• 대한기계학회논문집
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• 제16권12호
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• pp.2261-2267
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• 1992

본 연구에서는 시일 립의 간섭량과 접촉력에 관련된 이론적 연구를 수행한다. 시일의 접촉면에서 축방향 접촉력이 크게 설계되면 시일 립 선단에서는 마찰과 마멸이 심하게 진행되어 시일수명을 크게 단출시킬 우려가 있고, 접촉력이 작으면 밀봉된 유 체의 누설유려가 증가되면서 볼과 레이스사이의 윤활상태를 나쁘게 하여 베어링 수명 을 크게 단축하는 결과를 초래하게 되므로 시일 립의 접촉력에 관련된 연구는 대단히 중요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.49-54
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• 2014

Background: Hydrogels are a class of polymers that can absorb water or biological fluids and swell to several times their dry volume, dependent on changes in the external environment. In recent years, hydrogels and hydrogel nanocomposites have found a variety of biomedical applications, including drug delivery and cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation. Materials and Methods: In this work, synthesis of hydrogel nanocomposites containing magnetic nanoparticles are studied. At first, magnetic nanoparticles ($Fe_3O_4$) with an average size 10 nm were prepared. At second approach, thermo and pH-sensitive poly (N-isopropylacrylamide -co-methacrylic acid-co-vinyl pyrrolidone) (NIPAAm-MAA-VP) were prepared. Swelling behavior of co-polymer was studied in buffer solutions with different pH values (pH=5.8, pH=7.4) at $37^{\circ}C$. Magnetic iron oxide nanoparticles ($Fe_3O_4$) and doxorubicin were incorporated into copolymer and drug loading was studied. The release of drug, carried out at different pH and temperatures. Finally, chemical composition, magnetic properties and morphology of doxorubicin-loaded magnetic hydrogel nanocomposites were analyzed by FT- IR, vibrating sample magnetometry (VSM), scanning electron microscopy (SEM). Results: The results indicated that drug loading efficiency was increased by increasing the drug ratio to polymer. Doxorubicin was released more at $40^{\circ}C$ and in acidic pH compared to that $37^{\circ}C$ and basic pH. Conclusions: This study suggested that the poly (NIPAAm-MAA-VP) magnetic hydrogel nanocomposite could be an effective carrier for targeting drug delivery systems of anti-cancer drugs due to its temperature sensitive properties.