• BMB Reports
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• v.56 no.4
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• pp.246-251
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• 2023

Obesity increases the risk of mortality and morbidity because it results in hypertension, heart disease, and type 2 diabetes. Therefore, there is an urgent need for pharmacotherapeutic drugs to treat obesity. We performed a screening assay using natural products with anti-adipogenic properties in 3T3-L1 cells and determined that tschimganidine, a terpenoid from the Umbelliferae family, inhibited adipogenesis. To evaluate the anti-obesity effects of tschimganidine in vivo. Mice were fed either a normal chow diet (NFD) or a high-fat chow diet (HFD) with or without tschimganidine for 12 weeks. Treatment with tschimganidine decreased lipid accumulation and adipogenesis, accompanied by reduced expression of adipogenesis and lipid accumulation-related factors. Tschimganidine significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and decreased that of AKT. Depletion of AMPK relieved the reduction in lipid accumulation resulting from tschimganidine treatment. Moreover, tschimganidine administration drastically reduced the weight and size of both gonadal white adipose tissue (WAT) and blood glucose levels in high-fat diet-induced obese mice. We suggest that tschimganidine is a potent anti-obesity agent, which impedes adipogenesis and improves glucose homeostasis. Tschimganidine can then be evaluated for clinical application as a therapeutic agent.

• Journal of the Institute of Convergence Signal Processing
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• v.23 no.3
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• pp.123-128
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• 2022

A lot of research is being done to develop a high-efficiency heat pump to save energy, and research to reduce or eliminate the phenomenon of frost occurring in the outdoor unit coil is also being conducted at the same time. In order to conduct a study that does not cause frost on the outdoor unit of the heat pump regardless of the season, a constant temperature chamber like a general room that can be tested under the same conditions as in the natural state was built. The experiment was conducted by providing an environment similar to the natural state to the outdoor unit of the heat pump installed in the constant temperature chamber. As a result, the lower the outdoor temperature, the lower the efficiency of the heat pump. It wat confirmed that the lower the value, the longer it is.

• Journal of Microbiology and Biotechnology
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• v.33 no.10
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• pp.1268-1280
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• 2023

Echinacoside (ECH) is a naturally occurring phenylethanoid glycoside, isolated from Echinacea angustifolia, and this study aimed to analyze its effect on thermogenesis and its interaction with dopaminergic receptors 1 and 5 (DRD1 and DRD5) in 3T3-L1 white adipocytes and mice models. We employed RT-PCR, immunoblot, immunofluorescence, a staining method, and an assay kit to determine its impact. ECH showed a substantial increase in browning signals in vitro and a decrease in adipogenic signals in vivo. Additionally, analysis of the iWAT showed that the key genes involved in beiging, mitochondrial biogenesis, and ATP-dependent thermogenesis were upregulated while adipogenesis and lipogenesis genes were downregulated. OXPHOS complexes, Ca²⁺ signaling proteins as well as intracellular Ca²⁺ levelswere also upregulated in 3T3-L1 adipocytes following ECH treatment. This was collectively explained by mechanistic studies which showed that ECH mediated the beiging process via the DRD1/5-cAMP-PKA and subsequent downstream molecules, whereas it co-mediated the α1-AR-signaling thermogenesis via the DRD1/5/SERCA2b/RyR2/CKmt pathway in 3T3-L1 adipocytes. Animal experiments revealed that there was a 12.28% reduction in body weight gain after the ECH treatment for six weeks. The effects of ECH treatment on adipose tissue can offer more insights into the treatment of obesity and metabolic syndrome.

• Journal of Distribution Science
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• v.22 no.8
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• pp.55-63
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• 2024

Purpose: This study focuses on the golden banana (Kluai Hom Thong) from the Ban Khok Banana Community Enterprise Group in Sang Khom District, Udon Thani Province, Thailand. Despite its potential as an export crop and minimal disease or insect management issues, the group's products struggled to reach international markets due to lack of marketing opportunities, distribution channels, and proper packaging. The research aims to analyze and develop packaging and logos to test market potential for the group's products. Research design, data and methodology: Data was collected through questionnaires developed in conjunction with three printing and packaging design experts. Market testing involved 100 randomly sampled consumers of the group's products. Results: The new packaging design was perceived as more international, modern, and suitable as a souvenir for adults. Conclusions: Integrating ethnic elements and local materials into packaging design can enhance product appeal. For example, creating cloth bags from fabric scraps for carrying local woven products can impress consumers. This approach could help overcome market barriers and improve prospects for golden banana products in international markets while maintaining the intact ecosystem and environment of the production area. The study highlights the importance of effective packaging and branding in addressing market access challenges for local agricultural enterprises, potentially opening new opportunities for community-based businesses.

• Geophysics and Geophysical Exploration
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• v.7 no.4
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• pp.245-250
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• 2004

Horizontal-axes on the seismic section have been represented in a distance unit by applying horizontal-distance correction transformation on a 2-D seismic section of single channel marine seismic data. By drawing horizontal-axes in a distance unit, distortion of horizontal distances shown on the seismic section when the ship speed varies during a survey can be diminished considerably. Position information obtained by GPS and stored in each trace of seismic data as well as data collection windows were used for horizontal distance correction. The minimum window length was decided by considering ship speed and shot interval, and the maximum window length wat determined by reflecting radius of the 1st Fresnel zone. In choosing an optimum window length, horizontal resolution and stacking effect were considered simultaneously. By applying horizontal distance correction we could get a 2-D seismic section which is considered at reflecting the real subsurface structure analogously.

• Korean journal of food and cookery science
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• v.1 no.1
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• pp.65-73
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• 1985

In this study, we tried to compare and determine wat the effects will be to the sensory characteristics and textures of a meat balls when the proportion of the textu-rized soy protein (TSP) varies from 0, 10, 20, 30, and 40％. Evaluation was conducted through sensory evaluation and objective evaluation. The results are as follows: 1. As the level of 40％ TSP increased the meat ball maintained a better appearance. 2. Color, beef flavor, tenderness, juiciness and acceptability shelved the tendency to decrease as TSP proportion increased. (1) No significant change to the outside color revealed to the level of 20％. How-ever, inside color showed a significant change after the level exceeded 20％. (2) Soy flavor tended to increased and beef flavor tended to decrease as the TSP proportion increased. However up to the level of 30％ one could not taste the flavor of soy. (3) Tenderness tended to decrease as the TSP proportion increased however difference was not significant. (4) Juiciness decreased as TSP proportion increased. (5) Acceptability tended to decrease as the TSP proportion increased but to a 40％ addition, the level of TSP did not have much effect on the sensory characteristics as long as sufficient seasonings were added. 3. Instron measurement incidated that springiness, cohesiveness and shear force tended to dcrease as the TSP proportion increased but hardness increased and chewi-ness was the highest at 20％ TSP level. 4. Color and difference meter indicated that the figure L and b tended to increase and AE decreased as the TSP proportion increased. 5. Cooking retention tended to increase as the TSP proportion increased. From thiss tudy, we can conclude that the level of up to 40％ of TSP in making meat ball did not affect the preference.

• Horticultural Science & Technology
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• v.33 no.3
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• pp.340-348
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• 2015

Mowing turfgrasses, especially fast growing species like perennial ryegrass, is one of the most time and money consuming tasks of their management. Trinexapac-ethyl (TE) is a popular plant growth regulator used to reduce mowing requirements, improve stress tolerance, and enhance turf quality. This study was conducted to investigate the effect of TE rate and frequency of applications on growth response and traffic tolerance of perennial ryegrass. The experiment was a split-plot laid out in a randomized complete block (RCB) design with three replications. TE was applied to main plots at 0.00, 0.25, and $0.50kg\;a.i.\;ha^{-1}$. Application pattern included an initial application, followed by two sequential applications at 6-wk intervals. Traffic treatment was applied to subplots with a cleated roller. Results demonstrated that TE consistently reduced vertical shoot growth, clippings dry weight, with maximum growth reduction of 59% and 65%, for 0.25 and $0.50kg\;a.i.\;ha^{-1}$, respectively, occurring at 2 weeks after initial TE treatment (WAT). Traffic also dramatically reduced vertical shoot growth and clippings dry weight. Overall, quality of perennial ryegrass was enhanced by sequential TE applications, however, turf quality and surface coverage reduced greatly under traffic, regardless of TE treatment. Total chlorophyll, chlorophyll a and chlorophyll b and total carbohydrates (TC) contents were also positively influenced following sequential TE application. Our results indicated that TE reduces mowing frequency and enhances turf quality rather than influencing traffic resistance.

• Proceedings of the Korea Association of Information Systems Conference
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• 1996.11a
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• pp.5-26
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• 1996

This study has two research objectives related to end-user computing (EUC). One of the research objectives was to investigate the current status of EUC of Korean firms. Another research objective was to examine the relationship between individual differences of end-users and EUC success. Using survey data from 752 end-users of 23 firms, the surrent status of EUC and the relationship between individual differences of end-users and EUC success were investigated. The current status of EUC was examined from six perspectives: 1). what is the characteristics of EUC strategy of Korean firms, 2). what are the individual characteristics of end-users in Korean Firms, #0. what are the characteristics of tasks performed by end-users using computer, 4). what are the application a areas of EUC, 5). How end-users are satisfied with the support of firms, 6). what are system usage and satisfaction of end-users. It was also foud that individual differences of end-users are related to EUC success. More specifically, it wat shown that the male gender, younger age, higher level of education, higher rank and organizational tenure, higher math ability, thinking type of cognitive style, positive and optimistic attitudes toward computer, more experience with computer, more computer education and knowledge are individual differences variables associated with EUC success. The results of stepwise regression analysis suggested that the individual difference variables accounted for 14%, 25%, 39% and 30% of the variances of four EUC success variables, satisfaction for outcome, satisfaction for ability, frequency of computer use, and the number of tasks, respectively. These empirical findings suggest that EUC managers should consider individual differences of end-users in managing EUC, such as education, training, support, and human resource management, to maximize potential benefits of EUC.

• Archives of design research
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• v.16 no.3
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• pp.341-350
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• 2003

The topic of 21st century's culture is the appearance of digital media. It made changes as big as the industrial revolution, and our society is now ruled by the digital media. The main objective of this study is to forecast the direction of current visual design education by researching and analyzing how the introduction of digital media is influencing the evolution of visual design's identity, which is an ever changing and developing science. Also, since the rain target of digital media is the young generation, the change in the method of expressing visual language is inevitable In fact, there have been a lot of changes in the methods of creating and distributing visual communication due to the introduction of digital media. In the past, most educational institutions of design had similar objectives, curriculums and teaching methods to provide education that prepares students for practical business. However, in this digital media era, the application and utilization of visual design are uncomparably diversified, and it is generally classified as interaction. The purpose of this study is to find a wat to train visual design professionals in this digital era. For this purpose, this study will identify a new educational system that fulfills the demands of this society by fusing the traditional education and the new digital education, and will suggest what an design education institute that is ahead of the demands of society should be like.

• Environmental Analysis Health and Toxicology
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• v.22 no.1 s.56
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• pp.83-90
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• 2007

This study was investigated the effort of growth and gonadal development in olive flounder, Paralichthys olivaceus exposed to PCBs Effluent Allowance Concentration, 3.0 ppb in Korea. Total length, body weight and weight gam of fish were no significant differences between two treatments (control: T.L.-110.0 mm, T.W.-9.61 g: treatment: T.L.-112.8 mm, T.W.-9.68 g), however, weight gain of fish unexposed to PCBs wat observed to increase gradually from 100 days after hatching (30 days after treatment). In the indifferentiated gonad to the juvenile stage, the differentiation of the ovary occured at 60 days after hatching (20 days after treatment) and that of the testis occured at 70 days after hatching (30 days after treatment) in two groups. In the ovary, the oogonia and ovarian lamellar appeared 130 days after hatching (50 days after treatment). The spermatogonia and resticular lobule of the testis were observed at 130 days after hatching (50 days after treatment). Testicular cyst appeared 140 days after hatching (60 days After treatment). There was no difference on the development of ovary and testis. There was no obvious difference of sex ratios. Therefore, These results considerate that PCBs have any effect for growth and gonadal development, but a little act for early growth in olive flounder.