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Effects of ${\beta}2-Adrenergic$ Receptor Polymorphism on Obesity (베타 2-아드레날린 수용체의 유전자 변이형이 비만도에 미치는 영향)

  • Kim, Kil-Soo;Oh, Hyun-Hee;Choi, Sun-Mi;Yang, Hyun-Sung;Bae, Jung-Hwan;Yoon, Yoo-Sik
    • Journal of Korean Medicine for Obesity Research
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    • v.3 no.1
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    • pp.7-16
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    • 2003
  • Objectives : The lipolytic effects of catecholamines in adipose tissue are mediated by members of adrenergic receptors. This study was conducted to examine the effects of ${\beta}2-AR$ Gln27Glu (Q27E) polymorphism on obesity indices and risk among obesity clinic patients. Methods : 532 subjects, 38 men and 494 women, who attended a weight loss program in a local obesity clinic were analyzed. Height, weight, BMI, WHR and obesity index were measured or calculated. Body composition was measured by bio-impedance analysis. Genotype of ${\beta}2-AR$ polymorphism in codon 27 was analyzed by PCR-RFLP method. Serum concentrations of fasting glucose, total and HDL cholesterol, and triglyceride were determined by autobiochemical analyzer. Results: The Genotype distributions of ${\beta}2-AR$ gene were QQ type 81.3%, QE type 17.9% and EE type 8%. Therefore, the frequency of E allele of ${\beta}2-AR$ gene was 0.170 in the total subjects. The frequency of the ${\beta}2-AR$ variant genotype(QE+EE) was significantly higher in obese group($BMI{\geqq}25$) compared with non-obese group(p=0.027). Weight was significantly higher in variant(QE+EE) type compared with normal(QQ) type in total subjects(p=0.001), male(p=0.022) and female(p=0.013). BMI, obesity index and WHR were also significantly higher in QE+EE type. Body fat man was significantly higher in QE+EE type in total subjects(p=0.005) and female(p=0.027). When forward stepwise regression analysis was used to create a model of risk predictors of obesity($BMI{\geqq}25$), QE+EE type of ${\beta}2-AR$ gene was found to be a significant risk factor for obesity (p=0.042, ORs 1.597). Conclusions: QE+EE genotype of ${\beta}2-AR$ was associated with increased obesity indices and might be a significant risk factor for obesity.

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The Effects of Diet Methods on Blood Lipid Profiles and Metabolic Risk Factors in Obese Female College Students (다이어트 방법이 비만여대생들의 혈중지질성분 및 대사성위험요인에 미치는 영향)

  • Woo, Jinhee;Park, Sungchul
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.4
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    • pp.1145-1155
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    • 2018
  • The purpose of this study was to investigate the effect of dietary restriction(DG), aerobic exercise(EG), dietary restriction with aerobic exercise(DEG) on weight, improvement of obesity, blood lipid profiles and metabolic risk factors of obese female college students. Experiments was conducted 5 times a week for 8 weeks. DG spent 300kcal/day, and EG used 300kcal/day to run, DEG each consumed 150kcal/day limits. As s result, in case of body composition, weight(p<.011) and BMI(p<.008) were decreased in DG group, and weight(p<.044, p<.017), body fat(p<.047, p<.018), BMI(p<.03, p<.008), body fat%(p<.036, p<.015) and WHR(p<.049, p<.027) were decreased in EG and DEG groups. In case of blood lipid profiles's change, there are some differences on TC(p<.006), TG(p<.047) according to the time. In DG:HDL-C(p<.028), in EG:TG(p<.038), in DEG:TC(p<.014), LDL-C(p<.007) have decreased. In case of metabolic risk factor's change, there are some differences on FBG(p<.001), insulin(p<.004), HOMA-IR(p<.001), leptin(p<.000), adiponectin(p<.038), resistin(p<.010) according to time. In DG:HOMA-IR(p<.035) and leptin(p<.007), EG:FBG(p<.043) and leptin(p<.003), DEG:FBG(p<.014), insulin(p<.005), HOMA-IR(p<.005), leptin(p<.016), and resistin(p<.040) have decreased. In conclusion, combined treatment of eating restriction with aerobic exercise was the most effective way to improvement of weight, blood lipid profiles and metabolic risk factors in obese female college students rather than respectively alone treatment.

The Effects of Functional Electrical Stimulation on Abdominal Obesity Improvement of Adult Women by EMG, Ultrasound and DITI (근전도, 초음파와 DITI를 이용한 전기자극의 성인여성 복부비만 개선 효과 관찰)

  • Lee, Hyun-Ju;Tae, Ki-Sik
    • Journal of the Korean Society for Precision Engineering
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    • v.31 no.11
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    • pp.1051-1058
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    • 2014
  • In this study, we investigated the improvement effect of obesity by treatment with a developed low frequency electrical stimulation system. Thirty female in their 20's as an experiment subjects divided 3 groups(control, commercialized device, developed device) were treated with electrical stimulation on abdomen for 4 weeks. The body weight, body mass index(BMI), waist-hip ratio(WHR), muscle strength, muscle(transverse abdominis(TrA), internal obliquus abdominis(IO), external obliquus abdominis(EO)), fat thickness and abdominal surface temperature were measured by electromyogram(EMG), ultrasound and digital infrared thermal image(DITI). In the result, the body weight and BMI were decreased. Subcutaneous abdominal fat were significantly reduced after 4 weeks. The muscle strength and TrA muscle thickness was increased 13.2%(p<0.05), and 35.5%, respectively. The fat thickness showed decrease in abdomen (p<0.05). Infrared measurement on abdominal surface temperature as a parameter of improvement in blood circulation was significantly increased(p<0.05). Therefore, the low frequency stimulation showed positive effects on parameters of the obesity improvement.

The Effect of Mother's Routine Exercise on Exercise Regularity, Obesity Indices, Psychosocial Well-being Index and Nutrient Intake in Her Daughter (어머니의 운동이 여대생 딸의 운동, 비만지표, 사회심리적 건강지수 및 영양소 섭취에 미치는 영향)

  • Cho, Kang-Ok;Kim, Yeun-Soo
    • The Korean Journal of Community Living Science
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    • v.19 no.2
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    • pp.191-199
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    • 2008
  • The purpose of this study was to obtain an understanding of the effect of regular exercise on obesity indices, the psychosocial wellbeing index, dietary factors and exercise regularity among 146 healthy mothers and 146 their daughters. "Mother" subjects were divided into two groups classified as regular exercise group(REG) and none exercise group(NEG). The exercise regularity of REG's daughters(30.8%) and of NEG's daughters (2.0%) was significantly different(p<0.001). The Obesity Indices(Body Mass Index (BMI), Waist Hip Ratio(WHR) and Percentage of Ideal Body Weight(PIBW)) of NEG's daughters were significantly higher than those of REG's daughters(p<0.001). But the psychosocial wellbeing index was not significantly different between REG's daughters and NEG's daughters. Intake of total energy, protein, fat, Ca, niacin and Fe were significantly different(p<0.001) between REG's daughters and NEG's daughters. Especially, vitamin C intake of REG's daughters was significantly higher than that of NEG's daughters(p<0.001). The exercise regularity of mothers was mainly related with Obesity Indices and nutrient intake in their daughters. Therefore, it might be necessary to maintain exercise regularity to prevent obesity and diet related problems in mothers and their daughters.

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A Study on the Relationship between the Aspect Ratio of Rt. Lung was Devided by Chest PA and Constitution, Body Composition and Questionnaire on the Differentiation of Syndromes (흉부 X선을 통한 우폐의 종횡비와 체질, 체성분분석 및 변증설문검사와의 상관성에 관한 연구)

  • Sin, Sun-Mi;Lee, Hyung-Kwon;Ko, Heung
    • The Journal of Internal Korean Medicine
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    • v.29 no.2
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    • pp.512-521
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    • 2008
  • Objective : The purpose of this study was to evaluate the Sasang constitution and body composition of the two groups devided by chest PA. Method : This study was carried out on 60 students of Semyung University. The students were selected according to the aspect ratio of rt. lung from chest PA. They were divided into two groups(length group and width group) and administered QSCCII & body composition analysis. Result : The 30 students of the length group were classified as Soumin(15), Soyangin(9), and Taeumin(6). The 30 students of the width group were classified as Taeumin(20), Soyangin(9), and Soumin(1). In the width group, weight, total body water, amount of total body fat, muscles, viceral fat area(VFA), waist hip ratio(WHR), were significantly higher than in the length group. Conclusion : There were significant relationships between the shape of lung and constitution and body composition. These findings indicate that actual organ condition could be expressed in body shape.

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Body Adiposity Index and Metabolic Syndrome Risk Factors in Korean Adults: A Comparison with Body Mass Index and Other Parameters

  • Shin, Kyung-A;Hong, Seung Bok;Shin, Kyeong Seob
    • Biomedical Science Letters
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    • v.23 no.2
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    • pp.57-63
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    • 2017
  • A new body adiposity index (BAI) has been proposed that is expected to replace body mass index (BMI). We evaluated the correlations between metabolic syndrome risk factors and BAI, BMI, and other adiposity indices, such as waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), by sex in the Korean population. We also evaluated whether BAI would be useful to diagnose metabolic syndrome. A total of 20,961 Korean adults who underwent health examinations were included in this study. The metabolic syndrome diagnostic criteria used in this study were those set by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). In men (12,719), BMI and WHtR were more strongly correlated to metabolic syndrome risk than BAI, and in women (8,242), WHtR showed the strongest association with metabolic syndrome risk. BAI (area under the curve [AUC] = 0.678) presented lower discriminatory capacity than that of BMI (AUC = 0.836) for diagnosing metabolic syndrome. Moreover, BAI underestimated fat levels in men and women when considering the ability to discriminate overweight and obese individuals. In conclusion, WHtR and BMI in men, and WHtR in women may be better candidates than BAI to evaluate metabolic risk factors in Korean adults.

Study on a clothes-sizing system for elderly obese women for the activation of the silver clothing industry (실버 의류산업 활성화를 위한 노년 비만여성의 의복 사이즈체계 연구)

  • Seong, Ok jin
    • The Research Journal of the Costume Culture
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    • v.24 no.2
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    • pp.233-247
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    • 2016
  • The purpose of this study is to propose a specialized clothes-sizing system for elderly (aged 60~79) obese women satisfying the following conditions based on the data from the fifth Korean Agency for Technology and Standards (2004): a Rohrer's index of over 1.6, a BMI of over 25, and a WHR of over 0.85. The lower bodies of elderly obese women tends to be shorter and wider than average. Particularly, their torsos from the chest to the waist tend to be more obese than other areas. According to the KS standards, the clothes-sizing system sets up its size intervals as follows: 5cm in stature, 5cm and 3cm in bust, 3cm in waist, and 3cm in hip. Based on the dualistic distribution of each section, the names of the sections indicating high distribution are suggested. For suit tops, 11 sizes are selected as distributed in the 145-155cm stature section and 91-103cm bust section. For casual tops, nine sizes are selected as distributed in the 145-155cm stature section and 90-105cm bust section. For bottoms, 11 sizes are selected as distributed in the 82-97cm waist section and 91-97cm hip section. According to the KS standards, detailed sizes are suggested in the division of basic and reference areas.

Comparison of Obesity Management Between a Behavior Modification Program and an Aerobic Exercise Program in Overweight Adolescent Girls (행동수정프로그램과 에어로빅 운동의 과체중 여자 중학생 비만관리 효과 비교)

  • 문정순;정승교
    • Journal of Korean Academy of Nursing
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    • v.26 no.4
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    • pp.799-807
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    • 1996
  • This study was done to compare the effects of managing obesity using a behavior modification program and an aerobic exercise in adolescent girls. Thirty three subjects were selected from one girls' middle school located in Seoul. Seventeen girls participated in the behavior modification program by joining 60-90 minute group sessions weekly. The aerobic exercise program was given to 16 girls three times per week for 60 minutes each. These iterventions continued for eight weeks from October 17 to December 10, 1995. The data were obtained before and after the interventions by measuring degree of obesity, body weight, blood pressure, serum lipid, %body fat, and waist to hip ratio(WHR). Data ware analysed by using paired t-test. The results are as follows. 1. Subjects in both the behavior modification and the aerobic exercise groups showed significant decrese in the degree of obesity, body weight, diastolic blood pressure, total cholesterol, low density lipoprotein, %body fat and fat mass after the 8-week interventions. 2. Systolic bood pressure, high density lipoprotein cholesterol and waist to hip ratio were significantly decreased after the 8-week intervention in the behavior modification program group while triglyceride was significantly decreased after the 8-week intervention in the aerobic exercise program group. These findings indicate that both behavior modification and aerobic exercise programs are good strategies for managing obesity among adolescent girls.

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Childhood Trauma, Metabolic Syndrome, and Physical Health among Outpatients with Schizophrenia (조현병 외래 환자의 아동기 외상과 대사증후군 및 신체 건강과의 관계)

  • Jung, Tae Hwa;Kim, Dae Ho
    • Korean Journal of Biological Psychiatry
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    • v.24 no.4
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    • pp.196-203
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    • 2017
  • Objectives Childhood trauma increases substantial risks for later developing not only mental health issues including psychotic illnesses such as schizophrenia but also physical illness. In this study, possible associations of childhood trauma with metabolic syndrome and physical heath indices were tested among outpatients with schizophrenia. Methods A final sample of 46 adult outpatients with schizophrenia was recruited from an outpatient psychiatric unit of Hanyang University Guri Hospital. Participants completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), laboratory tests and physical measurement including Body Mass Index (BMI) and Waist to hip ratio (WHR). The Clinical Global Impression (CGI) scale and the Global Assessment of Functioning scale (GAF) were also administered. Results We did not find significant correlations between total scores of childhood trauma and any of these variables, but physical neglect was negatively associated with BMI (r = -0.329, p = 0.026) and waist circumference (r = -0.304, p = 0.040). Conclusions In this preliminary study, we noted that subtypes of childhood trauma could contribute to physical health status separately. Clinicians need to consider the possibility that childhood trauma may affect physical health as well as psychological aspect of schizophrenic illness.

A Study on Body Compositions and Food Behaviors of Middle Aged Men Living in Jeonbuk Province by Percentage of Body Fat (전북지역 일부 중년남성의 비만도에 따른 체성분 분석과 식행동에 관한 연구)

  • Chang, Hye-Soon;Kim, Mi-Ra
    • Korean Journal of Community Nutrition
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    • v.11 no.1
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    • pp.72-82
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    • 2006
  • The purpose of this study was to compare the body compositions and food behaviors of middle aged men with different obesity indices. The subjects were 62 middle aged men who lived Gunsan city. Heights, body weights, soft/lean masses, fat masses, percentages of body fat, and fat distributions were measured. Food habits and health-related lifestyle habits were evaluated based on questionnaires. The subjects were assigned to one of the following groups based on their percentage of body fat ($\%$Fat) ; normal, overweight and obesity. The results were as follows: their heights, fat masses, percentages of body fat, WHR, RBW, BMI and fitness scores were significantly higher in the obese subjects when compared to the normal and overweight subjects. Self-perceptions of weight and desires of weight control were significantly related with their percents of Fat. The overweight and the obese groups skipped meals, ate supper out, ate snacks, smoked tobacco, and exercised less frequently than the normal group. There were no significant differences in the scores of the dietary habits and drinking of alcohol among the three groups. Therefore, proper nutritional education on regular meals and intervention is required if middle aged men want to be of normal weight and have healthy lifestyles.