• The Korea Journal of Herbology
• /
• v.29 no.4
• /
• pp.45-52
• /
• 2014

Objectives : The purpose of this study was to evaluate the efficacy of HT008 on pain relief and functional improvement in participants with mild knee osteoarthritis (OA) in comparison with that of glucosamine sulfate. Methods : This randomized double-blind trial was conducted at Kyung Hee University Medical Center in Seoul where participants with knee pain for more than 6 months and degenerative osteoarthritis were enrolled. The 100 participants were received either HT008 or glucosamine sulfate 750 mg twice daily for 8 weeks and evaluated at baseline, 4 and 8 weeks after the treatment. We primarily evaluated the differences between two groups with respect to changes in the visual analogue score (VAS) for pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score from baseline to week 8. Secondarily the difference between and within two groups with respect to changes in WOMAC stiffness and physical function score, and Lequesne Functional Severity Index (LFI) were also evaluated. Results : At week 8, treatment with HT008 resulted in a significant reduction of the VAS for pain and WOMAC pain scores compared to the glucosamine sulfate (both p=0.003). Patients receiving HT008 experienced statistically significantly greater improvements in WOMAC physical function scores and LFI (p = 0.014 and p=0.016, respectively) than glucosamine sulfate-treated group. The within-group change in WOMAC physical function and stiffness, and LFI during the 8-week intervention revealed significant improvements in HT008-treated group. Conclusions : HT008 treatment allows significant pain reduction and functional improvement compared with glucosamine sulfate. These data confirm HT008 as an effective and safe symptomatic drug for knee OA.

• Journal of Pharmacopuncture
• /
• v.13 no.4
• /
• pp.129-137
• /
• 2010

This case was report of intra-articular bee venom pharmacopuncture injection on the patient with Acute Traumatic Partial tear of meniscus. We used intra-articular bee venom pharmacopuncture injection to Acute Traumatic Partial tear of meniscus diagnosed by symptoms and MR imaging. Be under treatment if necessary we prescribed herbal medication and physiotherapy. The state of patient was measured by Visual Analog Scale(VAS) and Walking time and Western Ontario and McMaster Universities(WOMAC) Index score. After several times of treatments, noticeable reduction of pain was measured and increased time of walking on floor and decreased WOMAC score. This results suggest that intra-articular bee venom pharmacopuncture injection are effective to treatments of Acute Traumatic Partial tear of meniscus.

• Journal of Acupuncture Research
• /
• v.33 no.3
• /
• pp.153-159
• /
• 2016

Objectives : The purpose of this study is to report the effect of Miniscalpel acupuncture therapy on a patient with traumatic tears of both meniscuses. Methods : We treated a patient with tears in both meniscuses stemming from a traffic injury. The clinical effects of this treatment are measured by Visual Analog Scale (VAS), European Quality of Life - 5 Dimensions (EQ-5D), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results : After Miniscalpel acupuncture therapy, the VAS score of the left knee changed from 7 to 3, while the VAS score of the right knee changed from 7 to 2~3. WOMAC of both knees changed from 70 to 8. Night pain and day-to-day pain have disappeared, with only a slightly heavy feeling remaining. Conclusion : These results suggest that Miniscalpel acupuncture therapy may be effective for treating traumatic meniscus tear.

• The Korean Journal of Pain
• /
• v.37 no.3
• /
• pp.264-274
• /
• 2024

Background: Radiofrequency ablation is an effective treatment modality in the symptomatic treatment of knee osteoarthritis. Our aim was to compare the efficacy of radiofrequency ablation of the superomedial and inferomedial genicular nerves (2 branches) with the superolateral, superomedial, and inferomedial genicular nerves (3 branches) and to show whether the 2-branch procedure is inferior to the 3-branch procedure. Methods: This study is a prospective, randomized, single-blind clinical study. Eligible participants were randomized into 2 groups: group A, which applied the procedure to the superomedial and inferomedial genicular nerves, and group B, which applied it to the superomedial, superolateral and inferomedial genicular nerves. Pain was evaluated with the numerical rating scale, quality of life with the Short Form-36 (SF-36), and disability with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index before, and at 1 and 3 months after the procedure. Results: A total of 41 patients were included. There were no differences between the groups except for the SF-36 physical health sub-score at baseline. A significant improvement was seen in the numeric rating scale (NRS) score, SF-36 sub-scores, WOMAC Index total, as well as pain and physical function scores in both groups, though no significant difference was detected between the groups during follow-up. Conclusions: Although we were unable to establish the noninferiority of conventional radiofrequency ablation (CRFA) applied to 2 branches to CRFA applied to 3 branches, in this trial, significant and similar improvement was observed in NRS, WOMAC total, pain, and physical function and SF-36 scores in both groups.

• Journal of Acupuncture Research
• /
• v.23 no.1
• /
• pp.187-215
• /
• 2006

Objectives : To determine whether the pragmatic acupuncture treatment provides more effective pain relief than treatment using the same acupuncture point to the all patients. Methods : We randomly allocated participants to treatment group 1 and 2. The group 1 is the pragmatic treatment group and the group 2 is using the same acupuncture point to the all patients. Primary outcomes were measured by the Western Ontario and McMaster Universities Osteoarthritis index(WOMAC) pain and function scores at 4, 8, and 14 weeks. Secondary outcomes were measured by 100mm VAS(Visual Analog Scale), ROM(Range of Motion) using Goniometer, and pain threshold using pressure algometer. Results : When patients were extension of the knee, they were statistically significant in improvement of the ROM in 14 weeks. Whole body condition and pain rate through VAS measurement were improved significantly in 14 weeks. Also pain score and function score of WOMAC were improved significantly in 14 weeks. We could get difference in pain score of two acupuncture groups significantly in 14 weeks. But we could not get difference in whole score of two acupuncture groups significantly. Local temperature using T.C thermometer was changed significantly in 14 weeks. But we could not get difference in whole score of two acupuncture groups significantly. Excluding above item, DITI, pain threshold, and ROM of the knee flexion were no difference in before and after treatment.

• Journal of muscle and joint health
• /
• v.19 no.1
• /
• pp.71-83
• /
• 2012

Purpose: The purpose of this study was to develop and evaluate the effects of Tai Chi Self-help program for Hemophilic Arthritis Patients. Method: A quasi-experimental design was used. The subjects were 48 patients who underwent orthopedic surgery (24 experimental group, 24 control group). The subjects of experimental group were participated in the Tai Chi self-help group program in which 16 times for 8 weeks. The program consisted of health education on hemophilia, Tai Chi exercise, and workshop and its outcomes have been evaluated on WOMAC(Western Ontario and McMaster scale), mobility, pain, fatigue, muscle strength, depression, and quality of life(SF-36). The obtained data were analyzed by using the t-test or Fisher's exact test of PASW 18.0. Results: 1) The score of WOMAC, pain, fatigue, and depression decreased significantly in the experimental group as compared to the control group. 2) The score of mobility, muscle strength, and quality of life increased significantly in the experimental group as compared to the control group. Conclusion: Considering these research results, the program could be useful to improve joint movement, strength and psychological condition for patient with hemophilic arthritis, particularly in those who underwent orthopedic surgery.

• Journal of the Korean Arthroscopy Society
• /
• v.16 no.2
• /
• pp.167-174
• /
• 2012

Purpose: The purpose of this study is investigation of clinical and functional outcomes in homogeneous group with positive culture after arthroscopic management for pyogenic knee arthritis and analysis of factors affecting those outcomes. Materials and Methods: Thirty-two patients with positive culture after arthroscopic management were included. Mean follow-up period was 41.6 months. Clinical evaluation included death related to infection, recurrence, time to normalize erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), duration of administration of intravenous antibiotics and readmission. Radiographic evaluation was performed according to Kellgren and Lawrence. The prevalence of total knee arthroplasty was investigated and functional evaluation included modified Lysholm, Tegner activity and Korean version of the Western Ontario and McMaster Universities (K-WOMAC) score. Results: Staphylococcus aureus was identified in 21 patients. Time to normalize ESR and CRP was 78.0 and 67.6 days, respectively. Two patients died while there were six recurrences and five readmissions. Rate of recurrence was significantly high in patients with chronic renal failure (P=0.034) and incidence of readmission was associated with higher radiographic grade of osteoarthritis and rate of reoperation (P=0.032 and P=0.006, respectively). At the final follow-up, radiographic grade worsened in 21 patients and was associated with those at first visit. Five arthroplasties were performed. Average modified Lysholm score, Tegner activity score and K-WOMAC score were 53.5, 2.7, 44.2 points, respectively. Conclusion: The severity of osteoarthritis on final radiographs was associated with those at first visit. Patients with higher grade of osteoarthritis at first visit showed higher incidence of readmission and those with chronic renal failure demonstrated higher chances of recurrence.

• Journal of Korean Medicine Rehabilitation
• /
• v.29 no.3
• /
• pp.113-128
• /
• 2019

Objectives To evaluate the pattern identification tool for knee osteoarthritis and to investigate the relationship between pattern identification tool and knee ROM (range of motion), VAS (visual analog scale) and WOMAC (Western Ontario & McMaster Universities osteoarthritis index). Methods We studied 50 patients who are diagnosed as degenerative osteoarthritis. With one patient dropping out, total of 49 patient went through pattern identification tool. Re-test of the pattern identification tool was implemented after about a week. The reliability was analyzed by calculating ICC (intraclass correlation coefficient). Also, reliability of each pattern identification score was calculated along with influence factor and correlation between knee ROM, VAS and WOMAC. Results Reliability of the pattern identification tool was evaluated as 'poor agreement beyond chance' with ICC value of 0.396. Reliablility of each pattern identification score was calculated and four out of five were measured 'good' with one 'moderate' reliability. Two of inter-item consistency were 'good', two were 'acceptable' and one was 'questionable'. Correlation between each pattern identification and knee ROM showed 'clear negative linear relationship' with two patterns. VAS showed 'clear positivie linear relationship' with all five patterns. WOMAC showed 'positivie linear relationship' with all five patterns. Conclusions According to the results, pattern identification tool for knee osteoarthritis seems to have meaningful relationship with other agnedas. Also, further research is needed to develop the tool.

• Journal of the Korean Society of Physical Medicine
• /
• v.12 no.4
• /
• pp.147-158
• /
• 2017

PURPOSE: Balance exercise as well as lower extremity strengthening exercise (LESE) is known to be effective in patients with knee osteoarthritis (KOA). The purpose of this study was to investigate the effectiveness of performing LESE in conjunction with balance exercise on lower extremity function, range of motion, muscle strength, and balance in patients with KOA. METHODS: The subjects of this study were 25 patients with KOA who were recruited and randomly divided into two groups: 1) those who performed LESE with balance exercise; and 2) those who performed only LESE. Both the groups also received general physical therapy and performed aerobic exercise. The interventions were performed 3 times a week for 4 weeks. To determine the effectiveness of the interventions, we measured Western Ontario and MacMaster Universities Arthritis Index (WOMAC) score, numerical rating scale (NRS) score, passive range of motion (PROM), chair stand test (CST), and Berg Balance Scale (BBS) score at the initiation of the interventions and again after 4 weeks, at the time of completion of the interventions. RESULTS: After 4 weeks of the interventions, both the groups showed significantly improved WOMAC (p<.01), NRS (p<.01), PROM (p<.05), CST (p<.05), and BBS (p<.01) scores. However, there was no significant difference between the groups in terms of the clinical outcomes observed. CONCLUSION: These results suggest that the addition of balance exercise to a LESE regimen in patients with KOA did not provide any additional benefit.

• The Korea Journal of Herbology
• /
• v.28 no.2
• /
• pp.75-82
• /
• 2013

Objective : This study was to evaluate the effectiveness of the prescription Dokhwalkigisaengtangagambang(DGG) and Gamisayuktanggagambang(GSG), which has been utilized in the treatment of joint disease, for improving low back and knee joint pain. Methods : In the patients for the clinical studies, control group was 28 cases, experimental group was 41 cases. All subjects had low back pain and knee pain. The experimental group was treated with DGG or GSG, the control group was treated with 17 prescriptions. VAS (Visual Analag Scale), WOMAC (Western Ontario and McMasters Universties Osteoarthritis Index) and ODI (Oswestry Low back pain Disability index) measured before and after the prescription administration. Results : In the difference of VAS score, the experimental group (p <0.001) and the control group (p <0.001) were decreased significantly before and after the administration of prescription, and in the comparisons between the experimental group and the control group, experimental group was decreased significantly compared to the control group(p = 0.008). In the WOMAC score, there was no significant difference between the experimental group and the control group. In the difference of ODI items score, lifting (p = 0.020) and sleeping (p = 0.028) index were decreased significantly before and after the administration of prescription. Conclusion : The results indicated that the prescription DGG and GSG can reduce knee pain and low back pain. This study will be helpful for improving joint disease.