• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.596-602
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• 2016

Staphylococcus aureus, like other gram-positive pathogens, has evolved a large repertoire of virulence factors as a powerful weapon to subvert the host immune system, among which alpha-hemolysin (Hla), a secreted pore-forming cytotoxin, plays a preeminent role. We observed a concentration-dependent reduction in Hla production by S. aureus in the presence of sub-inhibitory concentrations of isorhamnetin, a flavonoid from the fruits of Hippophae rhamnoides L., which has little antibacterial activity. We further evaluate the effect of isorhamnetin on the transcription of the Hla-encoding gene hla and RNAIII, an effector molecule in the agr system. Isorhamnetin significantly down-regulated RNAIII expression and subsequently inhibited hla transcription. In a co-culture of S. aureus and lung cells, topical isorhamnetin treatment protected against S. aureus-induced cell injury. Isorhamnetin may represent a leading compound for the development of anti-virulence drugs against S. aureus infections.

• 대한수의학회지
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• 제40권4호
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• pp.763-767
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• 2000

본 연구는 1998년부터 1999년까지 서울대학교 수의과대학 부속동물병원에 내원한 개중 자 궁축농중으로 진단된 개의 자궁내용물로부터 균을 분리, 동정하고 항생제 감수성 검사를 실시하여 개 자궁축농증 치료를 위한 기초 자료로 사용하고자 하였다. 위 병원에 내원하여 자궁축농증으로 진단된 개는 16두였으며, 이들로부터 자궁적출술을 이용하여 자궁을 적출한 후 원인균을 분리하였고, 분리된 균에 대하여 15종의 항균제에 대하여 감수성 검사를 실시하였다. 16두의 개로부터 분리된 균은 Escherichia coli 11주, Serratia marcescens 2주, Staphylococcus aureus 및 Salmonella spp 각 l주 씩 이었다. 이들 균주들에 대하여 항균제 감수성 검사를 실시한 결과, 대부분의 균주들이 enrofloxacin, norfloxacin, chloramphenicol, nalidixic acid, gentamicin, Trimethprim-sulfamethazole, tetracycline에 대하여는 높은 감수성을 나타내었고, carbenicillin, amikacin, ampicillin, neomycin에 대하여는 중등도의 감수성을 나타내었으나, vancomycin, streptomycin, bacitracin, colistin에 대하여는 저항성을 나타내었다.

• 한국임상수의학회지
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• 제38권3호
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• pp.147-151
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• 2021

A 5-year-old castrated male Maine Coon cat presented with chronic otitis on the right ear. The clinical signs, scratching and head shaking, were recurrent despite symptomatic treatment, including antibiotics and antifungal agents. Video otoscopic examination and computed tomography (CT) examination revealed a polyp in the right ear canal. The polyp was removed via per-endoscopic trans-tympanic traction (PTT) with a grasping forceps. After treatment, Horner's syndrome occurred in the right eye but spontaneously resolved a week later. The mass was diagnosed as inflammatory polyp with a fibrovascular stroma containing plasma cells, lymphocytes, and neutrophils. All clinical signs were improved, and no recurrence was observed after 3 weeks of follow-up. This case report demonstrates that CT scan is effective in identifying the margin of polyp and PTT technique is non-invasive method for treating inflammatory polyp in cats without severe complications.

• Journal of Veterinary Science
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• 제23권6호
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• pp.81.1-81.10
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• 2022

Background: Snakebites remain a devastating and life-threatening environmental hazard. While the management of snakebites has been well described in humans, few clinical data and guidelines exist for dogs, especially in Korea. Objectives: This retrospective study evaluated the clinical features of 70 dogs with snakebite wounds in Korea. Methods: The medical records of 72 dogs that presented to three animal hospitals from June 2008 to July 2021 were reviewed; among these, 70 dogs that met the inclusion criteria were enrolled. Their signalment, history, clinical signs, physical examination, blood analysis, treatment, and prognosis were also evaluated. Results: Of 70 dog owners, 35 (50%) witnessed the bite, with a mean time between bite and hospital presentation of 9.7 ± 4.1 h in 58 dogs. Blood smears were evaluated in 45 dogs, of which 28 (62%) showed echinocytosis. Anemia and acute kidney injury were found in 21 (29%) and 2 dogs (3%), respectively. A total of 37 dogs (53%) were hospitalized, 5 (7%) of which died. Conclusions: The most significant finding was the high prevalence of echinocytosis. The data from this retrospective study could inform the management of dogs bitten by snakes in Korea.

• 대한수의학회지
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• 제52권2호
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• pp.147-151
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• 2012

Radiography, ultrasonography with hydrogram, and contrast studies using radiopaque markers were applied to evaluate alimentary lymphoma in two cats. The hydrogram facilitated the differentiation of pseudo-thickening from true wall thickening, and enabled an evaluation of wall layering and lymph nodes. In case 1, mechanical obstruction of the duodenum was confirmed with barium-impregnated polyethylene spheres (BIPS), a radiopaque marker; however, results obtained in case 2 were not as definitive. We expect that hydrograms and BIPS can be used as valuable alternative methods to evaluate the gastrointestinal (GI) tract although further studies in cases involving GI tumors are needed.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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• pp.122-122
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• 2003

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2009년도 추계학술대회
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• pp.243-243
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• 2009

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2009년도 추계학술대회
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• pp.242-242
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• 2009

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 추계학술대회
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• pp.183-183
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• 2008

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.607-607
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• 2007