• 한국컴퓨터그래픽스학회논문지
• /
• 제8권2호
• /
• pp.9-14
• /
• 2002

복잡한 도시환경의 경우, 주어진 셀에 대해 적은 수의 오브젝트들만이 보이므로 이러한 가상환경에 대해 가시성 검사를 수행하는 것은 렌더링 성능을 향상시키기 위한 매우 효과적인 방법 중 하나이다. 본 논문에서는 주어진 공간에 대해 잠재적으로 보이는 오브젝트들을 효과적으로 계산하는 새로운 가시성 전처리 방법론을 제안한다. 제안하는 방법론은 일반적인 3차원의 폴리곤 모델을 다루며, 다수의 occluder에 의해 가려지는 오브젝트들을 다룰 수 있다. 제안하는 접근법은 볼륨 가시성 문제를 점 가시성 문제들로 나누고, 점가시성 문제를 하드웨어 가시성 큐어리, 특히 HP_occlusion_test 와 NV_occlusion_query를 이용하여 계산한다. 본 논문에서는 다양한 대규모 가상환경에 대한 실험을 수행하고 이를 통해 본 논문에서 제안하는 알고리즘의 성능을 보인다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권3호
• /
• pp.1571-1576
• /
• 2016

Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제13권12호
• /
• pp.6190-6213
• /
• 2019

For small-scale vector data, restrictions on watermark scheme capacity and robustness limit the use of copyright protection. A watermarking scheme based on robust geometric features and capacity maximization strategy that simultaneously improves capacity and robustness is presented in this paper. The distance ratio and angle of adjacent vertices are chosen as the watermark domain due to their resistance to vertex and geometric attacks. Regarding watermark embedding and extraction, a capacity-improved strategy based on quantization index modulation, which divides more intervals to carry sufficient watermark bits, is proposed. By considering the error tolerance of the vector map and the numerical accuracy, the optimization of the capacity-improved strategy is studied to maximize the embedded watermark bits for each vertex. The experimental results demonstrated that the map distortion caused by watermarks is small and much lower than the map tolerance. Additionally, the proposed scheme can embed a copyright image of 1024 bits into vector data of 150 vertices, which reaches capacity at approximately 14 bits/vertex, and shows prominent robustness against vertex and geometric attacks for small-scale vector data.

• Journal of Power Electronics
• /
• 제3권1호
• /
• pp.62-67
• /
• 2003

Recently, photovoltaic system has been studied widely as a renewable energy system, because it does not produce environmental pollution and it has infinity energy source from the sun. A study on photovoltaic system has a lot of problems like as reappearance and repetition of some situation in the laboratory experiment for development of MPPT algorithm and islanding detection algorithm. because output characteristics of solar cell are varied by irradiation and surface temperature of solar cell. Therefore, the assistant equipment which emulates the solar cell characteristics which can be controlled arbitrarily by researcher is require to the researchers for reliable experimental data. In this paper, the virtual implement of solar cell (VISC) system is proposed to solve these problems and to achieve reliable experimental result on photovoltaic system. VISC system emulates the solar cell output characteristics, and this system can substitute solar cell in laboratory experiment system. To realize the VISC, mathematical model of solar cell is studied for driving converter and the DC/DC converters are compared in viewpoint of tracking error using computer simulation. Output dynamic characteristic of PV array is varied by irradiation and PWM converter performance is studied using PSIM simulator.

• Journal of Information Processing Systems
• /
• 제16권1호
• /
• pp.132-144
• /
• 2020

Cloud computing is an emerging technology based on the concept of enabling data access from anywhere, at any time, from any platform. The exponential growth of cloud users has resulted in the emergence of multiple issues, such as the workload imbalance between the virtual machines (VMs) of data centers in a cloud environment greatly impacting its overall performance. Our axis of research is the load balancing of a data center's VMs. It aims at reducing the degree of a load's imbalance between those VMs so that a better resource utilization will be provided, thus ensuring a greater quality of service. Our article focuses on two phases to balance the workload between the VMs. The first step will be the determination of the threshold of each VM before it can be considered overloaded. The second step will be a task allocation to the VMs by relying on an improved and faster version of the meta-heuristic "simulated annealing (SA)". We mainly focused on the acceptance probability of the SA, as, by modifying the content of the acceptance probability, we could ensure that the SA was able to offer a smart task distribution between the VMs in fewer loops than a classical usage of the SA.

• Geomechanics and Engineering
• /
• 제22권1호
• /
• pp.65-80
• /
• 2020

This paper presents a theoretical investigation on the response of the thermo-mechanical bending of FG plate on variable elastic foundation. A quasi-3D higher shear deformation theory is used that contains undetermined integral forms and involves only four unknowns to derive. The FG plates are supposed simply supported with temperature-dependent material properties and subjected to nonlinear temperature rise. Various homogenization models are used to estimate the effective material properties such as temperature-dependent thermoelastic properties. Equations of motion are derived from the principle of virtual displacements and Navier's solution is used to solve the problem of simply supported plates. Numerical results for deflections and stresses of FG plate with temperature-dependent material properties are investigated. It can be concluded that the proposed theory is accurate and simple in solving the thermoelastic bending behavior of FG thick plates.

• Steel and Composite Structures
• /
• 제33권5호
• /
• pp.663-679
• /
• 2019

In this work, a simple four-variable trigonometric shear deformation model with undetermined integral terms to consider the influences of transverse shear deformation is applied for the dynamic analysis of anti-symmetric laminated composite and soft core sandwich plates. Unlike the existing higher order theories, the current one contains only four unknowns. The equations of motion are obtained using the principle of virtual work. The analytical solution is determined by solving the eigenvalue problem. The influences of geometric ratio, modular ratio and fibre angle are critically evaluated for different problems of laminated composite and sandwich plates. The eigenfrequencies obtained using the current theory are verified by comparing the results with those of other theories and with the exact elasticity solution, if any.

• The Journal of Advanced Prosthodontics
• /
• 제15권1호
• /
• pp.11-21
• /
• 2023

PURPOSE. To compare the sagittal condylar inclination (SCI) in dentate individuals measured by the different methods with mechanical articulator (MA), virtual articulator (VA), and a jaw tracking device (JTD) system. MATERIALS AND METHODS. A total of 22 healthy dentate participants were enrolled in this study. For MA workflow, the SCI was obtained by a semi-adjustable articulator with protrusive interocclusal records. The SCI was also set on a VA by aligning intraoral scan (IOS) with cone beam computed tomography (CBCT) and facial scan (FS), respectively. These virtual workflows were conducted in a dental design software, namely VAI_OS-CBCT and VAI_OS-FS. Meanwhile, a JTD system was also utilized to perform the measurement. Intraclass correlation was used to assess the repeatability within workflows. The bilateral SCI values were compared by Wilcoxon matched-pairs signed rank test for each workflow, and Kruskal-Wallis test and post hoc p-value Bonferroni correction were used to compare the differences among four workflows. The agreement of VAI_OS-CBCT, VAI_OS-FS, and JTD compared with MA was evaluated by Bland-Altman analysis. RESULTS. Intraclass correlation of the SCI revealed a high degree of repeatability for each workflow. There were no significant differences between the left and right sides (P > .05), except for VAI_OS-CBCT (P = .028). Significant differences were not found between MA and VAI_OS-FS (P > .05). Bland-Altman plots indicated VAI_OS-CBCT, VAI_OS-FS, and JTD were considered to substitute MA with high 95% limits of agreement. CONCLUSION. The workflow of VAI_OS-FS provided an alternative approach to measure the SCI compared with MA.

• 대한의생명과학회지
• /
• 제30권1호
• /
• pp.1-9
• /
• 2024

Although there have been several attempts to use virtual reality (VR) in the treatment of depression, the results have been inconsistent and existing studies have mostly relied on subjective measures to assess the effectiveness of VR in improving depression. The aim of this study was to investigate the effect of nature experience-based VR intervention on depressive symptoms in a young population using both subjective and objective measurements. The study population included 15 participants who had more than 14 identifiers of the Korean Beck Depression Inventory (K-BDI)-II. Participants received three weeks (four times per week) of VR intervention. The effectiveness of VR was assessed through changes in K-BDI-II scores and depression-related blood biomarkers. Nature experience-based VR intervention led to an approximately 50% reduction of K-BDI-II score (before 25.7±7.7 vs. after 12.5±8.3 (P<0.001)). Of these, loss of pleasure and fatigue showed the largest amount of improvement. However, levels of cortisol, brain-derived neurotrophic factor, and interleukin-6 did not differ from those at baseline. The findings of our pilot study suggest that nature experience-based VR can be a useful adjunctive treatment method for improving depressive symptoms in individuals who have difficulty accessing the real outside natural environment.

• Smart Structures and Systems
• /
• 제25권4호
• /
• pp.447-457
• /
• 2020

In this study, a simple two-dimensional shear deformation model is employed for buckling analysis of functionally graded (FG) plates. The proposed theory has a kinematic with integral terms which considers the influence of shear deformation without using "shear correction factors". The impact of varying material properties and volume fraction of the constituent on buckling response of the FG plate is examined and discussed. The benefit of this theory over other contributions is that a number of variables is reduced. The basic equations that consider the influence of transverse shear stresses are derived from the principle of virtual displacements. The analytical solutions are obtained utilizing the "Navier method". The accuracy of the proposed theory is proved by comparisons with the different solutions found in the literature.