• Herbal Formula Science
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• v.18 no.2
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• pp.227-239
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• 2010

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.15 no.6
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• pp.506-514
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• 2022

This paper is about developing an intravenous injection management system that can provide nurses with information related to intravenous injection in real-time to compensate for possible instability factors during intravenous injection. The intravenous injection management system consists of an app-based user S/W and a web-based administrator S/W. User S/W is implemented to provide users with the ability to identify patients who need intravenous injection through smartphones, tablet PCs, and nursing PDAs, recognize information codes given to patients, and enter and share treatment contents and treatment items after intravenous injection. As a result of intravenous injection treatment uploaded through the user app, the manager S/W can check the records of intravenous injection treatment items, perform user management functions, emergency notification registration and management functions, and data upload functions. The implemented system has not yet been tested on the EMR system used in the actual hospital. Therefore, through further research, S/W will be optimized and actual environmental application tests will be conducted through cooperation with hospitals.

• Korean Journal of Bronchoesophagology
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• v.13 no.2
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• pp.45-49
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• 2007

Background and Objective : Laryngeal Papillomatosis (LP) is the most common benign neoplasm of the larynx, but it tend to recur and it makes eradicating difficult. Meticulous $CO_2$ laser excision has been the most effective treatment to date. This article analyzes the clinical feature and therapeutic results of 42 LP patients who were undergone $CO_2$ laser excision. Methods : Forty two patients with recurrent LP were treated with $CO_2$ laser. And their medical records were reviewed retrospectively. Demographics, chief complaints at onset, initial distribution of papillomas, number of operations performed on each patient, and current results were evaluated. Results : Male in their twenties and forties are dominant in number in patient number. Most common site was anterior one thirds (69%) of glottis area (86%). LP recurred in 17 cases (40%), and in 4 cases, the lesion extended over the original margin. Patients were undergone surgery $1.62{\pm}0.87$ times, $2.53{\pm}0.72$ in recurred cases. Mean relapsing time was 6 momths (from 1momth to 8years). Ant. laryngeal web occurred in 2 cases (4.8%) and 1 case was combined with squamous cell carcinoma. Conclusion : Meticulously performed $CO_2$ laser excision can achieve significant voice and airway improvement and clinical cures. The $CO_2$ laser through microdirect laryngoscopy allows more precise and bloodless removal of papillomas.

• Journal of the Korean Society for Library and Information Science
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• v.40 no.2
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• pp.281-297
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• 2006

Government Information Locator Service(GILS) allows the users to access and utilize government information by including the content description about the resource as well as the secondary information about the resources such as location and access method. The following problems have been identified, while analyzing the electronic government offered GILS to come up with the service improvement plan. Firstly, it was difficult to comprehend the record labels from the user interface point of view. There were errors in the retrieval result screens. Secondly, there were a number of missing items in the records. Thirdly, there was no explicit explanation on how to access the information. Lastly, there were no clearly explained reasons that certain information is non-disclosed or partially disclosed. Thus, it is necessary to deal with the identified problems by improving the information collection method; reorganizing the record items; heavily investing in the public relation activities; and improving the web-based access method if the revitalization of GILS is to be achieved.

• Journal of Korea Multimedia Society
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• v.9 no.8
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• pp.1054-1066
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• 2006

This study proposes a new paradigm hospital information system through the nursing classification system and design of the HL7 clinical document architecture (Health Level Seven CDA) for information-sharing among various healthcare institutions. Nursing information CDA are included coding systems of nursing diagnosis, nursing intervention, nursing activity and outcomes. And, we have developed CDA generator for active generation of XML document. This study aims to facilitate the optimum care by providing health information required for individuals to nursing specialists in real-time, to help improvements in health, to improve the quality of productive life. This study has the following significance. First, an expansion and redefining process conducted, founded on the HL7 clinical document architecture and reference information model, to apply international standards to Korean contexts. Second, we propose a next-generation web based hospital information system that is based on the clinical document architecture. In conclusion, the study of the clinical document architecture will include an electronic health record (EHR) and a clinical data repository (CDR), and also make possible healthcare information-sharing among various healthcare institutions.

• Journal of Preventive Medicine and Public Health
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• v.44 no.3
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• pp.118-124
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• 2011

Objectives: Although cigarette smoking is known to be related to the exacerbation of asthma symptoms, several studies have indicated that the prevalence of cigarette smoking among asthmatic adolescents is similar to or even higher than that among non-asthmatic adolescents. The aim of this study was to evaluate the relationship between asthma and cigarette use behaviors and whether or not the presence of suicidal ideation modifies this relationship among Korean adolescents. Methods: We analyzed data from the 2008 Korea Youth Risk Behavior Web-based Survey, which included a nationally representative sample of middle and high school students. Multiple logistic regression models were used to calculate odd ratios and 95% confidence intervals of cigarette use behaviors among current asthmatics, former asthmatics, and nonasthmatics, after adjusting for gender, grade, school records, socioeconomic status, current alcohol use, and suicidal ideation. Results: Of 75 238 study participants, 3.5% were current asthmatics and 4.5% were former asthmatics. Compared with non-asthmatics, asthmatics were more likely to report current cigarette use, frequent and heavy cigarette use, and cigarette use before 13 years of age. There were statistically significant interactions between asthma and suicidal ideation in cigarette use behaviors. Conclusions: This study demonstrated that asthmatic adolescents are more likely than non-asthmatic adolescents to engage in cigarette use behaviors and the presence of suicidal ideation is an effect modifier of the relationship between asthma and cigarette use behaviors. Particular attention should be paid to the awareness of health risks of cigarette smoking and mental health problems among asthmatic adolescents.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.9
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• pp.2153-2159
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• 2013

In order to drive a vehicle safely, driver needs to check status of the car. Many moderns are having trouble to spare time to visit auto mechanic and have car mechanics to check their car other than their office hours. If the car status cannot be inspected regularly, it is likely to cause a big accident threatening the surroundings as well as driver's life. Inspection tool and system help driver to check their own vehicle status personally are required for preventing it. In this paper, it designed and realized system that records driving information based on changing data of vehicle (location and automotive internal data) and allows driver can check the vehicle status easily and further, driver can share the driving information with repair shop via the Internet to receive detailed inspection service for car status.

• Journal of the Korean Society for information Management
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• v.32 no.1
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• pp.153-169
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• 2015

The combined approach of using ego-centric network analysis and dynamic citation network analysis for refining the result of LDA-based topic modeling was suggested and examined in this study. Tow datasets were constructed by collecting Web of Science bibliographic records of White LED and topic modeling was performed by setting a different number of topics on each dataset. The multi-assigned top keywords of each topic were re-assigned to one specific topic by applying an ego-centric network analysis algorithm. It was found that the topical cohesion of the result of topic modeling with the number of topic corresponding to the lowest value of perplexity to the dataset extracted by SPLC network analysis was the strongest with the best values of internal clustering evaluation indices. Furthermore, it demonstrates the possibility of developing the suggested approach as a method of multi-faceted research trend detection.

• Steel and Composite Structures
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• v.23 no.3
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• pp.273-283
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• 2017

In this paper, it is aimed to present a detail investigation related to structural behavior of laterally unrestrained steel cantilever roof of tribune with slender cross section. The structure is located in Tutak town in $A{\breve{g}}r{{\i}}$ and collapsed on October 25, 2015 at eastern part of Turkey is considered as a case study. This mild sloped roof structure was built from a variable I beam, and supported on steel columns of 5.5 m height covering totally $240m^2$ closed area in plan. The roof of tribune collapsed completely without any indication during first snowfall after construction at midnight a winter day, fortunately before the opening hours. The meteorological records and observations of local persons are combined together to estimate the intensity of snow load in the region and it is compared with the code specified values. Also, the wide/thickness and height/thickness ratios for flange and web are evaluated according to the design codes. Three dimensional finite element model of the existing steel tribune roof is generated considering project drawings and site investigations using commercially available software ANSYS. The displacements, principal stresses and strains along to the cantilever length and column height are given as contour diagrams and graph format. In addition to site investigation, the numerical and analytical works conducted in this study indicate that the unequivocal reasons of the collapse are overloading action of snow load intensity, some mistakes made in the design of steel cantilever beams, insufficient strength and rigidity of the main structural elements, and construction workmanship errors.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6613-6618
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• 2014

Background: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility. Attention has been drawn upon associations of the XRCC3 Thr241Met polymorphism with breast cancer risk. However, the previous published findings remain controversial. Hence, we performed a meta-analysis to accurately evaluate any association between breast cancer and XRCC3 T241M (23, 812 cases and 25, 349 controls) in different inheritance models. Materials and Methods: PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: When all eligible studies were pooled into the meta analysis of XRCC3 T241M polymorphism, a significantly increased breast cancer risk was observed in heterozygote comparison (OR=1.06, 95%CI=1.01-1.12). No significant associations were found in other models. In subgroup analysis, this polymorphism seemed to be associated with elevated breast risk in Asians. No publication bias was detected. Conclusions: This meta-analysis suggests that the T241M polymorphism confers a weakly increased breast cancer risk. A study with the larger sample size is needed to further evaluate gene-gene and gene-environment interactions of the XRCC3 T241M polymorphism with breast cancer risk.