• Nuclear Engineering and Technology
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• 제55권7호
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• pp.2642-2649
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• 2023

A real-time unmeasured dynamic response prediction process for the nuclear power plant pressure pipeline is proposed and its performance is tested in the test-loop system (KAERI). The aim of the process is to predict unmeasurable or unreachable dynamic responses such as acceleration, velocity, and displacement by using a limited amount of directly measured physical responses. It is achieved by combining a well-constructed finite element model and robust inverse force identification algorithm. The pressure pipeline system is described by using the displacement-pressure vibro-acoustic formulation to consider fully filled liquid effect inside the pipeline structure. A robust multiphysics modal projection technique is employed for the real-time sensor synchronized prediction. The inverse force identification method is also derived and employed by using Bathe's time integration method to identify the full-field responses of the target system from the modal domain computation. To validate the performance of the proposed process, an experimental test is extensively performed on the nuclear power plant pressure pipeline test-loop under operation conditions. The results show that the proposed identification process could well estimate the unmeasured acceleration in both frequency and time domain faster than 32,768 samples per sec.

• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.201-207
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• 2011

Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors and their activation induces regulation of fatty acid storage and glucose metabolism. Therefore, the $PPAR\gamma$ is a major target for the treatment of type 2 diabetes mellitus. In order to generate pharmacophore model, 1080 known agonists database was constructed and a training set was selected. The Hypo7, selected from 10 hypotheses, contains four features: three hydrogen-bond acceptors (HBA) and one general hydrophobic (HY). This pharmacophore model was validated by using 862 test set compounds with a correlation coefficient of 0.903 between actual and estimated activity. Secondly, CatScramble method was used to verify the model. Hence, the validated Hypo7 was utilized for searching new lead compounds over 238,819 and 54,620 chemical structures in NCI and Maybridge database, respectively. Then the leads were selected by screening based on the pharmacophore model, predictive activity, and Lipinski's rules. Candidates were obtained and subsequently the binding affinities to $PPAR\gamma$ were investigated by the molecular docking simulations. Finally the best two compounds were presented and would be useful to treat type 2 diabetes.

• 한국음향학회지
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• 제43권4호
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• pp.414-421
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• 2024

본 논문에서는 누설에 의한 플랜트 대형사고 방지를 위한 기술로써, 다채널 음향 센서 모듈을 활용해 잔향 및 반향 영향이 큰 환경에서 배관 누설 소음을 탐지할 수 있는 시스템을 설계하고 검증한다. 정사면체 형태로 배열한 4채널 마이크로폰을 하나의 센서 모듈로 설계해, 3차원 음향 인텐시티 벡터를 측정한다. 잔향 및 반향 영향이 큰 환경에서는 센서 모듈 각각의 인텐시티 벡터 측정 오차가 평균적으로 증가하기 때문에, 다수의 센서 모듈을 현장에 배치하여 실제 음원 위치를 추정해야 한다. 따라서, 여러 쌍의 센서 모듈로부터 얻은 3차원 벡터 간 교점을 이용해 음원이 위치한 지점들을 추정해내고, 해당 지점들 중 이상치(예, 반사의 영향으로 현장 외부로 추정된 지점, 주변 구조물에 의한 회절 영향으로 평균 지점에서 먼 지점으로 추정된 지점 등)를 검출해 제외하는 알고리즘을 제안하였다. 현장의 도면상에 누설음 추정 위치 좌표를 1 s 이내에 가시화해 실시간으로 누설음이 발생한 위치를 발견해 즉각적인 대응이 가능한 시스템을 구성하고 검증한다. 본 연구는 대형 플랜트의 사고 대응 능력 향상 및 안전성 확보에도 기여할 수 있을 것으로 기대된다.

• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1707-1714
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• 2012

Grb2 is an adapter protein involved in the signal transduction and cell communication. The Grb2 is responsible for initiation of kinase signaling by Ras activation which leads to the modification in transcription. Ligand based pharmacophore approach was applied to built the suitable pharmacophore model for Grb2. The best pharmacophore model was selected based on the statistical values and then validated by Fischer's randomization method and test set. Hypo1 was selected as a best pharmacophore model based on its statistical values like high cost difference (182.22), lowest RMSD (1.273), and total cost (80.68). It contains four chemical features, one hydrogen bond acceptor (HBA), two hydrophobic (HY), and one ring aromatic (RA). Fischer's randomization results also shows that Hypo1 have a 95% significant level. The correlation coefficient of test set was 0.97 which was close to the training set value (0.94). Thus Hypo1 was used for virtual screening to find the potent inhibitors from various chemical databases. The screened compounds were filtered by Lipinski's rule of five, ADMET and subjected to molecular docking studies. Totally, 11 compounds were selected as a best potent leads from docking studies based on the consensus scoring function and critical interactions with the amino acids in Grb2 active site.

• Bulletin of the Korean Chemical Society
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• 제31권1호
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• pp.52-58
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• 2010

Human histamine H1 receptor (HHR1) is a G protein-coupled receptor and a primary target for antiallergic therapy. Here, the ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software. All ten generated pharmacophore models consist of five essential features: hydrogen bond acceptor, ring aromatic, positive ionizable and two hydrophobic functions. Best model had a correlation coefficient of 0.854 for training set compounds and it was validated with an external test set with a high correlation value of 0.925. Using this model Maybridge database containing 60,000 compounds was screened for potential leads. A rigorous screening for drug-like compounds unveiled RH01692 and SPB00834, two novel molecules for HHR1 with good CATALYST fit and estimated activity values. The new lead molecules were docked into the active site of constructed HHR1 homology model based on recently crystallized squid rhodopsin as template. Both the hit compounds were found to have critical interactions with Glu177, Phe432 and other important amino acids. The interpretations of this study may effectively be deployed in designing of novel HHR1 inverse agonists.

• 문화기술의 융합
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• 제9권6호
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• pp.245-250
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• 2023

현실공간의 정보를 가상의 공간으로 모사하는 디지털 트윈 기술은 다양한 분야에서 채택되고 있다. 디지털 트윈에 대한 관심은 Industry 4.0 기반의 스마트제조와 같은 첨단 제조 분야를 중심으로 관심이 커지고 있다. 그리고 디지털 트윈의 시스템을 운영하면 수많은 데이터가 발생하며 기술의 분야에 따라 발생하는 데이터는 특성이 다르기때문에 효율적으로 자원을 관리하고, 최적화된 디지털 트윈 플랫폼 기술이 필요하다. 첨단 제조 분야를 중심으로 디지털 트윈의 파이프라인에 대한 연구가 지속적으로 진행되어 왔으나 플랜트 분야의 데이터에 적합한 고속의 파이프라인 연구는 아직 부족하다. 그렇기에 본 논문에서는 Apache Kafka를 통해 고속으로 쏟아지는 플랜트분야의 디지털 트윈 데이터에 특화된 파이프라인 설계 방식을 제안한다. 제안된 모델은 플랜트의 정보를 revit 기반으로 적용하고, 플랜트에 특화된 데이터를 Apache Kafka 통해 수집하며, 경량화된 CFD엔진을 탑재하여 기존의 제조 분야의 디지털 트윈 기술보다 플랜트분야에 적합한 디지털 트윈의 모델을 구현할 수 있다.

• Nuclear Engineering and Technology
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• 제46권4호
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• pp.557-568
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• 2014

This paper presents the results of an analysis of wind characteristics and atmosphere dispersion modeling that are based on computational simulation and part of a preliminary study evaluating environmental radiation monitoring system (ERMS) positions within the Barakah nuclear power plant (BNPP). The return period of extreme wind speed was estimated using the Weibull distribution over the life time of the BNPP. In the annual meteorological modeling, the winds from the north and west accounted for more than 90 % of the wind directions. Seasonal effects were not represented. However, a discrepancy in the tendency between daytime and nighttime was observed. Six variations of cesium-137 ($^{137}Cs$) dispersion test were simulated under severe accident condition. The $^{137}Cs$ dispersion was strongly influenced by the direction and speed of the main wind. A virtual receptor was set and calculated for observation of the $^{137}Cs$ movement and accumulation. The results of the surface roughness effect demonstrated that the deposition of $^{137}Cs$ was affected by surface condition. The results of these studies offer useful information for developing environmental radiation monitoring systems (ERMSs) for the BNPP and can be used to assess the environmental effects of new nuclear power plant.

• 한국산업융합학회 논문집
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• 제14권4호
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• pp.157-165
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• 2011

The study figures out the alternatives of training BIM design experts which is the biggest obstacle in training manpower of professional BIM designer, the largest problem when the plant introduce BIM design about the change in Construction Environment by Equipment Based BIM Design in reality of design followed by equipment based BIM design, education institution plan. BIM is the system which is built to make these information be used easier and technique which enables design construction and maintenance in 3-dimensional virtual space by designing buildings in 3-dimensional space, and by data-basing the generated information of every life-cycle information. As the essential contents of the study, educational institutions with the public authority should invest the opening of educational programs, recruit of experts and development of textbooks from a long-term perspective. And also, the role of public institution is important above all for the development of construction industry.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2003년도 춘계전력전자학술대회 논문집(1)
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• pp.133-136
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• 2003

이 논문은 고리 $\#$1 원자력 발전소를 기준 발전소로 하여 개발되고 있는운전원 교육용 가상 시뮬레이터 의 일부로서, 제어봉 제어계통 모델링에 대한 내용을 제시하는 것이 주된 목적이다. 제어봉 제어 계통의 목적은 원자로 출력을 변화시키기 위하여 제어봉 집합체(RCCA)를 동작시켜 단기적인 반응도(Short Term Reactivity)를 조절하기 위한 것이다. 실제 발전소와 똑같은 제어봉 제어가 가능하면, 실제로 운전원이 가상 시뮬레이터를 통해서 모든 상황과 사고들을 대처하는 능력을 가질 수 있도록 설계되었다 본 논문에서는 고리 $\#$1 원자력 발전소 운전원 교육용 가상 시뮬레이터를 구현하기 위해 현재까지 설계된 제어봉 제어계통의 기능, 구성, 제어봉 제어에 대한 전반적인 내용을 제시하고자 한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.1840-1841
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• 2006

Plants with long time-delays can not be often controlled effectively using a simple PID controller. The main reason for this is that the additional phase lag contributed by the time-delay tends to destabilize the closed-loop system. The stability problem can be solved by smith predictor. However, in this case responses are very sensitive to the estimated model errors. To reduce sensitive problem, this paper is presented based on virtual reference feedback tuning of the time delay plant using the closed-loop test to find parameters for a PID controller using the closed-loop test data.