• Journal of Institute of Control, Robotics and Systems
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• v.10 no.12
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• pp.1164-1171
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• 2004

A new multi-scale simulation model is proposed to analyze heart mechanics. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. The ion transports across cell membrane initiated by action potential induce an excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to calculate the tension of cross bridge which is closely related to the ion dynamics in cytoplasm. To convert the tension on cell level into contraction force of cardiac muscle, we introduce a simple geometric model of ventricle with a thin-walled hemispheric shape. It is assumed that cardiac tissue is composed of a set of cardiac myocytes and its orientation on the hemispheric surface of ventricle remains constant everywhere in the domain. Application of Laplace law to the ventricle model enables us to determine the ventricular pressure that induces blood circulation in a body. A lumped parameter model with 7 compartments is utilized to describe the systemic circulation interacting with the cardiac cell mechanism via NL model and Laplace law. Numerical simulation shows that the ion transports in cell level eventually generate blood hemodynamics on system level via cross bridge dynamics and Laplace law. Computational results using the present multi-scale model are well compared with the existing ones. Especially it is shown that the typical characteristics of heart mechanics, such as pressure volume relation, stroke volume and ejection fraction, can be generated by the present multi-scale cardiovascular model, covering from cardiac cells to circulation system.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.46
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• pp.237-261
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• 2010

Resent East Asian economic growth has lead the increase of global trade volume and global logistics to the level of full-scale development as aiming to have quantitative growth in world trades in one hand and increasing mutual dependence among the East Asian Economic Bloc on the other. In other words, East Asian economic current growth is going along as connecting with 2 different process that are the increase of global trade volume and the technical development of global logistics system. And mutual dependence among the East Asian Economic Bloc shows the deepening trend in production and consumption. While having the flow of expansion in East Asian trade volume and logistics network in mind, this paper will study on trend in East Asian intra-trade and then study on change & tasks in the East Asian Logistics system.

• The KSFM Journal of Fluid Machinery
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• v.19 no.5
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• pp.50-60
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• 2016

A design methodology of the modeled test facility to conserve an injection performance of a passive safety injection system is proposed. This safety injection system is composed of a core makeup tank and a safety injection tank. Individual tanks are connected with pressure balance line on the top side and injection line on the bottom side. It is important to conserve the scaled initial injection flow rate and total injection time since this system can be operated by small gravity head without any active pumps. Differential pressure distribution of the injection line induced by the gravity head is determined by the vertical length and elevation of each tank. However, the total injection time is adjustable by the flow resistance coefficient of the injection line. The scaling methodology for the tank and flow resistance coefficient is suggested. A key point of this test facility design is a scaling analysis for the flow resistance coefficient. The scaling analysis proposed on this paper is based on the volume scaling law with the same vertical length to the prototype and can be extended to a model with a reduced vertical length. A set of passive injection test were performed for the tanks with the same volume and the different length. The test results on the initial flow rate and total injection time showed the almost same injection characteristics and they were in good agreement with the design values.

• Computers and Concrete
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• v.19 no.4
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• pp.375-385
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• 2017

In the present paper experimental and numerical analysis of hook-ended steel fiber reinforced concrete is carried out. The experimental tests are performed on notched beams loaded in 3-point bending using fiber volume fractions up to 1.5%. The numerical analysis of fiber reinforced concrete beams is performed at meso scale. The concrete is discretized with 3D solid finite elements and microplane model is used as a constitutive law. The fibers are modelled by randomly generated 1D truss finite elements, which are connected with concrete matrix by discrete bond-slip relationship. It is demonstrated that the presented approach, which is based on the modelling of concrete matrix using microplane model, able to realistically replicate experimental results. In all investigated cases failure is due to the pull-out of fibers. It is shown that with increase of volume content of fibers the effective bond strength and slip capacity of fibers decreases.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.2
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• pp.31.3-32
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• 2016

We present the radial variations of the scale heights and the vertical velocity dispersions in a sample of nearby edge-on galaxies using BIMA/CARMA $^{12}CO$ ($J=1{\rightarrow}0$), VLA/EVLA HI, and Spitzer $3.6{\mu}m$ data. Both the disk thicknesses and the velocity dispersions of gas and stars vary with radius, contrary to assumptions of previous studies. We investigate how the interstellar gas pressure and the gravitational instability parameter differ from values derived assuming constant velocity dispersions and scale heights. Using the measurement of the disk thicknesses and the derived radial profiles of gas and stars, we estimate the corresponding volume densities. The gravitational instability parameter Q follows a fairly uniform profile with radius and is ${\geq}1$ across the star-forming disk. The star formation law has a slope that is significantly different from those found in more face-on galaxy studies. The midplane gas pressure appears to roughly hold a power-law correlation with the midplane volume density ratio (${\rho}_{H2}/{\rho}_{HI}$).

• Coupled systems mechanics
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• v.7 no.5
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• pp.509-524
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• 2018

A hierarchical multi-scale modeling strategy devoted to the study of a Bitumen-Bound Gravel (BBG) is presented in this paper. More precisely, the paper investigates the temperature-dependent linear viscoelastic of the material when submitted to low deformations levels and moderate number of cycles. In such a hierarchical approach, 3D digital Representative Elementary Volumes are built and the outcomes at a scale (here, the sub-mesoscale) are used as input data at the next higher scale (here, the mesoscale). The viscoelastic behavior of the bituminous phases at each scale is taken into account by means of a generalized Maxwell model: the bulk part of the behavior is separated from the deviatoric one and bulk and shear moduli are expanded into Prony series. Furthermore, the viscoelastic phases are considered to be thermorheologically simple: time and temperature are not independent. This behavior is reproduced by the Williams-Landel-Ferry law. By means of the FE simulations of stress relaxation tests, the parameters of the various features of this temperature-dependent viscoelastic behavior are identified.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.6 no.1
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• pp.23-37
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• 2011

This paper is brought to carry out an empirical study whether evolution process of venture firm's scale is following the Gibrat's law; random evolution process, or Pareto law; self-organizing process. The empirical test, as attaching theoretical explanation, of this research utilize the serial data samples of 92 KOSDAQ listed companies from the year of 2005 through 2008. Summarizing the research results are as followed. First, Gini Coefficients representing the density of venture firm's scale has been constantly reduced since the year of 2005 in terms of number of employee, while these index increased during the same time period from the perspective of sales volume. Second, the evolution process of Korea venture firm's scale is following the Power Law related to Pareto Law. In particular, estimated Pareto coefficient, ${\alpha}$, is shown lower than 1 which is significant result. Third, the probability of joining in the top tier group of firm starting from the early stage growing is forecasted into 6.9%, the result which emphasize the starting scale of venture firm play an important role in long term evolution of venture firm.

• Advances in nano research
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• v.8 no.4
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• pp.283-292
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• 2020

In the present research, differential quadrature (DQ) method has been utilized for investigating free vibrations of porous functionally graded (FG) micro/nano beams in thermal environments. The exact location of neutral axis in FG material has been assumed where the material properties are described via porosity-dependent power-law functions. A scale factor related to couple stresses has been employed for describing size effect. The formulation of scale-dependent beam has been presented based upon a refined beam theory needless of shear correction factors. The governing equations and the associated boundary conditions have been established via Hamilton's rule and then they are solved implementing DQ method. Several graphs are provided which emphasis on the role of porosity dispersion type, porosity volume, temperature variation, scale factor and FG material index on free vibrational behavior of small scale beams.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.11
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• pp.5930-5938
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• 2013

The sigmoid functionally graded mateiral(S-FGM) theory is reformulated using the nonlocal elatictiry of Erigen. The equation of equilibrium of the nonlocal elasticity are derived. This theory has ability to capture the both small scale effects and sigmoid function in terms of the volume fraction of the constituents for material properties through the plate thickness. Navier's method has been used to solve the governing equations for all edges simply supported boundary conditions. Numerical solutions of biaxial buckling of nano-scale plates are presented using this theory to illustrate the effects of nonlocal theory and power law index of sigmoid function on buckling load. The relations between nonlocal and local theories are discussed by numerical results. Further, effects of (i) power law index, (ii) length, (iii) nonlocal parameter, (iv) aspect ratio and (v) mode number on nondimensional biaxial buckling load are studied. To validate the present solutions, the reference solutions are discussed.

• Journal of environmental and Sanitary engineering
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• v.14 no.1
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• pp.54-61
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• 1999

The industrial techniques of ultrasound have been used in the various fields, such as cleaning, medical surgery, emulsification, cell disruption etc. Especially the application of cell disruption was interested in the field of disinfection process in water by ultrasonic irradiation. It has been recognized that the ultrasounds are irradiated in aqueous solution, cavitation bubbles are generated and shock waves of high temperature and pressure are emitted as the bubbles are developed and finally broken, which function as a energy source to promote reaction efficiencies of various kinds of chemical reactions such as disinfection reaction in water. Therefore, this study was performed to apply the ultrasound for the disinfection method of infected drinking raw water and to discuss the limiting factors such as pH, sample volume and reaction temperature influenced on the removal efficiency of E. coli from experimental analysis of the results obtained in bench-scale plant. For the experiments to measure the influence of reaction parameters in the ultrasonic disinfection process, escalated reactivity of aqueous solutions was excellent when pH in aqueous solution was low, and sample volume was small. On the contrary, the reactivity of disinfection became elevated when reaction temperature was high. It was found that the rate constant of disinfection reaction was applied by Chick's law, reaction kinetics of Chick's law was irreversible and pseudo-first order at all the tested conditions.As a conclusion it appeared that the technology using ultrasonic irradiation can be applied to the treatment of disinfection in infected water which are difficult to be treated by conventional methods.