• Nutrition Research and Practice
• /
• v.10 no.3
• /
• pp.274-281
• /
• 2016

BACKGROUND/OBJECTIVES: The accumulation of amyloid-${\beta}$ ($A{\beta}$) in the brain is a hallmark of Alzheimer's disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE) and its major compound, rosmarinic acid (RA), have shown antioxidant and anti-inflammatory activities. We investigated whether administration of PFE and RA contributes to cognitive improvement in an $A{\beta}_{25-35}$-injected mouse model. MATERIALS/METHODS: Male ICR mice were intracerebroventricularly injected with aggregated $A{\beta}_{25-35}$ to induce AD. $A{\beta}_{25-35}$-injected mice were fed PFE (50 mg/kg/day) or RA (0.25 mg/kg/day) for 14 days and examined for learning and memory ability through the T-maze, object recognition, and Morris water maze test. RESULTS: Our present study demonstrated that PFE and RA administration significantly enhanced cognition function and object discrimination, which were impaired by $A{\beta}_{25-35}$, in the T-maze and object recognition tests, respectively. In addition, oral administration of PFE and RA decreased the time to reach the platform and increased the number of crossings over the removed platform when compared with the $A{\beta}_{25-35}$-induced control group in the Morris water maze test. Furthermore, PFE and RA significantly decreased the levels of nitric oxide (NO) and malondialdehyde (MDA) in the brain, kidney, and liver. In particular, PFE markedly attenuated oxidative stress by inhibiting production of NO and MDA in the $A{\beta}_{25-35}$-injected mouse brain. CONCLUSIONS: These results suggest that PFE and its active compound RA have beneficial effects on cognitive improvement and may help prevent AD induced by $A{\beta}$.

• Nutrition Research and Practice
• /
• v.9 no.5
• /
• pp.480-488
• /
• 2015

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide ($A{\beta}$) and oxidative stress in the brain are the most common causes of AD. MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an $A{\beta}_{25-35}$-injected AD mouse model. CA was administered at an oral dose of 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress. RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the $A{\beta}_{25-35}$-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the $A{\beta}_{25-35}$-injected control group. In particular, CA 50 mg/kg/day showed the stronger protective effect from cognitive impairment than CA 10 mg/kg/day. CONCLUSIONS: The present results suggest that CA improves $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.38 no.2
• /
• pp.87-95
• /
• 2020

South korea has been developing and managing the complete dimensions, around the rivers to rapid economic growth. In Korea, where water resources are scarce, administration and work are complicated and diversified in the computerization of related facilities and hydrologic data due to the indiscriminate development of river facilities. In general, dividing the water system based on object in remote sensing is relatively accurate in the image with the same spectral characteristics. However, the distinction between the reservoir and the river must be made manually due to the characteristics of remote sensing. Therefore, this study performed three classifications using GIS (Geographic Information System) to classify reservoirs and rivers. For the purpose of accuracy analysis, the land cover map provided by EGIS (Environmental Geographic Information Service) was used to evaluate the accuracy, and the average of 85.63% was found to be 75.40% of rivers, 89.50% of reservoirs, and 92.00% of others.

• Water Engineering Research
• /
• v.6 no.4
• /
• pp.161-168
• /
• 2005

With characteristics of river continuum, stream ecosystems have diverse components and environments from upstream channel to estuarine area. Therefore, the habitat requirements and composition of conservative object should be well understood before applying any improvement measure. In this paper, the causes of stream habitat changes were first illustrated with the categories and principles of habitat restoration methods. The structural restoration techniques of fish habitat improvement utilized by the authors or one three-year research project starting at 1990 were then presented. Through the introductions on the project background, planning guidelines, structure design, and ecological evaluation, this paper tried to provide some effective examples of stream restoration practices that ecological expert was invited for cooperation and advising.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 2001.10a
• /
• pp.505-508
• /
• 2001

Remote Sensing is one of effective methods for collecting, analyzing information and predicting the change of agricultural environments. The RS technique is based on the principle that the object reflects a peculiar radio wave according to types and environmental conditions. For collection RS base data, used spectroradiometer which measures reflection characteristics between $300{\sim}1,100nm$ and measured the reflection of Mi-ho stream's water resources which is located thong-won, Chung-buk province, Korea. The difference of reflectance represents the characteristic of bottom soil, water color and matters in water.

• Journal of Integrative Natural Science
• /
• v.6 no.3
• /
• pp.151-157
• /
• 2013

The ion exchange resins were synthesized from 1-aza-18-crown-6 macrocyclic ligand attached to styrene (2th petroleum in 4th class hazardous material) divinylbenzene (DVB) copolymer with crosslinks of 1%, 6%, and 15% by substitution reaction. These synthetic resins were confirmed by chlorine content, elementary analysis, surface area, and IR-spectrum. The object of this study was to seperate the metal ion absorbed in reinforcement water fire extinguishing agent. As the results of the effects of pH, equilibrium arrival time, and crosslink of synthetic resin on metal ion adsorption for resin adsorbent, the metal ions were showed high adsorption at pH 3 or over and adsorption equilibrium of metal ions was about 2 hours. In addition, adsorption selectivity for the resin in water was the order of Al (III) > Ni (II) > Sm (III) ions, adsorbability of the metal ions was in the crosslinks order of 1%, 6%, and 15%.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2001.04a
• /
• pp.535-539
• /
• 2001

The aim of this paper presents to develop a computer-aided design system for water gate on AutoCAD R2000system. The developed system has been written in AutoCAD and Visua ILISP with a personal computer, and is composed four modules which are the gate-lifter input module, guide-frame input module, template input module and upgrade module. Based on knowledge-based rules, the system is designed by considering several factors, such as width and height of a water gate, material, object of product and maximum depth of water. Employing the developed system enable the designer and manufactures of water gate to be more efficient in this field, and its potential capability for enhancement included FEM(Finite Element Method) and quotation system.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 2000.10a
• /
• pp.519-524
• /
• 2000

The goal of this research is the establishment of a connection of an existing water quality model to GIS. The water quality model investigated was the Water Quality Analysis Simulation Program (WASP5), while the actual linkage was performed using object-oriented programming. The runoff and the non-point source loadings into the Channel were determined using a grid-based model developed in GIS. Afterwards, scripts were written in the ArcView programming language, Avenue, in order for ArcView to perform the following tasks : 1) write the input file informations, 2) format the input information into the proper WASP5 file, 3) execute the WASP5 subprogram for modeling.

• Journal of computational fluids engineering
• /
• v.4 no.1
• /
• pp.1-7
• /
• 1999

The numerical methodology for computing tile impact forces and water entry behaviors of high speed water entry bodies was been developed. Since the present method assumed the impact occurs within a very short time interval. the viscous effects do not have enough time to play a significant role in the impact forces, that is, the flow around a water-entry object was assumed as an incompressible potential flow and is solved by the source panel method. The elements fully submerged into the water are routinely treated, but the elements intersected by the effective planar free surface are redefined and reorganized to be amenable to the source panel method. To validate the present code, it was applied to disk, cone and ogive model and compared with experimental data. Good agreement was obtained. The water entry behavior such as the bouncing phenomena from the free surface was also simulated using the impact forces and two degree of freedom dynamic equation. Physically acceptable results were obtained.

• Journal of Environmental Impact Assessment
• /
• v.20 no.5
• /
• pp.765-777
• /
• 2011

According to the total pollution load management system, exact prediction and analysis of water quality and discharge has been required in order to allocate the amount of pollution load to each local government. In this study, QUAL2E model was used for comparison with other water quality models and improve the inadequate to forecast future water quality. And Various calibration and verification methods were applied to deal with existing uncertainties of parameter during modeling water quality. For user convenience, A GUI(Graphical User Interface) system named "QL2-XP" model is developed by object-oriented language for the user convenience and practical usage. Suggested GUI system consist of hydraulic analysis, water quality analysis, optimized model calibration processes, and postprocessing the simulation results. Therefore this model will be effectively utilized to manage practical and efficient water quality.