• Journal of the Korean Society of Physical Medicine
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• v.3 no.4
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• pp.255-260
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• 2008

Purpose : This study was performed to find out the influence of the change on proprioception and coordination of the lower limb by experimentally induced paraspinal muscle fatigue, Methods : Twelve subjects(6 males, 6 females) with no history low back and lower limbs problem volunteered for this study. Subjects were pre-tested proprioception and coordination using the MR-FSS(Mornitored Rehab Functional Squat System). And then the subjects performed isometric paraspinal muscles contraction for induced muscle fatigue. Muscle fatigue was defined surface EMG(MP 150). After isometric contraction, the subjects were post-tested using the MR-FSS. Results : In comparison of coordination, deviation of concentric coordination was increased(from $0.50{\pm}0.13cm$ to $0.67{\pm}0.21$)(p<0.05) and deviation of eccentric coordination was also increased(from $0.51{\pm}0.15cm$ to $0.70{\pm}0.26cm$)(p<0.05). And deviation movement of proprioceptive test was increased(from $4.98{\pm}1.80cm$ to $5.69{\pm}1.98cm$), but there was no significant different(p>0.05). Conclusion : Fatigue of paraspinal muscles was decreased concentric and eccentric coordination of the lower limb.

• Strategy21
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• s.32
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• pp.160-191
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• 2013

This article is focused how the maritime strategy between continental powered country(the Soviet, the China) and maritime powered country(the U.S.) interact with attack and defense theory. We will know, what is the maritime strategy that the U.S. of military superiority has pursued with the point of view of attack, on the other hand, relatively what is the maritime strategy that the Soviet-Sino of military inferiority has pursued with the point of view of defense. In cold war, the Soviet has counteracted to 'blue belt defense' in active defense as to the U.S. 'sea strike' and in post cold war, the China counteract to 'A2/AD' as to the U.S. 'Air-Sea Battle'. The difference between the Soviet-Sino maritime strategy is that the China has emerged the second an economic power and their leadership has a strong's will to strengthen their navy's power. although the U.S. declare the pivot to Asia, the influence on Asia of the U.S. tend to decrease because of sequest. therefore, the China will seek to the more active defense beyond the first island chain. Meanwhile, the U.S. has reinforced of 'hub and spoke strategy' to solidify the U.S. formal allies to band together regional powers and to overcome the A2/AD challenge, the U.S. has been developed that the Air-Sea Battle concept meshes with Washington's 'rebalancing' policy toward the Asia-Pacific as its vital missions to safeguard core island or semi-island allies-namely, Korea and Japan-and crucial sea lanes of communication in the region are conducted mostly from or over the sea.

• Korean Journal of Veterinary Research
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• v.35 no.1
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• pp.107-113
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• 1995

Four Holstein calves 7-day-old were infected with C parvum oocysts for parasitological and pathological investigations of bovine cryptosporidiosis. Of those calf 1 was orally administered with $7{\times}10^6$ oocysts of C parvum isolated from a Korean mouse (VRI-CN91), and calf 2 with same number of C parvum oocysts provided by Washington State University(WSU). The rest (calf 3 and 4) were orally administered with $1{\times}10^8$ oocysts of VRI-CN91 strain. Calf 1 commenced to discharge oocysts in feces at days 6 post inoculation(PI), and it reached a peak $1.4{\times}10^7$ oocysts per gram of feces(OPG) on day 8 PI. Calf 2 commenced to discharge oocysts in feces at day 4 PI, and it reached a peak $3.75{\times}10^6$ OPG on day 7 PI. Calf 3 and 4 commenced to discharge oocysts in feces at day 3 and day 4 PI, and it reached a peak on day 7 PI (calf 3, $7.8{\times}10^6$ OPG; calf 4, $1.7{\times}10^6$ OPG). Clinically, the calves began to show mucoid-watery diarrhea at day 3 to 5 PI, and the sign lasted 5 to 7 days. Calf 2 died on day 9 PI with a severe dehydration. On necropsy the intestine was found to be congested and hemorrhagic. Protozoan oocysts were observed mainly in the ileum and occasionally in jejunum. The results in the present study indicate that the Korean isolate was pathogenic in calves.

• Korean Journal of Veterinary Research
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• v.58 no.1
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• pp.9-16
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• 2018

A preliminary study into the protective mechanisms of adaptive immunity against porcine reproductive and respiratory syndrome virus (PRRSV) in piglets (n = 9) born to a gilt challenged intranasally with a type-2 PRRSV. Immune parameters (neutralizing antibodies, $CD3^+CD4^+$, $CD3^+CD8^+$, $CD3^+CD4^+CD8^+$ T-lymphocytes, and PRRSV-specific interferon $(IFN)-{\gamma}$ secreting T-lymphocytes) were compared with infection parameters (macro- and microscopic lung lesion, and PRRSV-infected porcine alveolar macrophages ($CD172{\alpha}^+PRRSV-N^+\;PAM$) as well as with plasma and lymphoid tissue viral loads. Percentages of three T-lymphocyte phenotypes in 14-days post-birth (dpb) peripheral blood mononuclear cell (PBMC) had significant negative correlations with percentages of $CD172{\alpha}^+PRRSV-N^+\;PAM$ (p < 0.05) as well as with macroscopic lung lesion (p < 0.01). Plasma and tissue viral loads had significant (p < 0.05) negative correlations with $CD3^+CD4^+CD8^+$ T-lymphocyte percentage in PBMC. Frequencies of $CD3^+CD8^+$ and $CD3^+CD4^+$ T-lymphocytes in 14-dpb PBMC had significant negative correlations with of lymph node (p = 0.04) and lung (p = 0.002) viral loads. $IFN-{\gamma}$-secreting T-lymphocytes frequency had a significant negative correlation with gross lung lesion severity (p = 0.002). However, neutralizing antibody titers had no significant negative correlation (p > 0.1) with infection parameters. The results indicate that T-lymphocytes contribute to controlling PRRSV replication in young piglets born after in-utero infection.

• Journal of the Mineralogical Society of Korea
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• v.26 no.3
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• pp.175-187
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• 2013

In-situ Raman and X-ray diffraction experiments have been performed on mineral natrolite (Na-zeolite) to investigate the dehydration behavior under high temperature and high pressure-temperature conditions. XRD data show reversible dehydration up to $450^{\circ}C$ whereas Raman data show irreversible change when the material is heated up to $630^{\circ}C$. The existence of post-natrolite was newly identified to form from ${\beta}$-metanatrolite at $380^{\circ}C$ upon cooling. The formation of dehydrated metanatrolite under simultaneous high temperature-pressure (room temperature < T < $300^{\circ}C$, 0 GPa < P < 2.1 GPa) conditions was not observed.

• Korean Journal of Veterinary Research
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• v.42 no.1
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• pp.29-33
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• 2002

This study was carried out to investigate the optimal activation condition for parthenogenetic development. In order to activate oocytes at 24 hrs post onset of maturation, the oocytes were cultured $3{\sim}13{\mu}M\;Ca^{2+}$ for 5 min., $5-8{\mu}g/ml$ cytoclacin for 6 hrs, 0.5~2.0 mM 6-dimethylaminopurine(DMAP) for 3 hrs alone or combination. The activated oocytes were cultured in TCM-199 media at 5% $CO_2$, 95% air, $38^{\circ}C$. The cleavage rate after 48 hrs culture of oocytes treated with $3-13{\mu}M\;Ca^{2+}$, $5-8{\mu}g/ml$ cytoclacin and 0.5~2.0 mM DMAP for 5 min., 6 hrs and 3 hrs were 9.6%~20.0%, 0.0%~7.3% and 9.4%~21.8%, 0.0%~7.3% and 9.1%~21.8% and 0.0%~7.3%, respectively. When oocyte were treated with $10{\mu}M\;Ca^{2+}$, $10{\mu}g/ml$ cytoclacin and 2.0 mM DMAP the blastocyst formation rate was significantly higher than other group. The cleavage rate after 48 hrs culture of oocytes treated with $Ca^{2+}$ + cytoclacin, $Ca^{2+}$ + DMAP, cytoclacin + DMAP were 75.9%~93.5% and 9.7%~19.0%, respectively. When oocytes were treated with $Ca^{2+}$ followed by DMAP, the blastocyst formation rate was significantly higher than other group(p<0.05). When necleus transferred embryos co-cultured with bovine serum albumin(BSA), epithemal growth factor(EGF) and calf serum(CS), the developmental rate to blastocyst were higher than control group.

• Korean Journal of Radiology
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• v.21 no.6
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• pp.647-659
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• 2020

Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling. APT102, a soluble human recombinant ecto-nucleoside triphosphate diphosphohydrolase-1, can hydrolyze extracellular nucleotides to attenuate their prothrombotic and proinflammatory effects. The purpose of this study was to temporally evaluate the therapeutic effect of APT102 on IRI in rats and to elucidate the evolution of IRI in the acute stage using cardiovascular magnetic resonance imaging (CMRI). Materials and Methods: Fifty-four rats with MI, induced by ligation of the origin of the left anterior descending coronary artery for 60 minutes, were randomly divided into the APT102 (n = 27) or control (n = 27) group. Intravenous infusion of APT102 (0.3 mg/kg) or placebo was administered 15 minutes before reperfusion, and then 24 hours, 48 hours, 72 hours, and on day 4 after reperfusion. CMRI was performed at 24 hours, 48 hours, 72 hours, and on day 5 post-reperfusion using a 7T system and the hearts were collected for histopathological examination. Cardiac function was quantified using cine imaging and IMH/edema using T2 mapping, and infarct/MVO using late gadolinium enhancement. Results: The extent of infarction (p < 0.001), edema (p < 0.001), IMH (p = 0.013), and MVO (p = 0.049) was less severe in the APT102 group than in the control group. IMH size at 48 hours was significantly greater than that at 24 hours, 72 hours, and 5 days after reperfusion (all p < 0.001). The left ventricular ejection fraction (LVEF) was significantly greater in the APT102 group than in the control group (p = 0.006). There was a negative correlation between LVEF and IMH (r = -0.294, p = 0.010) and a positive correlation between IMH and MVO (r = 0.392, p < 0.001). Conclusion: APT102 can significantly alleviate damage to the ischemic myocardium and microvasculature. IMH size peaked at 48 hours post reperfusion and IMH is a downstream consequence of MVO. IMH may be a potential therapeutic target to prevent adverse remodeling in MI.

• Analyses & Alternatives
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• v.7 no.1
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• pp.229-258
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• 2023

For the main countries of the Asia-Pacific region, the United States, China and Russia, a situation of "new normality" is emerging. Moreover, for each of the countries, this "new normality" has its own meaning. For the United States, this is an aggravation of the military confrontation with China in the Taiwan Strait. For China, this is an increase in the degree of rivalry with the United States and a slowdown in the pace of economic development with a very high probability of their decline in the future. For Russia, this is an almost complete curtailment of relations with the United States against the background of a special military operation and imposed sanctions. These nuances, in addition to the results of the 20th CPC Congress, will determine the main trends in Sino-American and Sino-Russian relations. It seems that China's attitude towards Russia will not change against the background of the Ukrainian crisis. Beijing will maintain a position of "benevolent neutrality" towards Moscow. At the same time, the balance between "goodwill" and "neutrality" may vary depending on the scope of Sino-Russian cooperation. For example, in the economic sphere, Chinese companies will be afraid to cooperate with Russian partners for fear of secondary sanctions. However, in general, Russia will retain its importance for China as the strongest anti-American pole. In relations with the United States, China will continue to firmly defend its interests, while at the same time not excluding the normalization of relations with Washington in certain areas of cooperation: strategic stability, non-traditional threats, ecology, etc. In general, the decisions of the 20th CPC Congress do not allow us to say either in favor or against the idea of China's readiness to resume dialogue with the United States in the post-congress period. Sino-American relations, as noted above, have their own logic and will probably continue to develop within its framework. However, so are Sino-Russian relations. Within the framework of these logics, Beijing seems to continue to balance between the two vectors of its foreign policy. On the one hand, this is the development of bilateral cooperation with Russia in order to strengthen its own negotiating positions in the confrontation with the United States: military cooperation with an emphasis on joint exercises, political cooperation based on anti-Americanism, economic cooperation with an eye to the risks of secondary sanctions. On the other hand, it is unacceptable for China to recognize the collapse of Ukraine, the inadmissibility of a direct military clash with the United States and the extreme undesirability of further aggravation of relations with the United States on the factor of Chinese friendship with Russia.

• Korean Journal of Construction Engineering and Management
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• v.17 no.3
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• pp.125-133
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• 2016

The Project Risk Management is intended to result in the effective management by identifying in advance and mitigating all significant risks including project risks and opportunities during the entire project life cycle - from project inception to completion of construction. It is impossible to predict an exact budget and construction duration before finishing a project. So, Washington Department of Transportation mandates that workshop-based risk management is conducted for projects over specific cost. However, the domestic construction sites have depended on numerical risk analysis without any workshop and efficient risk management have not made. Therefore, in this study, we propose the effective risk management using the RBES program which is very useful for workshop-based risk management and pre & post mitigation, by workshop-based risk management techniques. This proposed risk management approach is applied to a domestic 'A' river recovery project. It is concluded that we may expect the effect to mitigate the total cost overrun problem and the construction duration delay effect in the project by identifying significant risks and by preparing effective risk mitigation strategies.

• Journal of Engineering Education Research
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• v.10 no.4
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• pp.78-92
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• 2007

This study presents how the engineering ethics instructional modules have been developed based on Korean culture and how they are implemented into the existing engineering curricula at Sungkyunkwan University. The engineering ethics instructional modules were designed to be taught by engineering faculty members who did not have any teaching experience in ethics. As a result, it was determined that the engineering ethics instructional modules should include a detailed instructor lesson plan and all supporting resources such as slides (Power Point base), and handouts, or assessment units (pre- and post-test). Two 75 minute modules developed in this study consist of the diverse instructional activities for various student group sizes. In order to improve students' interests and classroom attention, various visual and audio resources such as famous movies, cartoons, and poems were included in the instructional resources. In addition, a number of case studies which might happen in the students' daily lives were chosen. The resulting ethical module No. 1 has been instructed in the existing engineering classes during the 1st semester in 2007. Overall, the students reported positive impressions of the modules and the faculty members also reported favorable perceptions of the modules. Also, team based activities encouraged students to participate in constructing the event trees, which are a basic analysis tool for ethics case studies. The results of this study will provide a guideline of implementing engineering ethics into the engineering curricula to other engineering programs and schools.