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Qu-Ji-Du-Huang-Wan for Essential Hypertension : Systemic Review and Meta-analysis (본태성 고혈압에 대한 기국지황환(杞菊地黄丸)의 효과에 관한 체계적 고찰 및 메타 분석)

  • Han, In Sik;Shin, Ji Hye;Cho, Yoon Young;Park, Hae Mo;Yang, Chang Sop;Jeong, Min Jeong;Jang, Insoo;Sun, Seung Ho
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.31 no.2
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    • pp.118-125
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    • 2017
  • The purpose of this study is to investigate the blood pressure reducing effect of Qi-Ju-Di-Huang-Wan (QJDHW) in adults with essential hypertension by using methods of systemic review and meta-analysis. Major search engines, such as PubMed, EMBASE, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, KISS, NDSL, RISS, OASIS, DBpia and so on, were used. The search period we used is from the start date of the search engine to October 30, 2016 and no language limits were placed. Randomized controlled trials using QJDHW in adults with essential hypertension were searched and extracted by two independent researchers. Meta-analysis was performed on outcome variables of the total effective rate (TER), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Risk of bias (RoB) of Cochrane was used to assess methodological quality. Thirteen studies were finally selected. We observed that the combined treatment of QJDHW and antihypertensive drug had 3.6 times the odds ratio of TER for blood pressure lowering than a single use of an antihypertensive drug. Additionally, mean differences of SBP and DBP were -8.88 mmHg (95% Confidential Interval (CI) -12.77 mmHg, -5.00 mmHg, P<0.00001), -7.09 mmHg (95% CI -9.93, -4.25, P <0.00001), respectively. Single use of QJDHW did not reduce blood pressure more than an antihypertensive drug. All items of RoB were unclear and the methodological quality was low. Our analysis suggests that the combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug. But due to low methodological quality, careful interpretation will be needed and systematic long-term clinical trials will be required.

Awareness on the Establishing and Operation of the Makerspaces in School Libraries (학교도서관 메이커스페이스 조성 및 운영에 대한 인식)

  • Kang, Bong-Suk;Jung, Youngmi
    • Journal of the Korean Society for Library and Information Science
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    • v.52 no.3
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    • pp.171-192
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    • 2018
  • With the spread of the maker movement and matching of the standards for the 21st century learners and the maker competencies, there is a social and temporal need for makerspaces building and maker education in school libraries, Prior to the establishment of the school library makerspaces, we intended to investigate the awareness of the school librarian on the creation and operation of the school library makerspaces. For this purpose, a questionnaire was constructed based on the theoretical review and the response data of 171 school librarians were collected through a web survey. Technical statistics, cross-analysis, and ANOVA were conducted using SPSS window 19.0 and content analysis was conducted on open-ended questions. The Questionnaires consisted of questions about whether the school library makerspace was installed or not and necessity, reason, and difficulty in creating and operating the makerspace. As a result of the study, it was found that the establishment of the school library makerspace was very low at 2.3%, and the recognition of the makerspace of the school librarian was below the normal level. On the other hand, the perception of necessity appeared to be more than normal, and the school library was generally considered to be a suitable place for the makerspace installation. However, negative opinions about the school library makerspaces were also raised in various aspects.

Shear Capacity of Reinforced Concrete Continuous T-Beams Externally Strengthened with Wire Rope Units (와이어로프로 외부 보강된 철근콘크리트 연속 T형 보의 전단내력)

  • Yang, Keun-Hyeok;Sim, Jae-Il;Byun, Hang-Yong
    • Journal of the Korea Concrete Institute
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    • v.19 no.6
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    • pp.773-783
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    • 2007
  • A simple unbonded-type shear strengthening technique for reinforced concrete beams using wire rope units is developed. Six two-span continuous T-beams externally strengthened with wire rope units and an unstrengthened control beam were tested. The main variables investigated were the amount and prestressing force of wire rope units. All specimens had the same geometrical dimension and arrangement of internal reinforcement. Influence of the distribution of vertical stresses in beam web owing to the prestressing force of wire rope units on the diagonal shear cracking load and the ultimate shear capacity of beams tested is presented. Based on the current study, it can be concluded that the amount and initial prestress of wire rope should be limited to be above 2.5 times the minimum shear reinforcement ratio specified in ACI 318-05 and below 0.6 times its own tensile strength, respectively, to ensure the enhancement of shear capacity and ductile failure mode of the strengthened beams. A numerical analysis based on the upper-bound theorem is developed to assess the shear capacity of continuous T-beams strengthened with wire rope units. From the comparisons of measured and predicted shear capacities, a better agreement is achieved in the proposed numerical analysis than in empirical equations recommended by ACI 318-05.

A Study on Moment Gradient Factor for Inelastic Lateral-Torsional Buckling of Stepped I-Beam Subjected to Uniformly Distributed Load and End Moment (연속경간 하중을 받는 I형 스텝보의 비탄성 횡-비틀림 좌굴강도산정을 위한 모멘트 구배계수 연구)

  • Son, Ji-Min;Park, Jong-Sup
    • Journal of the Korean Society of Hazard Mitigation
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    • v.9 no.4
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    • pp.1-9
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    • 2009
  • This paper investigates inelastic lateral-torsional buckling of stepped beams subjected to uniformly distributed load and end moments. A three-dimensional finite-element program ABAQUS (2007) and a regression program MINITAB(2006) were used to analytically develop new design equation for singly and doubly stepped beams with simple boundary condition. The flanges of the smaller cross-section in the stepped beams were fixed at 30.48 by 2.54 cm, whereas the width and thickness of the flanges of the larger cross-section varied. The web thickness and height of the beams were kept at 1.65 cm and 88.9 cm, respectively. The ratios of the flange thickness, flange width, and stepped length of beam are considered with analytical parameters. Two groups of 27 cases and 36 cases, respectively, were analyzed for doubly and singly stepped beams in the inelastic buckling range. The combined effects of residual stresses and geometrical imperfection on inelastic lateral-torsional buckling of beams are considered. The distributions of residual stress of the cross-section is same as shown in Pi and Trahair (1995) and the initial geometric imperfection of the beam is set by central displacement equal to 0.1% of the unbraced length of beam. The comparisons between results from proposed equations and the results from finite element analyses were presented in this paper. The maximum differences of two results are of 13% for the doubly stepped beam and 10% for the singly stepped beam. The proposed equations definitely improve current design methods for the inelastic lateral-torsional buckling problem and increase efficiency in building and bridge design.

Elicitation of Collective Intelligence by Fuzzy Relational Methodology (퍼지관계 이론에 의한 집단지성의 도출)

  • Joo, Young-Do
    • Journal of Intelligence and Information Systems
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    • v.17 no.1
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    • pp.17-35
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    • 2011
  • The collective intelligence is a common-based production by the collaboration and competition of many peer individuals. In other words, it is the aggregation of individual intelligence to lead the wisdom of crowd. Recently, the utilization of the collective intelligence has become one of the emerging research areas, since it has been adopted as an important principle of web 2.0 to aim openness, sharing and participation. This paper introduces an approach to seek the collective intelligence by cognition of the relation and interaction among individual participants. It describes a methodology well-suited to evaluate individual intelligence in information retrieval and classification as an application field. The research investigates how to derive and represent such cognitive intelligence from individuals through the application of fuzzy relational theory to personal construct theory and knowledge grid technique. Crucial to this research is to implement formally and process interpretatively the cognitive knowledge of participants who makes the mutual relation and social interaction. What is needed is a technique to analyze cognitive intelligence structure in the form of Hasse diagram, which is an instantiation of this perceptive intelligence of human beings. The search for the collective intelligence requires a theory of similarity to deal with underlying problems; clustering of social subgroups of individuals through identification of individual intelligence and commonality among intelligence and then elicitation of collective intelligence to aggregate the congruence or sharing of all the participants of the entire group. Unlike standard approaches to similarity based on statistical techniques, the method presented employs a theory of fuzzy relational products with the related computational procedures to cover issues of similarity and dissimilarity.

Repair of Aortic Coarctation and Arch Hypoplasia in Infants and Children (영아 및 소아에서의 대동맥궁의 형성부전을 포함한 대동맥 교약증의 수술요법 -21년간의 수술 경험-)

  • Sin, Yun-Cheol;Lee, Jeong-Ryeol;Kim, Yong-Jin;No, Jun-Ryang
    • Journal of Chest Surgery
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    • v.29 no.3
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    • pp.285-291
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    • 1996
  • We have reviewed 157 cases of coarctation of aorta in the age of infancy and children from March 1973 to december 1994. Patients were 9) males and 64 females, and their age ranged from one month to fifteen years (23.8 $\pm$ 41.6months) with 113 infant cases. In the infantile age, congestive heart failure was the most common chief complaint (781113), and above that age, asymptom was most common (15/44). Isolated coarctation was present in 31 patients, and 9 patients had additional atrial septal defect (group I), 73 patients had associated ventricular septal defect (group II), and 44 patients had associated complex intracardiac lesions(group III). Aortic arch hypoplasia was present in 17 patients. , The operations perf'ormed were subclavian flap angioplasty in 71 patients, resection and anastomosis in 32 patients, patch aortoplasty in 26 patients, resd extended end-!o-end anastomosis in 27 patients, and direct angioplasty with resection of web in 1 patient. The early mortality was 17.2% (27/157) and re-coarctation rate was 18.0% (281157). The most common complication was respiratory problem in infants and postoperative hypertension in children.

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Updated Assessment of the Association of the XRCC1 Arg399Gln Polymorphism with Lung Cancer Risk in the Chinese Population

  • Yang, Hai-Yan;Yang, Si-Yu;Shao, Fu-Ye;Wang, Hai-Yu;Wang, Ya-Dong
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.2
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    • pp.495-500
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    • 2015
  • Background: Published studies have reported relationships between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and lung cancer risk in Chinese population. However, the epidemiological results remained controversial. The objective of this study was to clarify the association of XRCC1 Arg399Gln polymorphism with lung cancer risk in the Chinese population. Materials and Methods: Systematic searches were performed through the database of Medline/Pubmed, Web of Science, Embase, CNKI and WanFang Medical Online. Odds ratios (ORs) with 95% confidence interval (95%CI) were calculated to estimate the strength of the association. Results: Overall, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.36, 95%CI: 1.09-1.71) in the Chinese population on the basis of 19 studies with 5,416 cases and 5,782 controls. We did not observe any association between XRCC1 codon 399 Arg/Gln and Arg/Gln+Gln/Gln polymorphisms and lung cancer risk (OR=1.00, 95%CI: 0.92-1.08 and OR=1.05, 95%CI: 0.97-1.13, respectively). Limiting the analysis to studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.18, 95%CI: 1.01-1.38). When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43). Conclusions: Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population. Larger sample size studies are required to confirm our findings.

Gene Polymorphism of XRCC1 Arg399Gln and Cervical Carcinoma Susceptibility in Asians: A Meta-analysis Based on 1,759 Cases and 2,497 Controls

  • Liu, Yi-Ting;Shi, Jing-Pu;Fu, Ling-Yu;Zhou, Bo;Wang, Hai-Long;Wu, Xiao-Mei
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.189-193
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    • 2013
  • Many epidemiological studies in Asian populations have investigated associations between the Arg399Gln gene polymorphism of X-ray repair cross complementing gene 1 (XRCC1) and risk of cervical carcinoma, but no conclusions have been available because of controversial results. Therefore a meta-analysis was conducted for clarification. Relevant studies were identified by searching the Pubmed, Embase, the Web of Science, Cochrane Collaboration's database, Chinese National Knowledge Infrastructure (CNKI), Wanfang database and China Biological Medicinse (CBM) until September, 2012. A total of eight studies were included in the present meta-analysis, which described 1,759 cervical carcinoma cases and 2,497 controls. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) as effect size were calculated by fixed-effect or random-effect models. The overall results indicated that the XRCC1-399G/A polymorphism was marginally associated with cervical carcinoma in Asians: OR (95%CI): 1.16 (1.07, 1.26) in the G/A vs G/G inheritance model, 1.24 (0.87, 1.76)in A/A vs G/G inheritance model, 1.13 (1.01, 1.27) in the dominant inheritance model and 1.18 (0.94, 1.47) in the recessive inheritance model. Subgroup analyses on sample size showed no significant correlation in the small-sample size group but the large-sample size group was consistent with the outcomes of overall meta-analysis. In the subgroup analysis by regions, we only found significant association under the G/A vs G/G inheritance model in the Chinese population. For the non-Chinese populations, no correlation was detected in any genetic inheritance model. In the Asian populations, XRCC1-399G/A gene polymorphism was implied to be associated with cervical carcinoma.

A Study on Inelastic Lateral-Torsional Buckling of Stepped I-Beams Subjected to Pure Bending (균일모멘트를 받는 계단식 I형보의 비탄성 횡-비틀림 좌굴에 관한 연구)

  • Kim, Jong Min;Kim, Seung Jun;Park, Jong Sup;Kang, Young Jong
    • Journal of Korean Society of Steel Construction
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    • v.20 no.2
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    • pp.237-246
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    • 2008
  • The cross-sections of continuous multi-span beams sometimes suddenly increase, or become stepped, at the interior supports of continuous beams to resist high negative moments. The three-dimensional finite-element program ABAQUS (2006) was used to analytically investigate the inelastic lateral-torsional buckling behavior of stepped beams subjected to pure bending moment and resulted in the development of design equations. The flanges of the smaller cross-section were fixed at 30.48 by 2.54 cm, whereas the width and/or thickness of the flanges of the larger cross-section varied. The web thickness and height of beam was kept at 1.65 cm and 88.9 cm, respectively. The ratios of the flange thickness, flange width, and stepped length of beams are considered analytical parameters. Two groups of 27 cases and 35 cases, respectively, were analyzed for double and single stepped beams. The combined effects of residual stresses and geometrical imperfection on inelastic lateral-torsional buckling of beams are considered. First, the distributions of residual stress of the cross-section is same as shown in Pi, etc (1995), and the initial geometric imperfection of the beam is set by central displacement equal to 0.1% of the unbraced length of beam. The new proposed equations definitely improve current design methods for the inelastic LTB problem and increase efficiency in building and bridge design. The proposed solutions can be easily used to develop new design equation for inelastic LTB resistance of stepped beams subjected to general loading condition such as a concentrated load, a series of concentrated loads or uniformly distributed load.

Secular Trends and Influencing Factors for the Early Menarche among Korean Middle and High School Girls (우리나라 중고등학교 여학생의 조기 초경 경향과 영향요인)

  • Han, Dallong;Lee, Jongeun;Kim, Seonho
    • The Journal of the Korea Contents Association
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    • v.16 no.3
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    • pp.319-327
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    • 2016
  • The objective of this study is to identify the secular trend in age at menarche and to investigate the factors influence the early menarche(<12 years old) among Korean middle and high school girls. We analyzed data from the Korean Youth Risk Behavior Web-based Survey(KYRBWS) 2006-2014. This study was a descriptive study of 216,917 Korean middle and high school girls born between 1988 and 2002. Linear trends test performed to assess the trend age at menarche and percentage of early menarche. Multiple logistic regression analysis was to assess the risk factors influence the early menarche. Mean age at menarche decreased from $12.61{\pm}1.32$ years for middle and high school girls born 1988 to $11.88{\pm}0.75$ years for those born 2002(p for trends<.001). Percentage of early menarche increased from 19.7% to 25.2% between 1988 and 2002(p for trends<.001). Living in city, higher stress level, short sleep duration, and higher body mass index were associated with an early menarche among middle and high school girls(all p<.001). We found that age at menarche is still falling in the Korean adolescents, and it need intervention strategies to control the early menarche.