• Biomolecules & Therapeutics
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• v.1 no.2
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• pp.275-279
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• 1993

Single oral administration to SD rats of both sexes were performed to investigate the acute toxicity of two new cough and cold remedies, WHS-1 and WHS-2. WHS-1 is composed of acetaminophen, chlorpheniramine maleate, cloperastine hydrochloride, dl-methylephedrine hydrochloride, caffein anhydrous, thiamine hydrochloride, riboflavin and serratiopeptidase. WHS-2 is composed of similar formula except that thiamine hydrochloride and riboflavin is not added. The results were as follows. $LD_{50}$ values of WHS-1 were 4295.5 mg/kg for males and 4606.3 mg/kg for females, and $LD_{50}$ values of WHS-2 were 3236.7 mg/kg for males and 4360.5 mg/kg for females. Death occurred within 2~3 hours after administration at doses up to 2900 mg/kg in WHS-1 and 2500 mg/kg in WHS-2, the main cause of deaths seemed to be respiratory disturbance. General symptoms included decreased motor activity, salivation and loss of consciousness which were commonly observed in all dead animals treated with WHS-1 and WHS-2. No significant gross finding and body weight changes were observed at any dose level in the groups treated with WHS-1 and WHS-2.

• Safety and Health at Work
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• v.2 no.3
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• pp.218-228
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• 2011

Objectives: The objective of this study was to test the feasibility and acceptability of a new workers' health surveillance (WHS) for fire fighters in a Dutch pilot-implementation project. Methods: In three fire departments, between November 2007 and February 2009, feasibility was tested with respect to i) worker intent to change health and behavior; ii) the quality of instructions for testing teams; iii) the planned procedure in the field; and iv) future WHS organisation. Acceptability involved i) satisfaction with WHS and ii) verification of the job-specificity of the content of two physical tests of WHS. Fire fighters were surveyed after completing WHS, three testing teams were interviewed, and the content of the two tests was studied by experts. Results: Feasibility: nearly all of the 275 fire fighters intended to improve their health when recommended by the occupational physician. The testing teams found the instructions to be clear, and they were mostly positive about the organisation of WHS. Acceptability: the fire fighters rated WHS at eight points (out of a maximum of ten). The experts also reached a consensus about the optimal job-specific content of the future functional physical tests. Conclusion: Overall, it is feasible and acceptable to implement WHS in a definitive form in the Dutch fire-fighting sector.

• Journal of Genetic Medicine
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• v.2 no.2
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• pp.49-51
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• 1998

Wolf-Hirschhorn syndrome (WHS) is caused by a deletion of the short arm on chromosome 4 and is characterized by multiple congenital abnormalities, growth and mental retardation. In this case report, we performed amniocentesis for the chromosome analysis on a 25-year-old pregnant woman at 16 weeks of gestation whom we suspected of Edward's syndrome by the triple test of maternal serum and ultrasonography. The result of analysis revealed a karyotype of the fetus with 46,XY,del(4)(p15) by trypsin Giemsa's banding technique. With the result, we were able to diagnose the fetus as having WHS. As such, after therapeutic termination of the pregnancy, we confirmed WHS through the sampling of tissue by both trypsin Giemsa's banding and fluorescence in situ hybridization (FISH) method. To determine the origin of the WHS, we further tested the karyotypes of the parents. As parental karyotypes were found to be normal, we determined the case of the fetal WHS to be de novo.

• Food Science and Preservation
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• v.15 no.6
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• pp.909-914
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• 2008

This study investigated microbial populations and the sensory quality of sikhae including globefish (GLS), flounder (FLS), gastropods (GAS) and whelks (WHS) during storage at 4C for 16 d following fermentation at 10C for 4 d. General bacterial numbers increased to 102 in GLS and FLS, and to 1045 in WHS and GAS after the 20 d fermentation/storage period. Lactic acid bacteria increased to 108 log cycle in GLS and FLS after 10 d ripening time, and reached this level in GAS and WHS after 15 d and 20 d, respectively. After 20 days the number of lactic acid bacteria in each of the four samples was 108. There were 104105 yeast cells/g in each of the four samples after 20 d. The number of Leuconostoc increased to over 108 log cycle after 10 d in GLS and FLS, and 15 days in GAS for WHS the increase was to 107 log cycle. The pH values of GLS, FLS, GAS and WHS 4.42, 4.56, 4.31 and pH 4.26, respectively. The Sikhae acidity for all four samples ranged from 1.551.85%. From the sensory evaluation the overall acceptability was in the order of FLS > GLS > GAS > WHS.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.64 no.4
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• pp.336-343
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• 2019

Wet direct-seeding (WDS) is an important method for improving the competitiveness of rice production in South Korea. We analyzed the optimum direct-seeding date to establish the rice standing rate in each area and selected suitable areas for WHS by considering the heading stage limit date for improving cultivation safety. As a result, the rice direct-seeding date to control weedy rice was around 5.15, 5.17-5.19, and after 5.20 in southern Youngnam, southern Honam, and the Middle Coast areas, respectively. However, the optimum seeding date for good standing rice was in late March in most areas. Analyzing by area, most of the southern plains and parts of the central inland plain are suitable for WHS. However, most parts of Gwangwon-do, and the northern parts of Chungbuk, Gyeongbuk, and Yeonghonam areas are not suitable for WHS, and should therefore avoid WHS.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.63 no.4
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• pp.273-281
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• 2018

Wet hill seeding (WHS) is one of the more famous labor and money saving methods technology used for rice cultivation. In WHS, rice standing percentage and weedy rice occurrence are the most important factors considered to secure a rice yield. We investigated the optimum seeding date of WHS in the Southern Plain area of South Korea. Weedy rice needed two weeks at $15^{\circ}C$ to show over 80% emergence. Germinated rice seed grown at $20^{\circ}C$ needed over for 10 days to achieve a shoot length over 3 cm. In field cultivation, the mean temperature for ten days after seeding showed a highly positive correlation with rice standing rate, spikelet number per square meter and yield index that favorably compared to machine transplanting. With these data, we suggest that the optimum seeding date of WHS that can secure over 98% of yield index of machine transplanting in Southern part of Korea is May. 21~Jun. 5 in Honam and May. 16~Jun. 5 in Yeongnam area.