• Journal of Korean Medicine Rehabilitation
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• v.32 no.1
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• pp.1-19
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• 2022

Objectives This study aims to evaluate the wound healing effects of oral administered hot water extracts of Korean black ginseng (KBG). Methods 40 C57BL/6 mice were divided into five groups; normal, control, vitamin E 200 mg/kg, KBG 100 mg/kg, KBG 200 mg/kg, each n=8. Skin wounds were made in the back of all mice except normal group using biopsy punches. Wounds were observed on days 7 and 14 after injury. The anti-oxidant and inflammatory protein levels were evaluated using western blotting. Skin tissue was analyzed by hematoxylin & eosin and Masson's trichrome staining method. Results KBG significantly accelerated reducing wound area. KBG significantly decreased myeloperoxidase activity. KBG significantly decreased oxidative stress factors such as NADPH oxidase-4 and p22^phox and increased antioxidant enzymes including nuclear factor erythroid 2-related factor2, kelch-like ECH-associated protein-1, heme oxygenase-1, superoxide dismutase, catalase and glutathione peroxidase-1/2. Moreover, KBG significantly decreased inflammation factors including nuclear factor-κB, phosphorylated inhibitor of κBα, cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-α and interleukin (IL)-6 and increased anti-inflammation cytokine such as IL-4 and IL-10. In addition, KBG significantly increased tight junction proteins including claudin-1, claudin-3, claudin-4. In histopathologic, KBG made the epithelium thin and uniform, and accelerated the remodeling of collagen. Conclusions The results suggest that KBG has healing effects on skin wound in mice by anti-inflammatory and antioxidant activity.

• The Korea Journal of Herbology
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• v.34 no.1
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• pp.99-107
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• 2019

Objectives : Cudrania tricuspidata (C. tricuspidata) is well-known traditional herbal remedy and its root, leaf and fruit were used for treatment of inflammation, tumor and painkilling. However, effect of C. tricuspidata fruit on tight junction is still unknown. The aim of this research was to determine the effect of C. tricuspidata fruit extract on human keratinocyte HaCaT cells. Methods : The antioxidant effects of water extract of C. tricuspidata (WECT) and ethanol extract of C. tricuspidata (EECT) were analyzed by using an ABTS assay. To confirm the cytotoxicity of WECT and EECT, MTS assay was performed. The mRNA expression levels of tight junction related genes were analyzed using quantitative RT-PCR analysis. Furthermore, dispase assay was used to investigate the alteration of cell-cell adhesion strength of EECT treated HaCaT cells. Results : WECT and EECT showed strong antioxidant activity. No obvious cytotoxicity was observed in both WECT and EECT until $2.0mg/m{\ell}$ concentration. The mRNA expression level of Claudin 6 were significantly increased by EECT treatment, whereas the WECT did not affect the expression of Claudin 6. Furthermore, EECT treatment enhances cell-cell adhesion strength. Conclusions : In this study, we investigated the physiological activities of the extracts of Cudrania tricuspidata fruit extracts on human keratinocytes by two different extraction methods. EECT might have an anti-aging activity on the skin by reducing oxidative stress. Moreover, it may be a useful ingredient in atopic dermatitis and skin-moisturizing, given its effects of altering Claudin 6 gene expression and enhancing cell-cell adhesion strength.

• Journal of the Korean Geotechnical Society
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• v.38 no.8
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• pp.7-15
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• 2022

Most studies have conducted cryogenic triaxial compression tests with frozen specimens prepared in a separate mold by one-directional freezing. This method has the potential to generate residual stress in a frozen specimen and cannot be adopted to simulate the application of the artificial ground freezing method in the field. Therefore, in this study, novel equipment and procedure for the cryogenic triaxial compression test were proposed to overcome the limitations of existing test methods. Therefore, the mechanical characteristics of frozen sand, considering the effect of temperature and confining pressure, were evaluated. As the freezing temperature decreased, the brittleness of frozen sand increased, and the strength increased due to a decrease in the unfrozen water content and an increase in the ice strength. A higher confining pressure resulted in an increase in interparticle friction and the pressure melting phenomenon, which caused strength reduction. Thus, it was found that the mechanical behaviors of frozen sand were simultaneously affected by both temperature and confining pressure.

• Computers and Concrete
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• v.29 no.6
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• pp.407-418
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• 2022

This paper numerically investigates the effect of changes in the mechanical properties (displacement, strain, and stress) of the ultra-high-performance concrete (UHPC) without rebar and the reinforced concrete (RC) using steel re-bars. This reinforced concrete is mostly used in the concrete bridge decks. A mixture of sand, gravel, cement, water, steel fiber, superplasticizer, and micro silica was used to fabricate UHPC specimens. The extended finite element method as used in the ABAQUS software is applied for considering the mechanical properties of UHPC, RC, and ordinary concrete specimens. To calibrate the ABAQUS, some experimental tests have been carried out in the laboratory to measure the direct tensile strength of UHPC by the compressive-to-tensile load converting (CTLC) device. This device contains a concrete specimen and is mounted on a universal tensile testing apparatus. In the experiments, three types of mixed concrete were used for UHPC specimens. The tensile strength of these specimens ranges from 9.24 to 11.4 MPa, which is relatively high compared with ordinary concrete specimens, which have a tensile strength ranging from 2 to 5 MPa. In the experimental tests, the UHPC specimen of size 150×60×190 mm with a central hole of 75 mm (in diameter)×60 mm (in thickness) was specially made in the laboratory, and its direct tensile strength was measured by the CTLC device. However, the numerical simulation results for the tensile strength and failure mechanism of the UHPC were very close to those measured experimentally. From comparing the numerical and experimental results obtained in this study, it has been concluded that UHPC can be effectively used for bridge decks.

• Journal of Ginseng Research
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• v.19 no.1
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• pp.31-38
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• 1995

Antioxidant effect of Korean ginseng (Panax ginseng C.A. Meyer) was investigated in rats. Long-term administration of ginseng water extract protected the activity of liver cytosotic SOD, catalase and glutathione peroxidase from being significantly decreased with advancing age (p<0.05). It was more effective toward glutathione peroxidase than other antioxidant enzymes. However, the level of sulfhydryl compounds and its related enzymes such as glutathione reductase and glutathione-5-transferase was not significantly changed by the administration of ginseng. Liver microsomal formation of reactive oxygen species such as superoxide and hydrogen peroxide did not show a significant difference between two groups although it was slightly decreased with age, but lipid peroxidizability of microsomal membrane induced by a prooxidant was slightly lower in ginseng-treated rats. Interestingly, antioxidant capacity of plasma from ginseng treated rats on autooxidation of ok-brain homogenates was much higher than that of normal ones. However, resistance of RBC membrane against oxidative stress showed a similar tendency. The content of serum TBA reactive substances lowered consistently in the rats treated with r ginseng at all corresponding age and a significant difference between two groups was found at 24 months of age (p<0.05). Ginseng extract protected lipid peroxidation in brain and liver. This protection was more effective in the stressed rats imposed by immobilization than normal ones. In conclusion, ginseng water extract protected the age related deterioration of major antioxidant enzymes, and this effect was more striking with increasing duration of treatment. This comprehensive antioxidant action of ginseng seems to be bra certain action of ginseng other than a direct antioxidant action, which might be a long term normalizing effect through the harmony of various components.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.202-202
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• 2023

전 세계적으로 지구 온난화로 인해 발생한 가뭄은 사회적, 경제적, 환경적으로 막대한 피해를 야기하고 있다. 국내의 경우, 2022년부터 현재까지 지속되고 있는 가뭄 상황은 강수의 지역적 편차로 인해 남부 지역 중심으로 극심한 피해가 발생하였다. 남부 지역의 주요 용수공급원인 영산강, 섬진강권역의 용수 공급율은 예년의 57%(3.8억 톤)에 불과하며, 일부 도서·산간 지역은 용수공급이 제한되는 현상까지 발생하였다. 이러한 가뭄 피해를 대비하기 위해 초기에 모니터링을 통한 선제적 대응 방안을 구축해야 한다. 가뭄 모니터링의 경우 미계측 지역에 대한 모니터링 방법으로 주기적이고 균질한 자료를 제공 받을 수 있는 위성영상을 활용한 연구가 수행되고 있다. 가뭄을 정량적으로 분석하고 판단하기 위해 가뭄지수를 활용하고 있으며, 대표적인 가뭄지수는 지상 관측강수량자료를 활용한 확률분포 기반의 표준강수지수 (Standardized Precipitation Index, SPI)와 강수 및 기온의 변동성이 포함된 표준강수증발산지수 (Standardized Precipitation Evapotranspiration Index, SPEI)가 있으며, 위성영상 자료를 활용한 가뭄지수인 증발스트레스지수(Evaporative Stress Index, ESI) 등이 있다. 본 연구에서는 강수와 기온을 고려한 가뭄지수인SPEI와 위성영상 기반의 가뭄지수인 ESI를 활용하여 2022년 남부 지역의 가뭄 사상을 중심으로 지표별 시공간적 변화를 분석하고자 한다. SPEI의 경우 기상관측소 지점자료의 기온과 강수량을 활용하였으며, Terra 위성의 MODIS (Moderate Resolution Imaging Spectroradiometer) 센서에서 제공되는 위성영상자료를 활용한 ESI는 미계측 지역에 대한 가뭄 판단을 위해 시·군별로 세분화하여 산정하였다.

• Journal of the Korean Geotechnical Society
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• v.24 no.10
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• pp.25-32
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• 2008

Based on recent studies, the side resistance of rock socketed drilled shafts was affected by unconfined compressive strength of rock, socket roughness, rock types and joints, and initial normal stress. Especially, the socket roughness was affected by rock types and joints, drilling methods, and diameters of pile. In this study, a new roughness measurement system (BKS-LRPS, Backyoung-KyungSung Laser Roughness Profiling System) usable in water was developed. Based on the laboratory model tests, an EMD (Effective Measurement Distances) according to various turbidity was proposed as $EMD=1149.2{\times}T_{b}^{-0.64}$.

• Geomechanics and Engineering
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• v.33 no.2
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• pp.175-182
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• 2023

In general, the design of structures and its construction processes are fundamentally dependent on their foundation and supporting ground. Thus, it is imperative to understand the behavior of the soil under certain stress and drainage conditions. As it is well known that certain characteristics and behaviors of soils with fines are highly dependent on water content, it is critical to accurately measure and identify the status of the soils in terms of water contents. Liquid limit is one of the important soil index properties to define such characteristics. However, liquid limit measurement can be affected by the proficiency of the operator. On the other hand, dynamic properties of soils are also necessary in many different applications and current testing methods often require special equipment in the laboratory, which is often expensive and sensitive to test conditions. In order to address these concerns and advance the state of the art, this study explores a novel method to determine the liquid limit of cohesive soil by employing video-based vibration analysis. In this research, the modal characteristics of cohesive soil columns are extracted from videos by utilizing phase-based motion estimation. By utilizing the proposed method that analyzes the optical flow in every pixel of the series of frames that effectively represents the motion of corresponding points of the soil specimen, the vibration characteristics of the entire soil specimen could be assessed in a non-contact and non-destructive manner. The experimental investigation results compared with the liquid limit determined by the standard method verify that the proposed method reliably and straightforwardly identifies the liquid limit of clay. It is envisioned that the proposed approach could be applied to measuring liquid limit of soil in practical field, entertaining its simple implementation that only requires a digital camera or even a smartphone without the need for special equipment that may be subject to the proficiency of the operator.

• Journal of the Korean Geotechnical Society
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• v.22 no.8
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• pp.33-42
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• 2006

Geosynthetics reinforced soil (GRS) walls with a flexible wall face allow deformation. GRS walls constructed on the weak ground change in both horizontal earth pressures on wall faces and the tensile stress of geosynthetics, affecting the backfill in time until the deformation of the backfill and the foundation is completed. However, there are few studies that were done to measure and analyze the horizontal earth pressures and geosynthetics deformation on GRS walls constructed on the soft ground for a long period of time. Two field GRS walls in this study are constructed on a shallow layer of a weak foundation to measure and analyze geostynthetics deformation, horizontal earth pressures, and pore water pressures for the duration of approximately 16 months. Strain gauges are used to measure geosynthetics deformation; this study specifically suggests a new method of measuring nonwoven geotextile using strain gauges. Most geosynthetics deformation occurred within a month after the construction of GRS walls. The maximum deformation measured for approximately 16 months appeared as follows: nowoven geotextile: 6.05%, woven geotextile: 2.92%, and geogrid: 2.33%. Pore water pressures on the GRS wall can be ignored; however, horizontal earth pressures on the bottom and the upper part of the wall face appear larger than earth pressures at rest.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.3
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• pp.57-67
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• 2023

A flash drought is a rapid-onset drought that develops over a short period of time as weather and environmental factors change rapidly, unlike general droughts, due to meteorological abnormalities. Abnormally high evapotranspiration rates and rapid declines in soil moisture increase vegetation stress. In addition, crop yields may decrease due to flash droughts during crop growth and may damage agricultural and economic ecosystems. In this study, Flash Drought Intensity Index (FDII) based on soil moisture data from Gravity Recovery Climate Experiment (GRACE) was used to analyze flash drought. FDII, which is calculated using soil moisture percentile, is expressed by multiplying two factors: the rate of intensification and the drought severity. FDII was developed for domestic flash drought events from 2014 to 2018. The flash drought that occurred in 2018, Chungcheongbuk-do showed the highest FDII. FDII was higher in heat wave flash drought than in precipitation deficit flash drought. The results of this study show that FDII is reliable flash drought analysis tool and can be applied to quantitatively analyze the characteristics of flash drought in South Korea.