This study examined the serum lipid levels according to the obesity indices, and obtained the relationship between obesity indices and serum lipid levels among adults who underwent a health checkup in a university hospital. The subjects for this study were 4,112 adults aged 18 to 77 years who underwent medical examinations at the health center of a university hospital in Daejeon city from Jan 2012 to Dec 2013. The serum lipid levels (TC, HDL-C, LDL-C, TG, AI) and obesity indices (height, weight, waist circumference, body fat rate, BMI, WHR WSR) of the study subjects were surveyed from self-recorded questionnaires and medical examination charts of the hospital. As a result, the serum lipid levels (TC, HDL-C, LDL-C, TG, AI) of the study subjects were increased significantly with higher level of obesity indices (WC, body fat rate, BMI, WHR WSR) in both sexes. The TC, LDL-C, TG, and AI showed that positive correlated with the WC, body fat rate, BMI, and WSR in both sexes, but HDL-C was negatively correlated with the WC, body fat rate, BMI, and WSR in both sexes. The above results suggest that the obesity indices and the serum lipid levels are closely related, i.e., the serum lipid levels increase with increasing obesity indices.