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Efficacy of medications in adult patients with trigeminal neuralgia compared to placebo intervention: a systematic review with meta-analyses

  • Peterson-Houle, Georgia M.;AbdelFattah, Magda R.;Padilla, Mariela;Enciso, Reyes
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.21 no.5
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    • pp.379-396
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    • 2021
  • Background: Trigeminal neuralgia (TN) is characterized by brief, unilateral, sharp, stabbing, and shooting pain of the fifth cranial nerve. The objective of this systematic review with meta-analysis was to determine the effect of medications compared to placebo in adult patients with TN. Methods: Review authors identified randomized placebo-controlled trials (RCTs) from PubMed, Web of Science, Cochrane, and EMBASE up to February 2021. We assessed the inclusion and exclusion criteria as well as the risk of bias of the studies based on the Cochrane Handbook. A total of 324 unduplicated references were scanned independently and reduced to eight relevant RCTs, with 89 patients included. Medications investigated included oral carbamazepine, subcutaneous sumatriptan, lidocaine (intranasal, 8% spray on the oral mucosa or intravenous), buprenorphine (ganglionic local opioid analgesia), and oral Nav1.7, a selective sodium channel blocker. Results: Meta-analyses showed that overall patients receiving lidocaine reported a significantly lower post-treatment intensity of pain -3.8 points on a 0-10 scale (95% Cl = -4.653 to -2.873; P < 0.001). Patients who received lidocaine were 8.62 times more likely to have pain improvement than patients on placebo (P < 0.001). In one RCT, patients receiving oral carbamazepine showed a significant improvement in pain intensity of -32% compared to the placebo (P < 0.001). In one trial, patients receiving 3 mg subcutaneous sumatriptan had a significantly lower intensity of pain on average -6.1 points on a scale of 0-10 compared to placebo (P < 0.001) and a significant improvement in pain intensity of -75% compared to the improvement in the placebo group (P < 0.001). Patients who received subcutaneous sumatriptan were 10 times more likely to have pain improvement than those who received placebo (P = 0.001) in one study. Due to the unclear/high risk of bias and small sample size, the quality of the evidence for lidocaine in the treatment of TN was low. Conclusion: Further studies are needed for carbamazepine, sumatriptan, buprenorphine, and oral Nav1.7 sodium channel blockers, as only one study reported outcomes.

Database Design of Mediterranean Historical Archives Based-on Tag (태그 기반 지중해 역사기록물 데이터베이스 설계)

  • Kang, Ji-Hoon;Kim, Jung-Ha
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.9 no.10
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    • pp.753-762
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    • 2019
  • It is very important to use the raw material in a particular field of research or education. Research without raw materials are difficult to prove and often remain hypothesis. The use of the raw material is also important in area studies that study specific areas. However, research of area studies, especially Western history, raw material and historical archives are very important data, but it is difficult to obtain and refer to these data due to physical or spatial constraints. In order to solve this problem, there is a method of collecting and providing historical archives, but it is currently difficult to find a case of providing overseas historical archives as a web system in Korea. Accordingly, in this paper proposes the necessity of collecting historical archives, the method of collection, and the method of digital archiving of collected data structurally and systematically. In this regard, investigate the existing research cases on the archive system and database design, and it description the differentiation between the existing systems and the modeling method proposed in this study. Also, to improve the efficiency of the search, it proposes a method of adding a tag table when database modeling.

A Study on User Preference Test for Development of Guidelines on Standardized Modes (항해장비 표준화모드 지침 개발을 위한 사용자 선호도 조사에 관한 연구)

  • Ahn, Young-Joong;Jeon, Gye-Jeong;Jung, Jae-Hoon;Kang, Nam-Seon
    • Journal of Navigation and Port Research
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    • v.42 no.6
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    • pp.371-377
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    • 2018
  • Navigational equipment standardization mode is a function which is used to standardize key functions, screen display and operation method of major navigation equipment. This is aimed towards to quickly and accurately checking information relevant for safe navigation. Currently, the International Maritime Organization is working on the development of guidelines for the application of navigational equipment in the standardized mode to the task of NCSR Sub-Committee. This study was conducted to investigate users' opinions and preferences in the application of standardization modes and to reflect them in the development of guidelines. In addition, the test program was designed to investigate user preferences for ECDIS among the navigational equipment, such as the types of information and functions that are necessary or preferentially required to perform navigational duties, and the screen configuration. In the study, 333 preference surveys were conducted in 35 countries using a web - based test program. ECDIS users confirmed the content and screen layout of their preferred ECDIS information when conducting navigation duty. The results of the study are significant as they contribute to the development of effective guidelines by presenting user requirements to be considered in the standardization mode.

Investigation on Perceptions, Attitudes, and Contributing Factors to Spontaneous Adverse Drug Reaction Reporting among Community Pharmacists: Results from a Web-based Survey (지역 약사의 자발적 부작용 보고에 대한 인식 및 태도와 영향요인 조사: 설문조사 결과를 중심으로)

  • Lee, Mo-Se;Choi, Ah-Hyung;Jang, Bo-Hyun;Kim, Na-Young;Lee, Jung-Min;Shin, Ju-Young;Jeon, Ha-Lim
    • Korean Journal of Clinical Pharmacy
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    • v.29 no.2
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    • pp.125-132
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    • 2019
  • Objective: To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists and identify factors that influence reporting, by implementing a survey. Methods: A structured questionnaire was developed and distributed online. Request for the survey was posted on the website of pharmacy's billing program, and the survey was conducted for 8 days. We collected the participants' response on their work environment, experience of ADR reporting, and their perception and attitude on the reporting system. Multivariate logistic regression was used to evaluate factors influencing ADR reporting. Results: A total of 382 pharmacists participated in the survey. Significant contributing factors for reporting level were age (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96), knowledge of reporting method (OR, 53.56; 95% CI, 9.10-315.41), installation of reporting program (OR, 31.92; 95% CI, 4.16-244.75), and encouragement from the Korean pharmaceutical association (OR, 4.13; 95% CI, 1.11-15.35). Regarding the attitude toward spontaneous ADR reporting system, 'lack of time for reporting' (OR, 0.29; 95% CI, 0.15-0.53) and 'complexity of reporting procedure' (OR, 0.51; 95% CI, 0.31-0.84), were associated with a low likelihood of reporting. Conclusion: Our results indicated that the knowledge of ADR reporting method, installation of the reporting program, and encouragement from the Korean Pharmaceutical Association contribute to active reporting. It is necessary to simplify the reporting method, make the ADR reporting program user-friendly, and provide educational interventions to increase participation in spontaneous reporting by the community pharmacists.

The Short Term Effects of an Early Intervention Program for Alcoholism Prevention in Adults: A Pilot Study (성인대상 알코올중독 예방 조기개입의 단기효과: 예비 연구)

  • Kang, Kyong-Hwa
    • The Journal of the Korea Contents Association
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    • v.18 no.11
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    • pp.550-561
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    • 2018
  • The aim of this study was to investigate the short term effects of early intervention on alcohol knowledge, alcohol expectancies, drinking refusal self-efficacy for alcoholism prevention in adults and to examine its applicability in the field. This study was a non-equivalent control group pre-post quasi-experimental design. The participants were currently working, and were 12-25 points on result of the Alcohol Use Disorders Identification Test(AUDIT). The participants were a total of 25 men: 13 in the intervention group and 12 in the control group. The intervention group participated in early intervention program once a week for 4 weeks and the control group received only a booklet of alcohol related information. A chi-square test, t-test, Mann-Whitney U test were analyzed by using IBM SPSS Statistics 20.0. The intervention group had significantly higher the alcohol knowledge(t=1.258, p= .002), the negative alcohol expectancies(t=-1.346, p= .042), and the drinking refusal self-efficacy(t=2.817, p= .010) than the control group. In the future, it is need to apply the criteria of problem drinkers considering cultural characteristics, recruitment of participants, and motivational enhancement intervention using motivational interviewing. Especially, web-based alcohol related information providing program will help raise awareness of problem drinking. Early intervention program needs to be applied in community settings where problem drinkers are easily accessible.

Development of Air Flow Simulator in Agricultural Facility based on Virtual Reality (가상현실 기반 농업시설 공기유동 시뮬레이터의 개발)

  • Noh, Jae Seung;Kim, Yu Yong;Yoo, Young Ji;Kwon, Jin Kyung;Lee, In Bok;Kim, Rack Woo;Kim, Jun Gyu
    • Journal of Bio-Environment Control
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    • v.28 no.1
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    • pp.16-27
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    • 2019
  • Using virtual reality technology, users can learn and experience many interactions in virtual space like the actual physical space. This study was conducted to develop air flow simulator that allows farmers and consultants to consult air flow through VR devices by creating a greenhouse or pigpen model. It can help educate farmers about the importance of ventilation effects for agricultural facilities. We proposed CFD visualization system by building a virtual reality environment and constructing database of CFD and structure of agricultural facilities. After consultants can set up situations according to environmental conditions, the users experience the visualized air flow of agricultural facility according to the ventilation effects. Also it can provide a quantified environmental distribution in the agricultural facility. Currently, the CFD data in agricultural facilities are established during winter and summer. In order to experience various environmental conditions in the developed system, The experts need to run CFD data under various environmental conditions and register them in the system requirements.

Evaluation of the Effectiveness of Surveillance on Improving the Detection of Healthcare Associated Infections (의료관련감염에서 감시 개선을 위한 평가)

  • Park, Chang-Eun
    • Korean Journal of Clinical Laboratory Science
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    • v.51 no.1
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    • pp.15-25
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    • 2019
  • The development of reliable and objective definitions as well as automated processes for the detection of health care-associated infections (HAIs) is crucial; however, transformation to an automated surveillance system remains a challenge. Early outbreak identification usually requires clinicians who can recognize abnormal events as well as ongoing disease surveillance to determine the baseline rate of cases. The system screens the laboratory information system (LIS) data daily to detect candidates for health care-associated bloodstream infection (HABSI) according to well-defined detection rules. The system detects and reserves professional autonomy by requiring further confirmation. In addition, web-based HABSI surveillance and classification systems use discrete data elements obtained from the LIS, and the LIS-provided data correlates strongly with the conventional infection-control personnel surveillance system. The system was timely, acceptable, useful, and sensitive according to the prevention guidelines. The surveillance system is useful because it can help health care professionals better understand when and where the transmission of a wide range of potential pathogens may be occurring in a hospital. A national plan is needed to strengthen the main structures in HAI prevention, Healthcare Associated Prevention and Control Committee (HAIPCC), sterilization service (SS), microbiology laboratories, and hand hygiene resources, considering their impact on HAI prevention.

Bottlenecks in Building an Online Customer Base: A Experimental Field Study on Viral Marketing (온라인 고객 기반 확보의 장애 요인: 바이럴 마케팅의 현장 실험 연구)

  • Park, Sunju;Chung, Seungwha;Pyo, Na Sung;Hwang, Soonki
    • The Journal of the Korea Contents Association
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    • v.19 no.1
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    • pp.682-695
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    • 2019
  • In recent years, using a connected platform, companies have built and implemented a mobile viral marketing strategy to attract new customers and to have long-term relationships with existing customers. The emergence of interactive Web 2.0 has led to an explosive increase in customer engagement, and practitioners have become interested in connected platform to build close relationships with their customers. However, the study on the effectiveness of various customer influx methods using the connected platform that companies utilize for an increase of customer participation is insufficient. Based on the theoretical study of Sashi (2012), this study analyzes the actual mobile viral promotion of company A's open market shopping mall for the purpose of bringing new customers and having a long-term relationship with the new customers[1]. By analyzing the customer engagement type, the implications for the effectiveness of mobile viral promotion are suggested. First, as a result of the immediate effect of online viral promotion, promotions are partially effective in attracting new customers. Second, as a result of examining the change of customer engagement type in order to find out the long - term effect of online viral promotion, it was found that in most cases, new customers were not become satisfied customers and, Laggard Effect, which takes time to become a satisfied customer, has been confirmed.

Design of Programming Failure Feedback System Based on Control Flow of Test Case to Support Programming Training (프로그래밍 훈련 지원을 위한 테스트케이스의 제어흐름에 기반한 프로그래밍 실패 피드백 시스템 설계)

  • Lee, Sunghee;Kim, Deok Yeop;Seo, Kang Bok;Lee, Woo Jin
    • KIPS Transactions on Software and Data Engineering
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    • v.8 no.8
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    • pp.317-322
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    • 2019
  • Programming judge systems for programming training support are typically built on the Web, where the examiners uploads a programming problem, which the student reads and submits an answer to the problem. The judge system executes the submitted answer of source code to provide feedback such as pass, failure, and error messages. Students who receive the feedback except for the pass continues debugging the source code until they are judged to pass. We developed an online judge system to support programming training and analyzed answers submitted by the students and found that many of the students who were not judged to pass that test did not know exactly where they were wrong but continued to solve the problem. The current judge system generally feeds runtime error messages back to students. However, with only runtime error message, it is difficult for student who train to find the wrong part of the answer. Therefore, in this paper, we propose a system that provides the feedback of programming failure by analyzing the control flow of the test cases used in the source code submitted by the student. The proposed system helps students find the wrong parts more quickly by feeding back the paths where faults in the control flow may exist. In addition, we show that this system is applicable to the answer source code that the actual student submitted.

Effect of Simulator Sickness Caused by Head-mounted Display on the Stability of the Pupillary Rhythm (머리착용 디스플레이에 의해 유발된 멀미 증상이 동공 리듬의 안정성에 미치는 영향)

  • Park, Sangin;Lee, Don Won;Mun, Sungchul;Kim, Hong-Ik;Whang, Mincheol
    • Science of Emotion and Sensibility
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    • v.21 no.4
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    • pp.43-54
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    • 2018
  • The aim of this study is to determine the effect of motion sickness on pupil rhythm. Sixteen volunteers of both genders (8 male, 8 female, mean age $25.67{\pm}2.43$ years) experienced VR contents in both 2D and HMD versions for 15 minutes, and their pupillary rhythms were compared. The irregular pattern of the pupillary rhythms, as demonstrated by increasing mean pupil diameter (mPD) and standard deviation of the pupil diameter (sPD), revealed motion sickness after experiencing HMD condition. The pupillary response is strongly related to the cognitive load, and the motion sickness can be interpreted as a change in the cognitive load caused by the increasing volume of visual information that must be processed and the conflict or inconsistency between different sensory modalities. The method proposed in this study could be a non-contact measurement method for the monitoring of motion sickness using a web-camera rather than previous sensor-based methods.