• 대한약침학회지
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• 제17권3호
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• pp.16-24
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• 2014

Objectives: Alcohol abuse is a public issue and one of the major causes of liver disease worldwide. This study was aimed at investigating the protective effect of Ganoderma lucidum pharmacopuncture (GLP) against hepatotoxicity induced by acute ethanol (EtOH) intoxication in rats. Methods: Sprague-Dawley (SD) rats were divided into 4 groups of 8 animals each: normal, control, normal saline pharmacopuncture (NP) and GLP groups. The control, NP and GLP groups received ethanol orally. The NP and the GLP groups were treated daily with injections of normal saline and Ganoderma lucidum extract, respectively. The control group received no treatment. The rats in all groups, except the normal group, were intoxicated for 6 hours by oral administration of EtOH (6 g/kg BW). The same volume of distilled water was administered to the rats in the normal group. Two local acupoints were used: Qimen (LR14) and Taechung (LR3). A histopathological analysis was performed, and the liver function and the activities of antioxidant enzymes were assessed. Results: GLP treatment reduced the histological changes due to acute liver injury induced by EtOH and significantly reduced the increase in the alanine aminotransferase (ALT) enzyme; however, it had an insignificant effect in reducing the increase in aspartate aminotransferase (AST) enzyme. It also significantly ameliorated the superoxide dismutase (SOD) and the catalase (CAT) activities. Conclusion: The present study suggests that GLP treatment is effective in protecting against ethanol-induced acute hepatic injury in SD rats by modulating the activities of ethanol-metabolizing enzymes and by attenuating oxidative stress.

• 한국지반공학회논문집
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• 제34권7호
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• pp.29-38
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• 2018

액상화 시 지반-말뚝 시스템의 동적 거동을 정확히 예측하기 위해 상용 유한 차분 프로그램인 FLAC3D를 이용하여 시간영역에서 3차원 수치 모델링을 수행하였다. 지반의 전단변형에 따른 간극수압의 발달을 직접적으로 모사하기 위해 유효응력 해석법을 이용한 액상화 모델인 Finn model을 적용하였으며 Mohr-Coulomb 탄소성 모델에 접목되어 해석이 수행되었다. 이력감쇠모델을 적용하여 지반 비선형 거동을 고려하였으며 지반과 말뚝 간의 분리현상, 미끄러짐 현상을 모사하는 인터페이스 모델을 적용하였다. 경계조건으로써 단순화 연속체 모델링 기법을 도입하여 반사파의 생성을 막고 해석 효율을 증가시켰으며 적절한 최대지반탄성계수와 항복 깊이의 설정으로 비선형 거동을 정확히 모사하고자 하였다. Wilson(1998)이 수행한 원심모형시험 케이스 중 상부지반 상대밀도가 55%인 모델을 이용하여 제안된 모델링 기법의 캘리브레이션을 수행한 결과, 수치해석으로부터 도출된 깊이 별 과잉간극수압 비-시간 이력, 휨모멘트-시간이력, 말뚝 두부 변위-시간이력이 실험 결과를 잘 모사하였다. 상부지반 상대밀도가 30%인 모델의 결과를 이용하여 제안된 모델링 기법의 적용성 평가를 수행한 결과, 수치해석으로부터 도출된 지반 및 말뚝 응답이 실험 결과를 잘 모사하였으며 제안된 모델링 기법이 지반-말뚝 시스템의 액상화 거동을 적절히 모사한다고 판단되었다.

• Preventive Nutrition and Food Science
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• 제21권3호
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• pp.221-226
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• 2016

A new type of doenjang was manufactured by mixing soaked soybean, koji (Rhizopus oryzae), cheonggukjang (Bacillus amyloliquefaciens MJ1-4 and B. amyloliquefaciens EMD17), and Pichia farinosa SY80 as a yeast, salt, and water, followed by fermentation with koji that was made by fermenting whole wheat with R. oryzae. The mixed culture doenjang was designed to have a more palatable flavor and stronger biological activities than the conventional product. The extract of mixed culture doenjang showed higher antioxidant activity than the commercial doenjang as evaluated by the ferric reducing antioxidant power assay although it was not significantly different from the commercial product in 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities. Further, the mixed culture doenjang reduced intracellular reactive oxygen species levels and protected cells from glutamate-induced cytotoxicity more efficiently in human hippocampal HT22 neuroblastoma cells than the commercial doenjang. In conclusion, a newly-developed mixed culture doenjang had a strong antioxidant activity in vitro and cultured cell model systems, exhibited a potential to prevent oxidative stress-associated disorders although animal and clinical studies are needed to confirm its in vivo efficacy.

• 한국지반신소재학회논문집
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• 제2권1호
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• pp.47-55
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• 2003

14가지 니들펀치 부직포 지오텍스타일의 섬유구성인자인 두께, 기공도, 섬유장 및 직경 등이 수평투수성에 미치는 영향을 평가하였으며, 두께변화, 수평투수도, 압축 하중 하에서의 수평투수성을 구성방정식에 의해 분석, 평가하였다. 그리고 섬유 패킹 밀도가 다른 라미나(laminar) 지오텍스타일 복합재료를 제조하여 라미나 구조가 수직투수성에 미치는 영향을 평가하였다. 수평투수도는 부직포 지오텍스타일의 두께가 증가할수록 커졌으며, 기공도와 섬유직경이 커질수록 수평투수계수는 증가하였다. 수직응력이 증가할수록 기공도의 영향은 감소하였으며, 섬유장이 길수록 수평투수계수는 약간 크게 나타났다. 구성섬유의 직경이 클수록 수평 투수계수는 커지며, 직경의 비슷할수록 유사한 투수계수를 나타내었다. 라미나 지오텍스타일의 수직 투수성은 내부 경계면에서의 손실 수두에 영향을 받으며, 경계면에서 투수로의 연결형상은 bell mouth형이거나 부드러운 유입관 형태로 평가 되었다.

• 한국지반공학회논문집
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• 제21권10호
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• pp.61-71
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• 2005

Cemented Sand and Gravel(CSG)재료는 댐 수몰지로부터 쉽게 얻을 수 있는 하상자갈과 굴착토를 물, 시멘트와 함께 혼합한 재료를 총칭하는 것이다. 최근 일본에서는 가물막이댐과 본 댐 축조공사에 CSG 재료를 활용함으로써 댐 축조에 필요한 채석장 개발과 플랜트 건설에 투입되는 제반경비와 시공 공기를 줄일 수 있게 되었으며, 석산개발에 따른 환경훼손을 완화할 수 있게 됨으로써 경제성과 환경적 측면에서 그 활용성이 주목받고 있다. 본 연구에서는 CSG 재료의 기초적인 강도특성을 파악하기 위하여 단위시멘트량를 변화시켜 다짐시험, 일축압축시험 그리고 대형 삼축압축시험을 실시하고 단위 시멘트량과 재령에 따른 압축강도, 탄성계수 그리고 응력-변형특성 등을 검토하였으며 각 인자별 상관식을 제시함으로써 CSG 공법설계 및 해석에 필요한 기초적인 자료를 제공하고자 한다.

• 한국양식학회지
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• 제16권1호
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• pp.31-36
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• 2003

사육 염분의 급성교환 실험에서, 해수의 담수화가 1시간 이내에 이루어졌을 경우 농어, 유어들은 다소의 스트레스 반응과 이온의 변화가 있었으며. 24시간 뒤에도 정상 회복이 더딘 것으로 나타났다. 그러나 5시간에 걸친 담수화 과정 중에 스트레스 반응은 담수화 직후 높게 나타났지만, 24시간 후 빠르게 정상으로 회복되는 것을 알 수 있다. 장기간 염분별 사육실험 결과, 20 ppt가 가장 높은 사료섭식량을 나타내었고, 2 ppt구가 가장 낮았다. 사료효율 또한 2 ppt구이 가장 낮게 나타났고, 10 ppt구가 가장 높았으며, 실험구별 유어의 성장은 실험 종료시 10, 20 및 30 ppt구가 2 ppt보다 유의하게 높은 길이 성장을 보였다. 무게 성장은 실험 종료시 20 ppt가 가장 빠른 무게 성장을 나타내었고, 다음으로 30 ppt, 10 ppt. 2 ppt순으로 나타났다. 염분별 사육유어의 혈액 성상은 2 ppt~30 ppt 사육수에 있어 농어 유어들의 혈액 조성은 큰 차이가 없는 것으로 나타났다.

• Biomolecules & Therapeutics
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• 제4권3호
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• pp.285-290
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• 1996

This study was designed to determine the effect of newly synthesized antiulcer agent, 5-pyrrolyl-6-halo-2-(pyridyl-2-methylthio)benzimidazole derivatives (IY-81233), on various experimental ulcers and on the secretion of prostaglandin $E_2(PGE_2)$ into the gastric lumen of rat. IY-81233 was previously reported to have a strong inhibitory effect on $H^+/K^$-ATPase and on gastric acid secretion in rats. Oral administration of IY-81233 at concentrations of 0.2, 2.0, and 20 mg/kg inhibited gastric lesions and duodenal ulcer induced by indomethacin, HCI-ethanol, water-immersion stress, cysteamine, and acetic acid in a dose dependent manner. Their IC$IC_{50}$ values were 3.4, 1.4, 0.8, 1.3, and 1.2 mg/kg, respectively. These results indicate that IY-81233 is a potent antiulcer agent although it is slightly less potent than omeprazole in healing of gastritis and ulcers. The secretion of $PGE_2$ into gastric lumen was also investigated in relation to the cytoprotective effect by IY-81233 in rats. The $PGE_2$ level was not changed significantly by an oral administration of IY-81233, suggesting that IY-81233 has little effect on the gastric protection. Therefore, it can be concluded that IY-81233 exerts prominent antiulcer activity by suppressing gastric acid secretion via an inhibition of a proton pump and not by protecting the gastrointestinal mucosa against various ulcerative stimuli.

• Journal of Ginseng Research
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• 제30권3호
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• pp.106-111
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• 2006

Adverse changes in individual's biochemistry under heavy metal stress are directly linked with its metabolic activity and health status. The present investigation highlights the differences in protecting role of Panax ginseng extract against mercuric chloride induced alterations in serum proteins. The assessment was based on dividing fifty albino rats into two sets, one for acute and the other for sub-acute study. All the sets had five groups with five albino rats in each i.e. control group, mercuric chloride treated group, Panax ginseng extract treated group, mercuric chloride followed by Panax ginseng extract treated group and Panax ginseng extract followed by mercuric chloride treated group. Mercuric chloride was given orally 0.926 mg/kg body weight for acute set and 0.044 mg/kg body weight for sub-acute set after LD50 (9.26 mg/kg body weight) determination by probitt analysis. 10 mg/kg body weight Panax ginseng extract was given in both acute and sub-acute sets after incorporating safety trials. The control group received tween-20 and distilled water only. The result exhibited significantly reduction (P<0.01) in serum protein, albumin and globulin following mercuric chloride intoxication whereas significant (P<0.01) enhancement in other groups with Panax ginseng extract as an ingredient confirming its protective role. All serum samples were also electrophoresed in 10% SDS with standard marker using discontinuous buffering system. Gradual disappearance of alpha-2 and beta-1 globulin bands from electrophoretic pattern was observed, while a single sharp band was observed between beta-2 and gamma globulin in serum protein pattern of acutely mercuric chloride treated rats. However, this band could not be visualized in sub-acute studies. Panax ginseng extract exhibits a better protection after acute intoxication.

• 한국농공학회지
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• 제38권6호
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• pp.83-95
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• 1996

The normal cement concrete is widely used material to build the construction recently, but it has a fault to increase the dead load on account of its unit weight is large compared with strength. So, main purpose of this study was to establish the physical and mechanical properties of lightweight concrete using expanded polystyrene bead on fine aggregate and natural gravel, expanded clay and pumice stone on coarse aggregate. The test rusults of this study are summarized as follows; 1. The water-cement ratio of concrete using pumice stone was larger than that of the concrete using natural gravel and expanded clay. 2. The unit weights of concrete using pumice stone and expanded caly were shown less than 1,000g/$m^3$. 3. The compressive strengths of all types were shown less than 60kg/$cm^2$, tensile and bending strengths were shown less than l3kg/$cm^2$ and 3lkg/$cm^2$$^2$, respectively. 4. The pulse velocity of concrete was shown similar with using natural gravel and pumice stone, and shown the lowest using pumice stone. 5. The dynamic modulus of elasticity of concrete was shown considerably smaller, and shown the lowest using pumice stone. 6. The static modulus of elasticity of concrete using expanded clay and pumice stone were shown considerably smaller, and shown 22% ~29% as compared with the dynamic modulus of elasticity. 7. The stress-strain curves of concrete were shown similar, generally. And the curves were repeated at short intervals increase and decreased irregularly.

• 한국수산과학회지
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• 제36권6호
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• pp.716-722
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• 2003

This study determined the optimum dosage for coagulation reactions of red tide organisms (RTO) using a combination of ignited oyster shell powder (10sp) and loess and examined the electrokinetic and rheological characteristics of their flocs. Two kinds of RTO, Cylindrotheca closterium and Skeletonema costatum, were sampled in Masan Bay and cultured in the laboratory. Coagulation experiments were conducted using various concentrations of IOSP, loess, IOSP+1oess, RTO, and a jar tester RTO cell numbers were counted for both the supernatant and RTO culture solution. The removal rates increased rapidly with increasing IOSP concentrations up to 50 mg/L and loess concentrations up to 800 mg/L. A removal rate of $100\%$ was reached at 400 mg/L of IOSP and 6,400 mg/L of loess. The highest increment $(16.7\%)$ of the rates of coagulation reaction occurred using both IOSP and loess (50+200 mg/L) in comparison with IOSP alone. The rate of coagulation reaction using both IOSP and loess (50+200 mg/L), $90.6\%,$ was similar to employing either IOSP of 150 mg/L or loess of 3,200 mg/L. All of the coagulation liquids for RTO, IOSP (200 mg/L), loess (200 ma/L), and IOSP+1oess (200+200 mg/L) revealed non-Newtonian fluid properties and therefore their shear rate vs. shear stress curves were non-linear. The coagulation liquids revealed elastic body properties at a lower shear rate increasing in the following order: RTO, IOSP (200 mg/L), loess (200 mg/L), and IOSP+1oess (200+200 mg/L. IOSP+1oess (200+200 mg/L) especially demonstrated plastic flow properties at a lower shear rate.