. 3. 고사된 벼의 감수율은 무접종에 비하여 고사시기에 따라 $24\~62\%$였으며 출수후 고사일수(X)와 수량(Y)간에는 다음과 같은 관계가 있었다. o 수잉기이후가해 : $\hat{Y}=10.145X-16.374(r=0.9726^{**})$ o 출수기이후가해 : $\hat{Y}=9.792X+26.936(r=0.8850^{**})$.