• The Journal of Advanced Prosthodontics
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• 제16권3호
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• pp.151-162
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• 2024

PURPOSE. This study aimed to analyze factors influencing the success and failure of implant prostheses and to estimate the lifespan of prostheses using standardized evaluation criteria. An online survey platform was utilized to efficiently gather large samples from multiple institutions. MATERIALS AND METHODS. During the one-year period, patients visiting 16 institutions were assessed using standardized evaluation criteria (KAP criteria). Data from these institutions were collected through an online platform, and various statistical analyses were conducted. Risk factors were assessed using both the Cox proportional hazard model and Cox regression analysis. Survival analysis was conducted using Kaplan-Meier analysis and nomogram, and lifespan prediction was performed using principal component analysis. RESULTS. The number of patients involved in this study was 485, with a total of 841 prostheses evaluated. The median survival was estimated to be 16 years with a 95% confidence interval. Factors found to be significantly associated with implant prosthesis failure, characterized by higher hazard ratios, included the 'type of clinic', 'type of antagonist', and 'plaque index'. The lifespan of implant prostheses that did not fail was estimated to exceed the projected lifespan by approximately 1.34 years. CONCLUSION. To ensure the success of implant prostheses, maintaining good oral hygiene is crucial. The estimated lifespan of implant prostheses is often underestimated by approximately 1.34 years. Furthermore, standardized form, online platform, and visualization tool, such as nomogram, can be effectively utilized in future follow-up studies.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2489-2493
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• 2015

Background: Loss of heterozygosity (LOH) on chromosomal regions is crucial in tumor progression and this study aimed to identify genome-wide LOH in pancreatic cancer. Materials and Methods: Single-nucleotide polymorphism (SNP) profiling data GSE32682 of human pancreatic samples snap-frozen during surgery were downloaded from Gene Expression Omnibus database. Genotype console software was used to perform data processing. Candidate genes with LOH were screened based on the genotype calls, SNP loci of LOH and dbSNP database. Gene annotation was performed to identify the functions of candidate genes using NCBI (the National Center for Biotechnology Information) database, followed by Gene Ontology, INTERPRO, PFAM and SMART annotation and UCSC Genome Browser track to the unannotated genes using DAVID (the Database for Annotation, Visualization and Integration Discovery). Results: The candidate genes with LOH identified in this study were MCU, MICU1 and OIT3 on chromosome 10. MCU was found to encode a calcium transporter and MICU1 could encode an essential regulator of mitochondrial $Ca^{2+}$ uptake. OIT3 possibly correlated with calcium binding revealed by the annotation analyses and was regulated by a large number of transcription factors including STAT, SOX9, CREB, NF-kB, PPARG and p53. Conclusions: Global genomic analysis of SNPs identified MICU1, MCU and OIT3 with LOH on chromosome 10, implying involvement of these genes in progression of pancreatic cancer.

• 디지털융복합연구
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• 제17권8호
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• pp.373-378
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• 2019

다양한 문화와 문명 속에서 예술가들은 새로운 무언가를 창작하기 보다는 고전의 아름다움을 재해석하고 현대에 맞게 정의 하는 새로운 발상을 시도하고 있다. 즉, 현대의 문화 트렌드는 넘쳐나는 많은 정보들 속에서 고전의 감성과 예술가의 현대적 감각이 합쳐지는 새로운 문화가 수행되고 있는 시점이다. 본 연구는 이러한 문화의 변화에 맞춰 다양한 문화와 디자인의 결합을 시도하고자한다. 소설 이효석의 메밀꽃 필 무렵에 나타난 개인의 심리적 정서, 불가능한 체험의 세계를 표현한 특징을 바탕으로 현실과 상상 속 이분화 된 세계의 경계 부분인 불완전한 의식 영역은 사고와 잠재적인 세계로서 독자로 하여금 상상력을 일으키며, 이러한 문학적 서정성은 새로운 문화를 형성하는 분야이다. 또한 시각화하기 좋은 언어의 구성으로 연구자는 소설 속에서의 언어를 바탕으로 그 속에 내재되어 있는 상징적, 심상적 아름다움을 디자인의 소재로 활용하여 조형분석 하고자 한다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.40-40
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• 2023

Atopic dermatitis is a chronic inflammatory skin diseases caused by skin barrier dysfunction. Allium victoralis var. Platyphyllum (AVP) is a perennial plant used as vegetable and herbal medicine. The purpose of this study was to suggest that AVP is a new cosmetic material by examining the effects of AVP on the skin barrier and inflammatory response. A bibliometric network analysis was performed through keyword co-occurrence analysis by extracting author keyword from 69 articles retrieved from SCOPUS. We noted the anti-inflammatory activity shown by the results of clustering and mapping from network visualization analysis using VOSviewer software tool. HPLC-UV analysis showed that AVP contains 0.12 ± 0.02 mg/g of chlorogenic acid and 0.10 ± 0.01 mg/g of gallic acid. AVP at 100 ㎍/mL was shown to increase the mRNA levels of filaggrin and involucrin related to skin barrier function by 1.50-fold and 1.43-fold, respectively. In the scratch assay, AVP at concentrations of 100 ㎍/mL and 200 ㎍/mL significantly increased the cell migration rate and narrowed the scratch area. In addition, AVP suppressed the increase of inflammation-related factors COX-2 and NO and decreased the release of β-hexosaminidase. This study suggests that AVP can be developed as a functional cosmetic material for atopy management through skin barrier protection effects, anti-inflammatory and anti-itch effects.

• Applied Microscopy
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• 제42권2호
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• pp.105-109
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• 2012

Electron tomography (ET) of biological specimens is performed from a series of images obtained over a range of tilt angles in a transmission electron microscope. When using the high voltage electron microscope (HVEM), various noises appear in EM images acquired from thick sections by high voltage electron beam. In order to obtain an adequate result in electron tomograms that allow visualization of rather complex and mega-cellular structure such as brain tissue, it is necessary to remove the noise in each original tilt images of thick section. Using band-pass filtering of original tilt images, the filtered images are obtained and used to assemble a reconstructed tomogram. The qualified 3D tomogram from filtered images results in a considerable reduction of the noises compared to conventional tomogram. In conclusion, this study suggests that band-pass filtering is effective to improve the brightness and intensity of HVEM produced tomograms acquired from micron-thick sections of biological specimens.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2005년도 춘계공동학술대회 발표논문
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• pp.854-861
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• 2005

The functional behavior of a portable consumer electronic (PCE) product is nearly all expressed with human-machine interaction (HMI) tasks. Although physical prototyping and computer aided design (CAD) software can show the appearance of the product, they cannot properly reflect its functional behavior. In this paper, we propose a virtual prototyping (VP) system that incorporates virtual reality and HMI functional simulation in order to enables users to capture not only the realistic look of a PCE product but also its functional behavior. We obtain geometric part models of the product and their assembly and kinematics information with the help of CAD and reverse engineering tools, and visualize them with various display tools. We adopt state transition methodology to capture the HMI functional behavior of the product into a state transition chart, which is later used to construct a finite state machine (FSM) for the functional simulation of the product. The FSM plays an important role to control the transition between states of the product. The proposed VP system receives input events such as mouse clicks on buttons and switches of the virtual prototype model, and it reacts to the events based on the FSM by activating associated activities. The VP system provides the realistic visualization of the product and the vivid simulation of its functional behavior. It can easily allow users to perform functional evaluation and usability testing. Moreover, it can greatly reduce communication errors occurring in a typical product development process. A case study about VP of an MP3 player is given to show the usefulness of the proposed VP system.

• 한국의류학회지
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• 제40권4호
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• pp.660-668
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• 2016

In the $21^{st}$ century of digital information society, design is changing from an analog era that focuses on logical and rational knowledge to a new paradigm of an era focused on sensible communications that can react fast. Design becomes to fulfill sensible needs; moreover, full efforts are being made in the academic research of sensibility evaluation for the conceptualization, quantization, and visualization of design sensibilities based on the measurement and evaluation of sensibility. This study provides insight into a sensibility evaluation method to understand the global user's sensibility in the fashion design field. As for research methods, first, measurement methods of physical, psychological, and physiological reactions to design sensibility were examined through written research on sensibility evaluation in both domestic and overseas research. Next, studies on sensibility during the past 15 years from 2000 to 2014 in the field of domestic fashion design were analyzed to grasp research trends in sensibility evaluation methods; subsequently, suitable sensibility evaluation methods for current fashion design were discussed. As a result of the study, it was shown that most sensibility evaluation studies in the field of domestic fashion design are based on surveys using sensibility terms. However, it requires the process of translating among different terms in different lingual cultures and within the limits of a uniformed evaluation. In this regard, recent cases of overseas design studies have been applying new methods to measure physiological reactions such as eye tracking methods combined with IT. The analysis of multilateral sensibility evaluation methods in this study have significant meaning for use as basic data to establish a planning for an evaluation scale to measure the sensibility of global consumers towards modern fashion design more quantitatively.

• JSTS:Journal of Semiconductor Technology and Science
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• 제1권4호
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• pp.239-247
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• 2001

The Fluorescence-Activated Cell Sorter (FACS) is a well-established instrument used for identifying, enumerating, classifying and sorting cells by their physical and optical characteristics. For a miniaturized FACS device, a disposable plastic microchip has been developed which has a hydrodynamic focusing chamber using soft lithography. As the characteristics of the spatially confined sample stream have an effect on sample throughput, detection efficiency, and the accuracy of cell sorting, systematic fluid dynamic studies are required. Flow visualization is conducted with a laser scanning confocal microscopy (LSCM), and three-dimensional flow structure of the focused sample stream is reconstructed from 2D slices acquired at $1\mutextrm{m}$ intervals in depth. It was observed that the flow structure in the focusing chamber is skewed by unsymmetrical velocity profile arising from trapezoidal cross section of the microchannel. For a quantitative analysis of a microscopic flow structure, Confocal Micro-PIV system has been developed to evaluate the accelerated flow field in the focusing chamber. This study proposes a method which defines the depth of the measurement volume using a detection pinhole. The trajectories of red blood cells (RBCs) and their interactions with surrounding flow field in the squeezed sample stream are evaluated to find optimal shape of the focusing chamber and fluid manipulation scheme for stable cell transporting, efficient detection, and sorting

• 지역사회간호학회지
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• 제8권2호
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• pp.178-196
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• 1997

The purpose of this study is to identify the kind, the frequency, and the type of Stress Management Program(SMPs) throughout life-span used foreign, recent research. The period of this study was from July 1 to Dec. 10, 1997. The data were collected through Medline using two concepts: stress management programs and life-span. The number of these research were 106 and thirty-one experimental researches that were tested the effectiveness of SMPs throughout life span were selected. The data were analysed by the kind, frequency, and life-span. The results were as follows: 1. The kind and frequency of SMP : The total number of the kind of SMP were twenty-two. The most used SMP was relaxation therapy, 22 out of 31. The second biofeedback was 10, the third, cognitive behavior program was 9, the fourth, nutrition and diet, and education were 7. The others were coping skill(4), cognitive therapy(4), breathing(4), imagery(3), autogenic training(3), sleep and rest(2), meditation(2), information(2), desensitization(2), hypnosis(2), behavior therapy(1), time management (1), visualization(I), yoga(I), diversion(1), and problem solving skill. 2. Throughout life-span: Most SMPs were applied to adolescents, young adults, and middle-adults. Other subjects could not be found under the schooler. 3. The type of SMPs : 28(90.3%) out of 31 research used combined-SMP : two-combined SMP, 5: three-combined SMP, twelve: four-combined SMP, seven: five-combined SMP. 4. Afterward, further study such as meta-analysis are needed in order to identify effective ness of the SMPs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1831-1835
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• 2014

Background: To investigate the relationship between extracellular matrix parameters and texture of prostatic lesions evaluated by transrectal real-time tissue elastography (TRTE). Methods: 120 patients suspicious for prostate cancer underwent TRTE. Targeted biopsies were carried out after 12-core systematic biopsy. Epithelia were stained with hematoxylin-eosin, and Victoria blue and Ponceau S were used to stain elastic-collagen fibers, and picric acid-sirius red for visualization of collagen type I (Col1) and III (Col3). Smooth muscles were visualized by immunohistochemistry. All image analyses were performed in a blind manner using Image Pro Plus 6.0, and the area ratios of epithelium, elastic fibers, collagen fibers and Col1/Col3 were determined. Results: 42 patients with typical elastograms were included in the final data analysis. Significant differences were detected between the benign and malignant groups in the area ratios of epithelium (P = 0.01), smooth muscles and Col1/Col3 (P = 0.04, P = 0.02, respectively). There were no significant differences in the area ratios of epithelium, smooth muscle and elastic fibers between the stiff and soft lesion groups. The area ratio of Col1 was ($0.05{\pm}0.03$) in the stiff group, and ($0.02{\pm}0.01$) in the soft group (P= 0.00). However, the area ratio of Col3 was ($0.03{\pm}0.02$) in the stiff group, and ($0.05{\pm}0.04$) in the soft group (P = 0.16). Col1/Col3 in the stiff group ($1.99{\pm}1.59$) was greater than in the soft group ($0.71{\pm}0.64$) (P = 0.01). Conclusions: Tissue hardness of prostatic tumors was mainly dependent on the Col1 content, Col1/Col3 being higher in malignant than in benign lesions, so the prostate tissue texture can be used as a target for distinguishing between the two with TRTE.