• 한국의학물리학회지:의학물리
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• 제7권2호
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• pp.29-40
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• 1996

조사선량율 5mR/h 이상에서 동작하는 원통형 전리함을 설계ㆍ제작하고 상용의 전류계를 이용하여 전하수집 특성을 조사하였다. 전리함은 전체 길이 15.5cm, 직경 5.22cm인 원통형이고 활성체적은 190.4㎤이다. 전리함의 전극은 벽면, 중심축 및 보호전극으로 구성하고, 이들을 동심축상에 배치하여 바탕전류가 8.39$\times$$10^{-14}$ $\pm$1.5$\times$$10^{-15}$ A이 되게 하였다. 전리함에 인가된 전입이 400V일 때 Cs$^{137}$에 대하여 99.7%의 수집효율을 보였으며, 상용의 선량계와 비교한 결과 교정정수 4.531$\times$19$^{7}$ R/C를 구하였다. 에너지 응답특성은 Cs$^{137}$ 을 1로 하였을 때 Am$^{241}$과 Co$^{60}$ 는 각각 1.30, 1.05로 나타났다. 방사선이 전리함의 측면으로 입사할 경우 입사방향에 따른 응답특성의 차이는 무시할 수 있었다.

• 대한한의학방제학회지
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• 제21권1호
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• pp.71-79
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• 2013

Objectives : Yijin-tang has been used in the treatment of gastrointestinal diseases such as irritable bowel syndrome, gastritis, and gastric ulcer. In this study, a high-performance liquid chromatography (HPLC) method was established for simultaneous analysis of six compounds, liquiritin, glycyrrhizin, hesperidin, 6-gingerol, homogentisic acid, and 3,4-dihydroxybenzaldehyde in Yijin-tang, a traditional Korean herbal medicinal preparation. Methods : A Gemini C18 column was used for the separation of six constituents at $40^{\circ}C$. The mobile phase using gradient elution consist of two solvent systems, 1.0% acetic acid in water (A) and 1.0% acetic acid in acetonitrile (B). The flow-rate was 1.0 mL/min and injection volume was $10{\mu}g$. The detector was a photodiode array (PDA) detector set at 254 nm and 280 nm. Results : The calibration curves of six compounds showed good linearity in various concentration ranges ($R^2{\geq}0.9997$). The limits of detection (LOD) and limits of quantification (LOQ) were 0.028-$0.192{\mu}g/mL$ and 0.093-$0.540{\mu}g/mL$, respectively. The RSD (%) of the intra and inter day validations were 0.03-0.84% and 0.05 -1.00%, respectively. Recovery was 96.14-01.90% and RSD (%) was less than 1.5%. Conclusions : The established simultaneous analysis methods will help management to improve the quality of Yijin-tang.

• 대한기계학회논문집
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• 제14권6호
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• pp.1613-1620
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• 1990

본 연구에서는 일반적인 레이저 유속계를 사용하여 광전 증폭관내에 핀흘 대 신에 슬릿(slit)을 장치하고 광전증폭관을 측정영역에 90˚가 되도록 설치하여 in-situ calibration을 수행함으로써 분무의 입경과 속도를 동시에 계측할수 있다는 Yoon의 결과를 이용하고 모든 입자들의 궤적은 동일한 확률을 갖는다는 Yule와 Holve, Self의 가정을 기초로한 수학적인 Deconvolution에 의하여 계측방법에 발생되는 모순 점을 해결하였다. 일반적으로 분무특성해석을 위해서는 분무를 지배하는 기하학적인 변수, 입경분포, 액적의 속도분포, 밀도분포, 입경과 속도의 상관계수, 입자의 증발율 등이 규명 되어야하는데 본 연구에서는 이상류 동축노즐을 제작하고 이의 분무특성을 해석하기위하여 액적의 속도분포, 입경분포, 입경과 속도의 상관계수, 수밀도분포 등 을 계측하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.90-93
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• 2002

In particle radiotherapy, a shape of the beam to conform the irradiation field is statically defined by the compensator, collimator and potal devices at the outside of the patient body. However the target such as lung or liver cancer moves along with respiration. This increases the irradiated volume of normal tissue. Prior discussions about organ motions along with respiration have been mainly focused on inferior-superior movement that was usually perpendicular to beam axis. On the other hand, the change of the target depth along the beam axis is very important especially in particle radiotherapy, because the range end of beam (Bragg peak) is so sharp as to be matched to distal edge of the target. In treatment planning, the range of the particle beam inside the body is calculated using a calibration curve relating CT number and water equivalent path length (WEL) to correct the inhomogeneities of tissues. The variation in CT number along the beam path would cause the uncertainties of range calculation at treatment planning for particle radiotherapy. To estimate the uncertainties of the range calculation associated with patient breathing, we proposed the method using sequential CT images with respiration waveform, and analyzed organ motions and WELs at patients that had lung or liver cancer. The variation of the depth along the beam path was presented in WEL rather than geometrical length. In analyzed cases, WELs around the diaphragm were remarkably changed depending on the respiration, and the magnitude of these WEL variations was almost comparable to inferior-superior movement of diaphragm. The variation of WEL around the lung was influenced by heartbeat.

• 방송공학회논문지
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• 제25권4호
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• pp.598-608
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• 2020

본 논문에서는 실사 3차원 모델 생성용 다시점 카메라 시스템을 통해 획득된 영상에 대한 조명 보상 기법을 제안하고자 한다. 3차원 체적에 대한 촬영은 실내에서 이루어지고 시간에 따른 조명의 위치와 강도는 일정하다고 가정한다. 다시점 카메라는 총 8대를 사용하고, 공간의 중심을 향해서 수렴하는 형태이므로 조명이 일정하다고 할지라도 각 카메라에 입사되는 빛의 강도 및 각도는 다르다. 따라서 모든 카메라는 색상 보정 차트를 촬영하고, 색상 최적화 함수를 이용하여 획득된 8개의 영상 사이의 관계를 정의하는 색상 변환 매트릭스를 획득한다. 이것을 이용하여 색상 보정 차트를 기준으로 모든 카메라로부터 입력되는 영상을 보정한다. 본 논문은 3차원 객체를 8대의 카메라를 이용해 영상 취득할 시 카메라 간의 색차를 최소화하기 위한 컬러 보정 방법을 제안한 것으로 3차원 영상으로 복원 시 영상 간의 색차가 줄어드는 것을 실험적으로 증명하였다.

• 대한수의학회지
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• 제47권2호
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• pp.139-145
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• 2007

Measurement uncertainty could play an important role in the assessment of test results in laboratories and industries. We investigated measurement uncertainties possibly included in determination of flubendazole, a benzimidazole anthelmintic, in pork by HPLC. The concentration of flubendazole was 62.69 ng/g in a sample of pork. Uncertainty was estimated in the analytical procedure of flubendazole. A model equation was made for determination of flubendazole in pork. The four uncertainty components such as weight of sample, volume of sample, calibration curve, and recovery were selected to estimate measurement uncertainties. Standard uncertainty was calculated for each component and all the standard uncertainties were combined. The combined standard uncertainty was expanded to a sample population as an expanded uncertainty. The expanded uncertainty was calculated using k value on Student's t-table and effective degrees of freedom from Welch-Satterthwaite formula. The expanded uncertainty was calculated as 3.45 with the combined standard uncertainty, 1.584 6 and the k value, 2.18. The final expression can be ($62.69{\pm}3.45$) ng/g (confidence level 95%, k = 2.18). The uncertainty value might be estimated differently depending on the selection of the uncertainty components. It is difficult to estimate all the uncertainty factors. Therefore, it is better to take several big effecting components instead of many small effecting components.

• 생약학회지
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• 제47권1호
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• pp.62-72
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• 2016

Banhasasim-tang is a well-known traditional Korean herbal formula and has been used clinically for the treatment of gastric disease, including acute and chronic gastritis, diarrhea and gastric ulcers in Korea. In this study, an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer method was developed for the quantitative determination of the 13 marker constituents, homogentisic acid (1), 3,4-dihydroxybenzaldehyde (2), spinosin (3), liquiritin (4), baicalin (5), ginsenoside Rg1 (6), liquiritigenin (7), wogonoside (8), ginsenoside Rb1 (9), baicalein (10), glycyrrhizin (11), wogonin (12), and 6-gingerol (13) in Banhasasim-tang decoction. Separation of the compounds 1-13 was using an UPLC BEH $C_{18}$ ($100{\times}2.1mm$, $1.7{\mu}m$) column and column oven temperature was maintained at $45^{\circ}C$. The mobile phase consisted of 0.1% (v/v) formic acid in water (A) and acetonitrile (B) by gradient elution. The injection volume and flow rate were $2.0{\mu}L$ and 0.3 mL/min, respectively. Calibration curves of the compounds 1-13 were showed with $r^2$ values ${\geq}0.9908$. The limit of detection and limit of quantification values of the compounds 1-13 were 0.04-1.11 ng/mL and 0.13-3.33 ng/mL, respectively. Among the these compounds, the compounds 1-3 were not detected, while the compounds 4-13 were detected in the ranges of $3.20-107,062.98{\mu}g/g$ in Banhasasim-tang sample.

• 한국동물위생학회지
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• 제28권3호
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• pp.203-213
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• 2005

Oxytetracycline, tetracycline, chlortetracycline and doxycycline in honey were separated by solid phase extraction (SPE) and determined with high performance liquid chromatography (HPLC) with UV/Visible detector. Analysis was carried out using following conditions: XTerra $C_8$ column $(3.9\times150mm\;i.d. 5{\mu}m)$, mobile phase composed of 0.01M oxalic acid : methanol : acetonitrile (820 : 80 : 100, v/v/v), isocratic pump at a flow rate of 0.9 ml/min. and $50{\mu}l$ of injection volume, UV/Visible detector with wavelength of 360nm. The calibration curves of four tetracyclines showed linearity $(\gamma^2>0.999)$ at concentration range of $100\~1,000 ng/ml$. The recoveries in fortified honey represented more than $70\%$ with low coefficient of variation $(<10\%)$ for concentration range of four tetracyclines. The detection limits for oxytetracycline, tetracycline, chlortetracycline and doxycycline were 13.8, 14.6, 26.2 and 24.9ng/g in acacia honey. respectively. We also monitored tetracyclines residue in domestic honey [n : 38, acacia (20), wild flower (18) ] and foreign honey [n=22, legally distributed (13), illegally distributed (9)] using modified Charm II screening and HPLC confirmation methods. Seven of the 60 samples $(11.7\%)$ were suspect positive using modified Charm II screening test. Chlortetracycline residue was found in one foreign honey (illegally distributed) tested at concentrations of 0.22 ppm. Conclusively, for more effective control of tetracyclines used in beekeeping should be further survey for residues in honey and also national guidelines (maximum residue limit : MRL) and methods should be obligatory.

• 한국동물위생학회지
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• 제36권4호
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• pp.303-309
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• 2013

This study was conducted to determine the content of 7 mycotoxins (aflatoxin $B_1$, $B_2$, $G_1$, $G_2$, $M_1$, ochratoxin A and zearalenone) using LC-MS/MS in pork available on the Korean markets. The analysis was carried out using following conditions; C18 column ($2.1{\times}100mm$, $1.7{\mu}m$), mobile phase composed of $H_2O$ (0.1 mM $NH_4Ac$ 0.01% HCOOH) : Methanol (0.1 mM $NH_4Ac$ 0.01% HCOOH), binary pump at a flow rate of 0.5 mL/min and $2{\mu}L$ of injection volume, MS/MS detector with ESI positive and negative mode. The quantication of mycotoxins was based on matrix-matched calibration curves with a correlation coefficient in excess of 0.99 for the 7 mycotoxins. The dectection limits were ranged 0.74~2.13 ng/g, with mean recoveries between 73.10~97.46% except aflatoxin $B_1$ (61.31%). We also monitored mycotoxin residues in 208 pork samples. The test results, mycotoxins were not found except one sample. Ochratoxin A in one sample of the test samples was detected below the quantification limit.

• 한국농공학회논문집
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• 제48권5호
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• pp.29-38
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• 2006

Geographic Information System has extended to higher assessment of water resources. GIS linking with hydrological model becomes a trend in water resource assessment modeling. One of the most popular models is SWAT2000 which have effectiveness in multi-purpose processes for predicting the impact of land management practices on water, sediments and chemicals yields in large complex watershed with varying soils, land uses, and management conditions over long period of time. In this study, SWAT2000 model was applied to Gap stream watershed in Daejeon city where TMDL (Total Maximum Daily Load) Regulation would be implanted. The Gap Stream watershed was partitioned into 8 subbasins, however, only 3 out of 8 subbaisns were observed for having practical gauged data on the basis of streamflow from the year of 2002 to 2005. Gauged streamflow data of Indong, Boksu and Hoeduck stations were used for calibration and validation of the SWAT Streamflow simulation. Estimation Efficiency Analysis (COE), Regression Analysis ($R^{2}$), Relative Error (R.E.) were used for comparing observed streamflow data of the 3 subbasins on the daily and monthly basis with estimated streamflow data in order to fix optimized parameters for the best fitted results. COE value for the daily and monthly streamflow was ranged from 0.45 to 0.96. $R^{2}$ values for daily and monthly streamflow ranged from 0.51 to 0.97. R.E. values for total streamflow volume ranged from 3 % to 22.5 %. The accuracy of the model results shows that the SWAT2000 model can be applicable to Korean watersheds like the Gap Stream watershed that needs to be partitioned into a number of subbasins for TMDL regulation.