• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.385-388
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• 2009

Objective : We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter in World Health Organization (WHO) grade III gliomas in association with other molecular markers to evaluate their prevalence. Methods : The samples of a total of 36 newly WHO grade III glioma patients including 19 anaplastic oligodendrogliomas (AO), 7 anaplastic oligoastrocytomas (AOA), and 10 anaplastic astrocytomas (AA) were analyzed. The methylation status of the MGMT gene promoter was confirmed by methylation-specific polymerase chain reaction. The 1p/19q chromosomal deletion status and EGFR amplification were assessed by Fluorescence In-Situ Hybridization. MGMT, EGFR, EGFRvlll, and p53 expression were analyzed by immunohistochemical staining. Results : The MGMT gene promoter was methylated in 32 (88.9%) and unmethylated in 4 (11.2%) Among them, all of the AO and AOA had methylated MGMT gene promoter without exception. Significant associations between MGMT gene promoter hypermethylation and 1p/19q deletion was observed (p=0.003). Other molecular markers failed to show significant associations between MGMT gene promoter statuses. Conclusion : There was extensive epigenetic silencing of MGMT gene in high grade gliomas with oligodendroglial component. Together with frequent 1p/19q co-deletion in oligodendroglial tumors, this may add plausible explanations supporting the relative favorable prognosis in oligodendroglial tumors compared with pure astrocytic tumors.

• International journal of advanced smart convergence
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• 제7권4호
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• pp.185-196
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• 2018

Based on World Health Organization (WHO) children and adults have a problem with their oral health, such as Dental cavities and periodontal disease. It is not easy to obtain the high convince level of result of the dental and periodontal diseases. Because each of them have different degrees of uncertainty and there have several discounting factors (error rates) in different of survey. To solve this problem we propose the Dezert-Smarandache Theory (DSmT) for efficient combination of uncertain, imprecise and highly conflicting sources of information. Moreover, we apply the SEFP as a context reasoning. Finally, we make the simulation by using 12 surveys and compare Propotional Conflict Redistribution 5 (PCR5) and Dempster-Shafer Theory (DST) to show the belief or probability for the low, a heavy, high and ultra-high risk situation.

• Journal of Preventive Medicine and Public Health
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• 제57권4호
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• pp.379-387
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• 2024

Objectives: Mental health issues have become a growing concern worldwide. Research has shown that regular physical activity (PA) can positively affect mental health. This study investigated the associations between PA and mental health problems (MHPs) in middle-aged Indonesians. Methods: The study utilized data from the 2018 Indonesian Basic Health Research Survey and used a cross-sectional approach. The participants included individuals aged 40-60 years who completed the 20-question Self-Reporting Questionnaire. A logistic regression was performed to analyze a sample of 263 930 data points. Results: Nearly 10.4% of the participants suffered from mental health issues. Notably, among those who did not engage in moderate and vigorous PA, a sign of MHPs was found in 12.5% of participants. Those who met World Health Organization standards for PA were less likely to experience MHPs (10.1%). This study found a significant association between PA and mental health. After adjusting for smoking, alcohol consumption, non-communicable diseases, and socio-demographic variables like age, sex, education, occupation, marital status, and residence, the connection between PA and mental health became even stronger (adjusted odds ratio, 0.81; 95% confidence interval, 0.78 to 0.85; p<0.001). Conclusions: Regular PA has been shown to affect mental health positively. Therefore, it is important to improve health education and efforts to raise awareness among middle-aged Indonesians about the importance of PA in maintaining good mental health.

• 한국통신학회논문지
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• 제40권5호
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• pp.886-891
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• 2015

최근 전 세계적으로 인류의 건강을 위협하는 요소로 대기오염이 대두되고 있는 가운데 세계보건기구(WHO : World Health Organization)의 발표에 의하면 대기오염으로 인해 사람의 건강을 해친다고 발표했으며, 서울시의 '2011~2014년 7월 다중이용시설 실내 공기 질 측정 결과'에 의하면 대부분의 다중이용시설에서 실내공기오염도 기준을 위반한 것으로 조사되었다. 이러한 실내에서 발생하는 대기오염은 폐 질환, 천식, 기관지염 등의 질병을 유발하며 본 논문에서는 이와 관련하여 환경센서를 이용하여 실내공기질을 측정하고, 측정된 데이터를 분석하여 환기 개선에 필요한 액츄에이터 신호를 생성하고 실시간으로 실내 공기 질 측정 모니터링 시스템을 구현하여, 우리 생활에서 대기오염을 자율적으로 관리할 수 있도록 한다.

• 한국환경과학회지
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• 제29권2호
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• pp.191-200
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• 2020

This study provides a basis for research to establishing air quality standards in Gyeongnam. The trends and deviations in air quality concentrations and short-term environmental standards were analyzed. Furthermore, the regional standards and World Health Organization's (WHO) air quality guidelines (AQGs) were taken into account. The annual average PM₁₀ standard for cities anc counties ate 40 ㎍/㎥ and 30 ㎍/㎥, respectively. SO₂ and NO₂ are achieving national standards and need to be strengthened to the minimum regional standard and WHO AQGs. The PM_2.5 standard, which has not reached national standards, needs to be set at the level of national standards, and is also the target level for 2024 of the Gyeongsangnam and national PM_2.5 management plans.

• 대한한의학회지
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• 제39권1호
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• pp.55-62
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• 2018

Objectives: This study aims to investigate on the nomenclature of acupoints for the Healthcare Terminology Standard. Methods: We investigated the name of acupoints in "Standard Acupuncture Nomenclature (Second Edition)" of WHO, "WHO Standard Acupuncture Point Locations in The Western Pacific Region", "Principles of Meridians & Acupoints", "Details of Meridians & Acupoints" and "Acupuncture Medicine". Results: In books, we found that the name of acupoints was used differently in LI19, TE22, HT3, SI8, ST16, SI16, GB16 and BL8 acupoints. Conclusions: 口禾髎(LI19), 耳和髎(TE22), 少海(HT3), 小海(SI8), 膺窗(ST16), 天窗(SI16), 目窗(GB16), 絡卻(BL8) and 淵腋(GB22) in confused acupoints have been established as the terms of acupoints for the Healthcare Terminology Standard.

• 간호행정학회지
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• 제23권1호
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• pp.1-7
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• 2017

Nursing research in the United States (US) spans several decades. Many of the priorities/trends have stayed through the years. Today, the goal of producing evidence to support nursing care interventions coupled with the drive for Magnet Recognition has encouraged academic nurses (faculty) to work with nurse clinicians to form research teams. Interdisciplinary research teams have also formed to address growing concerns over patient safety and quality care. These issues are not just US issues but global ones. This article addresses US trends with the link to global research trends. The role that organizations such as the International Council of Nurses (ICN), the World Health Organization (WHO), and the Council of International Neonatal Nurses, Inc. (COINN) pay in shaping research agendas and promoting nursing research is highlighted. It emphasizes the key role that nurses, especially nurse leaders/administrators play in changing health outcomes through support of nursing research.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2019년도 춘계학술발표대회
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• pp.542-544
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• 2019

Changes in a person's health affect one's lifestyle and work activities. According to the World Health Organization (WHO), abnormal activity is growing faster in people aged 60 or more than any other age group in almost every country. This trend steadily continues and expected to increase further in the near future. Abnormal activity put these people at high risk of expected incidents since most of these people live alone. Human abnormal activity analysis is a challenging, useful and interesting problem among the researchers and its particularly crucial task in life and health care areas. In this paper, we discuss the problem of abnormal activities of old people lives alone at home. We propose Convolutional Neural Network (CNN) based model to detect the abnormal behaviors of elderlies by utilizing six simulated action data from daily life actions.

• 대한임상검사과학회지
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• 제50권3호
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• pp.245-252
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• 2018

한국 노인을 대상으로 대사증후군 예측인자로서 혈중 Non HDL-콜레스테롤과 중성지방/HDL-콜레스테롤 비율의 임상적용 가능성을 평가하고자 하였다. 2015년 1월부터 2017년 12월까지 경기지역 종합병원의 건강검진센터를 내원하여 건강검진을 실시한 65세 이상 노인을 1,543명을 대상으로 하였다. 대사증후군은 American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI)기준에 따라 진단하였다. 복부비만은 World Health Organization (WHO) West Pacific Region에서 제시하는 아시아-태평양인의 기준을 적용하였다. Non HDL-콜레스테롤은 총콜레스테롤과 HDL-콜레스테롤의 차이로 계산하였다. 대사증후군 예측력은 Non HDL-콜레스테롤보다 중성지방/HDL-콜레스테롤 비율이 높게 나타났다. 관련요인을 보정한 후 중성지방/HDL-콜레스테롤 비율은 1사분위수보다 4사분위수의 대사증후군 발병 위험이 높았다. 또한 대사증후군 발병을 예측하는 중성지방/HDL-콜레스테롤 비율의 적정 기준값은 2.8이었다. 중성지방/HDL-콜레스테롤 비율은 대사증후군 위험을 평가하는 간단하고 실용적인 지표가 될 수 있겠다.

• 한국임상약학회지
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• 제17권1호
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• pp.19-32
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• 2007

Objectives : It is necessary to monitor consumption of drugs in order to enhance promote appropriate use of drugs. Defined Daily Dose(DDD) of World Health Organization(WHO) has been used for evaluating the amount of medicine use. However, DDD of some drugs must be determined for drugs in Korea which are not listed by WHO. Our formulary follows ourself classification and DDD of some drugs must be determined since they exist only in Korea. This study was aimed to determine DDD value using RAND Appropriateness Methods and evaluate the amount of antibiotics use using DDD value. Methods : J01 antibiotics of WHO anatomical therapeutic chemical(ATC) classification were extracted from drug formulary. Antibiotics list without DDD was identified to determine their DDD with comprehensive review of references and recommendation of experts. defined. Review of reference was executed. of Expert panels were comprised of clinical pharmacist and clinical doctors. Modified Delphi Method was applied by survey and consensus meeting. Amount of antibiotic use was calculated by DDD/1000 inhabitants/day in the national level using health insurance claim data. Results : The result of 1 round, DDD values of 28 ingredients were determined from the first round of consensus meeting. With 2nd round meeting, 3 ingredients were deleted and DDD of 17 ingredients were decided. Analysis of antibiotic use in health insurance claim data showed 22.97 DDD/1000 inhabitants/day in 2003 year. Conclusion : This study can contribute to the establishment of DDD assignment and thus quantifying drug uses.