• Journal of Sasang Constitutional Medicine
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• v.27 no.2
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• pp.270-287
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• 2015

Objectives To evaluate the neuroprotective effects of modified Yuldahanso-tang (MYH) in a Parkinson's disease mouse model. Methods 1) Four groups (each of 8 rats per group) were used in this study. 2) The neuroprotective effect of MYH was examined in a Parkinson's disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. 3) The brains of 2 mice per group were removed and frozen at $-20^{\circ}C$, and the striatum-substantia nigra part was seperated. The protein volume was measured by Bradford method following Bio-Rad protein analyzing kit. Using mouse/Rat Dopamine ELISA Assay Kit. 4) The brains of 2 mice per group were separated and removed. TH-immunohistochemical was examined in the MPTP-induced Parkinson's disease mice to evaluate the neuroprotective effects of MYH on ST and SNpc. 5) Two mice out of each group were anesthetized and skulls were opened from occipital to frontal direction to take out the brains. The brains added TTC solution for 20 minutes for staining. 6) The water tank used for morris water maze test was filled with $28^{\circ}C$ water, and a round platform of 10cm in diameter was installed for mice to step on. The study was carried out once a day within 30 seconds, keep exercising to step on the platform in the pool. 7) The brains of two mice out of each group were fixed in 10% formaldehyde solution and paraphillin substance was infiltrated. They were fragmented by microtome, and observed under an optical microscope after Hematoxylin & Eosin staining. 8) A round acrylic cylinder with its upper side open was filled with clean water and depressive mouse models were forced to swim for 15 minutes. After 24 hours the animals were put in the same equipment for 5 minutes and were forced to swim. 9) The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of Neurotransmitters in MPTP-MYH group. Results 1) MYH possess Dopamine cell protective effect on MPTP-induced injury in striatum and substantia nigra pars compacta. 2) MYH inhibits the loss of tyrosine hydroxylase-immunoreacitive (TH-IR) cells in the striatum and substantia nigra pars compacta on MPTP-induced injury in C57BL/6 mice. 3) MYH possesses improvement effect on MPTP-induced memory deterioration in C57BL/6 mice through the reduction of prolongated Sort of lost time by MPTP injection using the Morris water maze test. 4) MYH possesses hippocampal neuron protective effect on MPTP-induced injury in C57BL/6 mice. 5) MYH possesses improvement effect on MPTP-induced motor behaviour deficits and depression in C57BL/6 mice through the reduction of prolongated losing motion by MPTP injection using the Forced swimming test. 6) MYH increases serotonin product amount on MPTP-induced injury in C57BL/6 mice. Conclusions This experiment suggests that the neuroprotective effect of MYH is mediated by the increase in Dopamin, TH-ir cell, Hippocampus and Serotonin. Furthermore, MYH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson's disease.

• Journal of Animal Environmental Science
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• v.10 no.3
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• pp.175-182
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• 2004

A study was conducted to develop a management policy of animal waste in Northern Chungbuk province through investigating the status of animal waste management. In management of swine manure, rotary composting including a simple piling method has a portion of $64\%$ using as a liquefied fertilizer $18\%$, purification $9\%$ and ocean dumping $9\%$ respectively. Most of them use the animal waste as a fertilizer to the agricultural land. The exercise ground of dairy farms was bedded with $70\%$ of sawdust and $30\%$ of conventional soil ground besides the stall. They had a storage tank for the waste water from milking parlor. Korean beef cattle farms mostly run sawdust stall, which changed new one in a term of 6$\~$12 months. In case of layer, manure management was conducted in the order of simple piling method, rotary composting and ventilation into the piling mostly. Comparing the amount of excreted animal manure with that of possible spreading, the latter can be spread more than 2.9 times than the former in Northern Chungbuk province. The Northern Chungbuk province is an appropriate place to carry out an environmentally friendly animal production. An utilization model as a liquefied fertilizer should be developed for paddy field, upland field, orchard, and forage field to in-crease the value of animal waste effectively.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.5
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• pp.632-639
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• 2011

In order to design a wave energy generate system, a 6-Degree of freedom motion analysis technique was applied to the three-Dimensional CFD analysis on two floating body and the behavior was interpreted according to the nature of the incoming wave. The waves are generated by the same type of wave in the model of tank using the piston type, but due to the shallow water that is generated from the bottom of the wave energy is attenuated by Ekman boundary layer. According to the wavelength of waves generated by the result of evaluating the behavior of floating body, it is concluded that 0.3m is the maximum amplitude of wavelength of 5m, and 0.15m is the minimum amplitude of wavelength of 1m. 1.06m is the maximum distance between the two floaters of wavelength of 6m.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.4
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• pp.125-132
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• 2012

Urea-SCR system, which converts nitrogen oxides to nitrogen and water in the presence of a reducing agent, usually AdBlue urea solution, is known as one of the powerful NOx reduction systems for mobile as well as stationary applications. For its consistent and reliable operation in mobile applications, such various problems as transient injection, ammonia slip, and freezing in cold weather have to be resolved. In this work, therefore, numerical study on three-dimensional unsteady heating problems were analyzed to understand the melting and heat transfer characteristics such as urea liquid volume fraction, temperature profiles and generated natural convection behavior in urea solution by using the commercial software Fluent 6.3. After validating by comparing numerical and experimental data with pure gallium melting phenomena, numerical experiment for urea melting is conducted with three different coolant heating models named CH1, 2, and 3, respectively. Finally, it can be found that the CH3 model, in which more coolant is concentrated on the lower part of the urea tank, has relatively better melting capability than others in terms of urea quantity of $1{\ell}$ for start-up schedule.

• Journal of the Society of Naval Architects of Korea
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• v.52 no.6
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• pp.471-477
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• 2015

When a ship sails in a seaway, the resistance on a ship increases due to incident waves and winds. The magnitude of added resistance amounts to about 15–30% of a calm-water resistance. An accurate prediction of added resistance in waves, therefore, is essential to evaluate the performance of a ship in a real sea state and to design an optimum hull form from the viewpoint of the International Maritime Organization (IMO) regulations such as Energy Efficiency Design Index (EEDI) and Energy Efficiency Operational Indicator (EEOI). The present study considers added resistance problem of AFRAMAX-class tankers with the conventional bow and Ax-bow shapes. Added resistance due to waves is successfully calculated using 1) a three-dimensional time-domain seakeeping computations based on a Rankine panel method (three-dimensional panel) and 2) a commercial CFD program (STAR-CCM+). In the hydrodynamic computations of a three-dimensional panel method, geometric nonlinearity is accounted for in Froude-Krylov and restoring forces using simple wave corrections over exact wet hull surface of the tankers. Furthermore, a CFD program is applied by performing fully nonlinear computation without using an analytical formula for added resistance or empirical values for the viscous effect. Numerical computations are validated through four degree-of-freedom model-scale seakeeping experiments in regular head waves at the deep towing tank of Hyundai Heavy Industries.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.37 no.3
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• pp.249-254
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• 2004

The hydro-acoustic method is widely used for estimating biomass and distribution of fisheries resources along the coast and in the ocean. High costs and time are necessary to construct systems for this method and to initially educate specialists. It has been used in fisheries of advanced nations like Japan and Norway, because it is more efficient than other methods. In order to research the behavior of fish around an artificial reef using an echo sounder, volume backscattering strength (SV) and fish per cubic meter (FPCM) of darkbanded rockfish around the model artificial reef in a water tank were measured. Moreover, behavior of fish was observed in an adjacent artificial reef, which was constructed at Tongyeong marine ranching area. Following that, an acoustics survey was conducted at Mirukdo around the Tongyeong marine ranching area, in order to understand the spatial distribution and strength of fisheries resources. Very high patches of fish were found in a wide area around the artificial reef. It is thought that an approaching fish school around the artificial reef can be measured accurately by using an echo sounder of high resolution. Moreover, use of other monitoring methods like of diving or ROV simultaneous with an echo sounder is required in order to grasp the species and ecology of fish inhabiting the area around the artificial reef.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.41 no.4
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• pp.296-305
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• 2005

Acoustic target strength (TS) of 12 commercially important fish species caught in the Korean waters had been investigated and their results were presented. Laboratory measurements of target strength on 12 dominant fish species were carried out at a frequencies of 75 kHz by single beam method under the controlled condition of the water tank with the 241 samples of dead and live fishes. The target strength pattern on individual fish of each species was measured as a function of tilt angle, ranging from $-45^{\circ}$ (head down aspect) to $45^{\circ}$ (head up aspect) in $0.2^{\circ}$ intervals, and the averaged target strength was estimated by assuming the tilt angle distribution as N ($-5.0^{\circ}$, $^15.0{\circ}$). The 75 to fish length relationship for each species was independently derived by a least - squares fitting procedure. Also, a linear regression analysis for all species was performed to reduce the data to a set of empirical equations showing the variation of target strength to fish length and fish species. An empirical model for fish target strength(TS, dB) averaged over the dorsal aspect of 158 fishes of 7 species and which spans the fish length(L, m) to wavelength(${\lambda}$, m) ratio between 6.2 and 21.3 was derived: TS: 27.03 Log(L)-7.7Log(${\kanbda}$)-17.21, ($r^2$=0.59).

• Journal of the Society of Naval Architects of Korea
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• v.28 no.2
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• pp.318-328
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• 1991

The present paper describes the experimental study on the fixed-type wave-energy conversion system, consisting of the OWC-type wave-energy absorbing chamber and the duct for the air turbine. For simplicity, a screen of wire mesh was employed in place of an air turbine in order to simulate its effects on OWC chamber. Experiments were performed at the towing tank in regular waves with the frequency range of 0.22-0.75Hz. Comparison wish the numerical prediction using a potential flow-based method [4] was made to validate the capability of numerical code. It was shown that the agreements between measured and calculated results are quite good, giving a confidence in prediction method. Simulation of air turbine using a wire-mesh screen was successful, at least in a qualitative sense, to investigate the inter action between the OWC chamber and an air turbine. Results also showed that the effects of a wire-mesh screen on chamber efficiency are negligible, and the present model can be effectively utilized for the practical use in ocean waves with the frequency range under 0.3Hz.

• The Journal of the Acoustical Society of Korea
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• v.34 no.2
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• pp.117-129
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• 2015

A parametric array is a nonlinear phenomenon that generates a narrow beam of low-frequency sound using the nonlinearity of the medium. The low-frequency sound so generated has a low sound pressure compared with that of sound generated directly. Consequently, a transducer that can generate a primary wave with high directivity and level is required. This study designed, fabricated, and evaluated a multi-resonance transducer as a parametric array source. The designs of the unit transducers and array transducer were based on an analysis model. The design process was repeated to fabricate the optimum transducer. The fabricated transducer array can generate a 189 dB, 190 dB primary wave level at 6.3 m and a 134 dB difference frequency wave using the parametric array phenomenon. The difference frequency wave has a frequency of 15 kHz and high directivity with an $8^{\circ}$ half power beam width in a $12{\times}18{\times}10m$ water tank.

• Nuclear Engineering and Technology
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• v.46 no.3
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• pp.439-446
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• 2014

An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole cameras was a new approach for the exact and stable position control on the IRWST strainer, unlike a traditional robot for underwater facility inspection. The developed robot will be practically used to enhance the efficiency and reliability of the inspection of nuclear power plant components.