• Proceedings of the KSME Conference
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• 2000.04b
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• pp.835-840
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• 2000

The objective of the present study is to investigate the characteristics of pressure wave propagation of viscous fluid flow in a circular pipe line. The goal of this study is to select the best frequency of each control factor of a circular pipe. We intend to approach a formalized mathematical model by a very exact and reasonable polynomial for fluid transmission lines. and we computed this mathematical model by computer. The results show that the oil viscosity decreased as the length of the circular pipe increases. and The energy of pressure wave propagation decreased as the pipe diameter decreases. The factor is that density of oil was changed resonant frequency. It has been found the viscosity characteristics is changed largely by length of hydraulic pipe and volume of cavity tank.

• Asia pacific journal of information systems
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• v.11 no.3
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• pp.105-126
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• 2001

The objective of research is to find out exogenous variables that influence the usage and performance EDI in the Korea firms. Specifically the goals of this research are; (1) to examine relationships between exogenous variables, such as management, technology, inter-firm relationship characteristics, and EDI performance, and (2) to measure EDI volume, EDI diversity, EDI depth among Korea firms. The questionnaire consists of two versions; One for the EDI system managers and the other for the EDI users. The analysis of this study is designed as cross level to examine the causal relationship among variables in different analysis level. The reliability and validity of data was tested by explanatory factor analysis, Cronbach's alpha coefficient, confirmatory factor analysis, and correlation analysis. Also, the structural equation model(SEM) analysis was performed to test the usefulness of the model. The analysis results revealed that education level, IS growth, trust, support, power are major influential variables on the usage level and performance of EDI. Especially, persuasive power turned out to be more important than coercive power, and technical financial support from organizations was also found to be a significant variables.

• Korea Trade Review
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• v.42 no.2
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• pp.277-296
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• 2017

More than 95% of imports and exports in the World are being transported by vessels. In other words, marine transportation accounts for a large portion of share in the world trade. The purpose of this study is to analyze factors of seaborne trade volume according to items affecting on the world economy. This study conducted a linear regression analysis between seaborne trade volume and the world economy (world GDP) to estimate the correlation between them. Panel data analysis and random effects model analysis have been applied to examine the effect of seaborne trade volume. For this study, the seaborne trade volume is categorized into 10 items, and estimated how much global GDP will be affected when the trade volume changes. In addition, the granger causality test was conducted to verify the relationship between seaborne trade volume and the world GDP. As a result, seaborne trade volume and the world GDP were mutually influenced each other. However, seaborne trade volume affects the world economy more significantly. The items affecting world economic growth include petroleum products, crude oil, chemical products, and so on. The estimated value of the coefficients of petroleum products, crude oil and chemical products were 1.014, 1.013 and 1.010, respectively. The estimated value 1.014 of petroleum products means that the growth rate is 1.014 times higher than the current world GDP growth rate when the seaborne trade volume of petroleum products increased by one unit Lastly, this study examines the seaborne trade volume of 10 categories and then verifies whether the growth rate of world GDP will increase when the volume of seaborne trade increased. This study is expected to provide policy-makers with useful information about formulating policies related to international trade.

• International Journal of Air-Conditioning and Refrigeration
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• v.9 no.3
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• pp.46-56
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• 2001

The present study concerns the numerical simulation of a supply airflow control in a variable air volume (VAY) system. A stratified thermal model (multi-zone model) is suggested to predict a local thermal response of an air-conditioned space. The effects of various thermal parameters such as the cooling system capacity, the thermal mass of an air-conditioned space, the time delay of thermal effect, and the building envelope heat transmission are investigated. Further, the influence of control parameters such as the supply air temperature, the PI control factor and the thermostat location on a VAV system is quantitatively delineated. The results obtained show that the previous homogeneous lumped thermal model (single zone model) may overestimate the time taken to the set point temperature. It is also found that there exist the appropriate ranges of the control parameters for the optimal airflow control of the VAV system.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.7
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• pp.632-641
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• 2000

The present study concerns the simulation of supply-air control in a variable air volume (VAV) system. A stratified lumped thermal model (multi-zone model) is suggested to predict local thermal response of an air-conditioned space. The effects of various thermal parameters such as the cooling system capacity, the thermal mass of air-conditioned space, the time delay of thermal effect, and the building envelope heat transmission are investigated in detail. Further, the influence of control parameters, PI control factor and the sensor location on a VAV system is quantitatively delineated. The results obtained show that the previous homogeneous lumped thermal model (1-zone model) may predict a significantly different thermal response in the air-conditioned space according to the sensor location.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.3
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• pp.177-185
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• 2010

Introduction: Epidermal growth factor receptor (EGFR) is expressed in human epithelial tumors including salivary cancers, and known to be correlated with tumor progression and poor clinical courses in some epithelial tumors. In this study, we determined the therapeutic effect of the anti-EGFR monoclonal antibody Erbitux (C225, cetuximab) in combination with the DNA topoisomerase I inhibitor irinotecan (CPT-11) on human salivary adenoid cystic carcinoma (SACC) cells growing in nude mice. Materials and Methods: At first, immunocytochemical analysis for the expression of EGFR and phosphorylated EGFR (pEGFR) on a human salivary ACC cell line (ACC3). To determine the in vivo effects of Erbitux and CPT-11, nude mice with orthotopic parotid tumors were randomized to receive intraperitoneal Erbitux (1 mg) two times per week, intraperitoneal Irinotecan (50 mg/kg) once per week, Erbitux plus CPT-11, or placebo. (control) Tumor volume and weight were measured. And mechanisms of in vivo activity of Erbitux and/or CPT-11 were determined by immunohistochemical/ immunofluorescent analyses. Results: Immunocytochemical staining of ACC3 demonstrated that EGFR was expressed and phosphorylated. CPT-11 inhibited ACC tumor growth in nude mice. Tumors of mice treated with CPT-11 and CPT-11 plus Erbitux exhibited increased tumor cell apoptosis and decreased microvessel density, which correlated with a decrease in the tumor volume in nude mice. But, CPT-11 seems not to be synergistic with Erbitux in our ACC3 model system. Conclusion: These results suggest that anti-EGFR monoclonal antibody and the DNA topoisomerase I inhibitor will be effective in the treatment of recurred or metastatic lesions of salivary ACC.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.437-442
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• 2015

Aim: To establish a pancreatic cancer stem cell model using human pancreatic cancer cells in nude mice to provide a platform for pancreatic cancer stem cell research. Materials and Methods: To establish pancreatic cancer xenografts using human pancreatic cancer cell line SW1990, nude mice were randomly divided into control and gemcitabine groups. When the tumor grew to a volume of $125mm^3$, they treated with gemcitabine at a dose of 50mg/kg by intraperitoneal injection of 0.2ml in the gemcitabine group, while the mice in control group were treated with the same volume of normal saline. Gemcitabine was given 2 times a week for 3 times. When the model was established, the proliferation of pancreatic cancer stem cells was observed by clone formation assay, and the protein and/or mRNA expression of pancreatic stem cell surface markers including CD24, CD44, CD133, ALDH, transcription factors containing Oct-4, Sox-2, Nanog and Gli, the key nuclear transcription factor in Sonic Hedgehog signaling pathway was detected by Western blot and/or RT-PCR to verify the reliability of this model. Results: This model is feasible and safe. During the establishment, no mice died and the weight of nude mice maintained above 16.5g. The clone forming ability in gemcitabine group was stronger than that of the control group (p<0.01). In gemcitabine group, the protein expression of pancreatic cancer stem cell surface markers including CD44, and ALDH was up-regulated, the protein and mRNA expression of nuclear transcription factor including Oct-4, Sox-2 and Nanog was also significantly increased (P<0.01). In addition, the protein expression of key nuclear transcription factor in Sonic Hedgehog signaling pathway, Gli-1, was significantly enhanced (p<0.01). Conclusions: The pancreatic cancer stem cell model was successfully established using human pancreatic cancer cell line SW1990 in nude mice. Gemcitabine could enrich pancreatic cancer stem cells, simultaneously accompanied by the activation of Sonic Hedgehog signaling pathway.

• Computers and Concrete
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• v.1 no.4
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• pp.389-400
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• 2004

The examinations carried out have confirmed a relationship existing between the character of fracture surfaces and the composition and structure of (basalt and gravel) concretes. For both concretes investigated, a very good correlation was obtained between the profile line development factor, $R_L$, and the fracture surface development factor, $R_S$. With the increase in the $R_L$ parameter, the fracture surface development factor $R_S$ also increased. Agreement between the proposed relationship of $R_S=f(R_L)$ and the proposal given by Coster and Chermant (1983) was obtained. Stereological examinations carried out along with fractographic examinations made it possible to obtain a statistical model for the determination of $R_L$ (or $R_S$) based on the volume of air voids in concrete, $V_{air}$, the specific surface of air pores, $S_V_{air}$ the specific surface of coarse aggregate, $S_{Vagg.}$, and the volume of mortar, $V_m$. An effect of coarse aggregate type on the obtained values of the profile line development factor, $R_L$, as well as on the relationship $R_S=f(R_L)$ was observed. The increment in the fracture surface development factor $R_S$ with increasing $R_L$ parameter was larger in basalt concretes than in gravel concretes, which was a consequence of the level of complexity of fractures formed, resulting chiefly from the shape of coarse aggregate grains.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.50 no.2
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• pp.176-184
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• 2014

Nowadays, consumption of fisheries products is increasing. There are several factors, one of which is a quantitative development through aquaculture. Another factor is an increase qualitative consumption of fish which require that fish be supplied alive. This requires a lot of technical effort to transport the live fish that have low survival rate (c.f. tuna and mackerel) in coastal waters and in the open sea. To develop a towing cage for transporting the live fish, model test in a circulate water channel and simulation by computer tool were carried out. In order to spread vertically, floats were attached at the upper part of the cage, and iron chains attached at the lower part of the cage. For horizontal spreading, kites were attached on the cage. The tension and spreading performance of the cage were measured. The result shows that the tension and reduction ratio of inside volume of the cage were tended to increase with increased towing speeds. The suitable operation condition in towing cage was 1.0 m/s towing speeds with vertical spreading force 8.7 kN, horizontal spreading force 5.6 kN; in this case the reduction ratio of inside volume of the cage was estimated as 25%.

• Journal of IKEEE
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• v.21 no.3
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• pp.288-296
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• 2017

The enhancement of photoluminescence of Au-$TiO_2$ nanoparticles by surface plasmon resonance has been studied extensively by experiment in recent years. For the purpose of optimizing the photoluminescence property of Au-$TiO_2$ nanoparticles, the manufacturing parameters related to the Au nanoparticles and $TiO_2$ nanoparticles need to be considered. In this paper, Drude model and Maier's effective volume method are used to analyze the variation of the metal nanoparticle radius, separation between metal nanoparticle and dielectric molecule, and total absorption cross-section with original radiative efficiency on the photoluminescence property of Au-$TiO_2$ nanoparticles. The results show that to obtain the optimized enhancement factor for photoluminescence process, the size of Au nanoparticle is about 13 - 20 nm, the separation between Au nanoparticle and $TiO_2$ molecule is about 5 -15 nm, the total absorption cross-section of $TiO_2$ molecules is about $1-100nm^2$ and the original radiative efficiency of $TiO_2$ molecule is weak about 0.001- 0.1. With these fabrication parameters, the photoluminescence property of Au-$TiO_2$ nanoparticles can be enhanced several thousand times compared to traditional $TiO_2$ nanoparticles.