• Korean Journal of Veterinary Research
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• v.35 no.2
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• pp.217-228
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• 1995

The study was designed to investigate the effects of progesterone on the reproductive system. This investigation was performed by immunohistochemical methods using anti-bromodeoxyuridine-antibody following bromodeoxyuridine(Brdur) injection for labeling proliferating cells in the uterus and ovary of rats. Sixteen female rats(Wistar), weighing initially 300g, were randomly allotted into ovariectomized and unovariectomized large groups. These two large groups were subdivided into three subgroups of control, 3-day and 6-day groups, respectively. 3-days and 6-days group were injected with 1mg of progesterone/rat/day for 3 or 6 days, respectively. In gross findings, the uterus of ovariectomized groups markedly atrophied, and were not hypertrophied by progesterone injection for 3 days or 6 days and the uterus of unovariectomized groups also were not hypertrophied. Labeling index(LI, %) was measured by counting the number of Brdur-positive cells from 300 to 3,000 cells per layer in the uterus tissue. The average LI of the uterus in unovariectomized groups was higher than that of ovariectomized groups. The subgroups with higher LI in unovariectomized groups were ordered as 6-day group, 3-day group. So progesterone considerably effected to the proliferating of the cells in the uterus of unovariectomized groups. The layers with higher LI in the uterus wall were ordered as the functional zone of endometrium, epithelial layer of endometrium, basal zone of endometrium, myometrium and perimetrium. The cell types with higher LI in the uterus of unovariectomized groups were ordered as the surface epithelial cells, stromal cells, glandular epithelial cells and muscle cells. Growing follicles with proliferating cells from secondary and tertiary follicles in the ovary of unovariectomized groups appeared to be 37.66% in control group, 39.23% in 3-day groups, 39.47% in 6-day groups. Mature follicles in the ovary were more number in control group than those in 3-day groups but not appeared in 6-day groups. So progesterone not nearly effects to the number of the growing follicles but appeared to be related to suppression of the development and protrusion of the mid-tertiary and mature follicles on the ovary surface. The cell types with higher LI in the ovary of unovariectomized groups were respectively ordered as granulosa cells, theca interns cells in secondary follicles; theca interna cells, granulosa cells, theca externa cells in tertiary follicles; fibroblasts, theca in terns cells in atretic follicles; fibroblasts, luteal cells in corpus luteum.

• Tuberculosis and Respiratory Diseases
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• v.46 no.1
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• pp.75-81
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• 1999

Background : Recently, there are many patients with lipoid pneumonia by ingestion of shark liver oil in Korea, but only a few animal experimentations have been carried out. The purpose of this study is to evaluate sequential change of the lung after aspiration of shark liver oil and to provide the radiologic-pathologic correlation. Methods: A single intratracheal administration of shark liver oil was given to 14 white rabbits. They were then sacrificed sequentially from 1 week to 6 weeks after injection. We investigated the HRCT and pathologic findings Results: One was sudden death immediately after injection. Six of the 13 rabbits showed pneumonic infiltrations on the HRCT. There were air space consolidation with air-bronchogram on the HRCT of the first week. They were associated with the volume loss in the 4th week, and the traction bronchiectasis in the 6th week. The important pathologic findings were peribronchial alveolar inflammation with septal widening and cuboidal metaplasia of the alveolar wall. The number of macrophages in an alveoli was peaked in the second week and then gradually decreased. On the 6th week, we could find the proliferation of fibroblasts. Conclusion: We can prove the development of lipoid pneumonia after aspiration of squalene by animal experimentation, and the understanding of HRCT and pathologic findings may be helpful in proper evaluation of pneumonia due to aspiration of fish-extracted lipid.

• The Journal of Korean Medicine
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• v.20 no.2
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• pp.146-156
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• 1999

The present study was performed to investigate the effect of Yangkyuksanhoa-tang on the morphological changes of the basilar artery after experimentally induced subarachnoid hemonrrhages(SAH). Yangkyuksanhoa-tang has been used freguently for cerebrovascular accident Sprague Dawley rats weighing between 350-400 g were used. The 6 normal rats and 24 SAH elicited rats were used, The SAH induced by injection of the fresh autologus heart blood (0.3-0.4 ml) into the cisterna magna through the posterior atlanta-occipital membrane, Sample group was given 3.3 ml/kg/day of Yangkyuksanhoa-tang extracts for 2 days after SAH. The experimental animals were killed at 48hrs after SAH. The morphological changes of the arterial walls were examined by light and electron microscopy. Following are the obtained results: 1. In SAH elicited rats, the size of the lumen in basilar artery was diminished by about 45% and the thickness of arterial wall was increased by about 82%. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was merely diminished by about 18% and the thickness of arterial wall was merely increased by about 19%. 2. In light microscopic examination, the endothelium was swollen into a cuboid shape and the layer of smooth muscle was increased in the basilar artery of SAH elicited rats. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was enlarged and the thickness was decreased than in SAH elicited rats. The endothelium was flattened into a squamous shape and the layer of smooth muscle was decreased more than in SAH elicited rats. 3. In electron microscopic examination, the endothelial cells with fragmentation nuclei were changed into a cuboid shape and the internal elastic lamina were folded at the basilar artery of SAH elicited rat. The nuclei of smooth muscle cells were changed into a round or crumpled shape. The length of smooth muscle was shorten and thickness was increased. But all kinds of morphologic changes were diminished in SAH elicited rats with Yangkyuksanhoa-tang treatment. Conclusion : Yangkyuksanhoa-tang extracts were effective to treat cerebral vasospasm after experimentally induced subarachnoid hemorrhage in rats.

• Journal of the Korean Recycled Construction Resources Institute
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• v.5 no.4
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• pp.442-449
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• 2017

In this study, a method to inject small amount of activation agent from the outside of the pipeline to the inside wall of the pipe was newly proposed to enhance pumping efficiency of cementitious materials. The activation agent is injected into the slip-layer, which is generally formed in the vicinity of the inside wall of the pipe during pumping cementitous materials. Through the injections, it is expected to decrease viscosity of slip-layer, namely, the friction between the mateirals and the pipe. The proposed method was verified by lab-scale pumping tests with mortars having water to cement ratio of 47%. The tests were performed with two different type of activation agents(superplasticizer and anionic surfactant) and three different amount of the agents(0.14, 0.28, 0.42% of the mortar volume). The compressive strength were measured with and without injecting the activation agent, and the internal pressures of pipeline were measured. When the anionic surfactant was used, there was no change in the compressive strength. As the amount of anionic surfactant increased, the pumping pressure decreased up to 71.4% at the maximum.

• 한국해양학회지
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• v.30 no.4
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• pp.355-364
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• 1995

A heavy fluid is injected to a rotating cylindrical container of flat or inclined bottom filled with homogeneous lighter fluid. Continuous flow-in and spreading patterns over the bottom of the container are observed and at the same time upper-layer motions induced by the movement of the heavy fluid are traced by thymol blue solution. Regardless of bottom geometry, the injected denser fluid is deflected toward "western wall" and continuous its path along the boundary with radial spreading which occurs in the bottom boundary layer to make a quite asymmetric flow. When the bottom contains a slope(${\beta}$-plane), increased pressure gradient causes the fluid move faster to produce a stronger Coriolis force. This makes the width of the flow narrower than that of f-plane. But, when the denser flow reaches the southern part of the container, a local-depth of denser fluid increases (much greater than the Ekman-layer depth) such that the spreading velocity along the wall is reduced and the interfacial slope increases to make the upper-layer adjust geographically to have oppositely directed upper-layer motion along the interfacial boundary. The role of the denser fluid in terms of vorticity generation in the upper-layer is such that it produces local topographic effect over the western half of the container and also induces vortex-tube stretching which is especially dominant in the f-plane.

• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.6
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• pp.629-636
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• 2022

Domestic eco-friendly vehicles currently account for 5.8% of the total registered vehicles in Korea. Hydrogen vehicles, one of the representative eco-friendly vehicles, have grown rapidly as they have been expanded to the market based on the government's policy to boost the hydrogen industry. Therefore, it is time to expand the safety review of hydrogen vehicles in various directions according to the increase in supply. In this study, the effect of internal heat damage was analyzed when a jet flame was generated by a hydrogen car in a road tunnel. It was simulated using Fluent, and the amount of jet flame injection was selected in consideration of the hydrogen tank capacity of commercial hydrogen vehicles for road tunnels. In addition, the study was conducted with the direction of the jet flame and the nozzle distance from the tunnel wall as variables. From the results, when the jet flame erupted in the road tunnel, high radiant heat emission of more than 20 kW/m² was generated in most areas within ±5 m in the longitudinal direction based on the vehicle (spray nozzle) and 5 to 7 m in the lateral direction based on the adjacent tunnel wall.

• Journal of the Korean Society of Propulsion Engineers
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• v.16 no.5
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• pp.1-9
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• 2012

The gas jet from a coaxial porous injector for two-phase flows is discharged from the porous surface, which encloses the center liquid jet, and the gas and liquid jet interact with each other physically. The wall injected gas jet transfers the radial momentum effectively while the radial gas jet develops to axial jet, and the performance of atomizing and mixing can be improved. In this study, the Weber number and the ratio of momentum flux were controlled by changing the gas injection area and the mass flow rate of the gas jet, and a study on the spray characteristics at the cold-flow test using water and air simulant was performed. It is concluded that the radial momentum transfer concept of a coaxial porous injector gives a positive effect on the atomization and mixing of the two-phase spray.

• Tunnel and Underground Space
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• v.24 no.5
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• pp.395-403
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• 2014

In this study, a steel pipe type rockbolt manufactured from special material was developed which has high strength and lightweight characteristics. Achievement of grout filling between rockbolt and hole wall was investigated through grout injection tests. Yield force of the developed rockbolt was also examined through tensile tests, which was compared with that of the deformed bar type rockbolt. In addition, the strength and elongation properties of the developed rockbolt were investigated through pull-out tests at three domestic sites showing different RMR classes. It is finally supposed that the developed rockbolt can be suitable for the permanent tunnel support because it has high strength and high durability rather than deformed bar type rockbolt.

• Journal of Chest Surgery
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• v.42 no.2
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• pp.272-274
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• 2009

Xiphodynia is a term used to describe a painful xiphoid process, and this is a rare musculoskeletal disorder that can radiate to the anterior chest, epigastrium, neck, shoulders and back. Clinical awareness of xiphodynia is important for making its correct diagnosis. We report here on two cases of xiphodynia. The diagnosis was suggested by the reproduction of the anterior chest pain or/and the epigastrium pain with light pressure on the xiphoid process. The patient of case 1 had suffered from xiphodynia throughout the years, and this patient underwent surgical excision of the xiphoid process. The patient of case 2 received an injection of local anesthetic agent to the xiphoid process.

• Journal of Microbiology and Biotechnology
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• v.21 no.4
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• pp.391-399
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• 2011

Free fatty acids (FFAs) are known to have bacteriocidal activity and are important components of the innate immune system. Many FFAs are naturally present in human and animal skin, breast milk, and in the bloodstream. Here, the therapeutic potential of FFAs against methicillin-resistant Staphylococcus aureus (MRSA) is demonstrated in cultures and in mice. Among a series of FFAs, only oleic acid (OA) (C18:1, cis-9) can effectively eliminate Staphylococcus aureus (S. aureus) through cell wall disruption. Lauric acid (LA, C12:0) and palmitic acid (PA, C16:0) do not have this ability. OA can inhibit growth of a number of Gram-positive bacteria, including hospital and community-associated MRSA at a dose that did not show any toxicity to human sebocytes. The bacteriocidal activities of FFAs were also demonstrated in vivo through injection of OA into mouse skin lesions previously infected with a strain of MRSA. In conclusion, our results suggest a promising therapeutic approach against MRSA through boosting the bacteriocidal activities of native FFAs, which may have been co-evolved during the interactions between microbes and their hosts.