• International Journal of Ocean System Engineering
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• 제3권2호
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• pp.102-110
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• 2013

The purpose of this study was to improve the properties of epoxy resin using titanium oxide nanoparticles. The effects of particle weight fraction, dispersion agent, and curing agents with different molecular weights on the thermal and mechanical properties of titanium-oxide-reinforced epoxy resin were investigated. In addition, the effect of the particle dispersion condition on the mechanical properties of nanocomposites was studied. As a result, it was found that the glass transition temperature of film-shaped nanocomposites decreased with an in-crease in the nanoparticle content. Because nanoparticles interrupted the cross linkage between the epoxy resin and the amine curing agent, the cross-link density of the epoxy became lower and led to a decrease in $T_g$ in the nanocompo-sites. The tensile strength and modulus in film-shaped nanocomposites also increased with the particles content. But in the case of dog-bone-shaped nanocomposites, the values were not similar to the trend for the film-shaped nanocompo-sites. This was probably a result of the different nanoparticles dispersions in the epoxy resins resulting from the respective-thicknesses of the film and dog-bone-shaped samples.

• Toxicological Research
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• 제27권4호
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• pp.261-267
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• 2011

Artemisia iwayomogi, a member of the Compositae, is a perennial herb easily found in Korea and used as a traditional medicine to treat liver disease. AIP1, a water-soluble carbohydrate fraction from Artemisia iwayomogi, showed anti-tumor and immuno-modulating activities in animal studies. A subacute toxicological evaluation of AIP1 was performed for 4 weeks in ICR mice. After administration of AIP1 (0, 20, 100, 500 mg/kg/day), the clinical signs, mortalities, body weight changes, hematology, blood clinical biochemistry, urinalysis, organ histopathology, organ weights and gross finding were examined. The results showed that there were no significant differences in body weight changes, food intakes, water consumptions, or organ weights among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally treated with AIP1 and the control group, there was no statistical significance in hematological test or serum biochemical values. Histopathological examination showed no abnormal changes in AIP1 groups. These results suggest that no observed adverse effect level (NOAEL) of the oral administration of AIP1 for 4 weeks was considered to be more than 500 mg/kg/day in mice under the condition investigated in current study.

• 한국식품영양과학회지
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• 제29권2호
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• pp.288-293
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• 2000

This study was carried out to investigate the effect of crude saponin fracton from Korean red ginseng on physiological events of ovariectomized rats. The saponin fractions was prepared by Diaion HP-20 adsorption chromatography and spirit. Total 50 rats were divided into 5 groups : normal control (NC), sham-ovariectomized (SO), ovariectomized (OR), ovariectomized and saponin treated (OS), and normal control treated with saponin (NS). Saponin was intraperitonally administered for 8 weeks. Ovariectomy was carried out at 1 st and 2nd weeks of experiment. Right-side ovary of rat was removed at 1st week, the otehr was done at 2nd week. The body weights fo ovariectomized rats showed no significant changes but that of NS group showed significant increase (p<0.05) compared with NC group. Ovariectomy of rats reduced the weights of femur by 6 to 8% compared with that of NC group. In addition, femur weight of NS group was 5 to 6% higher than that of NC. Uterus weight showed no significant differences by saponin treatment or ovariectomy. Serum testosterone level of ovariectomized rats increased by 60 times compared with that of NC. However, administration of crude saponin to ovariectomized rat attenuated testosterone level to almost that of NC. These results suggest that Korean red ginseng saponin attenuates physiological disorders induced by malfunction of ovary.

• 한국축산식품학회지
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• 제38권6호
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• pp.1168-1178
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• 2018

The present study aimed to characterise anti-oxidant peptides from water-soluble protein extracts of Hanwoo beef and evaluate their anti-proliferative effect on human colorectal carcinoma cells (HCT116). Antioxidant peptides were purified from the low-molecular-weight fraction (<3 kDa) of Hanwoo beef extract. Antioxidant activity of peptide fractions was determined using the oxygen radical absorbance capacity (ORAC) assay. Purified peptide (P3) displayed higher ORAC activity than the low-molecular-weight fraction ($202.66{\mu}M\;TE/g$ vs $167.38{\mu}M\;TE/g$ of dry matter, respectively) (p<0.05). The peptide sequence of P3 was Cys-Cys-Cys-Cys-Ser-Val-Gln-Lys (888.30 Da). The novel peptide P3, at $250{\mu}g/mL$, also significantly inhibited HCT116 cell proliferation up to 25.24% through phosphorylation of ERK, JNK, and p38 kinase (p<0.05). Hence, antioxidant peptide P3 from Hanwoo beef extract can be used as an antioxidative and anticancer agent in the functional food industry.

• Steel and Composite Structures
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• 제31권5호
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• pp.529-539
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• 2019

Current paper deals with thermoelastic static and free vibrational behaviors of axisymmetric thick cylinders reinforced with functionally graded (FG) randomly oriented graphene subjected to internal pressure and thermal gradient loads. The heat transfer and mechanical analyses of randomly oriented graphene-reinforced nanocomposite (GRNC) cylinders are facilitated by developing a weak form mesh-free method based on moving least squares (MLS) shape functions. Furthermore, in order to estimate the material properties of GRNC with temperature dependent components, a modified Halpin-Tsai model incorporated with two efficiency parameters is utilized. It is assumed that the distributions of graphene nano-sheets are uniform and FG along the radial direction of nanocomposite cylinders. By comparing with the exact result, the accuracy of the developed method is verified. Also, the convergence of the method is successfully confirmed. Then we investigated the effects of graphene distribution and volume fraction as well as thermo-mechanical boundary conditions on the temperature distribution, static response and natural frequency of the considered FG-GRNC thick cylinders. The results disclosed that graphene distribution has significant effects on the temperature and hoop stress distributions of FG-GRNC cylinders. However, the volume fraction of graphene has stronger effect on the natural frequencies of the considered thick cylinders than its distribution.

• Journal of Applied Biological Chemistry
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• 제62권1호
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• pp.101-107
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• 2019

The objectives of this study were to evaluate the anti-aging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (<1 kDa), and high molecular weight fractions (>1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (>20%) lower with all samples. Also, the digested FCHs and their <1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the <1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries.

• Computers and Concrete
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• 제30권6호
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• pp.433-443
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• 2022

In the current paper, the nonlinear resonance response of functionally graded graphene platelet reinforced (FG-GPLRC) beams by considering different boundary conditions is investigated using the Euler-Bernoulli beam theory. Four different graphene platelets (GPLs) distributions including UD and FG-O, FG-X, and FG-A are considered and the effective material parameters are calculated by Halpin-Tsai model. The nonlinear vibration equations are derived by Euler-Lagrange principle. Then the perturbation method is used to discretize the motion equations, and the loadings and displacement are all expanded, so as to obtain the first to third order perturbation equations, and then the asymptotic solution of the equations can be obtained. Then the nonlinear amplitude-frequency response is obtained with the help of the modified Lindstedt-Poincare method (Chen and Cheung 1996). Finally, the influences of the distribution types of GPLs, total GPLs layers, GPLs weight fraction, elastic foundations and boundary conditions on the resonance problems are comprehensively studied. Results show that the distribution types of GPLs, total GPLs layers, GPLs weight fraction, elastic foundations and boundary conditions have a significant effect on the nonlinear resonance response of FG-GPLRC beams.

• Structural Engineering and Mechanics
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• 제85권4호
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• pp.445-459
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• 2023

The current investigation is the first endeavor to apply the full layerwise finite element method (FEM) in free vibration analysis of functionally graded (FG) composite plates reinforced with graphene nanoplatelets (GPLs) in thermal environment. Unlike the equivalent single-layer (ESL) theories, the layerwise FEM focuses on all three-dimensional (3D) effects. The GPLs weight fraction is presumed invariable in each layer but varies through the plate thickness in a layerwise model. The modified Halpin-Tsai model is employed to acquire the effective Young's modulus. The rule of mixtures is applied to specify the effective Poisson's ratio and mass density. First, the current method is validated by comparing the numerical results with those stated in the available works. Next, a thorough numerical study is performed to examine the influence of various factors involving the pattern of distribution, weight fraction, geometry, and size of GPLs, together with the thickness-to-span ratio, thermal environment, and boundary conditions of the plate, on its free vibration behaviors. Numerical results demonstrate that employing a small percentage of GPL as reinforcement considerably grows the natural frequencies of the pure epoxy. Also, distributing more square-shaped GPLs, involving a smaller amount of graphene layers, and vicinity to the upper and lower surfaces make it the most efficient method to enhance the free vibration behaviors of the plate.

• Earthquakes and Structures
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• 제26권4호
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• pp.251-259
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• 2024

In this paper, the thermal post-buckling behavior of graphene platelets reinforced metal foams (GPLRMFs) plate with initial geometric imperfections on nonlinear elastic foundations are studied. First, the governing equation is derived based on the first-order shear deformation theory (FSDT) of plate. To obtain a single equation that only contains deflection, the Galerkin principle is employed to solve the governing equation. Subsequently, a comparative analysis was conducted with existing literature, thereby verifying the correctness and reliability of this paper. Finally, considering three GPLs distribution types (GPL-A, GPL-B, and GPL-C) of plates, the effects of initial geometric imperfections, foam distribution types, foam coefficients, GPLs weight fraction, temperature changes, and elastic foundation stiffness on the thermal post-buckling characteristics of the plates were investigated. The results show that the GPL-A distribution pattern exhibits the best buckling resistance. And with the foam coefficient (GPLs weight fraction, elastic foundation stiffness) increases, the deflection change of the plate under thermal load becomes smaller. On the contrary, when the initial geometric imperfection (temperature change) increases, the thermal buckling deflection increases. According to the current research situation, the results of this article can play an important role in the thermal stability analysis of GPLRMFs plates.

• 한국축산식품학회지
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• 제35권6호
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• pp.738-747
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• 2015

Angiotensin-converting enzyme (ACE) inhibitory activity was evaluated for the low-molecular-weight fraction (<3 kDa) obtained from milk fermentation by Bifidobacterium longum KACC91563. The ACE inhibitory activity in this fraction was 62.3%. The peptides generated from the <3 kDa fraction were identified by liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrometry analysis. Of the 28 peptides identified, 11 and 16 were identified as β-casein (CN) and α_s1-CN, respectively. One peptide was identified as κ-CN. Three peptides, YQEPVLGPVRGPFPIIV, QEPVLGPVRGPFPIIV, and GPVRGPFPIIV, from β-CN corresponded to known antihypertensive peptides. We also found 15 peptides that were identified as potential antihypertensive peptides because they included a known antihypertensive peptide fragment. These peptides were as follows: RELEELNVPGEIVE (f1-14), YQEPVLGPVRGPFP (f193-206), EPVLGPVRGPFPIIV (f195-206), PVLGPVRGPFPIIV (f196-206), VLGPVRGPFPIIV (f197-206), and LGPVRGPFPIIV (f198-206) for β-CN; and APSFSDIPNPIGSENSEKTTMPLW (f176-199), SFSDIPNPIGSENSEKT- TMPLW (f178-199), FSDIPNPIGSENSEKTTMPLW (f179-199), SDIPNPIGSENSEKTTMPLW (f180-199), DIPNPIGSENSEKTTMPLW (f181-199), IPNPIGSENSEKTTMPLW (f182-199), PIGSENSEKTTMPLW (f185-199), IGSENSEKTTMPLW (f186-199), and SENSEKTTMPLW (f188-199) for α_s1-CN. From these results, B. longum could be used as a starter culture in combination with other lactic acid bacteria in the dairy industry, and/or these peptides could be used in functional food manufacturing as additives for the development of a product with beneficial effects for human health.