• 한국식품위생안전성학회지
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• 제24권2호
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• pp.128-135
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• 2009

본 연구는 여자 대학생의 손 씻기 의식, 실천/이행, 그리고 그 차이를 알아보고자 수행되었다. 한 대학교의 여자 대학생들에 대하여 손 씻기 의식에 관한 설문조사를 수행하고, 동 대학교 캠퍼스 내의 화장실에서 손 씻기 실천/이행을 직접 관찰조사를 통하여 수행하였으며, 그 차이 여부를 검증하였다. 조사대상 여자 대학생들은 설문조사에서 손 씻기 빈도, 손 씻는 제제사용 여부, 손 씻는 부위/범위 및 손 말리는 방법 등에서 전공분야별로 차이를 보였으나 화장실 사용 후 손 씻기에 대한 의식에는 차이를 보이지 않았다. 또 화장실 사용 후 손 씻기에 대한 의식(97.4%)과 실천/이행(98.2%)은 높은 편이었다. 그러나 설문조사에서 10초 이상 손을 씻는다는 응답(46.4%)에 비하여 관찰조사에서 실제로 10초 이상 씻은 사람은 6.3%에 불과하였다. 관찰조사에서 비누를 사용한 사람은 0.9%로 설문조사의 60.9%에 비하여 아주 저조하였고 손 씻는 부위/범위에 있어 네 부위를 씻은 사람도 0.9%에 불과하였다. 손을 씻은 후 말리는 방법으로는 설문조사와 관찰조사에서 모두 휴지/종이타올을 선호하였다. 손 씻는 시간, 비누 사용여부, 손 씻는 부위/범위 및 손 말리는 방법 등 주요항목에서 관찰조사와 설문조사 사이에 매우 유의한 차이가 나타나(p<0.01) 조사대상 여자 대학생들의 경우 손씻기 의식과 그 실천/이행에는 차이가 있음을 알 수 있다. 그러나 손 씻기 행동을 대학 캠퍼스 이외의 화장실에서 장기간 관찰해볼 필요가 있다.

• Journal of Pharmaceutical Investigation
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• 제35권5호
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• pp.355-360
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two cetirizine HCl tablets, Zyrtec tablet (UCB Pharm. Co., Ltd. Korea, reference product) and Zyrix tablet (Kukje Pharm. Co., Ltd., Korea, test product), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (diazepam), plasma samples were extracted using 1 mL of dichloromethane. Compounds extracted were analyzed by reverse-phase HPLC with ultra-violet detector. This method for determination cetirizine is proved accurate and reproducible with a limit of quantitation of 10 ng/mL in male plasma. Twenty-four healthy male Korean volunteers received each medicine at the cetirizine HCl dose of 10 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of cetirizine were monitored for over a period of 24 hr after the administration. AUC (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed AUC and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 $(e.g.,\;log\;0.93-log\;1.08\;for\;AUC_{0-t},\;log\;0.91-log\;1.08\;for\;AUC_{0-{\infty}}\;and\;log\;1.01-log\;1.11\;for\;C_{max})$. The major parameters, AUC and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that Zyrix tablet is bioequivalent to Zyrtec tablet.

• 대한간호학회지
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• 제29권6호
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• pp.1284-1293
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• 1999

This study was designed to investigate the effect of aromatherapy on skin xerosis and pruritus in patients undergoing maintenance hemodialysis. Twenty one subjects of this study were selected from St. Paul's Hosipital in Seoul. All the subjects were received the mineral oil massage at the arm without fistular three timesper week for 4 weeks. After 2 weeks period of wash-out, the subjects were received the aromatherapy of lavender and tea tree essence oil in the same way. This study was carried out from March 20 to June 13, 1998. Pruritus score, skin pH and stratum corneum hydration were measured before and after each treatment. But, biochemical parameters were measured before the treatment of the mineral oil massage, after the treatment of the mineral oil massage and the aromatherapy. Data of this study were analyzed by paired t-test, repeated measures ANOVA, Bonferroni multiple comparisons and Pearson correlation coefficient. The results were as follows ; 1. Pruritus score was significantly decreased after the aromatherapy, while no significant change after the treatment of the mineral oil massage. Therefore, there was a significant difference in the priritus score between the two treatments. 2. Stratum corneum hydration was significantly increased after the aromatherapy, while no significant change after the treatment of the mineral oil massage. Therefore, there was a significant difference in the stratum corneum hydration between the two treatments. 3. Skin pH was significantly increased after the treatment of the mineral oil massage, while no significant change after the aromatherapy. Therefore, there was no significant difference in the skin pH between the two treatments.4. After the aromatherapy, the serum calcium was significantly increased. Whereas the serum parathyroid hormone intact was significantly decreased compared with the treatment of the mineral oil massage. But the level of the serum Ca and PTH-intact were within the normal range. 5. Stratum corneum hydration was decreased corresponding to the duration of hemodialysis, while pruritus score and skin pH showed no change corresponding to the duration of hemodialysis and the age of the subjects. The correlation of pruritus score on skin pH, stratum corneum hydration and biochemical parameters was not significant. In conclusion, this findings indicate that aromatherapy may be effective in decreasing skin xerosis and pruritus score in uremic pruritus patients undergoing maintenance hemodialysis.

• 한국생활과학회지
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• 제18권2호
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• pp.477-489
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• 2009

In this study, elementary school students' satisfaction in school food service and their dietary behaviors were investigated, based on survey performed on 453 elementary school students (233 boy and 221 girl students) in the range of 4th grade to 6th grade. 85.7% of the students had agreed to the necessity of school food service. The point of overall satisfaction in school food service was $3.53{\pm}0.83$. The highest satisfactory factor was menu of school food service$(3.64{\pm}0.77)$, while the lowest satisfactory was service$(3.41{\pm}0.85)$. The point of boy students' satisfaction in menu(p<0.05), sanitation & facility(p<0.001), and service(p<0.05) of school food service was higher than girl students'. The students' responses indicate that: 36.9% of the students wash their hands before meal; 19.9% of the students brush their teeth after meal; 36.1% of the students arrange their table after meal; 22.1% of the students do not disturb others during their meal. 46.5% of the students always have meals pleasantly, while 22.8% of the students have meals without any particular feelings. 74.6% of the students always eat proper amount. 51.3% of the students turned out to eat snacks between meals out of hunger (50.7%) once a day with their friends(59.8%). 61.8% of the students believe that their tastes are affected by their parents and 57.8% of the students are aware of their unbalanced diet to be corrected. In summary, to provide satisfactory school food service for students, the improvements in the facilities and hygienic standard and the taste and nutrition have to be preceded, and the students have to be advised about the healthy dietary habits and the hazard of biased diet.

• 패션비즈니스
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• 제5권1호
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• pp.117-130
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• 2001

The purpose of this research focuses mainly on the establishment of: the image of the police that can be adopted to meet the demands of reality through the development of the design of policewomen's uniform in the times that require reestablishment of the image of the police; the image of the police that is appropriate for the organic structure of the society; and the image of the police that cooperate with the citizens. For background research I have considered the police and their uniforms from a theoretical point of view and have examined the process by which Korean policewomen's uniforms have changed. Actual research was carried out policewomen of Seoul Regional Police Station, was conducted and the results were utilized to figure out what the problem was. This research suggests an improvement measure by making four suits of summer and spring-and-autumn work-uniforms, and six suits of spring-andautumn and winter full-dress uniform. First the colors of work-uniforms and full-dress uniforms are not blue, which incites a feeling of coldness and stiffness, but are colors that are feminine and emit warmth---red, ivory, khaki, black, and beige. second pure, natural fiber is difficult to wash and is not an appropriate material for policewomen's uniforms when considering its cost and etc., fabrics that are a mix of synthetic fiber and natural fiber were chosen. Because mixed fabrics are cheaper and their ability to maintain shape is superior to that of natural fiber, mixed fabric is an appropriate material for policewomen's uniforms. third the feminine image of policewomen was considered; therefore, masculine image, which is rigid and strong, was avoided and the image was expressed in a serene and beautiful way. Also slim line was added to the current uniforms to emphasize feminine beauty. The conclusion of this study is that police officers in the 21st century want to be seen as the citizens cane and benevolent volunteers that live together with the citizens, not as suppressive and powerful people.

• 동의생리병리학회지
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• 제21권2호
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• pp.432-437
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• 2007

Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on substantia gelatinosa (SG) neurons in spinal cord slice of neonatal rats to investigate the effects of ROS on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, induced a electrical hyperexcitability during t-BuOOH wash-out followed by a brief inhibition of excitability in SG neurons. Application of t-BuOOH depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. Phenyl-N-tert-buthylnitrone (PBN), an ROS scavenger, antagonized t-BuOOH induced hyperexcitability. IN voltage clamp conditions, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). In order to determine the site of action of t-BuOOH, miniature excitatory postsynaptic currents (mEPSCs) were recorded. t-BuOOH increased the frequency and amplitude of mEPSCs, indicating that it may modulate the excitability of the SG neurons via pre- and postsynaptic actions. These data suggest that ROS generated by peripheral nerve injury can induce central sensitization in spinal cord.

• 한국응용과학기술학회지
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• 제31권1호
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• pp.14-22
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• 2014

본 연구에서는 거동이 불편한 환자와 바쁜 현대인들을 위하여 헹굼이 필요없는 에탄올베이스 드라이샴푸를 제조했다. 물로 헹구지 않는 드라이샴푸에는 저자극 세정원료의 적용이 필요하다. 이 실험에서 세정원료는 저자극 세정원료를 첨가하고 세정원료의 세포독성실험과 드라이샴푸의 피부자극, 항균효과를 확인하였다. 본 연구에서 펜틸렌글리콜을 적용하여 제조한 에탄올베이스 드라이샴푸가 항균력을 갖고 피부에 가장 안전함을 확인 하였다. 또한 미용목적뿐만 아니라 위생적인 모발관리를 가능하게 하여 젖은 샴푸를 할 수 없는 상황에서도 청결과 위생, 안전성을 동시에 만족할 수 있을 것으로 기대된다.

• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.311-317
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• 2004

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

• 한방재활의학과학회지
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• 제29권1호
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• pp.63-73
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• 2019

Objectives The purpose of this study is to evaluate the safety of Ojeok-san extract powder and soft extract in healthy male volunteers. Methods Randomized controlled, cross over study was carried out in healthy male volunteers. Total 27 of 31 subjects meeting the inclusion criteria were enrolled and three subjects for waiting were included. To each group 12 subjects were randomly allocated by random number table. Group A took the extract powder in the first period and then took the soft extract in the second period. Group B took the medicine in the opposite order. Trial was conducted through two times of hospitalizations and all subjects had a seven-days of wash out period. Vital sign and laboratory test were checked before and after the medication. The mean difference of safety evaluation variables were analyzed by paired t-test (p<0.001) or wilcoxon signed rank test (p<0.05). The mean difference between two groups were analyzed by independent t-test (p<0.05) or Mann whitney test (p<0.05). Results As a result of all data related to vital sign and laboratory test in both group, There were no significant differences associated with the clinical trial drug between before and after the medication. And there was no adverse event associated with the clinical trial drug. Conclusions Both Ojeok-san extract powder and soft extract were found to be safe for healthy male volunteers.

• 한국의류학회지
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• 제31권12호
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• pp.1784-1792
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• 2007

현대의 패션의 다양화, 개성화로 패션 스타일을 구현하는데 있어서 모자는 더욱 부각되어 수요자 층이 확대되고 있지만, 다양한 재료와 형태로 세탁 및 관리에 어려움을 갖는다. 이에 본 연구는 모자제품의 관리방법에 대한 소비자의 현황을 조사, 분석함으로써 모자 레이블 부착의 문제점과 개선책 방안을 모색해 보고자 하며, 나아가 모자의 보관이나 세탁방법에 대한 정확하고 충분한 정보를 제공함으로써 제품을 오랫동안 유지할 수 있게 하고자 한다. 소비자들의 모자제품의 세탁 및 관리행동에 관한 조사를 하기 위하여 서울 및 도시에 거주하며 모자를 소유하고 있는 20대, 30대, 40대, 50대 이상의 남녀 395명을 대상으로 연령과 성별을 고려한 할당 표본추출방법을 통하여 설문지 조사를 실시하였다. 조사기간은 2007년 3월에서 4월까지 이루어 졌으며, 설문은 총 42문항으로 구성되었다. 모자 착용실태, 세탁방법, 건조방법, 보관방법에 관한 문항은 선다형으로, 모자 소비자 불만, 소비자 모자 레이블 인식에 관한 문항은 5점 리커트 척도로 측정하고, 자료분석을 위하여 SPSS 12.0 프로그램으로 빈도, 백분율, 평균, 표준오차, 교차분석, t-test, 일원분산분석 통계처리를 하였다. 그 결과에 의하면 첫째, 모자 소비자의 세탁방법 인식도와 실천정도는 보통 수준으로 나타났다. 남성보다는 세탁경험이 많은 여성이 모자 세탁 방법에 대하여 잘 알고 실천하고 있었으며, 편안함을 추구하는 젊은 세대보다 높은 연령대가 세탁방법을 더 잘 실천하는 것으로 조사되었다. 둘째, 모자 소비자들은 다른 의복 아이템과 비교하여 울세제로 세탁망에 넣어 세탁기로 돌리거나 손으로 직접 빠는 세심한 관리를 하는 경우가 많았다. 세탁빈도는 더러움이 탈 때마다 하는 것으로 조사되었으며, 세탁의 주 목적은 얼룩제거로 나타났지만, 여성은 남성에 비해 모자의 형태보전과 냄새제거를 중요한 요인으로 평가하는 것으로 나타났다. 건조장소에 있어서는 그늘에서 건조한다는 응답이 가장 많았고 대부분 집게로 집어 빨래 줄에 말리는 경우가 많았다. 모자 세탁 시 세탁방법, 건조방법, 건조장소의 요인들보다 세제종류가 세탁 후 변형에 영향을 미치는 것으로 조사되어 적절한 세제를 사용할 수 있는 정보를 소비자에게 인지시켜 피해를 줄이는데 노력하여야 할 것이다. 또 보관방법으로는 대부분 옷장 선반에 두고 있었으며 보관 후 형태변화 결과를 경험한 소비자의 비율이 높은 것으로 보아 적합한 모자 보관으로 형태유지에 각별한 주의가 요구된다. 셋째, 대부분의 모자 소비자들은 레이블에 대한 중요성을 인지하고 있으나 다른 의복 아이템에 비하여 모자레이블에 대한 신뢰도는 더 낮게 나타나, 공급자들은 정확하고 실질적인 레이블을 표기하여 신뢰도 회복을 기해야 할 것이다. 많은 소비자들이 모자의 치수 체계 이해에 어려움을 갖고 있으며, 특히 남성의 경우 레이블에 대한 전반적인 인지도가 낮게 나타나 남성 소비자에게도 전반적인 레이블에 대해 교육시키도록 구체적인 노력이 이루어져야만 하겠다. 후속연구에서는 모자의 다양한 형태나 재료에 따른 세탁 및 관리 방법을 보완하여 연구가 수행되어서 보다 구체적인 자료가 제공되어야 할 것으로 보인다.